{"id":"https://openalex.org/W2331978393","doi":"https://doi.org/10.1093/femspd/ftv014","title":"Signature-tagged mutagenesis and co-infection studies demonstrate the importance of P fimbriae in a murine model of urinary tract infection","display_name":"Signature-tagged mutagenesis and co-infection studies demonstrate the importance of P fimbriae in a murine model of urinary tract infection","publication_year":2015,"publication_date":"2015-02-11","ids":{"openalex":"https://openalex.org/W2331978393","doi":"https://doi.org/10.1093/femspd/ftv014","mag":"2331978393","pmid":"https://pubmed.ncbi.nlm.nih.gov/25673667","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4542639"},"language":"en","primary_location":{"id":"doi:10.1093/femspd/ftv014","doi":"https://doi.org/10.1093/femspd/ftv014","is_oa":true,"landing_page_url":"https://doi.org/10.1093/femspd/ftv014","pdf_url":"https://academic.oup.com/femspd/article-pdf/73/4/ftv014/10749562/ftv014.pdf","source":{"id":"https://openalex.org/S2735191819","display_name":"Pathogens and Disease","issn_l":"2049-632X","issn":["2049-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens and Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/femspd/article-pdf/73/4/ftv014/10749562/ftv014.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009022430","display_name":"Eric L. Buckles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric L. Buckles","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017902609","display_name":"Courtney Luterbach","orcid":"https://orcid.org/0000-0003-2509-0842","observed_orcids":["https://orcid.org/0000-0003-2509-0842"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney L. Luterbach","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395175","display_name":"Xiaolin Wang","orcid":"https://orcid.org/0000-0003-3675-945X","observed_orcids":["https://orcid.org/0000-0003-3675-945X","https://orcid.org/0000-0002-0102-0092"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaolin Wang","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077856075","display_name":"C. Virginia Lockatell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Virginia Lockatell","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109361078","display_name":"David E. Johnson","orcid":"https://orcid.org/0000-0002-1509-9782","observed_orcids":["https://orcid.org/0000-0002-1509-9782"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Johnson","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA Department of Veterans Affairs, Baltimore, MD 21201, USA","Department of Veterans Affairs, Baltimore, MD 21201, USA","Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA Department of Veterans Affairs, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1322918889"]},{"raw_affiliation_string":"Department of Veterans Affairs, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I1322918889"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006179322","display_name":"Harry L. T. Mobley","orcid":"https://orcid.org/0000-0001-9195-7665","observed_orcids":["https://orcid.org/0000-0001-9195-7665"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry L. T. Mobley","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089121517","display_name":"Michael S. Donnenberg","orcid":"https://orcid.org/0000-0002-8818-3184","observed_orcids":["https://orcid.org/0000-0002-8818-3184"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael S. Donnenberg","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA mdonnenb@umaryland.edu","Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA mdonnenb@umaryland.edu","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, HSF II, 20 Penn Street, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5089121517"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":{"value":2500,"currency":"GBP","value_usd":3297},"apc_paid":null,"fwci":2.3386,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.8676345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"73","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-fimbriae","display_name":"P fimbriae","score":0.9210000038146973},{"id":"https://openalex.org/keywords/papc","display_name":"papC","score":0.6259999871253967},{"id":"https://openalex.org/keywords/uropathogenic-escherichia-coli","display_name":"uropathogenic Escherichia coli","score":0.9660000205039978},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cystitis","display_name":"cystitis","score":0.796999990940094},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.8790000081062317},{"id":"https://openalex.org/keywords/signature-tagged-mutagenesis","display_name":"signature-tagged mutagenesis","score":0.859000027179718},{"id":"https://openalex.org/keywords/coinfection","display_name":"co-infection","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bacterial-colonization","display_name":"bacterial colonization","score":0.5220000147819519},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C39103817","wikidata":"https://www.wikidata.org/wiki/Q1810775","display_name":"Fimbria","level":4,"score":0.9743120670318604},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.858924150466919},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8181284070014954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8109837770462036},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7911575436592102},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.6470171213150024},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.5650791525840759},{"id":"https://openalex.org/C2776927270","wikidata":"https://www.wikidata.org/wiki/Q815962","display_name":"Colonization","level":2,"score":0.5607645511627197},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5415601134300232},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5234862565994263},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.5041855573654175},{"id":"https://openalex.org/C179470777","wikidata":"https://www.wikidata.org/wiki/Q356661","display_name":"Bacterial adhesin","level":4,"score":0.4971325695514679},{"id":"https://openalex.org/C174832134","wikidata":"https://www.wikidata.org/wiki/Q934786","display_name":"Pilus","level":4,"score":0.4955631494522095},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.4538194239139557},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4293445646762848},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3446142375469208}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001422","descriptor_name":"Bacterial Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001422","descriptor_name":"Bacterial Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001422","descriptor_name":"Bacterial Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056689","descriptor_name":"Uropathogenic Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056689","descriptor_name":"Uropathogenic Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056689","descriptor_name":"Uropathogenic Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056689","descriptor_name":"Uropathogenic Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056689","descriptor_name":"Uropathogenic Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056689","descriptor_name":"Uropathogenic Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060085","descriptor_name":"Coinfection","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D060085","descriptor_name":"Coinfection","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D060085","descriptor_name":"Coinfection","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/femspd/ftv014","doi":"https://doi.org/10.1093/femspd/ftv014","is_oa":true,"landing_page_url":"https://doi.org/10.1093/femspd/ftv014","pdf_url":"https://academic.oup.com/femspd/article-pdf/73/4/ftv014/10749562/ftv014.pdf","source":{"id":"https://openalex.org/S2735191819","display_name":"Pathogens and Disease","issn_l":"2049-632X","issn":["2049-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens and Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4542639","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4542639","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathog Dis","raw_type":"Text"},{"id":"pmid:25673667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25673667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens and disease","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/femspd/ftv014","doi":"https://doi.org/10.1093/femspd/ftv014","is_oa":true,"landing_page_url":"https://doi.org/10.1093/femspd/ftv014","pdf_url":"https://academic.oup.com/femspd/article-pdf/73/4/ftv014/10749562/ftv014.pdf","source":{"id":"https://openalex.org/S2735191819","display_name":"Pathogens and Disease","issn_l":"2049-632X","issn":["2049-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens and Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1593294659","display_name":"Molecular mechanisms of uropathogenesis","funder_award_id":"R01AI059722","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2032687367","display_name":null,"funder_award_id":"AI-059722","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3751895368","display_name":null,"funder_award_id":"2P01 DK 49720","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5860453432","display_name":null,"funder_award_id":"P01 DK049720","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7859147068","display_name":"Vaccine to prevent E. coli urinary tract infection","funder_award_id":"R01AI116791","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2331978393.pdf","grobid_xml":"https://content.openalex.org/works/W2331978393.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W75985248","https://openalex.org/W113802592","https://openalex.org/W1528475631","https://openalex.org/W1543330266","https://openalex.org/W1602361928","https://openalex.org/W1604470024","https://openalex.org/W1636002209","https://openalex.org/W1766948196","https://openalex.org/W1787690277","https://openalex.org/W1824289027","https://openalex.org/W1824614244","https://openalex.org/W1890589065","https://openalex.org/W1919890156","https://openalex.org/W1978608255","https://openalex.org/W1985712951","https://openalex.org/W1990731735","https://openalex.org/W1999823179","https://openalex.org/W2000750186","https://openalex.org/W2000807569","https://openalex.org/W2001932212","https://openalex.org/W2007789712","https://openalex.org/W2011711317","https://openalex.org/W2013955149","https://openalex.org/W2014646139","https://openalex.org/W2020326478","https://openalex.org/W2020354602","https://openalex.org/W2033313498","https://openalex.org/W2034048814","https://openalex.org/W2038169339","https://openalex.org/W2043098646","https://openalex.org/W2044652625","https://openalex.org/W2044835571","https://openalex.org/W2053138162","https://openalex.org/W2054941036","https://openalex.org/W2056097976","https://openalex.org/W2067759009","https://openalex.org/W2073699143","https://openalex.org/W2082345749","https://openalex.org/W2083275944","https://openalex.org/W2083870383","https://openalex.org/W2084376380","https://openalex.org/W2084752926","https://openalex.org/W2088732289","https://openalex.org/W2090919148","https://openalex.org/W2094940364","https://openalex.org/W2099926472","https://openalex.org/W2099963994","https://openalex.org/W2100122962","https://openalex.org/W2101637688","https://openalex.org/W2102249573","https://openalex.org/W2102850224","https://openalex.org/W2107277218","https://openalex.org/W2107818256","https://openalex.org/W2109044013","https://openalex.org/W2109331431","https://openalex.org/W2109359144","https://openalex.org/W2109962467","https://openalex.org/W2115332881","https://openalex.org/W2117190793","https://openalex.org/W2118085294","https://openalex.org/W2123724054","https://openalex.org/W2123779514","https://openalex.org/W2126180048","https://openalex.org/W2128900866","https://openalex.org/W2130749080","https://openalex.org/W2133188879","https://openalex.org/W2134075283","https://openalex.org/W2143106471","https://openalex.org/W2144498842","https://openalex.org/W2144624514","https://openalex.org/W2149010596","https://openalex.org/W2150436768","https://openalex.org/W2153139855","https://openalex.org/W2153664745","https://openalex.org/W2153765180","https://openalex.org/W2154075906","https://openalex.org/W2154122150","https://openalex.org/W2160308056","https://openalex.org/W2163136815","https://openalex.org/W2164097967","https://openalex.org/W2164648927","https://openalex.org/W2165222007","https://openalex.org/W2168409672","https://openalex.org/W2192125289","https://openalex.org/W2318916999","https://openalex.org/W2337712693","https://openalex.org/W2403098959","https://openalex.org/W2410401228","https://openalex.org/W4231450883"],"related_works":["https://openalex.org/W2094940364","https://openalex.org/W2109429796","https://openalex.org/W2104859832","https://openalex.org/W2102249573","https://openalex.org/W2047335243","https://openalex.org/W1970012260","https://openalex.org/W1546752757","https://openalex.org/W2123779514","https://openalex.org/W174831603","https://openalex.org/W2415444538"],"abstract_inverted_index":{"Escherichia":[0],"coli":[1,38,118],"is":[2,155],"the":[3,13,23,34,126,132,146,156],"leading":[4],"cause":[5],"of":[6,12,36,54,65,85,114,135,172],"urinary":[7],"tract":[8],"infections":[9,16,86],"(UTIs),":[10],"one":[11],"most":[14],"common":[15],"in":[17,48,68,82,88,129,131,163,188],"humans.":[18,89],"P":[19,66,182],"fimbria":[20,183],"was":[21,123,168],"arguably":[22],"first":[24,157],"proposed":[25],"virulence":[26,186],"factor":[27,187],"for":[28,63,79,111],"uropathogenic":[29,80],"E.":[30,37,55,117],"coli,":[31],"based":[32],"on":[33],"capacity":[35],"isolated":[39],"from":[40],"UTIs":[41],"to":[42,44,75,158,178],"adhere":[43],"exfoliated":[45],"epithelial":[46],"cells":[47],"higher":[49],"numbers":[50],"than":[51],"fecal":[52],"strains":[53,81],"coli.":[56],"Overwhelming":[57],"epidemiologic":[58],"evidence":[59],"has":[60,71],"been":[61,72],"presented":[62],"involvement":[64],"fimbriae":[67],"colonization.":[69],"It":[70],"difficult,":[73],"however,":[74],"demonstrate":[76],"this":[77,91,139,153],"requirement":[78],"animal":[83],"models":[84],"or":[87],"In":[90],"study,":[92],"a":[93,98,165,185,189],"signature-tagged":[94],"mutagenesis":[95],"screen":[96],"identified":[97],"P-fimbrial":[99,121],"gene":[100],"(papC)":[101],"and":[102,138,175],"18":[103],"other":[104],"genes":[105,174],"as":[106,184],"being":[107],"among":[108],"those":[109],"required":[110],"full":[112],"fitness":[113],"cystitis":[115],"isolate":[116],"F11.":[119],"A":[120],"mutant":[122],"outcompeted":[124],"by":[125,170],"wild-type":[127],"strain":[128,167],"cochallenge":[130],"murine":[133],"model":[134],"ascending":[136],"UTI,":[137],"colonization":[140],"defect":[141],"could":[142],"be":[143],"complemented":[144,177],"with":[145],"cloned":[147],"pap":[148,173],"operon.":[149],"To":[150],"our":[151],"knowledge,":[152],"study":[154],"fulfill":[159],"molecular":[160],"Koch's":[161],"postulates":[162],"which":[164],"pathogenic":[166,190],"attenuated":[169],"mutation":[171],"then":[176],"restore":[179],"fitness,":[180],"confirming":[181],"clinical":[191],"isolate.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}