{"id":"https://openalex.org/W2332066720","doi":"https://doi.org/10.1158/1538-7445.am2011-pl03-03","title":"Abstract PL03-03: The clinical significance of intratumor diversity in breast cancer","display_name":"Abstract PL03-03: The clinical significance of intratumor diversity in breast cancer","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2332066720","doi":"https://doi.org/10.1158/1538-7445.am2011-pl03-03","mag":"2332066720"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-pl03-03","doi":"https://doi.org/10.1158/1538-7445.am2011-pl03-03","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-pl03-03","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014395742","display_name":"Korn\u00e9lia Poly\u00e1k","orcid":"https://orcid.org/0000-0002-5964-0382","observed_orcids":["https://orcid.org/0000-0002-5964-0382"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kornelia Polyak","raw_affiliation_strings":["1Dana-Farber Cancer Inst., Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Inst., Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014395742"],"corresponding_institution_ids":["https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"PL03","last_page":"03"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.972000002861023},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6200000047683716},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.9800000190734863},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cd24","display_name":"CD24","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-subpopulations","display_name":"tumor cell subpopulations","score":0.7229999899864197},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6460000276565552},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.795075535774231},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6695269346237183},{"id":"https://openalex.org/C2779492189","wikidata":"https://www.wikidata.org/wiki/Q1190762","display_name":"CD24","level":4,"score":0.6669526100158691},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5194084644317627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5011742115020752},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4905818998813629},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4645879566669464},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43712976574897766},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38453513383865356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33208680152893066},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27635377645492554},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18687298893928528}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-pl03-03","doi":"https://doi.org/10.1158/1538-7445.am2011-pl03-03","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-pl03-03","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2314296601","https://openalex.org/W2017570437","https://openalex.org/W2319085993","https://openalex.org/W7099142669","https://openalex.org/W2107773340","https://openalex.org/W2160076878","https://openalex.org/W2406335977","https://openalex.org/W2313328174","https://openalex.org/W1987819836","https://openalex.org/W2148847151"],"abstract_inverted_index":{"Abstract":[0],"Intratumor":[1],"diversity":[2,148,176],"for":[3,58,96,209],"hereditary":[4],"traits":[5],"is":[6],"the":[7,20,45,59,77,126,137,144,162,185,201,206],"driver":[8],"of":[9,22,41,62,120,146,164,174,187,200,205],"tumor":[10,30,50,82,87],"evolution,":[11],"including":[12],"disease":[13],"progression":[14,31,188],"and":[15,25,32,48,53,69,71,93,101,113,124,143,153,169,189],"therapeutic":[16,34,190],"resistance.":[17,191],"To":[18],"investigate":[19],"role":[21],"intratumor":[23,147,175],"genetic":[24,121],"phenotypic":[26,63],"heterogeneity":[27,122],"in":[28,33,131,134],"breast":[29,49],"responses,":[35],"we":[36,83],"performed":[37],"immunoFISH":[38],"(iFISH)":[39],"analyses":[40],"distant":[42,138],"metastases":[43,139],"from":[44],"same":[46],"patient":[47],"biopsies":[51],"before":[52],"after":[54],"treatment.":[55],"iFISH":[56,107],"allows":[57],"combined":[60],"analysis":[61],"markers":[64],"(e.g.,":[65],"such":[66],"as":[67,167,180],"CD24":[68],"CD44)":[70],"chromosomal":[72,97,105],"copy":[73],"number":[74],"gains":[75],"at":[76,99],"single-cell":[78],"level.":[79],"In":[80],"each":[81],"evaluated":[84,110],"four":[85,127],"distinct":[86],"cell":[88,129],"populations":[89],"(CD44+/CD24-,":[90],"CD44-/CD24+,":[91],"CD44+/CD24+,":[92],"CD44-/CD24-":[94],"cells)":[95],"gain":[98],"8q24":[100],"other":[102],"commonly":[103],"gained":[104],"regions.":[106],"data":[108],"was":[109,149,154],"using":[111],"ecological":[112],"evolutionary":[114],"models.":[115],"We":[116],"found":[117],"high":[118],"degree":[119,145],"within":[123],"between":[125],"different":[128],"subpopulations":[130],"some":[132,135],"tumors,":[133],"patients":[136],"were":[140],"highly":[141],"divergent,":[142],"altered":[150],"by":[151],"treatment":[152],"associated":[155],"with":[156],"clinical":[157],"characteristics.":[158],"Our":[159],"findings":[160],"demonstrate":[161],"power":[163],"analyzing":[165],"tumors":[166],"ecosystems":[168],"indicate":[170],"that":[171],"numerical":[172],"measures":[173],"can":[177],"be":[178],"used":[179],"clinically":[181],"useful":[182],"biomarkers":[183],"predicting":[184],"risk":[186],"Citation":[192],"Format:":[193],"{Authors}.":[194],"{Abstract":[195],"title}":[196],"[abstract].":[197],"In:":[198],"Proceedings":[199],"102nd":[202],"Annual":[203],"Meeting":[204],"American":[207],"Association":[208],"Cancer":[210,220],"Research;":[211],"2011":[212],"Apr":[213],"2-6;":[214],"Orlando,":[215],"FL.":[216],"Philadelphia":[217],"(PA):":[218],"AACR;":[219],"Res":[221],"2011;71(8":[222],"Suppl):Abstract":[223],"nr":[224],"PL03-03.":[225],"doi:10.1158/1538-7445.AM2011-PL03-03":[226]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}
