{"id":"https://openalex.org/W2332967595","doi":"https://doi.org/10.1016/j.jalz.2013.05.1132","title":"P3\u2013062: Correlation between CpG DNA methylation levels in peripheral CD4+ T cells and dorsal lateral prefrontal cortex tissue","display_name":"P3\u2013062: Correlation between CpG DNA methylation levels in peripheral CD4+ T cells and dorsal lateral prefrontal cortex tissue","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W2332967595","doi":"https://doi.org/10.1016/j.jalz.2013.05.1132","mag":"2332967595"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2013.05.1132","doi":"https://doi.org/10.1016/j.jalz.2013.05.1132","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2013.05.1132","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107840617","display_name":"Laura Rosenkrantz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laura Rosenkrantz","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022181877","display_name":"Gyan Prakash Srivastava","orcid":"https://orcid.org/0000-0002-3999-2145","observed_orcids":["https://orcid.org/0000-0002-3999-2145"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gyan Srivastava","raw_affiliation_strings":["BWH, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BWH, Boston, Massachusetts, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062071132","display_name":"Anna Kaliszewska","orcid":"https://orcid.org/0000-0001-6545-9822","observed_orcids":["https://orcid.org/0000-0001-6545-9822"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Kaliszewska","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048888729","display_name":"Selina H. Imboywa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selina Imboywa","raw_affiliation_strings":["Brigham and Womens' Hospital, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Womens' Hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026233962","display_name":"Cristin Aubin","orcid":"https://orcid.org/0000-0002-7209-7847","observed_orcids":["https://orcid.org/0000-0002-7209-7847"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristin McCabe","raw_affiliation_strings":["Broad Institute, Cambridge, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute, Cambridge, Massachusetts, United States","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024760189","display_name":"Julie A. Schneider","orcid":"https://orcid.org/0000-0003-0756-5007","observed_orcids":["https://orcid.org/0000-0003-0756-5007"]},"institutions":[{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Schneider","raw_affiliation_strings":["Rush University, Chicago, Illinois, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush University, Chicago, Illinois, United States","institution_ids":["https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014075642","display_name":"David Alan Bennett","orcid":"https://orcid.org/0000-0003-3689-554X","observed_orcids":["https://orcid.org/0000-0003-3689-554X"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Bennett","raw_affiliation_strings":["Rush University Medical Center, Chicago, Illinois, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush University Medical Center, Chicago, Illinois, United States","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049324919","display_name":"Philip L. De Jager","orcid":"https://orcid.org/0000-0002-8057-2505","observed_orcids":["https://orcid.org/0000-0002-8057-2505"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip De Jager","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5107840617"],"corresponding_institution_ids":["https://openalex.org/I1283280774"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.1492,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5763325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":"4S_Part_14","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cpg-methylation","display_name":"CpG methylation","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.799187421798706},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7826843857765198},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7504531145095825},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.597015380859375},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5931242108345032},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5489601492881775},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.47638124227523804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46483561396598816},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4394576847553253},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.43536388874053955},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.34276700019836426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2612646818161011},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2466965615749359},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23633494973182678},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1967202126979828},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18409216403961182},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1572950780391693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1054171621799469},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2013.05.1132","doi":"https://doi.org/10.1016/j.jalz.2013.05.1132","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2013.05.1132","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2308823953","https://openalex.org/W4405836348","https://openalex.org/W2105767248","https://openalex.org/W4411410983","https://openalex.org/W1990958459","https://openalex.org/W4226016725","https://openalex.org/W4413835934","https://openalex.org/W2035260765","https://openalex.org/W2104257412","https://openalex.org/W2560630567"],"abstract_inverted_index":{"Aging":[0,92],"is":[1,29,42,46,187,233,272],"a":[2,15,50,113,148,179,188,239,313,341],"multidimensional":[3],"process":[4],"characterized":[5],"by":[6],"both":[7],"genetic":[8],"and":[9,89,91,176,262],"epigenetic":[10],"changes.":[11],"Epigenetic":[12],"dysregulation":[13],"plays":[14],"key":[16],"role":[17],"in":[18,73,201,218,257,280,294,319,335,348],"the":[19,30,74,84,136,195,221,225,228,281,290,300,305,349],"development":[20],"of":[21,82,150,181,191,197,220,227,230,249,254,266,289,304,315],"diseases":[22],"associated":[23],"with":[24,70,98,251,277,326],"aging.":[25],"While":[26],"brain":[27,214,278,327],"tissue":[28,40,153],"preferred":[31],"medium":[32],"for":[33,125,144,312,344],"studies":[34],"relating":[35],"to":[36,48,57,167,171,216,243,285],"cognitive":[37],"aging,":[38],"this":[39],"type":[41],"limited":[43],"so":[44],"it":[45],"advantageous":[47],"find":[49],"surrogate":[51,342],"marker.":[52],"H":[53],"ere":[54],"we":[55,237],"aim":[56],"discover":[58],"whether":[59],"methylation":[60,71,199,215,217,258,271,279,317,328,334,345],"profiles":[61],"from":[62,79,109,147],"peripheral":[63],"blood":[64,159,261,282],"mononuclear":[65],"cell":[66,269],"samples":[67,283],"(PBMCs)":[68],"correlate":[69],"levels":[72,141,253,259,318],"brain.":[75,263,350],"Samples":[76],"were":[77,102,107,142],"collected":[78],"two":[80,157],"cohorts":[81],"aging:":[83],"Religious":[85],"Orders":[86],"Study":[87],"(ROS)":[88],"Memory":[90],"Project":[93],"(MAP).":[94],"Forty-eight":[95],"deceased":[96],"subjects":[97],"archived":[99],"frozen":[100,110,151],"PBMC":[101],"selected.":[103],"CD4+":[104,204,222,267,320,336],"T":[105,205,268,321,337],"cells":[106,206,322,338],"purified":[108],"PBMCs":[111],"using":[112,135],"Miltenyl":[114],"Biotec":[115],"Automacs":[116],"machine.":[117],"The":[118,264],"Qiagen":[119],"All-Prep":[120],"DNA":[121,126],"kit":[122],"was":[123,130],"used":[124],"extraction.":[127],"Epigenomic":[128],"data":[129],"obtained":[131,162,296],"on":[132],"470,913":[133],"CpGs":[134,250,270],"Illumina":[137],"Humanmethylation450":[138],"beadset.":[139],"Methylation":[140],"recorded":[143],"each":[145],"subject":[146],"sample":[149],"DLPFC":[152],"as":[154,156],"well":[155],"different":[158],"samples:":[160],"one":[161,177,219],"at":[163,297],"study":[164,301],"enrollment,":[165],"up":[166],"12":[168],"years":[169],"prior":[170],"death":[172,182,286],"(time":[173,183],"point":[174,184],"1)":[175],"within":[178],"year":[180],"2).":[185],"There":[186],"large":[189],"excess":[190,248],"positive":[192,255],"correlation":[193,256],"highlighting":[194],"existence":[196],"stable":[198],"signals":[200],"an":[202,247],"individual's":[203],"over":[207],"several":[208],"years'":[209],"time.":[210],"Further,":[211],"when":[212],"comparing":[213],"time":[223],"points,":[224],"mean":[226],"distribution":[229],"total":[231,291],"correlations":[232],"near":[234],"zero,":[235],"but":[236],"see":[238],"skewed":[240],"heavy":[241],"tail":[242],"these":[244],"distributions,":[245],"i.e.,":[246],"high":[252],"between":[260],"proportion":[265],"more":[273],"highly":[274],"correlated":[275,325],"(r>0.5)":[276],"proximal":[284],"(t2)":[287],"(11.5%":[288],"CpGs)":[292],"than":[293],"those":[295],"enrollment":[298],"into":[299],"(t1)":[302],"(4.3%":[303],"total).":[306],"These":[307],"initial":[308],"results":[309],"demonstrate":[310],"that":[311,332],"subset":[314],"CpGs,":[316],"are":[323],"strongly":[324],"levels.":[329],"This":[330],"suggests":[331],"CpG":[333],"could":[339],"be":[340],"marker":[343],"changes":[346],"occurring":[347]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}