{"id":"https://openalex.org/W2332665124","doi":"https://doi.org/10.15204/jkobgy.2013.26.1.001","title":"Effect of Gamijipaesan Extracts against Mastitis Induced by Staphylococcus aureus Infection in a Rat Model through Anti-inflammatory and Antibacterial Effects","display_name":"Effect of Gamijipaesan Extracts against Mastitis Induced by Staphylococcus aureus Infection in a Rat Model through Anti-inflammatory and Antibacterial Effects","publication_year":2013,"publication_date":"2013-02-22","ids":{"openalex":"https://openalex.org/W2332665124","doi":"https://doi.org/10.15204/jkobgy.2013.26.1.001","mag":"2332665124"},"language":"en","primary_location":{"id":"doi:10.15204/jkobgy.2013.26.1.001","doi":"https://doi.org/10.15204/jkobgy.2013.26.1.001","is_oa":true,"landing_page_url":"https://doi.org/10.15204/jkobgy.2013.26.1.001","pdf_url":"http://koreascience.or.kr:80/article/JAKO201317642691017.pdf","source":{"id":"https://openalex.org/S4210224348","display_name":"The Journal of Korean Obstetrics and Gynecology","issn_l":"1229-4292","issn":["1229-4292","2508-3619"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Oriental Obstetrics and Gynecology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://koreascience.or.kr:80/article/JAKO201317642691017.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046193782","display_name":"Ji-Myung Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138826464","display_name":"Daegu Haany University","ror":"https://ror.org/045wr3278","country_code":"KR","type":"education","lineage":["https://openalex.org/I138826464"]},{"id":"https://openalex.org/I4405258569","display_name":"Pohang Oriental Medicine Hospital of Daegu Haany University","ror":"https://ror.org/00xdzs422","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I138826464","https://openalex.org/I4405258569","https://openalex.org/I4405259464"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Myung Kwon","raw_affiliation_strings":["Dept. of Oriental Obstetric & Gynecology , College of Oriental Medicine , Daegu Haany University Daegu Haany Univ. Pohang Oriental Medicine Hospital , 907-8 , Daejam-dong , Nam-gu , Pohang-si , Gyeongsangbuk-do","Daegu Haany Univ. Pohang Oriental Medicine Hospital, 907-8, Daejam-dong, Nam-gu, Pohang-si, Gyeongsangbuk-do","Dept. of Oriental Obstetric & Gynecology, College of Oriental Medicine, Daegu Haany University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Oriental Obstetric & Gynecology , College of Oriental Medicine , Daegu Haany University Daegu Haany Univ. Pohang Oriental Medicine Hospital , 907-8 , Daejam-dong , Nam-gu , Pohang-si , Gyeongsangbuk-do","institution_ids":["https://openalex.org/I138826464","https://openalex.org/I4405258569"]},{"raw_affiliation_string":"Daegu Haany Univ. Pohang Oriental Medicine Hospital, 907-8, Daejam-dong, Nam-gu, Pohang-si, Gyeongsangbuk-do","institution_ids":["https://openalex.org/I4405258569"]},{"raw_affiliation_string":"Dept. of Oriental Obstetric & Gynecology, College of Oriental Medicine, Daegu Haany University","institution_ids":["https://openalex.org/I138826464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079589415","display_name":"Dong-Chul Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138826464","display_name":"Daegu Haany University","ror":"https://ror.org/045wr3278","country_code":"KR","type":"education","lineage":["https://openalex.org/I138826464"]},{"id":"https://openalex.org/I4405258569","display_name":"Pohang Oriental Medicine Hospital of Daegu Haany University","ror":"https://ror.org/00xdzs422","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I138826464","https://openalex.org/I4405258569","https://openalex.org/I4405259464"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Chul Kim","raw_affiliation_strings":["Dept. of Oriental Obstetric & Gynecology , College of Oriental Medicine , Daegu Haany University Daegu Haany Univ. Pohang Oriental Medicine Hospital , 907-8 , Daejam-dong , Nam-gu , Pohang-si , Gyeongsangbuk-do","Daegu Haany Univ. Pohang Oriental Medicine Hospital, 907-8, Daejam-dong, Nam-gu, Pohang-si, Gyeongsangbuk-do","Dept. of Oriental Obstetric & Gynecology, College of Oriental Medicine, Daegu Haany University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Oriental Obstetric & Gynecology , College of Oriental Medicine , Daegu Haany University Daegu Haany Univ. Pohang Oriental Medicine Hospital , 907-8 , Daejam-dong , Nam-gu , Pohang-si , Gyeongsangbuk-do","institution_ids":["https://openalex.org/I138826464","https://openalex.org/I4405258569"]},{"raw_affiliation_string":"Daegu Haany Univ. Pohang Oriental Medicine Hospital, 907-8, Daejam-dong, Nam-gu, Pohang-si, Gyeongsangbuk-do","institution_ids":["https://openalex.org/I4405258569"]},{"raw_affiliation_string":"Dept. of Oriental Obstetric & Gynecology, College of Oriental Medicine, Daegu Haany University","institution_ids":["https://openalex.org/I138826464"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":"1","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11226","display_name":"Milk Quality and Mastitis in Dairy Cows","score":0.7416999936103821,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11226","display_name":"Milk Quality and Mastitis in Dairy Cows","score":0.7416999936103821,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.08410000056028366,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mastitis","display_name":"mastitis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8820000290870667},{"id":"https://openalex.org/keywords/intramammary-infection","display_name":"intramammary infection","score":0.7459999918937683},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6679999828338623},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9039999842643738},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8539999723434448},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6129999756813049},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8379999995231628},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.45399999618530273},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.640999972820282},{"id":"https://openalex.org/keywords/traditional-korean-medicine","display_name":"traditional Korean medicine","score":0.43799999356269836},{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":0.7699999809265137},{"id":"https://openalex.org/keywords/piroxicam","display_name":"piroxicam","score":0.9829999804496765},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5339999794960022},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.831330418586731},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6235466003417969},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.5727547407150269},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4523324966430664},{"id":"https://openalex.org/C2776344049","wikidata":"https://www.wikidata.org/wiki/Q835061","display_name":"Mastitis","level":2,"score":0.4453832507133484},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38831424713134766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3482021689414978},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3208840489387512},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2159750759601593},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20229312777519226},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.19804754853248596},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.15204/jkobgy.2013.26.1.001","doi":"https://doi.org/10.15204/jkobgy.2013.26.1.001","is_oa":true,"landing_page_url":"https://doi.org/10.15204/jkobgy.2013.26.1.001","pdf_url":"http://koreascience.or.kr:80/article/JAKO201317642691017.pdf","source":{"id":"https://openalex.org/S4210224348","display_name":"The Journal of Korean Obstetrics and Gynecology","issn_l":"1229-4292","issn":["1229-4292","2508-3619"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Oriental Obstetrics and Gynecology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.15204/jkobgy.2013.26.1.001","doi":"https://doi.org/10.15204/jkobgy.2013.26.1.001","is_oa":true,"landing_page_url":"https://doi.org/10.15204/jkobgy.2013.26.1.001","pdf_url":"http://koreascience.or.kr:80/article/JAKO201317642691017.pdf","source":{"id":"https://openalex.org/S4210224348","display_name":"The Journal of Korean Obstetrics and Gynecology","issn_l":"1229-4292","issn":["1229-4292","2508-3619"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Oriental Obstetrics and Gynecology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2332665124.pdf","grobid_xml":"https://content.openalex.org/works/W2332665124.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W11212147","https://openalex.org/W56737107","https://openalex.org/W154723291","https://openalex.org/W1490298304","https://openalex.org/W1504567645","https://openalex.org/W1775749144","https://openalex.org/W1909177655","https://openalex.org/W1948073540","https://openalex.org/W1965693439","https://openalex.org/W1972089696","https://openalex.org/W1977351452","https://openalex.org/W1977605192","https://openalex.org/W1980027517","https://openalex.org/W1981816788","https://openalex.org/W1987244271","https://openalex.org/W1994352071","https://openalex.org/W1995292515","https://openalex.org/W1997035847","https://openalex.org/W1998875211","https://openalex.org/W2003129079","https://openalex.org/W2009048599","https://openalex.org/W2012992792","https://openalex.org/W2015169542","https://openalex.org/W2017028855","https://openalex.org/W2017081947","https://openalex.org/W2018285325","https://openalex.org/W2024337216","https://openalex.org/W2024450363","https://openalex.org/W2027572824","https://openalex.org/W2032521711","https://openalex.org/W2039421073","https://openalex.org/W2041675688","https://openalex.org/W2043729337","https://openalex.org/W2047577412","https://openalex.org/W2047647557","https://openalex.org/W2056593575","https://openalex.org/W2060699918","https://openalex.org/W2076999078","https://openalex.org/W2080391524","https://openalex.org/W2081815828","https://openalex.org/W2082405851","https://openalex.org/W2082603429","https://openalex.org/W2087571637","https://openalex.org/W2091704738","https://openalex.org/W2094070290","https://openalex.org/W2112881392","https://openalex.org/W2114919086","https://openalex.org/W2117449266","https://openalex.org/W2132382893","https://openalex.org/W2139328513","https://openalex.org/W2140287009","https://openalex.org/W2144005980","https://openalex.org/W2155864378","https://openalex.org/W2163434681","https://openalex.org/W2172084084","https://openalex.org/W2314649741","https://openalex.org/W2396982304","https://openalex.org/W2401808207","https://openalex.org/W4248036824"],"related_works":["https://openalex.org/W2340777754","https://openalex.org/W7125519987","https://openalex.org/W2611514065","https://openalex.org/W2367437280","https://openalex.org/W7015295000","https://openalex.org/W3009065442","https://openalex.org/W2389636777","https://openalex.org/W2043729337","https://openalex.org/W4394739171","https://openalex.org/W2323564152"],"abstract_inverted_index":{"Objectives:":[0],"The":[1,122,153,320],"object":[2],"of":[3,12,55,77,116,171,201,235,261,331,384,388,393],"this":[4,324,461],"study":[5,325],"was":[6],"to":[7],"observe":[8],"the":[9,68,71,100,103,125,144,166,202,265,381,391,394,402],"protective":[10],"effect":[11],"Gamijipaesan":[13],"aqueous":[14],"extracts(GJS),":[15],"which":[16],"has":[17],"been":[18],"traditionally":[19],"used":[20,360],"in":[21,24,41,81,143,147,165,254,276,279,311,314,323,341,378,398,437,440,460],"Korean":[22],"medicine":[23],"obstetrics":[25],"&":[26],"gynecological":[27],"fields":[28],"as":[29,180,239,247,295,307,361,415,431],"anti-infectious":[30,293,335,368,411,458],"and":[31,49,74,87,94,112,138,155,162,173,184,193,206,212,219,228,232,243,246,251,258,273,292,301,350,353,367,390,423,453],"anti-inflammatory":[32,156,305,366,429,451],"agents,":[33],"against":[34,57,175,224,337],"mastitis":[35],"induced":[36],"by":[37],"Staphylococcus":[38],"aureus":[39,59,146,177,278,313,339,439],"infection":[40,340],"a":[42,342],"rat":[43,151,343],"model":[44,344],"through":[45,345],"antibacterial,":[46,347],"antiinflammatory,":[47],"immunomodulatory,":[48],"anti-oxidant":[50,351],"effects.":[51],"Methods:":[52],"Antibacterial":[53],"activities":[54],"GJS":[56,172,192,236,262,285,332,357,389,405,425],"S.":[58,145,176,277,312,338,438],"were":[60,141,158,178,195,237,413],"detected":[61,179,238,414],"using":[62,210],"standard":[63],"agar":[64],"microdilution":[65],"methods,":[66],"with":[67,160,297,380,417,433],"effects":[69,101,157,294,306,336,352,412,430,459],"on":[70,102,124],"bacterial":[72,129,204,267],"invasion":[73,205],"intracellular":[75,207],"killing":[76,208],"individual":[78,385,399],"test":[79],"materials":[80],"human":[82],"mammary":[83,126],"gland":[84],"carcinoma":[85],"cell(MCF-7)":[86],"murine":[88],"macrophages(Raw":[89],"264.7)":[90],"at":[91,216],"MIC1/2,":[92,217],"MIC":[93,170,218],"MIC2":[95],"concentration":[96],"levels.":[97],"In":[98,190,401],"addition,":[99,191],"cell":[104,226],"viability,":[105],"nitric":[106,133],"oxide(NO),":[107],"tumor":[108],"necrosis":[109],"factor(TNF)-":[110],"${\\alpha}$":[111,137,231,272],"interleukin":[113],"(IL)-6":[114],"productions":[115],"LPS":[117],"activated":[118],"Raw":[119,213],"264.7":[120,214],"cells.":[121],"changes":[123],"tissue":[127],"viable":[128],"numbers,":[130],"myeloperoxidae(MPO),":[131],"inducible":[132],"oxide":[134],"synthetase(iNOS),":[135],"TNF-":[136,230,271],"IL-6":[139,233,274],"contents":[140,275],"observed":[142],"vivo":[148,280,315,441],"intramammary":[149,266,281,316,442],"infectious":[150,317,443],"model.":[152],"anti-bacterial":[154],"compared":[159,296,416,432],"ciprofloxacin":[161,174,194,298,418,446],"piroxicam,":[163,255],"respectively":[164],"present":[167,403],"study.":[168,462],"Results:":[169],"$0.860{\\pm}0.428$":[181],"(0.391-1.563)":[182],"mg/ml":[183],"$0.371{\\pm}0.262$":[185],"(0.098-0.782)":[186],"${\\mu}g/ml$":[187,253],",":[188],"respectively.":[189,222,256,284],"also":[196,263,302,424],"showed":[197,288,303,333,408,449,457],"marked":[198],"dosage-dependent":[199],"inhibition":[200],"both":[203,365],"assays":[209],"MCF-7":[211],"cells":[215],"$MIC{\\times}2$":[220],"concentrations,":[221],"$ED_{50}$":[223],"LPS-induced":[225],"viabilities":[227],"NO,":[229],"releases":[234],"0.72,":[240],"0.04,":[241],"0.08":[242],"0.11":[244],"mg/ml,":[245],"19.04,":[248],"4.18,":[249],"5.37":[250],"4.27":[252],"250":[257,329],"500":[259,286,406],"mg/kg":[260,287,300,330,407,420,436],"inhibit":[264],"growth,":[268],"MPO,":[269],"iNOS,":[270],"infected":[282],"rats,":[283,422,444],"quite":[289,409,427],"similar":[290,304,410,428],"antibacterial":[291],"40":[299,419],"piroxicam":[308,434,454],"10":[309,435],"mg/kg,":[310],"models.":[318],"Conclusions:":[319],"results":[321],"obtained":[322],"suggest":[326],"that":[327,356],"over":[328],"favorable":[334],"their":[346],"anti-inflammatory,":[348],"immunomodulatory":[349],"therefore":[354],"expected":[355],"can":[358],"be":[359,376],"alternative":[362],"therapies,":[363],"having":[364],"activities.":[369],"However,":[370],"more":[371],"detail":[372],"mechanism":[373],"studies":[374],"should":[375],"conducted":[377],"future":[379],"efficacy":[382],"tests":[383],"herbal":[386],"composition":[387],"screening":[392],"biological":[395],"active":[396],"compounds":[397],"herbs.":[400],"study,":[404],"treated":[421],"shows":[426],"but":[445],"did":[447,455],"not":[448,456],"any":[450],"effects,":[452]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}