{"id":"https://openalex.org/W2332371908","doi":"https://doi.org/10.1021/mp500065m","title":"Biomimetic Urothelial Tissue Models for the in Vitro Evaluation of Barrier Physiology and Bladder Drug Efficacy","display_name":"Biomimetic Urothelial Tissue Models for the in Vitro Evaluation of Barrier Physiology and Bladder Drug Efficacy","publication_year":2014,"publication_date":"2014-04-03","ids":{"openalex":"https://openalex.org/W2332371908","doi":"https://doi.org/10.1021/mp500065m","mag":"2332371908","pmid":"https://pubmed.ncbi.nlm.nih.gov/24697150"},"language":"en","primary_location":{"id":"doi:10.1021/mp500065m","doi":"https://doi.org/10.1021/mp500065m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/mp500065m","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103139368","display_name":"Simon C. Baker","orcid":"https://orcid.org/0000-0002-2755-6012","observed_orcids":["https://orcid.org/0000-0002-2755-6012"]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Simon C. Baker","raw_affiliation_strings":["Jack Birch Unit of Molecular\rCarcinogenesis, Department of Biology, University of York, Heslington, York YO10 5DD, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jack Birch Unit of Molecular\rCarcinogenesis, Department of Biology, University of York, Heslington, York YO10 5DD, U.K","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078678867","display_name":"Saqib Shabir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Saqib Shabir","raw_affiliation_strings":["Jack Birch Unit of Molecular\rCarcinogenesis, Department of Biology, University of York, Heslington, York YO10 5DD, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jack Birch Unit of Molecular\rCarcinogenesis, Department of Biology, University of York, Heslington, York YO10 5DD, U.K","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025375470","display_name":"Jennifer Southgate","orcid":"https://orcid.org/0000-0002-0135-480X","observed_orcids":["https://orcid.org/0000-0002-0135-480X"]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer Southgate","raw_affiliation_strings":["Jack Birch Unit of Molecular\rCarcinogenesis, Department of Biology, University of York, Heslington, York YO10 5DD, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jack Birch Unit of Molecular\rCarcinogenesis, Department of Biology, University of York, Heslington, York YO10 5DD, U.K","institution_ids":["https://openalex.org/I52099693"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103139368"],"corresponding_institution_ids":["https://openalex.org/I52099693"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.2094,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.1877551,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"7","first_page":"1964","last_page":"1970"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.38499999046325684,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.38499999046325684,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.23690000176429749,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.10360000282526016,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urothelium","display_name":"urothelium","score":0.9399999976158142},{"id":"https://openalex.org/keywords/biomimetic-tissue-models","display_name":"biomimetic tissue models","score":0.871999979019165},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.3930000066757202},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.7099999785423279},{"id":"https://openalex.org/keywords/urothelial-differentiation","display_name":"urothelial differentiation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/renal-excretion","display_name":"renal excretion","score":0.6919999718666077},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.5640000104904175},{"id":"https://openalex.org/keywords/cystitis","display_name":"cystitis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/preclinical-drug-testing","display_name":"preclinical drug testing","score":0.46700000762939453},{"id":"https://openalex.org/keywords/human-relevance","display_name":"human relevance","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6055227518081665},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5949422121047974},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43551838397979736},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4228660464286804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35398346185684204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11349278688430786}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019459","descriptor_name":"Urothelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032701","descriptor_name":"Biomimetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/mp500065m","doi":"https://doi.org/10.1021/mp500065m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/mp500065m","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:24697150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24697150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5896905506","display_name":"A combined in vitro and in virtuo multi-scale approach to understanding calcium signalling as a signature and integrator of cellular response.","funder_award_id":"090577/Z/09/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W61220348","https://openalex.org/W118551320","https://openalex.org/W1547406244","https://openalex.org/W1565351617","https://openalex.org/W1584652055","https://openalex.org/W1596625927","https://openalex.org/W1602509013","https://openalex.org/W1857532475","https://openalex.org/W1965812264","https://openalex.org/W1966684731","https://openalex.org/W1966766953","https://openalex.org/W1969608696","https://openalex.org/W1972504105","https://openalex.org/W1983826385","https://openalex.org/W1988216048","https://openalex.org/W1988328342","https://openalex.org/W1988525139","https://openalex.org/W1991458638","https://openalex.org/W1995723023","https://openalex.org/W1999453621","https://openalex.org/W2000622050","https://openalex.org/W2008427627","https://openalex.org/W2014472305","https://openalex.org/W2016085865","https://openalex.org/W2016557739","https://openalex.org/W2023969462","https://openalex.org/W2027513800","https://openalex.org/W2036441414","https://openalex.org/W2040978507","https://openalex.org/W2043568751","https://openalex.org/W2045084108","https://openalex.org/W2050757842","https://openalex.org/W2059083569","https://openalex.org/W2062085206","https://openalex.org/W2070147440","https://openalex.org/W2072446111","https://openalex.org/W2078373120","https://openalex.org/W2079433581","https://openalex.org/W2082609680","https://openalex.org/W2087492491","https://openalex.org/W2092301519","https://openalex.org/W2093929964","https://openalex.org/W2095581779","https://openalex.org/W2114831373","https://openalex.org/W2137609666","https://openalex.org/W2138093169","https://openalex.org/W2141853317","https://openalex.org/W2151805229","https://openalex.org/W2155021879","https://openalex.org/W2156721436","https://openalex.org/W2158172048","https://openalex.org/W2158260379","https://openalex.org/W2161441815","https://openalex.org/W2170356321","https://openalex.org/W2186368357","https://openalex.org/W2186659781","https://openalex.org/W2419337843","https://openalex.org/W2441871068","https://openalex.org/W4243086761"],"related_works":["https://openalex.org/W7084065497","https://openalex.org/W1972431666","https://openalex.org/W2412771430","https://openalex.org/W2795909808","https://openalex.org/W2153570372","https://openalex.org/W2397888449","https://openalex.org/W2767318948","https://openalex.org/W1985947423","https://openalex.org/W2055823779","https://openalex.org/W7220224291"],"abstract_inverted_index":{"The":[0,104],"bladder":[1,41],"is":[2,63,192,212],"an":[3],"important":[4],"tissue":[5,145],"in":[6,25,67,110,115,183,199],"which":[7,124],"to":[8,16,51,83,117,129,156,186,194,214],"evaluate":[9],"xenobiotic":[10],"drug":[11,21],"interactions":[12],"and":[13,22,53,86,152,158,176],"toxicities":[14],"due":[15],"the":[17,26,36,40,48,77,148,173,179],"concentration":[18],"of":[19,31,35,80,121,150],"parent":[20],"hepatic/enteric-derived":[23],"metabolites":[24],"urine":[27,52],"as":[28,69],"a":[29,98,131,169],"result":[30],"renal":[32],"excretion.":[33],"Breaching":[34],"barrier":[37,87],"provided":[38],"by":[39],"epithelial":[42],"lining":[43],"(the":[44],"urothelium)":[45],"can":[46,112,125,201],"expose":[47],"underlying":[49],"tissues":[50],"cause":[54],"harmful":[55],"effects":[56],"(e.g.,":[57],"cystitis":[58],"or":[59,71,133],"cancer).":[60],"Human":[61],"urothelium":[62,198],"most":[64],"commonly":[65],"represented":[66],"vitro":[68,116,200],"immortalized":[70],"established":[72],"cancer-derived":[73],"cell":[74,101],"lines,":[75],"but":[76,209],"compromised":[78],"ability":[79],"such":[81],"cells":[82,96],"undergo":[84],"differentiation":[85],"formation":[88],"means":[89],"that":[90,196,204],"nonimmortalized,":[91],"normal":[92],"human":[93,143,165,188,197],"urothelial":[94,108,144,166],"(NHU)":[95],"provide":[97,168,202],"more":[99],"relevant":[100],"culture":[102],"system.":[103],"impressive":[105],"capacity":[106],"for":[107],"self-renewal":[109],"vivo":[111,184],"be":[113,127],"harnessed":[114],"generate":[118],"experimentally-useful":[119],"quantities":[120],"NHU":[122],"cells,":[123],"subsequently":[126],"differentiated":[128],"form":[130],"functional":[132],"\"biomimetic\"":[134],"urothelium.":[135],"When":[136],"seeded":[137],"onto":[138],"permeable":[139],"membranes,":[140],"these":[141],"barrier-forming":[142],"models":[146],"enable":[147],"modeling":[149],"serum":[151],"luminal":[153],"(intravesical)":[154],"exposure":[155],"drugs":[157],"metabolites,":[159],"thus":[160],"supporting":[161],"efficacy/toxicity":[162],"assessments.":[163],"Biomimetic":[164],"constructs":[167],"potential":[170],"step":[171],"along":[172],"preclinical":[174],"trail":[175],"may":[177],"support":[178,215],"extrapolation":[180],"from":[181],"rodent":[182,207],"data":[185],"determine":[187],"relevance.":[189],"Early":[190],"evidence":[191],"beginning":[193],"demonstrate":[195],"information":[203],"supersedes":[205],"conventional":[206],"studies,":[208],"further":[210],"validation":[211],"needed":[213],"widespread":[216],"adoption.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}