{"id":"https://openalex.org/W2332933734","doi":"https://doi.org/10.1093/eurheartj/eht308.p1230","title":"Women treated with second-generation zotarolimus-eluting resolute stents and everolimus-eluting Xience V stents: two-year clinical outcome in the gender-stratified randomized, controlled TWENTE trial","display_name":"Women treated with second-generation zotarolimus-eluting resolute stents and everolimus-eluting Xience V stents: two-year clinical outcome in the gender-stratified randomized, controlled TWENTE trial","publication_year":2013,"publication_date":"2013-08-02","ids":{"openalex":"https://openalex.org/W2332933734","doi":"https://doi.org/10.1093/eurheartj/eht308.p1230","mag":"2332933734"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/eht308.p1230","doi":"https://doi.org/10.1093/eurheartj/eht308.p1230","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/eht308.p1230","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033855482","display_name":"Kenneth Tandjung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766299","display_name":"Medisch Spectrum Twente","ror":"https://ror.org/033xvax87","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801766299"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"K. Tandjung","raw_affiliation_strings":["Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands","institution_ids":["https://openalex.org/I2801766299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025633612","display_name":"Hanim Sen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766299","display_name":"Medisch Spectrum Twente","ror":"https://ror.org/033xvax87","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801766299"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H. Sen","raw_affiliation_strings":["Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands","institution_ids":["https://openalex.org/I2801766299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031852082","display_name":"Ming Kai Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766299","display_name":"Medisch Spectrum Twente","ror":"https://ror.org/033xvax87","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801766299"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. K. Lam","raw_affiliation_strings":["Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands","institution_ids":["https://openalex.org/I2801766299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036599056","display_name":"Martin G. Stoel","orcid":"https://orcid.org/0000-0002-4321-7328","observed_orcids":["https://orcid.org/0000-0002-4321-7328"]},"institutions":[{"id":"https://openalex.org/I2801766299","display_name":"Medisch Spectrum Twente","ror":"https://ror.org/033xvax87","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801766299"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. G. Stoel","raw_affiliation_strings":["Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands","institution_ids":["https://openalex.org/I2801766299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110251281","display_name":"Frits H.A.F. de Man","orcid":"https://orcid.org/0000-0001-5936-2338","observed_orcids":["https://orcid.org/0000-0001-5936-2338"]},"institutions":[{"id":"https://openalex.org/I2801766299","display_name":"Medisch Spectrum Twente","ror":"https://ror.org/033xvax87","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801766299"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"F. H. A. F. De Man","raw_affiliation_strings":["Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands","institution_ids":["https://openalex.org/I2801766299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069983884","display_name":"J. W. Louwerenburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766299","display_name":"Medisch Spectrum Twente","ror":"https://ror.org/033xvax87","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801766299"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. W. Louwerenburg","raw_affiliation_strings":["Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands","institution_ids":["https://openalex.org/I2801766299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038626392","display_name":"Gerard C.M. Linssen","orcid":"https://orcid.org/0000-0002-3339-1955","observed_orcids":["https://orcid.org/0000-0002-3339-1955"]},"institutions":[{"id":"https://openalex.org/I4210149617","display_name":"Ziekenhuis Groep Twente","ror":"https://ror.org/04grrp271","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210149617"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"G. C. M. Linssen","raw_affiliation_strings":["Ziekenhuisgroep Twente, Department of Cardiology, Almelo, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ziekenhuisgroep Twente, Department of Cardiology, Almelo, Netherlands","institution_ids":["https://openalex.org/I4210149617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113595977","display_name":"Rogier L. G. Nijhuis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149617","display_name":"Ziekenhuis Groep Twente","ror":"https://ror.org/04grrp271","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210149617"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R. Nijhuis","raw_affiliation_strings":["Ziekenhuisgroep Twente, Department of Cardiology, Hengelo, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ziekenhuisgroep Twente, Department of Cardiology, Hengelo, Netherlands","institution_ids":["https://openalex.org/I4210149617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111036593","display_name":"M. B. Nienhuis","orcid":"https://orcid.org/0000-0002-0526-6321","observed_orcids":["https://orcid.org/0000-0002-0526-6321"]},"institutions":[{"id":"https://openalex.org/I4210122377","display_name":"Streekziekenhuis Koningin Beatrix","ror":"https://ror.org/02vn5as77","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210122377"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. B. Nienhuis","raw_affiliation_strings":["Streekziekenhuis Koningin Beatrix, Department of Cardiology, Winterswijk, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Streekziekenhuis Koningin Beatrix, Department of Cardiology, Winterswijk, Netherlands","institution_ids":["https://openalex.org/I4210122377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062318295","display_name":"Clemens von Birgelen","orcid":"https://orcid.org/0000-0002-5128-2832","observed_orcids":["https://orcid.org/0000-0002-5128-2832"]},"institutions":[{"id":"https://openalex.org/I2801766299","display_name":"Medisch Spectrum Twente","ror":"https://ror.org/033xvax87","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801766299"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C. Von Birgelen","raw_affiliation_strings":["Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Spectrum Twente, Thoraxcentre, Department of Cardiology, Enschede, Netherlands","institution_ids":["https://openalex.org/I2801766299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"suppl 1","first_page":"P1230","last_page":"P1230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zotarolimus-eluting-stent","display_name":"zotarolimus-eluting stent","score":0.9160000085830688},{"id":"https://openalex.org/keywords/everolimus-eluting-stent","display_name":"everolimus-eluting stent","score":0.9340000152587891},{"id":"https://openalex.org/keywords/xience-v-stent","display_name":"Xience V stent","score":0.9950000047683716},{"id":"https://openalex.org/keywords/drug-eluting-stents","display_name":"drug-eluting stents","score":0.8840000033378601},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.7120000123977661},{"id":"https://openalex.org/keywords/target-vessel-failure","display_name":"target vessel failure","score":0.824999988079071},{"id":"https://openalex.org/keywords/target-lesion-revascularization","display_name":"target lesion revascularization","score":0.8650000095367432},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.8460000157356262},{"id":"https://openalex.org/keywords/long-term-clinical-outcomes","display_name":"long-term clinical outcomes","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9720624685287476},{"id":"https://openalex.org/C2780797203","wikidata":"https://www.wikidata.org/wiki/Q15410168","display_name":"Zotarolimus","level":5,"score":0.8068041801452637},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.7308434247970581},{"id":"https://openalex.org/C2781464078","wikidata":"https://www.wikidata.org/wiki/Q7685898","display_name":"Target lesion","level":4,"score":0.6061028242111206},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.5984077453613281},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5807714462280273},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.4989163875579834},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.48745250701904297},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4865473806858063},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4121996760368347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37265080213546753},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33966076374053955},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.24543970823287964},{"id":"https://openalex.org/C2777546689","wikidata":"https://www.wikidata.org/wiki/Q3973120","display_name":"Drug-eluting stent","level":4,"score":0.24131962656974792},{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.1837644875049591}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartj/eht308.p1230","doi":"https://doi.org/10.1093/eurheartj/eht308.p1230","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/eht308.p1230","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1588642868","https://openalex.org/W1988075354","https://openalex.org/W2105939236","https://openalex.org/W1544067555","https://openalex.org/W45324371","https://openalex.org/W2133272102","https://openalex.org/W2058646500","https://openalex.org/W2153614562","https://openalex.org/W2897889507","https://openalex.org/W1967767653"],"abstract_inverted_index":{"Purpose:":[0],"After":[1],"1":[2],"year":[3],"follow-up,":[4,131],"similar":[5,238],"clinical":[6,204,211],"outcome":[7,205,212,236],"following":[8],"the":[9,25,69,94,98,188],"implantation":[10],"of":[11,49,97,115,148,246],"Resolute":[12,30,74,123,228],"zotarolimus-eluting":[13],"stents":[14,20,52,232],"(ZES)":[15],"and":[16,47,89,118,124,137,222,229],"Xience":[17,32,76,125,230],"V":[18,33,77,126,231],"everolimus-eluting":[19],"(EES)":[21],"was":[22,101,154,206,233,237],"demonstrated":[23],"in":[24,38,53,161,175,203,220,239],"TWENTE":[26,99],"(the":[27],"real-world":[28],"endeavor":[29],"versus":[31],"drug-eluting":[34],"stent":[35,150,181],"(DES)":[36],"study":[37],"Twente)":[39],"trial.":[40],"Nevertheless,":[41],"limited":[42],"data":[43],"on":[44],"long-term":[45],"safety":[46,221],"efficacy":[48,223],"these":[50],"second-generation":[51,248],"\"real":[54],"world\"":[55],"female":[56],"patients":[57,63],"is":[58],"available.":[59],"Methods:":[60],"In":[61],"TWENTE,":[62],"were":[64,113,120],"stratified":[65],"for":[66,71,122],"gender":[67,201],"before":[68],"randomization":[70],"treatment":[72,243],"with":[73,227,244],"or":[75],"stents.":[78],"Target":[79],"vessel":[80,92],"failure":[81,178],"(TVF;":[82],"cardiac":[83],"death,":[84],"target":[85,91,157,176],"vessel-related":[86],"myocardial":[87],"infarction,":[88],"clinically-indicated":[90],"revascularization),":[93],"primary":[95],"endpoint":[96,141],"trial,":[100],"assessed":[102],"after":[103,242],"2":[104],"years.":[105],"Results:":[106],"Among":[107],"1391":[108],"patients,":[109],"382":[110],"(27.5%)":[111],"women":[112,147,163,191,225],"enrolled":[114],"whom":[116],"192":[117],"190":[119],"randomized":[121],"stents,":[127],"respectively.":[128],"At":[129,214],"2-year":[130,215],"TVF":[132],"(11.5%":[133,183],"vs.":[134,184],"10.5%;":[135],"p=0.77)":[136],"a":[138,155,193],"patient-oriented":[139],"composite":[140],"did":[142,169],"not":[143,170],"differ":[144],"significantly":[145],"between":[146,179,224],"both":[149,180,240,247],"arms.":[151],"Although":[152],"there":[153],"higher":[156,194],"lesion":[158,177],"revascularisation":[159],"rate":[160],"Resolute-treated":[162],"(5.2%":[164],"VS":[165],"1.1%,":[166],"p=0.02),":[167],"this":[168],"lead":[171],"to":[172],"significant":[173,200,218],"differences":[174],"arms":[182],"9.5%,":[185],"p=0.53).":[186],"Despite":[187],"fact":[189],"that":[190],"had":[192],"risk":[195],"profile":[196],"than":[197],"men,":[198],"no":[199,217],"difference":[202,219],"observed.":[207],"Table":[208],"1.":[209],"Two-year":[210],"Conclusions:":[213],"follow-up":[216],"treated":[226],"seen.":[234],"Clinical":[235],"genders":[241],"one":[245],"DES.":[249]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}