{"id":"https://openalex.org/W2332234402","doi":"https://doi.org/10.4049/jimmunol.190.supp.131.8","title":"Persistent inflammation and fibrosis of the lung are long-term complications of sepsis in baboons (P4015)","display_name":"Persistent inflammation and fibrosis of the lung are long-term complications of sepsis in baboons (P4015)","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W2332234402","doi":"https://doi.org/10.4049/jimmunol.190.supp.131.8","mag":"2332234402"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.190.supp.131.8","doi":"https://doi.org/10.4049/jimmunol.190.supp.131.8","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.190.supp.131.8","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056174184","display_name":"Florea Lupu","orcid":"https://orcid.org/0000-0003-1249-9278","observed_orcids":["https://orcid.org/0000-0003-1249-9278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florea Lupu","raw_affiliation_strings":["Cardiovascular Biology, Oklahoma Med. Res. Fndn. , Oklahoma City, OK","Pathology, Univ. of Oklahoma Hlth. Sci. Ctr. , Oklahoma City, OK","1Cardiovascular Biology, Oklahoma Med. Res. Fndn., Oklahoma City, OK","2Pathology, Univ. of Oklahoma Hlth. Sci. Ctr., Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Biology, Oklahoma Med. Res. Fndn. , Oklahoma City, OK","institution_ids":[]},{"raw_affiliation_string":"Pathology, Univ. of Oklahoma Hlth. Sci. Ctr. , Oklahoma City, OK","institution_ids":[]},{"raw_affiliation_string":"1Cardiovascular Biology, Oklahoma Med. Res. Fndn., Oklahoma City, OK","institution_ids":[]},{"raw_affiliation_string":"2Pathology, Univ. of Oklahoma Hlth. Sci. Ctr., Oklahoma City, OK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051793084","display_name":"Robert Silasi\u2010Mansat","orcid":"https://orcid.org/0000-0001-9590-6160","observed_orcids":["https://orcid.org/0000-0001-9590-6160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Silasi-Mansat","raw_affiliation_strings":["Cardiovascular Biology, Oklahoma Med. Res. Fndn. , Oklahoma City, OK","1Cardiovascular Biology, Oklahoma Med. Res. Fndn., Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Biology, Oklahoma Med. Res. Fndn. , Oklahoma City, OK","institution_ids":[]},{"raw_affiliation_string":"1Cardiovascular Biology, Oklahoma Med. Res. Fndn., Oklahoma City, OK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023330760","display_name":"Ravi Shankar Keshari","orcid":"https://orcid.org/0000-0002-4177-9095","observed_orcids":["https://orcid.org/0000-0002-4177-9095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ravi Keshari","raw_affiliation_strings":["Cardiovascular Biology, Oklahoma Med. Res. Fndn. , Oklahoma City, OK","1Cardiovascular Biology, Oklahoma Med. Res. Fndn., Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Biology, Oklahoma Med. Res. Fndn. , Oklahoma City, OK","institution_ids":[]},{"raw_affiliation_string":"1Cardiovascular Biology, Oklahoma Med. Res. Fndn., Oklahoma City, OK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113622348","display_name":"Glenn T. Peer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenn Peer","raw_affiliation_strings":["Medicine, Univ. of Oklahoma Hlth. Sci. Ctr. , Oklahoma City, OK","3Medicine, Univ. of Oklahoma Hlth. Sci. Ctr., Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Univ. of Oklahoma Hlth. Sci. Ctr. , Oklahoma City, OK","institution_ids":[]},{"raw_affiliation_string":"3Medicine, Univ. of Oklahoma Hlth. Sci. Ctr., Oklahoma City, OK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083245117","display_name":"Narcis Ioan Popescu","orcid":"https://orcid.org/0000-0002-4809-9885","observed_orcids":["https://orcid.org/0000-0002-4809-9885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Narcis Popescu","raw_affiliation_strings":["Cardiovascular Biology, Oklahoma Med. Res. Fndn. , Oklahoma City, OK","1Cardiovascular Biology, Oklahoma Med. Res. Fndn., Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Biology, Oklahoma Med. Res. Fndn. , Oklahoma City, OK","institution_ids":[]},{"raw_affiliation_string":"1Cardiovascular Biology, Oklahoma Med. Res. Fndn., Oklahoma City, OK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037595362","display_name":"Cristina Lupu","orcid":"https://orcid.org/0000-0001-8619-0893","observed_orcids":["https://orcid.org/0000-0001-8619-0893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina Lupu","raw_affiliation_strings":["Cardiovascular Biology, Oklahoma Med. Res. Fndn. , Oklahoma City, OK","1Cardiovascular Biology, Oklahoma Med. Res. Fndn., Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Biology, Oklahoma Med. Res. Fndn. , Oklahoma City, OK","institution_ids":[]},{"raw_affiliation_string":"1Cardiovascular Biology, Oklahoma Med. Res. Fndn., Oklahoma City, OK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056158088","display_name":"Fletcher B. Taylor","orcid":"https://orcid.org/0000-0002-1040-8013","observed_orcids":["https://orcid.org/0000-0002-1040-8013"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fletcher Taylor","raw_affiliation_strings":["Cardiovascular Biology, Oklahoma Med. Res. Fndn. , Oklahoma City, OK","1Cardiovascular Biology, Oklahoma Med. Res. Fndn., Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Biology, Oklahoma Med. Res. Fndn. , Oklahoma City, OK","institution_ids":[]},{"raw_affiliation_string":"1Cardiovascular Biology, Oklahoma Med. Res. Fndn., Oklahoma City, OK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074301183","display_name":"John D. Lambris","orcid":"https://orcid.org/0000-0002-9370-5776","observed_orcids":["https://orcid.org/0000-0002-9370-5776"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Lambris","raw_affiliation_strings":["Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia, PA","4Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"4Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059311893","display_name":"Gary T. Kinasewitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Kinasewitz","raw_affiliation_strings":["Medicine, Univ. of Oklahoma Hlth. Sci. Ctr. , Oklahoma City, OK","3Medicine, Univ. of Oklahoma Hlth. Sci. Ctr., Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Univ. of Oklahoma Hlth. Sci. Ctr. , Oklahoma City, OK","institution_ids":[]},{"raw_affiliation_string":"3Medicine, Univ. of Oklahoma Hlth. Sci. Ctr., Oklahoma City, OK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"190","issue":"Supplement_1","first_page":"131.8","last_page":"131.8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.32760000228881836,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.968999981880188},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/chronic-lung-inflammation","display_name":"chronic lung inflammation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/escherichia-coli-sepsis","display_name":"Escherichia coli sepsis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/baboon-model","display_name":"baboon model","score":0.906000018119812},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.7979999780654907},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9020000100135803},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9200000166893005},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.7300000190734863},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.8970000147819519},{"id":"https://openalex.org/keywords/fibroblast-proliferation","display_name":"fibroblast proliferation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nonhuman-primate-model","display_name":"nonhuman primate model","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.723991870880127},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.705199122428894},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6503134965896606},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6459953784942627},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6119428277015686},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5940835475921631},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.49898815155029297},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.48771581053733826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4620171785354614},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43862807750701904},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.4321780800819397},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.4294919967651367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34743940830230713},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.24686923623085022},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.15431490540504456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14725741744041443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.190.supp.131.8","doi":"https://doi.org/10.4049/jimmunol.190.supp.131.8","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.190.supp.131.8","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1940215786","https://openalex.org/W2135607481","https://openalex.org/W3174364191","https://openalex.org/W2064513002","https://openalex.org/W2149539659","https://openalex.org/W7161411415","https://openalex.org/W4406089367","https://openalex.org/W1592994035","https://openalex.org/W2989790713","https://openalex.org/W6922208511"],"abstract_inverted_index":{"Abstract":[0],"Sepsis-induced":[1],"inflammation":[2,60],"of":[3,25,37,48,81,88,155,159],"the":[4,32,40,62,69,86,105,132,156,179,186],"lung":[5,187],"leads":[6],"to":[7,95,125,192],"acute":[8,70],"respiratory":[9],"distress":[10],"syndrome":[11],"(ARDS),":[12],"which":[13,57],"may":[14,190],"trigger":[15],"persistent":[16,59],"fibrotic":[17,183],"responses.":[18],"We":[19],"have":[20],"developed":[21],"a":[22],"baboon":[23],"model":[24],"E.":[26,166],"coli":[27,167],"sepsis-induced":[28,168],"ARDS":[29,169,194],"and":[30,53,74,111,135,146,175,189,196],"characterized":[31],"long-term":[33],"(6-24":[34],"months)":[35],"effects":[36],"sepsis":[38,71,92],"on":[39],"lung.":[41],"By":[42],"immunocytochemistry,":[43],"we":[44,163],"detected":[45],"focal":[46],"accumulation":[47,103],"neutrophils,":[49],"M2":[50],"macrophages,":[51],"IL17":[52],"TGF-\u03b2":[54,151],"positive":[55],"cells,":[56],"indicates":[58],"in":[61,85,119,178,199],"lung,":[63],"months":[64],"after":[65],"clinical":[66],"recovery":[67],"from":[68],"episode.":[72],"Microscopical":[73],"biochemical":[75],"quantification":[76],"demonstrated":[77,115],"an":[78],"almost":[79],"doubling":[80],"collagen":[82,129,176],"content":[83],"amount":[84],"lungs":[87],"animals":[89],"that":[90,150,165],"survived":[91],"as":[93],"compared":[94],"age-matched":[96],"nonexposed":[97],"controls.":[98],"Electron":[99],"microscopy":[100],"showed":[101,127],"myofibroblast":[102],"within":[104,131],"alveolar":[106],"wall.":[107],"Co-staining":[108],"for":[109],"fibroblast":[110,173],"cell":[112,117],"proliferation":[113,118,174],"markers":[114],"active":[116,128],"fibroblastic":[120,133],"foci.":[121],"Immunostaining":[122],"with":[123,143],"antibodies":[124],"procollagens":[126],"synthesis":[130],"foci":[134],"interalveolar":[136],"septa.":[137],"These":[138,181],"fibroblasts":[139],"were":[140],"also":[141],"stained":[142],"phospho":[144],"Smad-2":[145],"CTGF":[147],"antibodies,":[148],"suggesting":[149],"signaling":[152],"was":[153],"one":[154],"main":[157],"mediators":[158],"fibrosis.":[160],"In":[161],"conclusion,":[162],"show":[164],"triggers":[170],"chronic":[171],"inflammation,":[172],"deposition":[177],"primate.":[180],"long-lasting":[182],"responses":[184],"perpetuate":[185],"injury":[188],"contribute":[191],"post":[193],"morbidity":[195],"mortality":[197],"observed":[198],"humans.":[200]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
