{"id":"https://openalex.org/W2332593577","doi":"https://doi.org/10.1158/1538-7445.am2011-1127","title":"Abstract 1127: Lack of MAPK activation in significant number of uveal melanomas with somatic mutation in GNAQ and GNA11","display_name":"Abstract 1127: Lack of MAPK activation in significant number of uveal melanomas with somatic mutation in GNAQ and GNA11","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2332593577","doi":"https://doi.org/10.1158/1538-7445.am2011-1127","mag":"2332593577"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-1127","doi":"https://doi.org/10.1158/1538-7445.am2011-1127","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-1127","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058519902","display_name":"Mohamed H. Abdel\u2010Rahman","orcid":"https://orcid.org/0000-0002-9493-7894","observed_orcids":["https://orcid.org/0000-0002-9493-7894"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed H. Abdel-Rahman","raw_affiliation_strings":["1Department of Ophthalmology, The Ohio State Univ., Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Ophthalmology, The Ohio State Univ., Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078438533","display_name":"Getachew Boru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Getachew Boru","raw_affiliation_strings":["1Department of Ophthalmology, The Ohio State Univ., Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Ophthalmology, The Ohio State Univ., Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062647105","display_name":"Colleen M. Cebulla","orcid":"https://orcid.org/0000-0002-5636-4968","observed_orcids":["https://orcid.org/0000-0002-5636-4968"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen M. Cebulla","raw_affiliation_strings":["1Department of Ophthalmology, The Ohio State Univ., Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Ophthalmology, The Ohio State Univ., Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111830436","display_name":"Benjamin N. Christopher","orcid":"https://orcid.org/0009-0007-3315-2755","observed_orcids":["https://orcid.org/0009-0007-3315-2755"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Christopher","raw_affiliation_strings":["1Department of Ophthalmology, The Ohio State Univ., Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Ophthalmology, The Ohio State Univ., Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086283574","display_name":"James B. Massengill","orcid":"https://orcid.org/0000-0003-1547-3970","observed_orcids":["https://orcid.org/0000-0003-1547-3970"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James B. Massengill","raw_affiliation_strings":["1Department of Ophthalmology, The Ohio State Univ., Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Ophthalmology, The Ohio State Univ., Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003053579","display_name":"Davidorf H. Frederick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Davidorf H. Frederick","raw_affiliation_strings":["1Department of Ophthalmology, The Ohio State Univ., Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Ophthalmology, The Ohio State Univ., Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"1127","last_page":"1127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gnaq-mutation","display_name":"GNAQ mutation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/gna11-mutation","display_name":"GNA11 mutation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mapk-activation","display_name":"MAPK activation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mek-phosphorylation","display_name":"MEK phosphorylation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.7490000128746033},{"id":"https://openalex.org/keywords/pd184352","display_name":"PD184352","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.656000018119812},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2779176653","wikidata":"https://www.wikidata.org/wiki/Q18026236","display_name":"GNAQ","level":4,"score":0.998684287071228},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.572466254234314},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5193818211555481},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.4874322712421417},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.46675777435302734},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4288955330848694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36866670846939087},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3438878655433655},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32767754793167114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2522406578063965},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22246351838111877}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-1127","doi":"https://doi.org/10.1158/1538-7445.am2011-1127","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-1127","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2948500780","https://openalex.org/W2150772498","https://openalex.org/W2090787537","https://openalex.org/W2039939270","https://openalex.org/W2010431901","https://openalex.org/W1973374541","https://openalex.org/W3083361140","https://openalex.org/W2077517114","https://openalex.org/W2024640232","https://openalex.org/W4362525543"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"The":[2,78,142,163],"aims":[3],"of":[4,33,41,62,68,80,96,128,144,167,178,189,237,246,291,302,344,349],"this":[5],"study":[6],"were":[7,58,101,160,197],"to":[8,28,333],"investigate":[9,29],"the":[10,30,69,94,129,168,180,183,187,192,201,247,266,345,350],"correlation":[11],"between":[12],"MAPK":[13,83,313],"activation":[14],"and":[15,20,27,47,52,71,98,117,135,152,158,223],"somatic":[16,173,305],"mutation":[17,174,253],"in":[18,23,43,65,74,89,107,175,194,215,218,221,225,234,286,307],"GNAQ":[19,46,70,113,138,181,207,241,252,292,308],"GNA11":[21,48,72,115,184,209,243,310],"genes":[22,73],"uveal":[24],"melanoma":[25],"(UM)":[26],"potential":[31],"utility":[32],"MEK":[34,148,275,318,326],"inhibition":[35,319],"as":[36],"a":[37,299],"target":[38],"for":[39,60,353],"therapy":[40],"UM":[42,119,130,155,170,203,238,248,278,287,303],"tumors":[44,171,205],"with":[45,112,206,239,251,304],"mutations.":[49,141,244],"Methods:":[50],"Sequencing":[51],"restriction":[53],"fragment":[54],"length":[55],"polymorphism":[56],"(RFLP)":[57],"utilized":[59],"detection":[61],"activating":[63],"mutations":[64,193,306],"codon":[66,139,176],"209":[67,140,177],"44":[75,90],"primary":[76,109,169,204],"UMs.":[77,91],"expression":[79,95,212,233,264],"phospho":[81],"p44/42":[82],"(pERK1/2)":[84],"was":[85,213],"assessed":[86],"by":[87],"immunohistochemistry":[88],"In":[92,258,316],"addition,":[93],"pERK1/2":[97,211,256],"pMEK":[99],"1/2":[100],"studied":[102],"using":[103],"Western":[104,228],"blot":[105,229],"analysis":[106],"17":[108],"UMs":[110],"(14":[111],"or":[114,182,242,309],"mutations)":[116],"five":[118],"cell":[120,131,156,249,279,288],"lines":[121,132,250,289],"(C918,":[122],"92.1,":[123],"OCM3,":[124],"MEL202,":[125],"MEL270).":[126],"Three":[127],"(92.1,":[133],"MEL202":[134],"MEL270)":[136],"have":[137],"effect":[143],"three":[145],"different":[146],"selective":[147,325],"inhibitors":[149,276,327],"(U126,":[150],"PD98059":[151],"PD184352)":[153],"on":[154],"proliferation":[157,280],"apoptosis":[159,285],"studied.":[161],"Results:":[162],"majority":[164],"(30/44,":[165],"68.2%)":[166],"showed":[172,230,254,261,269,311],"either":[179,195,240],"genes.":[185],"With":[186],"exception":[188],"one":[190,260,268],"tumor,":[191],"gene":[196],"mutually":[198],"exclusive.":[199],"Of":[200],"30":[202],"and/or":[208],"mutation,":[210],"absent":[214],"26.7%,":[216],"weak":[217,255,271],"33.3%,":[219],"moderate":[220],"23.3%,":[222],"high":[224],"only":[226],"16.7%.":[227],"no":[231,262,312],"pMEK1/2":[232,263,272],"6/14":[235],"(42.9%)":[236],"Two":[245],"expression.":[257,273],"addition":[259],"while":[265],"other":[267],"very":[270],"Selective":[274],"slowed":[277],"but":[281],"didn't":[282],"induce":[283],"significant":[284,300],"regardless":[290],"status.":[293],"Conclusions:":[294],"Our":[295],"results":[296],"indicate":[297],"that":[298,324],"number":[301],"pathway":[314],"activation.":[315],"UM,":[317],"is":[320],"mostly":[321],"cytostatic":[322],"suggesting":[323],"alone":[328],"may":[329],"not":[330],"be":[331],"sufficient":[332],"control":[334],"UM.":[335],"Citation":[336],"Format:":[337],"{Authors}.":[338],"{Abstract":[339],"title}":[340],"[abstract].":[341],"In:":[342],"Proceedings":[343],"102nd":[346],"Annual":[347],"Meeting":[348],"American":[351],"Association":[352],"Cancer":[354,364],"Research;":[355],"2011":[356],"Apr":[357],"2-6;":[358],"Orlando,":[359],"FL.":[360],"Philadelphia":[361],"(PA):":[362],"AACR;":[363],"Res":[365],"2011;71(8":[366],"Suppl):Abstract":[367],"nr":[368],"1127.":[369],"doi:10.1158/1538-7445.AM2011-1127":[370]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
