{"id":"https://openalex.org/W2331620337","doi":"https://doi.org/10.4149/endo_2011_02_91","title":"Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseases","display_name":"Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseases","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2331620337","doi":"https://doi.org/10.4149/endo_2011_02_91","mag":"2331620337","pmid":"https://pubmed.ncbi.nlm.nih.gov/21615193","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5241091"},"language":"en","primary_location":{"id":"doi:10.4149/endo_2011_02_91","doi":"https://doi.org/10.4149/endo_2011_02_91","is_oa":false,"landing_page_url":"https://doi.org/10.4149/endo_2011_02_91","pdf_url":null,"source":{"id":"https://openalex.org/S7498391","display_name":"Endocrine Regulations","issn_l":"1210-0668","issn":["1210-0668","1336-0329"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Regulations","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5241091","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050003203","display_name":"David S. Goldstein","orcid":"https://orcid.org/0000-0002-5709-9940","observed_orcids":["https://orcid.org/0000-0002-5709-9940"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. Goldstein","raw_affiliation_strings":["Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1620, USA. goldsteind@ninds.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1620, USA. goldsteind@ninds.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050003203"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"],"apc_list":null,"apc_paid":null,"fwci":1.3726,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.80937756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"2","first_page":"91","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allostatic-load","display_name":"allostatic load","score":0.9570000171661377},{"id":"https://openalex.org/keywords/allostasis","display_name":"allostasis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.7450000047683716},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8130000233650208},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lewy-body-disease","display_name":"Lewy body disease","score":0.9589999914169312},{"id":"https://openalex.org/keywords/autotoxicity","display_name":"autotoxicity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/neurotransmitter-storage","display_name":"neurotransmitter storage","score":0.5740000009536743},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7260000109672546},{"id":"https://openalex.org/keywords/homeostasis","display_name":"homeostasis","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C157541749","wikidata":"https://www.wikidata.org/wiki/Q3612637","display_name":"Allostasis","level":2,"score":0.9398751258850098},{"id":"https://openalex.org/C187150481","wikidata":"https://www.wikidata.org/wiki/Q4733156","display_name":"Allostatic load","level":2,"score":0.8363112211227417},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5296452045440674},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.44521480798721313},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3640289902687073},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32435140013694763},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3034287691116333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11827525496482849}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D052636","descriptor_name":"Allostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4149/endo_2011_02_91","doi":"https://doi.org/10.4149/endo_2011_02_91","is_oa":false,"landing_page_url":"https://doi.org/10.4149/endo_2011_02_91","pdf_url":null,"source":{"id":"https://openalex.org/S7498391","display_name":"Endocrine Regulations","issn_l":"1210-0668","issn":["1210-0668","1336-0329"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Regulations","raw_type":"journal-article"},{"id":"pmid:21615193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21615193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine regulations","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5241091","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5241091","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Endocr Regul","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5241091","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5241091","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Endocr Regul","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1896276880","display_name":"Mechanisms of Parkinson Disease and Related Disorders","funder_award_id":"Z01NS003033","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4988861893","display_name":null,"funder_award_id":"Z99 NS999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7092253186","display_name":"Biomarkers of Parkinson Disease and Related Disorders","funder_award_id":"Z01NS003034","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W165094843","https://openalex.org/W175006040","https://openalex.org/W1501013365","https://openalex.org/W1527671059","https://openalex.org/W1547461458","https://openalex.org/W1969617719","https://openalex.org/W1973033940","https://openalex.org/W2007271767","https://openalex.org/W2013503732","https://openalex.org/W2036709120","https://openalex.org/W2065722436","https://openalex.org/W2071627769","https://openalex.org/W2092858957","https://openalex.org/W2109379634","https://openalex.org/W2141410612","https://openalex.org/W2150348503","https://openalex.org/W2160818993"],"related_works":["https://openalex.org/W2612797345","https://openalex.org/W2934576446","https://openalex.org/W1978762354","https://openalex.org/W2060657561","https://openalex.org/W3084051604","https://openalex.org/W3044752815","https://openalex.org/W4313038351","https://openalex.org/W3122494154","https://openalex.org/W7167925367","https://openalex.org/W4387065701"],"abstract_inverted_index":{"As":[0],"populations":[1],"age,":[2],"the":[3,34,48,101,107,119,125,130,181,187,200,225],"prevalence":[4],"of":[5,36,50,98,109,114,116,121,129,137,140,158,215,224,228],"geriatric":[6],"neurodegenerative":[7],"diseases":[8,12,39],"will":[9],"increase.":[10],"These":[11,205],"generally":[13],"are":[14,190],"multifactorial,":[15],"arising":[16],"from":[17,195],"complex":[18],"interactions":[19],"among":[20],"genes,":[21],"environment,":[22],"concurrent":[23],"morbidities,":[24],"treatments,":[25],"and":[26,52,90,150,154,160,192,242],"time.":[27,243],"This":[28],"essay":[29],"provides":[30],"a":[31,78,84,91,138,222],"concept":[32],"for":[33,93],"pathogenesis":[35],"Lewy":[37,176],"body":[38,177],"such":[40],"as":[41,77,145],"Parkinson":[42,218],"disease,":[43],"by":[44,70],"considering":[45],"them":[46],"in":[47,82,169,186],"context":[49],"allostasis":[51],"allostatic":[53,146,167,229],"load.":[54],"Allostasis":[55],"reflects":[56,152],"active,":[57],"adaptive":[58],"processes":[59],"that":[60,184,193],"maintain":[61],"apparent":[62],"steady":[63],"states,":[64],"via":[65],"multiple":[66],"interacting":[67],"effectors":[68],"regulated":[69],"homeostatic":[71],"comparators-\"homeostats.\"":[72],"Stress":[73],"can":[74,132],"be":[75,133,221],"defined":[76],"condition":[79],"or":[80,111],"state":[81],"which":[83,231],"sensed":[85],"discrepancy":[86],"between":[87],"afferent":[88],"information":[89],"setpoint":[92],"response":[94],"leads":[95],"to":[96,106,164,175,180,212],"activation":[97,113],"effectors,":[99],"reducing":[100],"discrepancy.":[102],"\"Allostatic":[103],"load\"":[104],"refers":[105],"consequences":[108],"sustained":[110],"repeated":[112,238],"mediators":[115],"allostasis.":[117],"From":[118],"analogy":[120],"an":[122],"idling":[123],"car,":[124],"revolutions":[126],"per":[127],"minute":[128],"engine":[131,165],"maintained":[134],"at":[135],"any":[136],"variety":[139],"levels":[141],"(allostatic":[142],"states).":[143],"Just":[144],"load":[147,168],"(cumulative":[148],"wear":[149],"tear)":[151],"design":[153],"manufacturing":[155],"variations,":[156],"byproducts":[157],"combustion,":[159],"time,":[161],"eventually":[162,173],"leading":[163],"breakdown,":[166],"catecholaminergic":[170],"neurons":[171,206],"might":[172,220],"lead":[174],"diseases.":[178],"Central":[179],"argument":[182],"is":[183],"catecholamines":[185,194],"neuronal":[188],"cytoplasm":[189,201],"autotoxic":[191],"storage":[196],"visicles":[197],"leak":[198],"into":[199],"continuously":[202],"during":[203],"life.":[204],"therefore":[207],"depend":[208],"on":[209,233],"vesicular":[210],"sequestration":[211],"limit":[213],"autotoxicity":[214],"cytosolic":[216],"transmitter.":[217],"disease":[219,223],"elderly":[226],"because":[227],"load,":[230],"depends":[232],"genetic":[234],"predispositions,":[235],"environmental":[236],"exposures,":[237],"stress-related":[239],"catecholamine":[240],"release,":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
