{"id":"https://openalex.org/W2332428787","doi":"https://doi.org/10.1038/srep23836","title":"pH Induced Conformational Transitions in the Transforming Growth Factor \u03b2-Induced Protein (TGF\u03b2Ip) Associated Corneal Dystrophy Mutants","display_name":"pH Induced Conformational Transitions in the Transforming Growth Factor \u03b2-Induced Protein (TGF\u03b2Ip) Associated Corneal Dystrophy Mutants","publication_year":2016,"publication_date":"2016-03-31","ids":{"openalex":"https://openalex.org/W2332428787","doi":"https://doi.org/10.1038/srep23836","mag":"2332428787","pmid":"https://pubmed.ncbi.nlm.nih.gov/27030015","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4814907"},"language":"en","primary_location":{"id":"doi:10.1038/srep23836","doi":"https://doi.org/10.1038/srep23836","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep23836","pdf_url":"https://www.nature.com/articles/srep23836.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep23836.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081597413","display_name":"Elavazhagan Murugan","orcid":"https://orcid.org/0000-0001-6591-4856","observed_orcids":["https://orcid.org/0000-0001-6591-4856"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Elavazhagan Murugan","raw_affiliation_strings":["Duke-NUS Graduate Medical School, Singapore","Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke-NUS Graduate Medical School, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112261799","display_name":"Anandalakshmi Venkatraman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Anandalakshmi Venkatraman","raw_affiliation_strings":["Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674991","display_name":"Lei Zhou","orcid":"https://orcid.org/0000-0001-5893-6002","observed_orcids":["https://orcid.org/0000-0001-5893-6002","https://orcid.org/0000-0001-8251-3974","https://orcid.org/0009-0007-9394-309X"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Zhou Lei","raw_affiliation_strings":["Proteomics and Microanalysis laboratory, Singapore Eye Research Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics and Microanalysis laboratory, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031432993","display_name":"Victoria Mouvet","orcid":"https://orcid.org/0000-0002-8466-575X","observed_orcids":["https://orcid.org/0000-0002-8466-575X"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Victoria Mouvet","raw_affiliation_strings":["Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111008947","display_name":"Rayne R. Lim","orcid":"https://orcid.org/0000-0003-3292-9204","observed_orcids":["https://orcid.org/0000-0003-3292-9204"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Rayne Rui Yi Lim","raw_affiliation_strings":["Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064163160","display_name":"Muruganantham Nandhakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Nandhakumar Muruganantham","raw_affiliation_strings":["Ocular Chemistry and Anti-Infectives, Singapore Eye Research Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ocular Chemistry and Anti-Infectives, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049871126","display_name":"Eunice Tze Leng Goh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Eunice Goh","raw_affiliation_strings":["Ocular Chemistry and Anti-Infectives, Singapore Eye Research Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ocular Chemistry and Anti-Infectives, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073702318","display_name":"Gary S. L. Peh","orcid":"https://orcid.org/0000-0002-5387-4209","observed_orcids":["https://orcid.org/0000-0002-5387-4209"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Gary Swee Lim Peh","raw_affiliation_strings":["Duke-NUS Graduate Medical School, Singapore","Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke-NUS Graduate Medical School, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007551999","display_name":"Roger Wilmer Beuerman","orcid":"https://orcid.org/0000-0002-0725-9336","observed_orcids":["https://orcid.org/0000-0002-0725-9336"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I2799299286","display_name":"Singapore National Eye Center","ror":"https://ror.org/029nvrb94","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2799299286"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Roger W. Beuerman","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, NUS, Singapore","Duke-NUS Graduate Medical School, Singapore","Ocular Chemistry and Anti-Infectives, Singapore Eye Research Institute, Singapore","Singapore National Eye Centre, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, NUS, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Duke-NUS Graduate Medical School, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Ocular Chemistry and Anti-Infectives, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Singapore National Eye Centre, Singapore","institution_ids":["https://openalex.org/I2799299286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026681511","display_name":"Shyam Sunder Chaurasia","orcid":"https://orcid.org/0000-0001-8725-676X","observed_orcids":["https://orcid.org/0000-0001-8725-676X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Shyam S. Chaurasia","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, NUS, Singapore","Duke-NUS Graduate Medical School, Singapore","Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, NUS, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Duke-NUS Graduate Medical School, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035157534","display_name":"Rajamani Lakshminarayanan","orcid":"https://orcid.org/0000-0001-8214-5315","observed_orcids":["https://orcid.org/0000-0001-8214-5315"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Lakshminarayanan Rajamani","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, NUS, Singapore","Duke-NUS Graduate Medical School, Singapore","Ocular Chemistry and Anti-Infectives, Singapore Eye Research Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, NUS, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Duke-NUS Graduate Medical School, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Ocular Chemistry and Anti-Infectives, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050145910","display_name":"Jodhbir Singh Mehta","orcid":"https://orcid.org/0000-0001-6362-4898","observed_orcids":["https://orcid.org/0000-0001-6362-4898"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I2799299286","display_name":"Singapore National Eye Center","ror":"https://ror.org/029nvrb94","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2799299286"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Jodhbir S. Mehta","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, NUS, Singapore","Duke-NUS Graduate Medical School, Singapore","Singapore National Eye Centre, Singapore","Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, NUS, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Duke-NUS Graduate Medical School, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Singapore National Eye Centre, Singapore","institution_ids":["https://openalex.org/I2799299286"]},{"raw_affiliation_string":"Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035157534","https://openalex.org/A5050145910"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I2799299286","https://openalex.org/I4210116917","https://openalex.org/I4210126319"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.4441,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.80489997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"23836","last_page":"23836"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.2590000033378601,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.2590000033378601,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.1103999987244606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.10440000146627426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-beta-induced-protein","display_name":"TGFBIp","score":0.746999979019165},{"id":"https://openalex.org/keywords/corneal-dystrophy","display_name":"corneal dystrophy","score":0.8040000200271606},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.5199999809265137},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/corneal-stromal-fibroblasts","display_name":"corneal stromal fibroblasts","score":0.9779999852180481},{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.5759999752044678},{"id":"https://openalex.org/keywords/chemical-stability","display_name":"chemical stability","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.814836859703064},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6736499071121216},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6249247789382935},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5934528112411499},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5344297885894775},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.4263579845428467},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36037957668304443},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34842926263809204},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3261360228061676},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2749004364013672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20453083515167236},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.08662128448486328},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05508780479431152}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099222","descriptor_name":"betaIG-H3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003317","descriptor_name":"Corneal Dystrophies, Hereditary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003317","descriptor_name":"Corneal Dystrophies, Hereditary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003319","descriptor_name":"Corneal Stroma","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003319","descriptor_name":"Corneal Stroma","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058227","descriptor_name":"Amyloidogenic Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058227","descriptor_name":"Amyloidogenic Proteins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D058227","descriptor_name":"Amyloidogenic Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D061251","descriptor_name":"Primary Cell Culture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/srep23836","doi":"https://doi.org/10.1038/srep23836","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep23836","pdf_url":"https://www.nature.com/articles/srep23836.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4814907","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4814907","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:27030015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27030015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:tampub.uta.fi:10024/99722","doi":null,"is_oa":true,"landing_page_url":"http://tampub.uta.fi/handle/10024/99722","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"publishedVersion"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/182487","doi":null,"is_oa":true,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/182487","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Unpaywall 20201031","raw_type":"Article"},{"id":"pmh:oai:trepo.tuni.fi:10024/99722","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/99722","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"publishedVersion"}],"best_oa_location":{"id":"doi:10.1038/srep23836","doi":"https://doi.org/10.1038/srep23836","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep23836","pdf_url":"https://www.nature.com/articles/srep23836.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7872310265","display_name":null,"funder_award_id":"R978/87/2012","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2332428787.pdf","grobid_xml":"https://content.openalex.org/works/W2332428787.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W117408561","https://openalex.org/W1513861898","https://openalex.org/W1545674592","https://openalex.org/W1736452538","https://openalex.org/W1957715649","https://openalex.org/W1964661966","https://openalex.org/W1966880532","https://openalex.org/W1968233003","https://openalex.org/W1968280815","https://openalex.org/W1971862042","https://openalex.org/W1972567838","https://openalex.org/W1977191559","https://openalex.org/W1979351412","https://openalex.org/W1979775028","https://openalex.org/W1981521582","https://openalex.org/W1983773767","https://openalex.org/W1984189188","https://openalex.org/W1988211271","https://openalex.org/W1989018026","https://openalex.org/W1997415160","https://openalex.org/W1997830142","https://openalex.org/W1997926601","https://openalex.org/W2004329874","https://openalex.org/W2009178842","https://openalex.org/W2009604591","https://openalex.org/W2014881995","https://openalex.org/W2020796799","https://openalex.org/W2025346736","https://openalex.org/W2025485746","https://openalex.org/W2027796579","https://openalex.org/W2030511334","https://openalex.org/W2032664459","https://openalex.org/W2037768391","https://openalex.org/W2049624857","https://openalex.org/W2061084111","https://openalex.org/W2068918178","https://openalex.org/W2081288740","https://openalex.org/W2084343306","https://openalex.org/W2084980913","https://openalex.org/W2091075515","https://openalex.org/W2093059651","https://openalex.org/W2094118845","https://openalex.org/W2096336861","https://openalex.org/W2098097053","https://openalex.org/W2101657669","https://openalex.org/W2116489922","https://openalex.org/W2122076384","https://openalex.org/W2129034006","https://openalex.org/W2136000113","https://openalex.org/W2144535585","https://openalex.org/W2144874527","https://openalex.org/W2153742411","https://openalex.org/W2155653247","https://openalex.org/W2156858209","https://openalex.org/W2161866238","https://openalex.org/W2187816012","https://openalex.org/W2263836074","https://openalex.org/W2313165569","https://openalex.org/W2754085602","https://openalex.org/W4211108204","https://openalex.org/W4243773797","https://openalex.org/W6604797248","https://openalex.org/W6640793062"],"related_works":["https://openalex.org/W1190789970","https://openalex.org/W2161866238","https://openalex.org/W2084343306","https://openalex.org/W2068918178","https://openalex.org/W2320798261","https://openalex.org/W6945864646","https://openalex.org/W2145994647","https://openalex.org/W1985272358","https://openalex.org/W2789349266","https://openalex.org/W131841850"],"abstract_inverted_index":{"Most":[0],"stromal":[1,158],"corneal":[2,157],"dystrophies":[3],"are":[4],"associated":[5],"with":[6,66,85],"aggregation":[7,40,177],"and":[8,32,41,47,62,80,128,132,174,179],"deposition":[9],"of":[10,22,26,39,55,120,140,149,164],"the":[11,27,37,42,45,52,58,67,104],"mutated":[12],"transforming":[13],"growth":[14],"factor-\u03b2":[15],"induced":[16],"protein":[17],"(TGF\u03b2Ip).":[18],"The":[19,118,147,162],"4(th)_FAS1":[20,53],"domain":[21],"TGF\u03b2Ip":[23,56],"harbors":[24],"~80%":[25],"mutations":[28,59],"that":[29,95,138],"forms":[30],"amyloidogenic":[31,46],"non-amyloidogenic":[33,48],"aggregates.":[34],"To":[35],"understand":[36],"mechanism":[38],"differences":[43],"between":[44],"phenotypes,":[49],"we":[50],"expressed":[51],"domains":[54],"carrying":[57],"R555W":[60,70],"(non-amyloidogenic)":[61],"H572R":[63,79,141],"(amyloidogenic)":[64],"along":[65],"wild-type":[68],"(WT).":[69],"was":[71],"more":[72],"susceptible":[73],"to":[74,78,115,145,154],"acidic":[75,92],"pH":[76,93],"compared":[77,144],"displayed":[81],"varying":[82],"chemical":[83,175],"stabilities":[84],"decreasing":[86],"pH.":[87,129],"Thermal":[88],"denaturation":[89],"studies":[90,136],"at":[91,125],"showed":[94,137],"while":[96],"WT":[97],"did":[98],"not":[99],"undergo":[100],"any":[101],"conformational":[102],"transition,":[103],"mutants":[105,122,151,166],"exhibited":[106],"a":[107],"clear":[108],"pH-dependent":[109],"irreversible":[110],"conversion":[111],"from":[112],"\u03b1\u03b2":[113],"conformation":[114],"\u03b2-sheet":[116],"oligomers.":[117],"\u03b2-oligomers":[119,139,148,163],"both":[121,150,165],"were":[123,142,152],"stable":[124],"physiological":[126],"temperature":[127],"Electron":[130],"microscopy":[131],"dynamic":[133],"light":[134],"scattering":[135],"larger":[143],"R555W.":[146],"cytotoxic":[153],"primary":[155],"human":[156],"fibroblast":[159],"(pHCSF)":[160],"cells.":[161],"exhibit":[167],"variations":[168],"in":[169],"their":[170],"morphologies,":[171],"sizes,":[172],"thermal":[173],"stabilities,":[176],"patterns":[178],"cytotoxicities.":[180]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}