{"id":"https://openalex.org/W2332509366","doi":"https://doi.org/10.2131/jts.22.supplementii_405","title":"REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF TALTIRELIN HYDRATE (4) PERINATAL AND POSTNATAL STUDY IN RATS BY ORAL ADMINISTRATION","display_name":"REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF TALTIRELIN HYDRATE (4) PERINATAL AND POSTNATAL STUDY IN RATS BY ORAL ADMINISTRATION","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2332509366","doi":"https://doi.org/10.2131/jts.22.supplementii_405","mag":"2332509366","pmid":"https://pubmed.ncbi.nlm.nih.gov/9430098"},"language":"ja","primary_location":{"id":"doi:10.2131/jts.22.supplementii_405","doi":"https://doi.org/10.2131/jts.22.supplementii_405","is_oa":true,"landing_page_url":"https://doi.org/10.2131/jts.22.supplementii_405","pdf_url":"https://www.jstage.jst.go.jp/article/jts1976/22/SupplementII/22_SupplementII_405/_pdf","source":{"id":"https://openalex.org/S148595626","display_name":"The Journal of Toxicological Sciences","issn_l":"0388-1350","issn":["0388-1350","1880-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697822","host_organization_name":"Japanese Society of Toxicological Sciences","host_organization_lineage":["https://openalex.org/P4322697822"],"host_organization_lineage_names":["Japanese Society of Toxicological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jts1976/22/SupplementII/22_SupplementII_405/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055229142","display_name":"Hiroshi Imahie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi IMAHIE","raw_affiliation_strings":["Safety Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Safety Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akane KOGUCHI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akane KOGUCHI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081750005","display_name":"Takashi Kobayashi","orcid":"https://orcid.org/0000-0001-7776-6846","observed_orcids":["https://orcid.org/0000-0001-7776-6846"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi KOBAYASHI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Yuzo ASANO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuzo ASANO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3351,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.81745863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"SupplementII","first_page":"405","last_page":"417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone-analogue","display_name":"thyrotropin-releasing hormone analog","score":0.9480000138282776},{"id":"https://openalex.org/keywords/perinatal-toxicity","display_name":"perinatal toxicity","score":0.8539999723434448},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.8090000152587891},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.7329999804496765},{"id":"https://openalex.org/keywords/reproductive-toxicity","display_name":"reproductive toxicity","score":0.7990000247955322},{"id":"https://openalex.org/keywords/gestation","display_name":"gestation","score":0.503000020980835},{"id":"https://openalex.org/keywords/offspring-development","display_name":"offspring development","score":0.4880000054836273},{"id":"https://openalex.org/keywords/no-observed-effect-level","display_name":"no-observed-effect level","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.9087960124015808},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.7320994138717651},{"id":"https://openalex.org/C179335377","wikidata":"https://www.wikidata.org/wiki/Q5266825","display_name":"Developmental toxicity","level":4,"score":0.6797810196876526},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5942364931106567},{"id":"https://openalex.org/C99432707","wikidata":"https://www.wikidata.org/wiki/Q3427345","display_name":"Reproductive toxicity","level":3,"score":0.5157651901245117},{"id":"https://openalex.org/C65290608","wikidata":"https://www.wikidata.org/wiki/Q631521","display_name":"Teratology","level":4,"score":0.494834840297699},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4946446120738983},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.47402623295783997},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46999654173851013},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.456582248210907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4348723590373993},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.43216636776924133},{"id":"https://openalex.org/C59659247","wikidata":"https://www.wikidata.org/wiki/Q11990","display_name":"Reproduction","level":2,"score":0.41549187898635864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3866119086742401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3563079833984375},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.10562723875045776},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008431","descriptor_name":"Maternal-Fetal Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011270","descriptor_name":"Pregnancy, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2131/jts.22.supplementii_405","doi":"https://doi.org/10.2131/jts.22.supplementii_405","is_oa":true,"landing_page_url":"https://doi.org/10.2131/jts.22.supplementii_405","pdf_url":"https://www.jstage.jst.go.jp/article/jts1976/22/SupplementII/22_SupplementII_405/_pdf","source":{"id":"https://openalex.org/S148595626","display_name":"The Journal of Toxicological Sciences","issn_l":"0388-1350","issn":["0388-1350","1880-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697822","host_organization_name":"Japanese Society of Toxicological Sciences","host_organization_lineage":["https://openalex.org/P4322697822"],"host_organization_lineage_names":["Japanese Society of Toxicological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Toxicological Sciences","raw_type":"journal-article"},{"id":"pmid:9430098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9430098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of toxicological sciences","raw_type":"English Abstract"}],"best_oa_location":{"id":"doi:10.2131/jts.22.supplementii_405","doi":"https://doi.org/10.2131/jts.22.supplementii_405","is_oa":true,"landing_page_url":"https://doi.org/10.2131/jts.22.supplementii_405","pdf_url":"https://www.jstage.jst.go.jp/article/jts1976/22/SupplementII/22_SupplementII_405/_pdf","source":{"id":"https://openalex.org/S148595626","display_name":"The Journal of Toxicological Sciences","issn_l":"0388-1350","issn":["0388-1350","1880-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697822","host_organization_name":"Japanese Society of Toxicological Sciences","host_organization_lineage":["https://openalex.org/P4322697822"],"host_organization_lineage_names":["Japanese Society of Toxicological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Toxicological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2332509366.pdf","grobid_xml":"https://content.openalex.org/works/W2332509366.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W74945236","https://openalex.org/W2018021139","https://openalex.org/W2047431072","https://openalex.org/W2077669642","https://openalex.org/W2090303153","https://openalex.org/W2322731653","https://openalex.org/W2513823873"],"related_works":["https://openalex.org/W2604132549","https://openalex.org/W2321595605","https://openalex.org/W2321498638","https://openalex.org/W2322731653","https://openalex.org/W2322816662","https://openalex.org/W4205423597","https://openalex.org/W2315744792","https://openalex.org/W2334875658","https://openalex.org/W2049971751","https://openalex.org/W4233241440"],"abstract_inverted_index":{"Perinatal":[0],"and":[1,53,91,102,128,138,142,148,172,180],"postnatal":[2],"study":[3],"of":[4,27,38,81,145,150,161,178],"taltirelin":[5,22,82,162],"hydrate,":[6],"a":[7,25],"thyrotropin":[8],"releasing":[9],"hormone":[10],"analogue,":[11],"was":[12,94],"carried":[13],"out":[14],"in":[15,96,170],"Sprague-Dawley":[16],"rats.":[17],"Female":[18],"rats":[19,47],"were":[20,48,56],"given":[21],"hydrate":[23,83,115,163],"at":[24],"dose":[26,159],"0":[28],"(control),":[29],"0.15,":[30],"1.5,":[31],"or":[32],"15":[33,60,173],"mg/kg":[34,61,104,166,174],"from":[35],"day":[36,41],"17":[37],"gestation":[39,76],"to":[40,50],"20":[42],"after":[43],"delivery.":[44],"All":[45],"pregnant":[46],"allowed":[49],"deliver":[51],"spontaneously":[52],"their":[54,182],"offspring":[55],"examined.":[57],"In":[58,99],"the":[59,63,66,85,100,106,157],"group,":[62],"dams":[64,179],"showed":[65],"central":[67],"nervous":[68],"effects":[69,121],"such":[70],"as":[71],"wet":[72],"dog":[73],"shaking":[74],"during":[75],"periods.":[77],"No":[78],"adverse":[79,112,120],"effect":[80],"on":[84,122],"body":[86],"weight":[87],"gain,":[88],"food":[89],"consumption":[90],"reproductive":[92,143,176],"performance":[93,144],"observed":[95],"this":[97],"group.":[98],"0.15":[101],"1.5":[103,165],"groups,":[105],"drug":[107],"did":[108,116],"not":[109,117],"have":[110,118],"any":[111,119],"effects.":[113],"Taltirelin":[114],"viability,":[123],"growth,":[124],"physical":[125],"differentiation,":[126],"functional":[127],"behavioral":[129],"development":[130,149],"(coordinated":[131],"activity,":[132],"auditory":[133],"function,":[134],"emotionality,":[135],"learning":[136],"ability,":[137],"spontaneous":[139],"motor":[140],"activity),":[141],"F1":[146],"offspring,":[147],"F2":[151],"fetuses.":[152],"These":[153],"results":[154],"show":[155],"that":[156],"no-toxic":[158],"levels":[160],"are":[164],"for":[167,175,181],"general":[168],"toxicity":[169],"dams,":[171],"function":[177],"offspring.":[183]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
