{"id":"https://openalex.org/W2332701550","doi":"https://doi.org/10.1158/1538-7445.am2011-4403","title":"Abstract 4403: Differential cytotoxic effects of atorvastatin in human hepatocellular carcinoma and pancreatic adenocarcinoma cells","display_name":"Abstract 4403: Differential cytotoxic effects of atorvastatin in human hepatocellular carcinoma and pancreatic adenocarcinoma cells","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2332701550","doi":"https://doi.org/10.1158/1538-7445.am2011-4403","mag":"2332701550"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-4403","doi":"https://doi.org/10.1158/1538-7445.am2011-4403","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-4403","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020149497","display_name":"Maria Bonaria Lai","orcid":"https://orcid.org/0000-0001-6065-5525","observed_orcids":["https://orcid.org/0000-0001-6065-5525"]},"institutions":[{"id":"https://openalex.org/I106969075","display_name":"Idaho State University","ror":"https://ror.org/0162z8b04","country_code":"US","type":"education","lineage":["https://openalex.org/I106969075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria B. Lai","raw_affiliation_strings":["1Idaho State University, Pocatello, ID"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Idaho State University, Pocatello, ID","institution_ids":["https://openalex.org/I106969075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045669863","display_name":"Vikas Bhardwaj","orcid":"https://orcid.org/0000-0003-3364-8711","observed_orcids":["https://orcid.org/0000-0003-3364-8711"]},"institutions":[{"id":"https://openalex.org/I106969075","display_name":"Idaho State University","ror":"https://ror.org/0162z8b04","country_code":"US","type":"education","lineage":["https://openalex.org/I106969075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikas Bhardwaj","raw_affiliation_strings":["1Idaho State University, Pocatello, ID"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Idaho State University, Pocatello, ID","institution_ids":["https://openalex.org/I106969075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108397426","display_name":"James C. K. Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106969075","display_name":"Idaho State University","ror":"https://ror.org/0162z8b04","country_code":"US","type":"education","lineage":["https://openalex.org/I106969075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James CK Lai","raw_affiliation_strings":["1Idaho State University, Pocatello, ID"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Idaho State University, Pocatello, ID","institution_ids":["https://openalex.org/I106969075"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000506692","display_name":"Alok Bhushan","orcid":"https://orcid.org/0000-0002-4800-5009","observed_orcids":["https://orcid.org/0000-0002-4800-5009"]},"institutions":[{"id":"https://openalex.org/I106969075","display_name":"Idaho State University","ror":"https://ror.org/0162z8b04","country_code":"US","type":"education","lineage":["https://openalex.org/I106969075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alok Bhushan","raw_affiliation_strings":["1Idaho State University, Pocatello, ID"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Idaho State University, Pocatello, ID","institution_ids":["https://openalex.org/I106969075"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I106969075"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"4403","last_page":"4403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.996999979019165},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.847000002861023},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5770000219345093},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/hmg-coa-reductase-inhibition","display_name":"HMG-CoA reductase inhibition","score":0.906000018119812},{"id":"https://openalex.org/keywords/differential-drug-response","display_name":"differential drug response","score":0.460999995470047},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.6259999871253967},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.7829999923706055},{"id":"https://openalex.org/keywords/aspc-1-cells","display_name":"AsPC-1 cells","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.9335911273956299},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6469223499298096},{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.6177934408187866},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.5857858061790466},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5820693373680115},{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.552483320236206},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.469733327627182},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4509550631046295},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44534674286842346},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.430669903755188},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4086143374443054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34623581171035767},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34389883279800415},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.3420392870903015},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20169156789779663},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1867588460445404},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1430831253528595},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05436563491821289}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-4403","doi":"https://doi.org/10.1158/1538-7445.am2011-4403","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-4403","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2978950114","https://openalex.org/W2072703569","https://openalex.org/W2888576749","https://openalex.org/W2566084983","https://openalex.org/W7095270266","https://openalex.org/W2131246886","https://openalex.org/W2584895338","https://openalex.org/W2337102724","https://openalex.org/W2022681821","https://openalex.org/W4385064101"],"abstract_inverted_index":{"Abstract":[0],"Statins":[1],"are":[2,21],"lipid-lowering":[3],"drugs":[4],"that":[5,52,97,135,163,269,296],"inhibit":[6,62,67],"3-hydroxy-3-methylglutaryl-CoA":[7],"(HMG-CoA)":[8],"reductase,":[9],"the":[10,35,68,77,125,206,235,286,336,341],"rate-limiting":[11],"step":[12],"in":[13,48,85,104,172,196,200,208,224,261,320],"cholesterol":[14,17,63],"synthesis.":[15],"During":[16],"synthesis,":[18,64],"isoprenoid":[19],"intermediates":[20],"also":[22,66],"formed":[23],"which":[24,255],"prenylate":[25],"Ras":[26,38],"and":[27,32,39,58,90,106,116,151,248,309],"Rho":[28,40],"proteins.":[29],"Upon":[30],"prenylation":[31],"transportation":[33],"to":[34,46,55,146,213,311],"plasma":[36],"membrane,":[37],"may":[41,272,283],"interact":[42],"with":[43,137,194,198,219,226,245],"other":[44],"molecules":[45],"partake":[47],"a":[49,82,112,140,276],"signaling":[50],"cascade":[51],"eventually":[53],"lead":[54],"cell":[56,113,127,156,184,209,263,299],"survival":[57,114,157,185,210,300],"proliferation.":[59],"When":[60],"statins":[61],"they":[65],"formation":[69],"of":[70,81,102,143,158,164,222,229,237,335,340],"these":[71],"isoprenoid.":[72],"Our":[73,132,265],"studies":[74],"focus":[75],"on":[76,182],"potential":[78],"anticancer":[79],"effects":[80,101,236],"statin":[83,270,302],"(atorvastatin)":[84],"human":[86],"hepatocellular":[87],"carcinoma":[88],"(HepG2)":[89],"pancreatic":[91,280],"adenocarcinoma":[92],"(AsPC-1)":[93],"cells.":[94,109,166],"We":[95],"hypothesized":[96],"atorvastatin":[98,130,138,171,195],"enhances":[99],"cytotoxic":[100],"cisplatin":[103,199,214,230,238],"HepG2":[105,165,183,201,247],"AsPC-1":[107,159,173,249],"treated":[108,174],"By":[110],"utilizing":[111],"assay":[115],"western":[117],"blot":[118],"analysis,":[119],"we":[120],"found":[121],"marked":[122],"differences":[123],"between":[124],"two":[126],"lines":[128],"after":[129],"treatment.":[131],"results":[133],"indicate":[134],"treatment":[136,215,218,239,271,303],"at":[139,189],"concentration":[141],"range":[142],"0.1":[144],"\u00b5M":[145,148,191,221,228],"20":[147,190,227],"for":[149,170,231,279,289,344],"48":[150,242],"72":[152,232],"hours":[153,233],"significantly":[154],"decreased":[155],"cells,":[160],"but":[161,282],"not":[162,204,284,305],"The":[167,292],"IC50":[168],"value":[169],"cells":[175,202,250],"was":[176,186],"3.5":[177],"\u00b5M;":[178],"whereas,":[179],"no":[180],"effect":[181],"observed":[187],"even":[188],"concentration.":[192],"Treatment":[193],"combination":[197,225],"did":[203],"potentiate":[205],"decrease":[207,297],"as":[211,275],"compared":[212],"alone.":[216,240],"However,":[217],"10":[220],"atrovastatin":[223],"antagonized":[234],"After":[241],"hour":[243],"treatments":[244],"atorvastatin,":[246],"had":[251],"differential":[252],"p-ERK":[253],"expression,":[254],"could":[256],"be":[257,273,312],"an":[258],"important":[259],"factor":[260],"atorvastatin-induced":[262],"death.":[264],"preliminary":[266],"findings":[267],"suggest":[268],"beneficial":[274],"therapeutic":[277],"avenue":[278],"cancer":[281,298],"have":[285,304],"same":[287],"benefits":[288],"liver":[290],"cancer.":[291],"specific":[293],"molecular":[294],"mechanisms":[295],"following":[301],"been":[306],"well":[307],"understood":[308],"needs":[310],"further":[313],"studied.":[314],"[Our":[315],"project":[316],"is":[317],"supported":[318],"by":[319],"part":[321],"from":[322],"NIH":[323],"INBRE":[324],"Grant":[325],"P20RR016454].":[326],"Citation":[327],"Format:":[328],"{Authors}.":[329],"{Abstract":[330],"title}":[331],"[abstract].":[332],"In:":[333],"Proceedings":[334],"102nd":[337],"Annual":[338],"Meeting":[339],"American":[342],"Association":[343],"Cancer":[345,355],"Research;":[346],"2011":[347],"Apr":[348],"2-6;":[349],"Orlando,":[350],"FL.":[351],"Philadelphia":[352],"(PA):":[353],"AACR;":[354],"Res":[356],"2011;71(8":[357],"Suppl):Abstract":[358],"nr":[359],"4403.":[360],"doi:10.1158/1538-7445.AM2011-4403":[361]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}
