{"id":"https://openalex.org/W2332370501","doi":"https://doi.org/10.1097/00002142-200210000-00002","title":"Bone Microstructure in Osteoporosis: Transilial Biopsy and Histomorphometry","display_name":"Bone Microstructure in Osteoporosis: Transilial Biopsy and Histomorphometry","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W2332370501","doi":"https://doi.org/10.1097/00002142-200210000-00002","mag":"2332370501","pmid":"https://pubmed.ncbi.nlm.nih.gov/12464743"},"language":"en","primary_location":{"id":"doi:10.1097/00002142-200210000-00002","doi":"https://doi.org/10.1097/00002142-200210000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002142-200210000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S90952882","display_name":"Topics in Magnetic Resonance Imaging","issn_l":"0899-3459","issn":["0899-3459","1536-1004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Topics in Magnetic Resonance Imaging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036463343","display_name":"M. Janet Barger-Lux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. Janet Barger-Lux","raw_affiliation_strings":["Osteoporosis Research Center, Creighton University School of Medicine, 601 North 30th Street, Omaha, NE 68131, USA. jbarger@creighton.edu","reprint requests to M. Janet Barger-Lux, 601 North 30th Street, Suite 5766, Omaha, NE 68131, or [email\u00a0protected]","the Osteoporosis Research Center, Creighton University School of Medicine, Omaha, Nebraska, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osteoporosis Research Center, Creighton University School of Medicine, 601 North 30th Street, Omaha, NE 68131, USA. jbarger@creighton.edu","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"reprint requests to M. Janet Barger-Lux, 601 North 30th Street, Suite 5766, Omaha, NE 68131, or [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"the Osteoporosis Research Center, Creighton University School of Medicine, Omaha, Nebraska, U.S.A","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052478195","display_name":"Robert R. Recker","orcid":"https://orcid.org/0000-0002-8774-1404","observed_orcids":["https://orcid.org/0000-0002-8774-1404"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert R. Recker","raw_affiliation_strings":["the Osteoporosis Research Center, Creighton University School of Medicine, Omaha, Nebraska, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Osteoporosis Research Center, Creighton University School of Medicine, Omaha, Nebraska, U.S.A","institution_ids":["https://openalex.org/I114493937"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036463343"],"corresponding_institution_ids":["https://openalex.org/I114493937"],"apc_list":null,"apc_paid":null,"fwci":2.7107,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.89675727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"5","first_page":"297","last_page":"305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bone-microarchitecture","display_name":"bone microarchitecture","score":0.9789999723434448},{"id":"https://openalex.org/keywords/histomorphometry","display_name":"histomorphometry","score":0.9509999752044678},{"id":"https://openalex.org/keywords/trabecular-connectivity","display_name":"trabecular connectivity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cortical-bone-thickness","display_name":"cortical bone thickness","score":0.5899999737739563},{"id":"https://openalex.org/keywords/cancellous-bone-volume","display_name":"cancellous bone volume","score":0.9259999990463257},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bone-fragility","display_name":"bone fragility","score":0.8479999899864197},{"id":"https://openalex.org/keywords/microdamage","display_name":"microdamage","score":0.8019999861717224},{"id":"https://openalex.org/keywords/bone-strength","display_name":"bone strength","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2776350087","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cancellous bone","level":2,"score":0.8283787965774536},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7960002422332764},{"id":"https://openalex.org/C2910974163","wikidata":"https://www.wikidata.org/wiki/Q95370697","display_name":"Bone biopsy","level":3,"score":0.5503242015838623},{"id":"https://openalex.org/C2781451080","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cortical bone","level":2,"score":0.5264642834663391},{"id":"https://openalex.org/C3018268312","wikidata":"https://www.wikidata.org/wiki/Q2671642","display_name":"Trabecular bone","level":3,"score":0.48397088050842285},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4667420983314514},{"id":"https://openalex.org/C2781121420","wikidata":"https://www.wikidata.org/wiki/Q750873","display_name":"Trabecular meshwork","level":3,"score":0.45300590991973877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4449104964733124},{"id":"https://openalex.org/C2777241971","wikidata":"https://www.wikidata.org/wiki/Q7831065","display_name":"Trabecula (gastropod)","level":3,"score":0.4336399435997009},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.37861257791519165},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25233474373817444},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.10763701796531677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06958281993865967},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.0},{"id":"https://openalex.org/C157369684","wikidata":"https://www.wikidata.org/wiki/Q34740","display_name":"Genus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005272","descriptor_name":"Femur Neck","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005272","descriptor_name":"Femur Neck","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007085","descriptor_name":"Ilium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007085","descriptor_name":"Ilium","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00002142-200210000-00002","doi":"https://doi.org/10.1097/00002142-200210000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002142-200210000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S90952882","display_name":"Topics in Magnetic Resonance Imaging","issn_l":"0899-3459","issn":["0899-3459","1536-1004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Topics in Magnetic Resonance Imaging","raw_type":"journal-article"},{"id":"pmid:12464743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12464743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Topics in magnetic resonance imaging : TMRI","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1225575464","https://openalex.org/W1964771995","https://openalex.org/W1977271471","https://openalex.org/W1977273464","https://openalex.org/W1982011920","https://openalex.org/W1993090130","https://openalex.org/W1999076184","https://openalex.org/W1999320000","https://openalex.org/W2001149002","https://openalex.org/W2009399798","https://openalex.org/W2019693617","https://openalex.org/W2030359163","https://openalex.org/W2032637635","https://openalex.org/W2039198142","https://openalex.org/W2043362084","https://openalex.org/W2051391248","https://openalex.org/W2051807370","https://openalex.org/W2064442862","https://openalex.org/W2065942289","https://openalex.org/W2070189071","https://openalex.org/W2074205584","https://openalex.org/W2075269759","https://openalex.org/W2078644561","https://openalex.org/W2079327979","https://openalex.org/W2087378917","https://openalex.org/W2087733742","https://openalex.org/W2096734348","https://openalex.org/W2102024055","https://openalex.org/W2103036353","https://openalex.org/W2123621865","https://openalex.org/W2125892636","https://openalex.org/W2156600737","https://openalex.org/W2159837057","https://openalex.org/W2165678091","https://openalex.org/W4234497896","https://openalex.org/W4255217118"],"related_works":["https://openalex.org/W1999076184","https://openalex.org/W56226922","https://openalex.org/W2520922410","https://openalex.org/W2121684618","https://openalex.org/W2464332109","https://openalex.org/W2410298333","https://openalex.org/W2156287580","https://openalex.org/W2041108114","https://openalex.org/W2372383332","https://openalex.org/W2235011778"],"abstract_inverted_index":{"The":[0],"bone":[1,13,19,39,77,86,97,142,194],"fragility":[2],"of":[3,17,27,35,49,72,94,104,113,117,173,181,190],"osteoporosis":[4,126,182],"is":[5,29,62,78,151],"not":[6],"fully":[7],"explained":[8],"by":[9],"a":[10,70,170],"deficit":[11,71,98],"in":[12,52,148],"mass.":[14],"Histomorphometric":[15,41,164],"examination":[16],"transilial":[18,149,167],"biopsies":[20,150,168],"has":[21],"identified":[22],"microstructural":[23],"defects":[24],"that-in":[25],"light":[26],"what":[28],"known":[30],"about":[31,175,187],"the":[32,44,47,55,95,139,154,176,188],"mechanical":[33],"properties":[34],"structural":[36,177],"materials-further":[37],"compromise":[38],"strength.":[40],"measures":[42,116],"describe":[43],"biopsy":[45],"specimen,":[46],"configuration":[48],"its":[50,59],"trabeculae":[51],"space,":[53],"and":[54,75,84,131,153,178,183],"extent":[56],"to":[57,89,102,110,161],"which":[58],"trabecular":[60,106,118,129],"lattice":[61],"intact.":[63],"In":[64],"postmenopausal":[65],"women":[66,123],"with":[67,124],"established":[68,125],"osteoporosis,":[69],"both":[73,81],"cortical":[74,82],"cancellous":[76,85,96,141],"typical,":[79],"i.e.,":[80],"thickness":[83],"volume":[87],"tend":[88],"be":[90,100,159],"substantially":[91],"reduced.":[92],"Much":[93],"can":[99],"attributed":[101],"loss":[103],"entire":[105],"elements":[107],"rather":[108],"than":[109,134],"generalized":[111],"thinning":[112],"trabeculae.":[114],"Direct":[115],"connectivity":[119],"confirm":[120],"this":[121],"impression:":[122],"have":[127],"fewer":[128],"nodes":[130],"more":[132],"termini":[133],"healthy":[135],"women,":[136],"even":[137],"at":[138],"same":[140],"volume.":[143],"Evidence":[144],"for":[145],"accumulated":[146],"microdamage":[147],"circumstantial,":[152],"phenomenon":[155],"itself":[156],"may":[157],"well":[158],"localized":[160],"fracture":[162],"sites.":[163],"data":[165],"from":[166],"comprise":[169],"large":[171],"body":[172],"information":[174,186],"functional":[179],"character":[180],"provide":[184],"valuable":[185],"effects":[189],"new":[191],"treatments":[192],"on":[193],"microstructure.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}