{"id":"https://openalex.org/W2332833835","doi":"https://doi.org/10.4164/sptj.41.867","title":"Percutaneous Absorption Study of Biodegradable PLGA Nano-spheres via Human Skin Biopsies","display_name":"Percutaneous Absorption Study of Biodegradable PLGA Nano-spheres via Human Skin Biopsies","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2332833835","doi":"https://doi.org/10.4164/sptj.41.867","mag":"2332833835"},"language":"en","primary_location":{"id":"doi:10.4164/sptj.41.867","doi":"https://doi.org/10.4164/sptj.41.867","is_oa":true,"landing_page_url":"https://doi.org/10.4164/sptj.41.867","pdf_url":"https://www.jstage.jst.go.jp/article/sptj1978/41/12/41_12_867/_pdf","source":{"id":"https://openalex.org/S4210167913","display_name":"Journal of the Society of Powder Technology Japan","issn_l":"0386-6157","issn":["0386-6157","1883-7239"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323999587","host_organization_name":"The Society of Powder Technology, Japan","host_organization_lineage":["https://openalex.org/P4323999587"],"host_organization_lineage_names":["The Society of Powder Technology, Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Society of Powder Technology, Japan","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/sptj1978/41/12/41_12_867/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hiroyuki Tsujimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Tsujimoto","raw_affiliation_strings":["HOSOKAWA POWDER TECHNOLOGY RESEARCH INSTITUTE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HOSOKAWA POWDER TECHNOLOGY RESEARCH INSTITUTE","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033311803","display_name":"Kaori Hara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaori Hara","raw_affiliation_strings":["HOSOKAWA POWDER TECHNOLOGY RESEARCH INSTITUTE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HOSOKAWA POWDER TECHNOLOGY RESEARCH INSTITUTE","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014789397","display_name":"Toyokazu Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toyokazu Yokoyama","raw_affiliation_strings":["HOSOKAWA POWDER TECHNOLOGY RESEARCH INSTITUTE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HOSOKAWA POWDER TECHNOLOGY RESEARCH INSTITUTE","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101694839","display_name":"Hiromitsu Yamamoto","orcid":"https://orcid.org/0000-0002-9294-8872","observed_orcids":["https://orcid.org/0000-0002-9294-8872"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromitsu Yamamoto","raw_affiliation_strings":["Gifu Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifu Pharmaceutical University","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113615409","display_name":"Hirofumi Takeuchi","orcid":"https://orcid.org/0000-0002-7405-3944","observed_orcids":["https://orcid.org/0000-0002-7405-3944"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Takeuchi","raw_affiliation_strings":["Gifu Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifu Pharmaceutical University","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101820043","display_name":"Yoshiaki Kawashim\u00e0","orcid":"https://orcid.org/0000-0001-6139-5948","observed_orcids":["https://orcid.org/0000-0001-6139-5948"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Kawashima","raw_affiliation_strings":["Gifu Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifu Pharmaceutical University","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084705138","display_name":"Kunika Akagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122146667","display_name":"Prefectural University of Hiroshima","ror":"https://ror.org/0059h1f24","country_code":"JP","type":"education","lineage":["https://openalex.org/I122146667","https://openalex.org/I4405287296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunika Akagi","raw_affiliation_strings":["Hiroshima Prefectural University, School of BioSciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hiroshima Prefectural University, School of BioSciences","institution_ids":["https://openalex.org/I122146667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075797192","display_name":"Nobuhiko Miwa","orcid":"https://orcid.org/0000-0003-0136-5952","observed_orcids":["https://orcid.org/0000-0003-0136-5952"]},"institutions":[{"id":"https://openalex.org/I122146667","display_name":"Prefectural University of Hiroshima","ror":"https://ror.org/0059h1f24","country_code":"JP","type":"education","lineage":["https://openalex.org/I122146667","https://openalex.org/I4405287296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiko Miwa","raw_affiliation_strings":["Hiroshima Prefectural University, School of BioSciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hiroshima Prefectural University, School of BioSciences","institution_ids":["https://openalex.org/I122146667"]}]},{"author_position":"last","author":{"id":null,"display_name":"C. C. Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. C. Huang","raw_affiliation_strings":["Hosokawa Nano Particle Technology Center (USA) Summit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosokawa Nano Particle Technology Center (USA) Summit","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1688,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.73309949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"12","first_page":"867","last_page":"875"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plga-nanospheres","display_name":"PLGA nanospheres","score":0.9300000071525574},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.9700000286102295},{"id":"https://openalex.org/keywords/skin-absorption","display_name":"percutaneous absorption","score":0.8880000114440918},{"id":"https://openalex.org/keywords/emulsion-solvent-diffusion","display_name":"emulsion solvent diffusion","score":0.6940000057220459},{"id":"https://openalex.org/keywords/coumarin-6","display_name":"coumarin 6","score":0.9039999842643738},{"id":"https://openalex.org/keywords/skin-penetration","display_name":"skin penetration","score":0.546999990940094},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.7739999890327454},{"id":"https://openalex.org/keywords/skin-care","display_name":"skin care","score":0.7519999742507935},{"id":"https://openalex.org/keywords/biodegradable-nanoparticles","display_name":"biodegradable nanoparticles","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.7981430292129517},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.6270511150360107},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.6100524663925171},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5344763398170471},{"id":"https://openalex.org/C2778123984","wikidata":"https://www.wikidata.org/wiki/Q187634","display_name":"Emulsion","level":2,"score":0.519871711730957},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.47477245330810547},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.4738909602165222},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.46996185183525085},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4459875822067261},{"id":"https://openalex.org/C2780357685","wikidata":"https://www.wikidata.org/wiki/Q154357","display_name":"Nano-","level":2,"score":0.4224734604358673},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.4219714105129242},{"id":"https://openalex.org/C2993661896","wikidata":"https://www.wikidata.org/wiki/Q6557468","display_name":"Liquid paraffin","level":2,"score":0.4143826961517334},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3603593409061432},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3458218574523926},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2938414216041565},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.25416499376296997},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1918405294418335},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.18857061862945557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09921771287918091},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4164/sptj.41.867","doi":"https://doi.org/10.4164/sptj.41.867","is_oa":true,"landing_page_url":"https://doi.org/10.4164/sptj.41.867","pdf_url":"https://www.jstage.jst.go.jp/article/sptj1978/41/12/41_12_867/_pdf","source":{"id":"https://openalex.org/S4210167913","display_name":"Journal of the Society of Powder Technology Japan","issn_l":"0386-6157","issn":["0386-6157","1883-7239"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323999587","host_organization_name":"The Society of Powder Technology, Japan","host_organization_lineage":["https://openalex.org/P4323999587"],"host_organization_lineage_names":["The Society of Powder Technology, Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Society of Powder Technology, Japan","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4164/sptj.41.867","doi":"https://doi.org/10.4164/sptj.41.867","is_oa":true,"landing_page_url":"https://doi.org/10.4164/sptj.41.867","pdf_url":"https://www.jstage.jst.go.jp/article/sptj1978/41/12/41_12_867/_pdf","source":{"id":"https://openalex.org/S4210167913","display_name":"Journal of the Society of Powder Technology Japan","issn_l":"0386-6157","issn":["0386-6157","1883-7239"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323999587","host_organization_name":"The Society of Powder Technology, Japan","host_organization_lineage":["https://openalex.org/P4323999587"],"host_organization_lineage_names":["The Society of Powder Technology, Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Society of Powder Technology, Japan","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2332833835.pdf","grobid_xml":"https://content.openalex.org/works/W2332833835.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1975928081","https://openalex.org/W1987555803","https://openalex.org/W2009513830","https://openalex.org/W2053894104","https://openalex.org/W2059590760","https://openalex.org/W2071026921","https://openalex.org/W2085387089","https://openalex.org/W2332342931","https://openalex.org/W2509461580","https://openalex.org/W3144999141"],"related_works":["https://openalex.org/W4243586134","https://openalex.org/W2391888113","https://openalex.org/W3081912103","https://openalex.org/W2607244820","https://openalex.org/W3018762551","https://openalex.org/W2744657864","https://openalex.org/W4389203853","https://openalex.org/W2039494878","https://openalex.org/W2945785281","https://openalex.org/W2142556382"],"abstract_inverted_index":{"The":[0],"objective":[1],"of":[2,10,49,76,141,152],"this":[3],"research":[4],"was":[5,171],"to":[6,87,96,117,127,173],"demonstrate":[7],"the":[8,31,37,57,97,134,139],"applicability":[9],"PLGA":[11,41,70,111,135,156,169],"nano":[12,42,71,112],"-spheres":[13,43,72,113],"for":[14,145,178],"transdermal":[15,179],"drug":[16,180],"deliveries.By":[17],"applying":[18],"spherical":[19],"crystallization":[20],"with":[21,44],"emulsion":[22],"solvent":[23],"diffusion":[24,65],"method":[25],"in":[26,61,91,122],"an":[27,45],"aqueous":[28],"PVA":[29],"solution,":[30],"pro":[32,107],"-vitamin":[33,108],"C":[34,109,126,131,144,154],"loaded":[35,40,69,110,155],"and":[36,54,81,93,164],"coumarin":[38,67,98],"-6":[39,68,99],"average":[46],"particle":[47],"size":[48],"215":[50],"nm":[51],"were":[52,114,167],"prepared":[53],"tested":[55],"via":[56],"human":[58],"skin":[59,79,147],"biopsies":[60],"a":[62,83,103,175],"modified":[63],"Bronaugh":[64],"chamber.The":[66],"showed":[73],"excellent":[74],"capability":[75],"passing":[77],"through":[78],"pores":[80],"had":[82],"superior":[84],"cutaneous":[85],"penetrability":[86],"deep":[88],"-epidermis,":[89],"both":[90],"speed":[92],"quantity":[94],"compared":[95],"dispersion":[100],"liquid":[101],"at":[102],"much":[104,119],"higher":[105],"concentration.The":[106],"also":[115],"found":[116],"be":[118,174],"more":[120],"effective":[121],"supplying":[123],"reduced":[124,142],"vitamin":[125,143],"deep-skin":[128],"than":[129],"provitamin":[130],"emulsion.In":[132],"addition,":[133],"nanospheres":[136],"could":[137],"prolong":[138],"retention":[140],"better":[146],"care":[148],"results.Furthermore,":[149],"inhibitory":[150],"effects":[151],"pro-vitamin":[153],"nano-spheres":[157],"on":[158],"DNA":[159],"double-strand":[160],"breaks":[161],"by":[162],"UV-A":[163],"UV-B":[165],"irradiations":[166],"confirmed.The":[168],"nano-sphere":[170],"proven":[172],"viable":[176],"vehicle":[177],"delivery":[181],"application.":[182]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2016-06-24T00:00:00"}
