{"id":"https://openalex.org/W2331693239","doi":"https://doi.org/10.1055/s-0033-1353301","title":"Central glucocorticoid system dysfunction in a mouse model of extreme anxiety: clinical implications","display_name":"Central glucocorticoid system dysfunction in a mouse model of extreme anxiety: clinical implications","publication_year":2013,"publication_date":"2013-09-13","ids":{"openalex":"https://openalex.org/W2331693239","doi":"https://doi.org/10.1055/s-0033-1353301","mag":"2331693239"},"language":"en","primary_location":{"id":"doi:10.1055/s-0033-1353301","doi":"https://doi.org/10.1055/s-0033-1353301","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0033-1353301","pdf_url":null,"source":{"id":"https://openalex.org/S4122505","display_name":"Pharmacopsychiatry","issn_l":"0176-3679","issn":["0176-3679","1439-0795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacopsychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035617536","display_name":"Sotnikov Sv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"SV Sotnikov","raw_affiliation_strings":["Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Wittmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Wittmann","raw_affiliation_strings":["Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071542314","display_name":"Yen Yc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"YC Yen","raw_affiliation_strings":["Department of Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049530707","display_name":"Carsten Tobias Wotjak","orcid":"https://orcid.org/0000-0002-2159-5379","observed_orcids":["https://orcid.org/0000-0002-2159-5379"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Wotjak","raw_affiliation_strings":["Department of Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111542748","display_name":"Rainer Landgraf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Landgraf","raw_affiliation_strings":["Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012041827","display_name":"Ludwig Czibere","orcid":"https://orcid.org/0000-0002-7508-5841","observed_orcids":["https://orcid.org/0000-0002-7508-5841"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Czibere","raw_affiliation_strings":["Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210145969"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"06","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-system","display_name":"glucocorticoid system","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hpa-axis-dysregulation","display_name":"HPA axis dysregulation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9010000228881836},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8569999933242798},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.44600000977516174},{"id":"https://openalex.org/keywords/contextual-fear","display_name":"contextual fear","score":0.6700000166893005},{"id":"https://openalex.org/keywords/passive-avoidance","display_name":"passive avoidance","score":0.878000020980835},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neuroendocrine-dysfunction","display_name":"neuroendocrine dysfunction","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.7867254018783569},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.734875500202179},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.6559371948242188},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.6082409620285034},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.563202440738678},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5527313947677612},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5219489932060242},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.5199076533317566},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4889923334121704},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.42807066440582275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32780784368515015},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19966650009155273},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.17676496505737305},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0033-1353301","doi":"https://doi.org/10.1055/s-0033-1353301","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0033-1353301","pdf_url":null,"source":{"id":"https://openalex.org/S4122505","display_name":"Pharmacopsychiatry","issn_l":"0176-3679","issn":["0176-3679","1439-0795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacopsychiatry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2135510152","https://openalex.org/W4402800597","https://openalex.org/W2920226987","https://openalex.org/W2039657852","https://openalex.org/W1911182391","https://openalex.org/W2067702743","https://openalex.org/W2048429102","https://openalex.org/W2128911292","https://openalex.org/W2041053664","https://openalex.org/W2044740725"],"abstract_inverted_index":{"Animal":[0],"models":[1],"of":[2,34,38,48,55,113,133,145,149,161,185,193,202],"psychiatric":[3,24,56,194],"disorders":[4,195],"are":[5],"useful":[6],"tools":[7],"for":[8,18,23],"elucidating":[9],"associations":[10],"between":[11],"behavioral":[12,189],"symptoms":[13],"and":[14,17,31,63,69,123,190],"biological":[15],"abnormalities":[16],"suggesting":[19],"possible":[20],"treatment":[21],"strategies":[22],"diseases.":[25],"Here":[26],"we":[27],"describe":[28],"phenotypic,":[29],"neuroendocrine":[30],"molecular":[32],"traits":[33],"a":[35,124,200],"mouse":[36,95,183],"model":[37,184],"extreme":[39],"inborn":[40],"high":[41,186],"anxiety-related":[42,76],"behavior":[43],"(HAB)":[44],"from":[45],"the":[46,114,182,197,203],"perspective":[47],"clinical":[49],"application":[50],"to":[51,74,87,103,127,169],"study":[52,208],"central":[53,204],"mechanisms":[54],"abnormalities.":[57],"HABs":[58,97],"consistently":[59],"show":[60],"higher":[61,138],"anxiety":[62,187],"depression-like":[64],"behavior,":[65],"increased":[66,159],"contextual":[67],"fear":[68],"inhibitory":[70],"avoidance":[71],"learning":[72],"compared":[73],"normal":[75],"behaviour":[77],"(NAB)":[78],"mice.":[79,175],"While":[80],"basal":[81],"blood":[82],"corticosterone":[83],"(CORT)":[84],"was":[85,209],"found":[86],"be":[88,170],"an":[89],"unimportant":[90],"endocrine":[91,191],"parameter":[92],"in":[93,130,140,152,164,173],"our":[94],"model,":[96],"responded":[98],"with":[99,196],"significantly":[100,137],"reduced":[101],"CORT":[102,151,165],"stressful":[104],"stimuli.":[105],"The":[106],"DEX-CRH":[107],"test":[108],"revealed":[109],"much":[110],"stronger":[111],"suppression":[112],"hypothalamic":[115],"pituitary":[116],"adrenal":[117],"(HPA)":[118],"axis":[119],"after":[120],"Dex":[121],"infusion":[122],"blunted":[125],"response":[126],"CRH":[128],"stimulation":[129],"HABs.":[131],"Analysis":[132],"glucocorticoid":[134,205],"receptors":[135],"showed":[136],"amounts":[139],"almost":[141],"all":[142],"brain":[143,154],"areas":[144],"HABs,":[146],"whereas":[147],"levels":[148],"free":[150],"these":[153,178],"regions":[155],"were":[156],"reduced.":[157],"An":[158],"expression":[160],"enzymes":[162],"involved":[163,172],"metabolism":[166],"is":[167],"likely":[168],"critically":[171],"HAB":[174],"All":[176],"together,":[177],"data":[179],"suggest":[180],"that":[181],"resembles":[188],"symptomatologies":[192],"focus":[198],"on":[199],"dysregulation":[201],"system.":[206],"This":[207],"supported":[210],"by":[211],"Max-Planck-Gesellschaft.":[212]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
