{"id":"https://openalex.org/W2332495005","doi":"https://doi.org/10.1248/bpb.16.521","title":"Cytotoxic Effect of Hinokitiol and Tropolone on the Growth of Mammalian Cells and on Blastogenesis of Mouse Splenic T Cells.","display_name":"Cytotoxic Effect of Hinokitiol and Tropolone on the Growth of Mammalian Cells and on Blastogenesis of Mouse Splenic T Cells.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2332495005","doi":"https://doi.org/10.1248/bpb.16.521","mag":"2332495005","pmid":"https://pubmed.ncbi.nlm.nih.gov/8364502"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.16.521","doi":"https://doi.org/10.1248/bpb.16.521","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.16.521","pdf_url":"https://www.jstage.jst.go.jp/article/bpb1993/16/5/16_5_521/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bpb1993/16/5/16_5_521/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000862574","display_name":"Yoshihiko Inamori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90237989","display_name":"Osaka University of Pharmaceutical Sciences","ror":"https://ror.org/029yaft79","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321","https://openalex.org/I90237989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiko INAMORI","raw_affiliation_strings":["Osaka University of Pharmaceutical Sciences, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka University of Pharmaceutical Sciences, Japan","institution_ids":["https://openalex.org/I90237989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077215453","display_name":"Hiroshi Tsujibo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi TSUJIBO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038773677","display_name":"Hirofumi Ohishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hirofumi OHISHI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057596354","display_name":"Fumio Ishii","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fumio ISHII","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037682743","display_name":"Michinao Mizugaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michinao MIZUGAKI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009909384","display_name":"Hisashi Aso","orcid":"https://orcid.org/0000-0001-5114-4651","observed_orcids":["https://orcid.org/0000-0001-5114-4651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisashi ASO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Nakao ISHIDA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nakao ISHIDA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8273,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.776485,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"5","first_page":"521","last_page":"523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hinokitiol","display_name":"hinokitiol","score":1.0},{"id":"https://openalex.org/keywords/tropolone","display_name":"tropolone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8939999938011169},{"id":"https://openalex.org/keywords/splenic-t-cells","display_name":"splenic T cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.8730000257492065},{"id":"https://openalex.org/keywords/mitogen-induced-proliferation","display_name":"mitogen-induced proliferation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7509999871253967},{"id":"https://openalex.org/keywords/hl60","display_name":"HL60","score":0.6610000133514404},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/thymidine-incorporation","display_name":"thymidine incorporation","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.8616206645965576},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.7837415933609009},{"id":"https://openalex.org/C2777509971","wikidata":"https://www.wikidata.org/wiki/Q19952843","display_name":"Tropolone","level":2,"score":0.7609697580337524},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.6422559022903442},{"id":"https://openalex.org/C51296783","wikidata":"https://www.wikidata.org/wiki/Q1645498","display_name":"Microgram","level":3,"score":0.6377832889556885},{"id":"https://openalex.org/C2777108182","wikidata":"https://www.wikidata.org/wiki/Q422464","display_name":"Thymidine","level":3,"score":0.5762969851493835},{"id":"https://openalex.org/C2778903051","wikidata":"https://www.wikidata.org/wiki/Q5630035","display_name":"HL60","level":3,"score":0.5625102519989014},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5604880452156067},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5402611494064331},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5240371823310852},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5003848075866699},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.4979372024536133},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.45943304896354675},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43005430698394775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42478200793266296},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.4118494391441345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3976229429244995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.317596971988678},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003208","descriptor_name":"Concanavalin A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014334","descriptor_name":"Tropolone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014334","descriptor_name":"Tropolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039821","descriptor_name":"Monoterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.16.521","doi":"https://doi.org/10.1248/bpb.16.521","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.16.521","pdf_url":"https://www.jstage.jst.go.jp/article/bpb1993/16/5/16_5_521/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:8364502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8364502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb.16.521","doi":"https://doi.org/10.1248/bpb.16.521","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.16.521","pdf_url":"https://www.jstage.jst.go.jp/article/bpb1993/16/5/16_5_521/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2332495005.pdf","grobid_xml":"https://content.openalex.org/works/W2332495005.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985009441","https://openalex.org/W2146792065","https://openalex.org/W3201041044","https://openalex.org/W7096249841","https://openalex.org/W7081711344","https://openalex.org/W2101119429","https://openalex.org/W1994650179","https://openalex.org/W7112849861","https://openalex.org/W3189583415","https://openalex.org/W2021917597"],"abstract_inverted_index":{"Hinokitiol":[0],"(I)":[1,153],"and":[2,16,20,36,47,58,92,148],"tropolone":[3],"(II)":[4],"showed":[5,73],"characteristic":[6],"cytotoxic":[7,27,75],"effects":[8,76],"in":[9,144],"vitro":[10],"on":[11,31,64,77,108],"five":[12],"kinds":[13],"of":[14,29,34,101,125,135,151],"human":[15,37],"murine":[17,35],"cell":[18,39,79],"lines":[19],"blastic":[21,103],"lymphocytes":[22],"from":[23],"mouse":[24,109],"splenocytes.":[25],"The":[26,105],"effect":[28,150],"I":[30,91,130],"the":[32,97,146],"growth":[33],"tumor":[38],"lines,":[40,80],"including":[41],"RL":[42],"male-1,":[43],"MH134,":[44],"HL60,":[45],"K562":[46],"KATO-III":[48],"was":[49,67,115],"definite":[50],"when":[51,86],"examined":[52],"by":[53],"thymidine":[54],"incorporation":[55,100],"into":[56],"DNA":[57],"its":[59],"50%":[60],"inhibitory":[61],"concentration":[62,124],"(IC50)":[63],"all":[65],"cells":[66],"0.3-0.6":[68],"microgram/ml.":[69,127],"Compound":[70],"II":[71,93],"also":[72,94,116],"comparable":[74],"these":[78],"indicating":[81],"a":[82,122],"little":[83],"lower":[84],"activity":[85,107],"compared":[87],"to":[88,113,133],"I.":[89],"Furthermore,":[90],"completely":[95],"suppressed":[96],"[3H]thymidine":[98],"([3H]TdR)":[99],"mitogen-induced":[102],"lymphocytes.":[104],"suppressive":[106],"lymphocyte":[110],"proliferative":[111],"response":[112],"concanavaline-A":[114],"found":[117],"with":[118],"both":[119],"compounds":[120],"at":[121],"low":[123,137],"0.32":[126],"As":[128],"compound":[129],"is":[131],"known":[132],"be":[134,155],"fairly":[136],"toxicity":[138],"(LD50:":[139],"453":[140],"+":[141],"24":[142],"mg/kg":[143],"mice),":[145],"antitumor":[147],"immuno-suppressive":[149],"hinokitiol":[152],"should":[154],"further":[156],"investigated.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}