{"id":"https://openalex.org/W2331794396","doi":"https://doi.org/10.1097/00001622-200005000-00014","title":"An update on prostate cancer research","display_name":"An update on prostate cancer research","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2331794396","doi":"https://doi.org/10.1097/00001622-200005000-00014","mag":"2331794396","pmid":"https://pubmed.ncbi.nlm.nih.gov/10841200"},"language":"en","primary_location":{"id":"doi:10.1097/00001622-200005000-00014","doi":"https://doi.org/10.1097/00001622-200005000-00014","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001622-200005000-00014","pdf_url":null,"source":{"id":"https://openalex.org/S179395531","display_name":"Current Opinion in Oncology","issn_l":"1040-8746","issn":["1040-8746","1080-8140","1531-703X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007578304","display_name":"Eric Jay Small","orcid":"https://orcid.org/0000-0003-3191-6268","observed_orcids":["https://orcid.org/0000-0003-3191-6268"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric J. Small","raw_affiliation_strings":["University of California, San Francisco, Comprehensive Cancer Center, 94115, USA. smalle@medicine.ucsf.edu","University of California, San Francisco, Comprehensive Cancer Center, San Francisco, CA, USA","e-mail:[email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, Comprehensive Cancer Center, 94115, USA. smalle@medicine.ucsf.edu","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]},{"raw_affiliation_string":"University of California, San Francisco, Comprehensive Cancer Center, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]},{"raw_affiliation_string":"e-mail:[email\u00a0protected]","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009958250","display_name":"David Reese","orcid":"https://orcid.org/0000-0001-5293-6175","observed_orcids":["https://orcid.org/0000-0001-5293-6175"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Reese","raw_affiliation_strings":["University of California, San Francisco, Comprehensive Cancer Center, San Francisco, CA, USA","e-mail:[email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, Comprehensive Cancer Center, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]},{"raw_affiliation_string":"e-mail:[email\u00a0protected]","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007578304"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"],"apc_list":null,"apc_paid":null,"fwci":0.3556,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.37961783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"3","first_page":"265","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.2565999925136566,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/genetic-and-environmental-factors","display_name":"genetic and environmental factors","score":0.8240000009536743},{"id":"https://openalex.org/keywords/prostate-cancer-screening","display_name":"prostate cancer screening","score":0.9900000095367432},{"id":"https://openalex.org/keywords/prostate-cancer-mortality","display_name":"prostate cancer mortality","score":0.8700000047683716},{"id":"https://openalex.org/keywords/localized-prostate-cancer","display_name":"localized prostate cancer","score":0.8040000200271606},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.9449999928474426},{"id":"https://openalex.org/keywords/molecular-prognostic-markers","display_name":"molecular prognostic markers","score":0.8700000047683716},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.9158797264099121},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8819584846496582},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6926190853118896},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5358494520187378},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5003705024719238},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.48093196749687195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4667755663394928},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4583981931209564},{"id":"https://openalex.org/C2778162587","wikidata":"https://www.wikidata.org/wiki/Q6664621","display_name":"Localized disease","level":4,"score":0.44902312755584717},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4210561215877533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00001622-200005000-00014","doi":"https://doi.org/10.1097/00001622-200005000-00014","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001622-200005000-00014","pdf_url":null,"source":{"id":"https://openalex.org/S179395531","display_name":"Current Opinion in Oncology","issn_l":"1040-8746","issn":["1040-8746","1080-8140","1531-703X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Oncology","raw_type":"journal-article"},{"id":"pmid:10841200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10841200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W118179536","https://openalex.org/W205209059","https://openalex.org/W1580523172","https://openalex.org/W1705165894","https://openalex.org/W1789534054","https://openalex.org/W1853704205","https://openalex.org/W1854708637","https://openalex.org/W1868905893","https://openalex.org/W1893347245","https://openalex.org/W1894827484","https://openalex.org/W1939806678","https://openalex.org/W1944765939","https://openalex.org/W1947533955","https://openalex.org/W1968629884","https://openalex.org/W1973089211","https://openalex.org/W1975159611","https://openalex.org/W1979792330","https://openalex.org/W1981391870","https://openalex.org/W1983629062","https://openalex.org/W1984808003","https://openalex.org/W1985827132","https://openalex.org/W2003579067","https://openalex.org/W2003985632","https://openalex.org/W2005383842","https://openalex.org/W2008971869","https://openalex.org/W2024468190","https://openalex.org/W2026029815","https://openalex.org/W2034245044","https://openalex.org/W2035999871","https://openalex.org/W2048766864","https://openalex.org/W2049153532","https://openalex.org/W2063113306","https://openalex.org/W2067291231","https://openalex.org/W2067910064","https://openalex.org/W2068836981","https://openalex.org/W2070428637","https://openalex.org/W2071879495","https://openalex.org/W2072779515","https://openalex.org/W2073365051","https://openalex.org/W2074622312","https://openalex.org/W2075512338","https://openalex.org/W2077338098","https://openalex.org/W2079821314","https://openalex.org/W2082333541","https://openalex.org/W2086428130","https://openalex.org/W2086457971","https://openalex.org/W2089863546","https://openalex.org/W2094608848","https://openalex.org/W2104660811","https://openalex.org/W2105548709","https://openalex.org/W2121495561","https://openalex.org/W2122860896","https://openalex.org/W2125894780","https://openalex.org/W2143965341","https://openalex.org/W2144271794","https://openalex.org/W2155679349","https://openalex.org/W2169618540","https://openalex.org/W2171724045","https://openalex.org/W2184174775","https://openalex.org/W2337912524","https://openalex.org/W2341209325","https://openalex.org/W2416621810","https://openalex.org/W2417000282","https://openalex.org/W4245562293"],"related_works":["https://openalex.org/W7126269294","https://openalex.org/W4416442166","https://openalex.org/W7169849418","https://openalex.org/W4404879929","https://openalex.org/W1996138786","https://openalex.org/W7082642896","https://openalex.org/W4320916985","https://openalex.org/W3177912378","https://openalex.org/W7124429387","https://openalex.org/W4205918537"],"abstract_inverted_index":{"The":[0],"pathogenesis":[1],"of":[2,31,100,127],"prostate":[3,26,48,93],"cancer":[4,27,49,94],"reflects":[5],"complex":[6],"interactions":[7],"among":[8],"environmental":[9],"and":[10,22,29,46,60,97],"genetic":[11],"factors.":[12],"Recent":[13],"advances":[14],"suggest":[15],"molecular":[16,32,84],"mechanisms":[17],"that":[18],"may":[19,52],"explain":[20],"geographic":[21],"ethnic":[23],"variations":[24],"in":[25,55,76,124],"incidence,":[28],"understanding":[30],"disease":[33,69,112],"progression":[34],"is":[35,70],"advancing":[36],"rapidly.":[37],"Clinically,":[38],"the":[39,98],"case":[40],"for":[41,65,89,108],"screening":[42],"has":[43],"become":[44],"stronger,":[45],"declining":[47],"mortality":[50],"rates":[51],"be":[53],"due":[54],"part":[56],"to":[57,81,121],"early":[58],"detection":[59],"treatment.":[61],"Improved":[62],"risk":[63],"assessment":[64],"patients":[66,90,109],"with":[67,91,110],"localized":[68,92],"now":[71],"available,":[72],"although":[73,116],"further":[74,103],"refinement":[75],"predictive":[77],"algorithms":[78],"will":[79],"need":[80],"incorporate":[82],"validated":[83],"prognostic":[85],"markers.":[86],"Treatment":[87],"options":[88],"have":[95,113],"expanded":[96],"role":[99],"androgen":[101],"deprivation":[102],"delineated.":[104],"Finally,":[105],"treatment":[106],"strategies":[107],"androgen-independent":[111],"also":[114],"expanded,":[115],"novel":[117],"therapies":[118],"are":[119],"required":[120],"improve":[122],"survival":[123],"this":[125],"group":[126],"patients.":[128]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}