{"id":"https://openalex.org/W2332392370","doi":"https://doi.org/10.1158/1538-7445.am10-4711","title":"Abstract 4711: The role ERK1/2 and Androgen Receptor phosphorylation at serine 81 in the progression from hormone naive to castrate resistant prostate cancer","display_name":"Abstract 4711: The role ERK1/2 and Androgen Receptor phosphorylation at serine 81 in the progression from hormone naive to castrate resistant prostate cancer","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2332392370","doi":"https://doi.org/10.1158/1538-7445.am10-4711","mag":"2332392370"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-4711","doi":"https://doi.org/10.1158/1538-7445.am10-4711","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-4711","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064469818","display_name":"Joanne Edwards","orcid":"https://orcid.org/0000-0002-7192-6906","observed_orcids":["https://orcid.org/0000-0002-7192-6906"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joanne Edwards","raw_affiliation_strings":["1Univ. of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103377039","display_name":"Pamela McCall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pamela McCall","raw_affiliation_strings":["1Univ. of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027690974","display_name":"Claire E. Adams","orcid":"https://orcid.org/0000-0002-3246-0816","observed_orcids":["https://orcid.org/0000-0002-3246-0816"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire Adams","raw_affiliation_strings":["1Univ. of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110352196","display_name":"Rono Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rono Mukherjee","raw_affiliation_strings":["1Univ. of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101552867","display_name":"Clare Orange","orcid":"https://orcid.org/0000-0001-9155-3468","observed_orcids":["https://orcid.org/0000-0001-9155-3468"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clare Orange","raw_affiliation_strings":["1Univ. of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076015010","display_name":"Morag M. Seywright","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morag Seywright","raw_affiliation_strings":["2NHS, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NHS, Glasgow, United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Mark Underwood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Underwood","raw_affiliation_strings":["2NHS, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NHS, Glasgow, United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"4711","last_page":"4711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.859000027179718},{"id":"https://openalex.org/keywords/hormone-naive-prostate-cancer","display_name":"hormone-naive prostate cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.8889999985694885},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8960000276565552},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.6100000143051147},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6759999990463257},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6200000047683716},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.6650000214576721},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.6309999823570251},{"id":"https://openalex.org/keywords/clinical-progression","display_name":"clinical progression","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.890923798084259},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7088992595672607},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6380540132522583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5514739751815796},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5491025447845459},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.548502504825592},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5227556228637695},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.5081415176391602},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.41976502537727356},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39749568700790405},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.33319318294525146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14620563387870789},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-4711","doi":"https://doi.org/10.1158/1538-7445.am10-4711","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-4711","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088012234","https://openalex.org/W3022810250","https://openalex.org/W2105165550","https://openalex.org/W2069484452","https://openalex.org/W2524542208","https://openalex.org/W1981170728","https://openalex.org/W2010333735","https://openalex.org/W3006786924","https://openalex.org/W221175224","https://openalex.org/W2892078335"],"abstract_inverted_index":{"Abstract":[0],"Prostate":[1,107],"cancer":[2,30,40,74,96,151],"incidence":[3],"in":[4,67,148,187,261,269,280,301,316,340,387,412,432],"the":[5,14,34,43,53,68,115,132,139,142,188,249,433,459,466,481,486],"UK":[6],"is":[7,31,146],"approximately":[8],"35,500":[9],"cases":[10],"per":[11],"year":[12],"and":[13,99,144,161,180,194,213,241,264,276,296,310,336,360,384,426,440],"second":[15],"most":[16],"common":[17],"cause":[18],"of":[19,36,45,87,127,131,155,176,238,245,251,256,319,325,331,382,396,438,447,480,485],"male":[20],"cancer-specific":[21],"death.":[22],"The":[23,129,199],"high":[24,277,337,436],"mortality":[25],"rate":[26],"associated":[27,284,344],"with":[28,52,158,166,192,285,308,345,370,424],"prostate":[29,39,73,95,150],"attributed":[32],"to":[33,76,93,136,173,197,216,253,288,470],"development":[35,44],"castrate":[37],"resistance":[38],"(CRPC).":[41],"Following":[42],"CRPC":[46,128,162,254,341,351],"there":[47],"are":[48],"few":[49],"therapeutic":[50,123],"options":[51],"mean":[54],"survival":[55,417],"period":[56],"being":[57],"only":[58],"18-24":[59],"months.":[60],"Cell":[61],"line":[62],"studies":[63],"implement":[64],"ERK1/2":[65,145,179,182,270,297,311,338,361,385,427,441],"activation":[66,84],"transition":[69,250],"from":[70],"hormone":[71],"nai\u0308ve":[72],"(HNPC)":[75],"CRPC.":[77,198],"Recent":[78],"evidence":[79],"suggests":[80,113],"that":[81,114],"ERK":[82,116],"kinase":[83,117],"induces":[85],"phosphorylation":[86],"AR":[88,143,295,357],"at":[89,202,209,232,273,327,333,407,458],"Serine":[90],"81":[91],"(AR81)":[92],"stimulate":[94],"cell":[97],"growth":[98],"induce":[100],"PSA":[101,272],"expression":[102,175,263,279,298,339,365,377,381,395,437],"(Shigemura":[103],"K":[104],"et":[105],"al":[106],"2009,":[108],"69(9)":[109],"949-955).":[110],"This":[111,453],"data":[112],"pathway":[118],"may":[119],"provide":[120],"a":[121,388,413,444],"novel":[122],"target":[124],"for":[125,489],"treatment":[126],"aim":[130],"current":[133,434],"study":[134],"was":[135,164,171,204,211,219,224,299,314,455,468],"investigate":[137],"if":[138],"relationship":[140],"between":[141,294,356],"upheld":[147],"clinical":[149,168],"specimens.":[152],"A":[153,291],"cohort":[154,189],"55":[156,185],"patients":[157,186,229,236,243,257],"matched":[159],"HNPC":[160,193,252,281,302],"tissue":[163],"established":[165],"full":[167],"follow-up.":[169],"Immunohistochemistry":[170],"employed":[172],"assess":[174],"AR,":[177],"AR81,":[178],"phosphorylated":[181],"(pERK).":[183],"All":[184],"were":[190,230,283,343,354,430],"diagnosed":[191],"subsequently":[195],"progressed":[196],"median":[200,206,214],"age":[201],"diagnosis":[203,210,274,328],"70(66-73),":[205],"Gleason":[207,321],"sum":[208,322],"8(6-9)":[212],"time":[215,287],"biochemical":[217,289],"relapse":[218,334],"2.3":[220],"years.":[221],"Mean":[222],"follow-up":[223],"7.5":[225],"(4.3-11.7)":[226],"years,":[227],"4":[228],"alive":[231],"last":[233],"follow-up,":[234],"35":[235],"died":[237,244],"their":[239],"disease":[240,347,391,415,449],"16":[242],"other":[246],"causes.":[247],"In":[248,350,419],"8%":[255],"exhibited":[258,266],"an":[259,267],"increase":[260,268],"AR81":[262,309,359,364,383,425,439],"20%":[265],"expression.":[271],"(p=0.034)":[275],"pERK":[278,313,429],"(p=0.03)":[282],"shorter":[286,346,390],"relapse.":[290],"negative":[292],"correlation":[293],"observed":[300,315,355,431],"(R2=-0.383,":[303],"p=0.004),":[304],"but":[305],"no":[306,352,422],"association":[307],"or":[312,358,362,405,428],"this":[317],"stage":[318],"disease.":[320],"(p=0.009),":[323],"presence":[324,330],"metastasis":[326,332],"(p=0.0002),":[329],"(p=0.003)":[335,342],"specific":[348,392,416,450],"survival.":[349,393,451],"correlations":[353,423],"pERK.":[363],"did":[366],"however":[367],"positively":[368],"correlate":[369],"proliferation":[371],"index":[372],"as":[373],"assessed":[374],"by":[375],"Ki67":[376],"(R2=0.339,":[378],"p=0.025).":[379],"Combined":[380],"resulted":[386,411],"significantly":[389],"Whereas,":[394],"these":[397],"protein":[398],"alone":[399],"(4.2":[400],"years":[401],"vs.":[402],"5.4":[403],"years)":[404,410],"not":[406,456],"all":[408],"(7.2":[409],"longer":[414],"p=0.0006.":[418],"conclusion,":[420],"although":[421],"study,":[435],"combined":[442],"had":[443],"synergistic":[445],"effect":[446],"decreased":[448],"Note:":[452],"abstract":[454],"presented":[457],"AACR":[460],"101st":[461,482],"Annual":[462,483],"Meeting":[463,484],"2010":[464,492],"because":[465],"presenter":[467],"unable":[469],"attend.":[471],"Citation":[472],"Format:":[473],"{Authors}.":[474],"{Abstract":[475],"title}":[476],"[abstract].":[477],"In:":[478],"Proceedings":[479],"American":[487],"Association":[488],"Cancer":[490,500],"Research;":[491],"Apr":[493],"17-21;":[494],"Washington,":[495],"DC.":[496],"Philadelphia":[497],"(PA):":[498],"AACR;":[499],"Res":[501],"2010;70(8":[502],"Suppl):Abstract":[503],"nr":[504],"4711.":[505]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}