{"id":"https://openalex.org/W2332298292","doi":"https://doi.org/10.1097/00002281-200001000-00003","title":"Are animal models of vasculitis suitable tools?","display_name":"Are animal models of vasculitis suitable tools?","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2332298292","doi":"https://doi.org/10.1097/00002281-200001000-00003","mag":"2332298292","pmid":"https://pubmed.ncbi.nlm.nih.gov/10647949"},"language":"en","primary_location":{"id":"doi:10.1097/00002281-200001000-00003","doi":"https://doi.org/10.1097/00002281-200001000-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002281-200001000-00003","pdf_url":null,"source":{"id":"https://openalex.org/S31702427","display_name":"Current Opinion in Rheumatology","issn_l":"1040-8711","issn":["1040-8711","1080-8175","1531-6963"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Rheumatology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012967877","display_name":"Ulrich Specks","orcid":"https://orcid.org/0000-0002-6559-1206","observed_orcids":["https://orcid.org/0000-0002-6559-1206"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ulrich Specks","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA. specks.ulrich@mayo.edu","Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA","e-mail: [email\u00a0protected]","to Ulrich Specks, MD, Division of Pulmonary and Critical Care Medicine, Thoracic Disease Research Unit, 200 First Street SW, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA. specks.ulrich@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"to Ulrich Specks, MD, Division of Pulmonary and Critical Care Medicine, Thoracic Disease Research Unit, 200 First Street SW, Rochester, MN 55905, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012967877"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":0.6942,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.58248175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"1","first_page":"11","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.10159999877214432,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-vasculitis","display_name":"systemic vasculitis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.8050000071525574},{"id":"https://openalex.org/keywords/rodent-models","display_name":"rodent models","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mrl-lpr-mice","display_name":"MRL/lpr mice","score":0.9449999928474426},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9850000143051147},{"id":"https://openalex.org/keywords/autoimmune-disease-genetics","display_name":"autoimmune disease genetics","score":0.6269999742507935},{"id":"https://openalex.org/keywords/genetic-linkage","display_name":"genetic linkage","score":0.5860000252723694},{"id":"https://openalex.org/keywords/environmental-factors","display_name":"environmental factors","score":0.6510000228881836},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.621999979019165},{"id":"https://openalex.org/keywords/brown-norway-rats","display_name":"Brown Norway rats","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.7310000061988831},{"id":"https://openalex.org/keywords/glomerulonephritis","display_name":"glomerulonephritis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6946978569030762},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6187403798103333},{"id":"https://openalex.org/C2776015282","wikidata":"https://www.wikidata.org/wiki/Q644318","display_name":"Vasculitis","level":3,"score":0.6006184816360474},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5908571481704712},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5512040853500366},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.5112693309783936},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4905702471733093},{"id":"https://openalex.org/C2777374719","wikidata":"https://www.wikidata.org/wiki/Q7663822","display_name":"Systemic vasculitis","level":4,"score":0.48533788323402405},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.4848543405532837},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.47537484765052795},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.4576931893825531},{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.45689699053764343},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.4200955927371979},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.395275741815567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19277164340019226},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18236935138702393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1758955419063568},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1651020348072052},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.11935579776763916},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002678","descriptor_name":"Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005921","descriptor_name":"Glomerulonephritis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008627","descriptor_name":"Mercuric Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014657","descriptor_name":"Vasculitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019463","descriptor_name":"Mice, Inbred MRL lpr","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00002281-200001000-00003","doi":"https://doi.org/10.1097/00002281-200001000-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002281-200001000-00003","pdf_url":null,"source":{"id":"https://openalex.org/S31702427","display_name":"Current Opinion in Rheumatology","issn_l":"1040-8711","issn":["1040-8711","1080-8175","1531-6963"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Rheumatology","raw_type":"journal-article"},{"id":"pmid:10647949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10647949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in rheumatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W116317464","https://openalex.org/W125031658","https://openalex.org/W281685021","https://openalex.org/W1496332753","https://openalex.org/W1505710072","https://openalex.org/W1508802322","https://openalex.org/W1561304291","https://openalex.org/W1563450803","https://openalex.org/W1563778496","https://openalex.org/W1968991342","https://openalex.org/W1969848809","https://openalex.org/W1971288007","https://openalex.org/W1973154834","https://openalex.org/W1974954588","https://openalex.org/W1984927734","https://openalex.org/W1987283726","https://openalex.org/W1990794875","https://openalex.org/W1995338407","https://openalex.org/W1996182204","https://openalex.org/W1997839877","https://openalex.org/W2016317279","https://openalex.org/W2019970750","https://openalex.org/W2023277595","https://openalex.org/W2023615599","https://openalex.org/W2027636780","https://openalex.org/W2028111124","https://openalex.org/W2028155932","https://openalex.org/W2028776435","https://openalex.org/W2033596950","https://openalex.org/W2033784825","https://openalex.org/W2036771863","https://openalex.org/W2039195878","https://openalex.org/W2039381722","https://openalex.org/W2041287254","https://openalex.org/W2044476867","https://openalex.org/W2051150504","https://openalex.org/W2054481561","https://openalex.org/W2056167547","https://openalex.org/W2063854682","https://openalex.org/W2064542417","https://openalex.org/W2065351142","https://openalex.org/W2068867207","https://openalex.org/W2073317648","https://openalex.org/W2081564035","https://openalex.org/W2083673157","https://openalex.org/W2096484097","https://openalex.org/W2109469752","https://openalex.org/W2109656144","https://openalex.org/W2156346523","https://openalex.org/W2157785787","https://openalex.org/W2243642129","https://openalex.org/W2276897932","https://openalex.org/W2281233368","https://openalex.org/W2314315424","https://openalex.org/W2326431654","https://openalex.org/W2330545957","https://openalex.org/W2413619357","https://openalex.org/W2415525725","https://openalex.org/W2464759531"],"related_works":["https://openalex.org/W3212685041","https://openalex.org/W2571035448","https://openalex.org/W2132778108","https://openalex.org/W3021173613","https://openalex.org/W2936905985","https://openalex.org/W88104161","https://openalex.org/W2908504248","https://openalex.org/W2085939342","https://openalex.org/W1965475850","https://openalex.org/W1036636799"],"abstract_inverted_index":{"Several":[0],"rodent":[1],"models":[2,121],"have":[3,34,99],"been":[4,16],"proposed":[5],"for":[6,22],"various":[7,49],"forms":[8],"of":[9,40,48,72,113],"systemic":[10,23],"vasculitis.":[11],"The":[12],"MRL-lpr":[13],"mouse":[14],"has":[15,53],"studied":[17],"extensively":[18],"as":[19,69],"a":[20],"model":[21],"lupus":[24],"erythematosus.":[25],"Backcross":[26],"experiments":[27],"in":[28,79],"combination":[29,47],"with":[30,76,86,93],"genetic":[31],"linkage":[32],"studies":[33],"firmly":[35],"established":[36],"that":[37,57],"the":[38,46,63,70,104,111,119],"phenotype":[39],"autoimmune":[41],"disease":[42,64],"is":[43],"dependent":[44],"on":[45],"background":[50],"genes.":[51],"It":[52],"also":[54],"become":[55],"apparent":[56],"environmental":[58],"factors,":[59],"particularly":[60],"infections,":[61],"modulate":[62],"phenotype.":[65],"Specific":[66],"interventions,":[67],"such":[68],"treatment":[71],"Brown":[73],"Norway":[74],"rats":[75],"agents":[77],"resulting":[78],"polyclonal":[80],"B":[81],"cell":[82],"stimulation":[83],"or":[84],"immunization":[85],"human":[87,128],"myeloperoxidase":[88],"and":[89,97,106,115,142],"subsequent":[90],"localized":[91],"perfusion":[92],"neutrophil":[94],"lysosomal":[95],"extract":[96],"H2O2,":[98],"provided":[100],"substantial":[101],"insights":[102],"into":[103],"cellular":[105],"molecular":[107],"mechanisms":[108],"leading":[109],"to":[110,136],"development":[112],"vasculitis":[114],"glomerulonephritis.":[116],"Even":[117],"though":[118],"existing":[120],"may":[122],"not":[123],"exactly":[124],"mirror":[125],"any":[126],"specific":[127,138],"disease,":[129],"they":[130],"offer":[131],"reproducible,":[132],"highly":[133],"controlled":[134],"conditions":[135],"answer":[137],"questions":[139],"about":[140],"pathogenesis":[141],"novel":[143],"therapeutic":[144],"approaches.":[145]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
