{"id":"https://openalex.org/W2332859613","doi":"https://doi.org/10.1055/s-0031-1282550","title":"Constituents of Asperula cypria","display_name":"Constituents of Asperula cypria","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2332859613","doi":"https://doi.org/10.1055/s-0031-1282550","mag":"2332859613"},"language":"en","primary_location":{"id":"doi:10.1055/s-0031-1282550","doi":"https://doi.org/10.1055/s-0031-1282550","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0031-1282550","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111573054","display_name":"HAA Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H Ibrahim","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Ege University, Bornova, 35100 \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Ege University, Bornova, 35100 \u0130zmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000817868","display_name":"K Tamer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"K Tamer","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Ege University, Bornova, 35100 \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Ege University, Bornova, 35100 \u0130zmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075058319","display_name":"YS Hasan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142608572","display_name":"Prince Sattam Bin Abdulaziz University","ror":"https://ror.org/04jt46d36","country_code":"SA","type":"education","lineage":["https://openalex.org/I142608572"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"YS Hasan","raw_affiliation_strings":["Department of Pharmacognosy, College of Pharmacy, Al Kharj University, Al Kharj, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, College of Pharmacy, Al Kharj University, Al Kharj, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I142608572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113737959","display_name":"AI Salih","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"AI Salih","raw_affiliation_strings":["Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025998247","display_name":"Ghussun S. Salih","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69050122","display_name":"Near East University","ror":"https://ror.org/02x8svs93","country_code":"CY","type":"education","lineage":["https://openalex.org/I69050122"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"G Salih","raw_affiliation_strings":["Near East University, Institute of Environmental Sciences, Nicosia, Northern Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Near East University, Institute of Environmental Sciences, Nicosia, Northern Cyprus","institution_ids":["https://openalex.org/I69050122"]}]},{"author_position":"last","author":{"id":null,"display_name":"B Erdal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"B Erdal","raw_affiliation_strings":["Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, 35100 \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, 35100 \u0130zmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28597025,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11973","display_name":"Plant chemical constituents analysis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rubiaceae","display_name":"Rubiaceae","score":0.9940000176429749},{"id":"https://openalex.org/keywords/secondary-metabolites","display_name":"secondary metabolites","score":0.7900000214576721},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8899999856948853},{"id":"https://openalex.org/keywords/iridoids","display_name":"iridoids","score":0.9860000014305115},{"id":"https://openalex.org/keywords/anthraquinone-glycosides","display_name":"anthraquinone glycosides","score":0.859000027179718},{"id":"https://openalex.org/keywords/triterpenoids","display_name":"triterpenoids","score":0.8029999732971191},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":0.8360000252723694},{"id":"https://openalex.org/keywords/quercetin-glycosides","display_name":"quercetin glycosides","score":0.8159999847412109},{"id":"https://openalex.org/keywords/asperuloside","display_name":"asperuloside","score":0.8569999933242798},{"id":"https://openalex.org/keywords/oleanolic-acid","display_name":"oleanolic acid","score":0.9509999752044678},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/endemic-plants","display_name":"endemic plants","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2780041788","wikidata":"https://www.wikidata.org/wiki/Q156569","display_name":"Rubiaceae","level":2,"score":0.7879542708396912},{"id":"https://openalex.org/C157369684","wikidata":"https://www.wikidata.org/wiki/Q34740","display_name":"Genus","level":2,"score":0.6967159509658813},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6206591129302979},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.6178452372550964},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5296635031700134},{"id":"https://openalex.org/C2778913731","wikidata":"https://www.wikidata.org/wiki/Q423174","display_name":"Anthraquinone","level":2,"score":0.5200117230415344},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.4858538806438446},{"id":"https://openalex.org/C2994380890","wikidata":"https://www.wikidata.org/wiki/Q11173","display_name":"Chemical constituents","level":2,"score":0.42043086886405945},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40963631868362427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.401226282119751},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37651610374450684},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.1715221107006073},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12275880575180054},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.054355740547180176}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0031-1282550","doi":"https://doi.org/10.1055/s-0031-1282550","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0031-1282550","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2333232136","https://openalex.org/W2002844564","https://openalex.org/W1982304955","https://openalex.org/W2951903489","https://openalex.org/W1971928587","https://openalex.org/W1973330052","https://openalex.org/W2409655079","https://openalex.org/W2354133796","https://openalex.org/W2297553708","https://openalex.org/W1768223777"],"abstract_inverted_index":{"The":[0,46,93,135,166],"family":[1],"Rubiaceae":[2],"is":[3],"represented":[4],"by":[5,24,53,182],"about":[6,13],"500":[7],"genera":[8],"and":[9,31,33,59,104,115,122,132,162,195],"6000":[10],"species,":[11],"with":[12,98,129],"200":[14],"known":[15,124,139],"Asperula":[16,19,51,71],"species":[17,20],"[1].":[18],"are":[21,39],"traditionally":[22],"used":[23],"Lebanese":[25],"people":[26],"to":[27,118,171],"reduce":[28],"blood":[29],"pressure":[30],"inflammation/edema,":[32],"for":[34,176],"diabetes":[35],"[2].":[36],"Moreover":[37],"they":[38],"rich":[40],"sources":[41],"of":[42,49,56,70,77,81,90,137,186],"antimicrobial":[43],"agents":[44],"[3].":[45],"chemical":[47],"composition":[48],"genus":[50],"characterized":[52],"the":[54,67,87,91,138,177,183],"presence":[55],"iridoids,":[57,131],"flavonoids":[58,127],"anthraquinone":[60],"glycosides":[61],"[4,5,6].":[62],"During":[63],"our":[64],"search":[65],"on":[66],"aerial":[68],"parts":[69],"cypria":[72],"Ehrend.,":[73],"an":[74],"endemic":[75],"plant":[76],"Cyprus,":[78],"a":[79,120,133,173],"number":[80],"secondary":[82],"metabolites":[83],"were":[84],"isolated":[85],"from":[86],"methanol":[88],"extract":[89],"plant.":[92],"isolation":[94],"was":[95,141,169],"carried":[96],"out":[97],"several":[99],"chromatographic":[100],"steps":[101],"using":[102],"VLC":[103],"open":[105],"column":[106],"chromatography":[107],"over":[108],"silica-gel,":[109],"reverse":[110],"phase":[111],"silica":[112],"gel":[113],"(RP-18)":[114],"Sephadex":[116],"LH-20":[117],"produce":[119],"new":[121,167],"seven":[123],"compounds,":[125],"four":[126],"together":[128],"two":[130],"triterpene.":[134],"structure":[136],"compounds":[140],"determined":[142],"as":[143],"kaempferol":[144,146],"(1),":[145],"3-O-\u03b2-D":[147],"glucopyranoside":[148],"(Astragalin)":[149],"(2),":[150],"quercetin-3-O-\u03b2-D-glucoside":[151],"(isoquercitrin)":[152],"(3),":[153],"quercetin-3-O-\u03b2-D-galactopyranoside":[154],"(hyperin)":[155],"(4),":[156],"asperulosidic":[157],"acid":[158,164],"(5),":[159],"asperuloside":[160],"(6),":[161],"oleanolic":[163],"(7).":[165],"compound":[168],"elucidated":[170],"be":[172],"phenylethane-C-glycoside,":[174],"encountered":[175],"first":[178],"time":[179],"in":[180],"nature,":[181],"extensive":[184],"use":[185],"1H":[187],"NMR,":[188],"13CNMR\\DEPT,":[189],"1H-1H":[190],"COSY,":[191],"NOESY,":[192],"HSQC,":[193],"HMBC":[194],"LC-MS":[196],"experiments.":[197],"References:":[198],"1.":[199],"Trease":[200],"GE,":[201],"Evans":[202],"WC":[203],"(1989)":[204],"Pharmacognosy.":[205],"English":[206],"Language":[207],"Book":[208],"Society.":[209],"Balliere":[210],"Tindall.":[211],"London.":[212],"2.":[213],"Loizzo":[214],"MR":[215],"et":[216,235,244],"al.":[217,236,245],"(2008)J":[218],"Ethnopharmacol":[219],"119:":[220],"109\u2013116.":[221],"3.":[222],"Kalyoncu":[223],"F":[224],"(2009)":[225],"Iran":[226],"J":[227],"Pharm":[228],"Res":[229],"8:":[230],"263\u2013268.":[231],"4.":[232],"Corrigan":[233],"D":[234],"(1978)":[237],"Phytochemistry":[238],"17:":[239],"1131\u20131133.":[240],"5.":[241],"Borisov":[242],"MI":[243],"(1972)":[246],"Khim":[247],"Prir":[248],"Soedin":[249],"3:":[250],"281\u2013285.":[251],"6.":[252],"Constantinescu":[253],"E":[254],"(1974)":[255],"Farmacia":[256],"22:":[257],"335\u2013344.":[258]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}