{"id":"https://openalex.org/W2331842","doi":null,"title":"Cefuroxime compared to amoxicillin-clavulanic acid in the treatment of community-acquired pneumonia.","display_name":"Cefuroxime compared to amoxicillin-clavulanic acid in the treatment of community-acquired pneumonia.","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W2331842","mag":"2331842","pmid":"https://pubmed.ncbi.nlm.nih.gov/8942221"},"language":"en","primary_location":{"id":"pmid:8942221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8942221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Singapore medical journal","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068883433","display_name":"H. M. L. Oh","orcid":"https://orcid.org/0009-0003-5038-3329","observed_orcids":["https://orcid.org/0009-0003-5038-3329"]},"institutions":[{"id":"https://openalex.org/I2802408685","display_name":"Tan Tock Seng Hospital","ror":"https://ror.org/032d59j24","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802408685"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"H M Oh","raw_affiliation_strings":["Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore","institution_ids":["https://openalex.org/I2802408685"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A W Ng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A W Ng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090290148","display_name":"S K Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S K Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2708,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.51590196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"37","issue":"3","first_page":"255","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cefuroxime","display_name":"cefuroxime","score":0.9739999771118164},{"id":"https://openalex.org/keywords/amoxicillin-clavulanic-acid","display_name":"amoxicillin-clavulanic acid","score":1.0},{"id":"https://openalex.org/keywords/community-acquired-pneumonia","display_name":"community-acquired pneumonia","score":1.0},{"id":"https://openalex.org/keywords/antibiotic-efficacy","display_name":"antibiotic efficacy","score":0.7200000286102295},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8669999837875366},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.7289999723434448},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9120000004768372},{"id":"https://openalex.org/keywords/mycoplasma-pneumoniae","display_name":"Mycoplasma pneumoniae","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hemolytic-streptococci","display_name":"hemolytic streptococci","score":0.8830000162124634},{"id":"https://openalex.org/keywords/beta-lactam-antibiotics","display_name":"beta-lactam antibiotics","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2777514703","wikidata":"https://www.wikidata.org/wiki/Q413728","display_name":"Cefuroxime","level":3,"score":0.9349015951156616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9161417484283447},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.8138218522071838},{"id":"https://openalex.org/C2779454058","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Clavulanic acid","level":4,"score":0.791813850402832},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.6758888959884644},{"id":"https://openalex.org/C2776102371","wikidata":"https://www.wikidata.org/wiki/Q460030","display_name":"Community-acquired pneumonia","level":3,"score":0.6373436450958252},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6179760694503784},{"id":"https://openalex.org/C2776205632","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Amoxicillin/clavulanic acid","level":5,"score":0.5390427112579346},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.492178350687027},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.4874153435230255},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47310447692871094},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.394776850938797},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.328677773475647},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.15223395824432373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002444","descriptor_name":"Cefuroxime","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002444","descriptor_name":"Cefuroxime","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002511","descriptor_name":"Cephalosporins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002511","descriptor_name":"Cephalosporins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002969","descriptor_name":"Clavulanic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002969","descriptor_name":"Clavulanic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017714","descriptor_name":"Community-Acquired Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017714","descriptor_name":"Community-Acquired Infections","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018410","descriptor_name":"Pneumonia, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018410","descriptor_name":"Pneumonia, Bacterial","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D019818","descriptor_name":"Clavulanic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8942221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8942221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Singapore medical journal","raw_type":"Clinical Trial"},{"id":"mag:2331842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8942221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2164163499","https://openalex.org/W97493058","https://openalex.org/W2138291467","https://openalex.org/W20528299","https://openalex.org/W2117137404","https://openalex.org/W2357404447","https://openalex.org/W2087682120","https://openalex.org/W2393025906","https://openalex.org/W1517434686","https://openalex.org/W2365763310"],"abstract_inverted_index":{"The":[0,70,85],"study":[1],"compared":[2],"the":[3,15,129,137,144,150,165,179],"efficacy":[4,175],"and":[5,31,51,79,99,111,117,140,159,161,170,176],"safety":[6,177],"of":[7,17,22,115,128,181],"cefuroxime":[8,169],"(CFX)":[9],"versus":[10],"amoxicillin-clavulanic":[11,171],"acid":[12,172],"(AC)":[13],"in":[14,107,125,136,143,149,178],"treatment":[16,80,180],"community-acquired":[18,182],"pneumonia.":[19,183],"A":[20],"total":[21],"48":[23,46,61],"patients":[24,109,113,148],"(mean":[25],"age":[26],"44":[27],"years;":[28],"32":[29],"males":[30],"16":[32],"females)":[33],"were":[34,73,90,133,162],"randomised":[35],"to":[36],"receive":[37],"sequential":[38,52],"intravenous/oral":[39,53],"CFX":[40,116,130,138],"(750":[41],"mg":[42,48,64],"i.v.":[43,57],"8H":[44],"for":[45,60,67,76],"H/500":[47],"p.o":[49],"bid)":[50],"AC":[54,118,145,151],"(1.2":[55],"g":[56],"8":[58],"H":[59],"H/":[62],"750":[63],"p.o.":[65],"tid)":[66],"7-14":[68],"days.":[69],"two":[71],"groups":[72],"well":[74],"matched":[75],"age,":[77],"sex":[78],"duration":[81],"(median":[82],"7":[83],"days).":[84],"most":[86],"frequent":[87],"causative":[88],"organisms":[89],"Mycoplasma":[91],"(3),":[92],"Klebsiella":[93],"species":[94],"(2),":[95],"Pseudomonas":[96],"aeruginosa":[97],"(2)":[98],"hemolytic":[100],"streptococcus":[101],"(2).":[102],"clinical":[103],"cure":[104],"was":[105,123],"obtained":[106],"20":[108],"(83.3%)":[110],"18":[112],"(75%)":[114],"group":[119,139,152],"respectively.":[120],"Clinical":[121],"improvement":[122],"observed":[124],"one":[126],"patient":[127],"group.":[131,146],"There":[132],"3":[134],"failures":[135,142],"4":[141],"Two":[147],"developed":[153],"adverse":[154],"drug":[155],"reactions":[156],"(namely":[157],"vomiting":[158],"rash)":[160],"withdrawn":[163],"from":[164],"study.":[166],"In":[167],"conclusion,":[168],"have":[173],"comparable":[174]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}