{"id":"https://openalex.org/W2331586092","doi":"https://doi.org/10.1038/protex.2011.231","title":"Identification of Molecular Subtypes in Pancreatic Adenocarcinoma with Predictive and Prognostic Importance","display_name":"Identification of Molecular Subtypes in Pancreatic Adenocarcinoma with Predictive and Prognostic Importance","publication_year":2011,"publication_date":"2011-04-04","ids":{"openalex":"https://openalex.org/W2331586092","doi":"https://doi.org/10.1038/protex.2011.231","mag":"2331586092"},"language":"en","primary_location":{"id":"doi:10.1038/protex.2011.231","doi":"https://doi.org/10.1038/protex.2011.231","is_oa":true,"landing_page_url":"https://doi.org/10.1038/protex.2011.231","pdf_url":"https://www.researchsquare.com/article/nprot-2053/latest.pdf","source":{"id":"https://openalex.org/S2764931282","display_name":"Protocol Exchange","issn_l":"2043-0116","issn":["2043-0116"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protocol Exchange","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.researchsquare.com/article/nprot-2053/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053519097","display_name":"Anguraj Sadanandam","orcid":"https://orcid.org/0000-0001-8485-5150","observed_orcids":["https://orcid.org/0000-0001-8485-5150"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Anguraj Sadanandam","raw_affiliation_strings":["Ecole Polytechnique Federale de Lausanne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ecole Polytechnique Federale de Lausanne","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053519097","display_name":"Anguraj Sadanandam","orcid":"https://orcid.org/0000-0001-8485-5150","observed_orcids":["https://orcid.org/0000-0001-8485-5150"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Anguraj Sadanandam","raw_affiliation_strings":["Ecole Polytechnique Federale de Lausanne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ecole Polytechnique Federale de Lausanne","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035793503","display_name":"Eric Andrew Collisson","orcid":"https://orcid.org/0000-0001-8037-9388","observed_orcids":["https://orcid.org/0000-0001-8037-9388","https://orcid.org/0000-0002-2829-355X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Collisson","raw_affiliation_strings":["University of California at San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004910026","display_name":"William J. Gibb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161586","display_name":"Genomic Health (United States)","ror":"https://ror.org/05njgh475","country_code":"US","type":"company","lineage":["https://openalex.org/I4210161586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Gibb","raw_affiliation_strings":["Genomic Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Health","institution_ids":["https://openalex.org/I4210161586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007537368","display_name":"Douglas Hanahan","orcid":"https://orcid.org/0000-0002-0883-5251","observed_orcids":["https://orcid.org/0000-0002-0883-5251"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Douglas Hanahan","raw_affiliation_strings":["Ecole Polytechnique Federale de Lausanne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ecole Polytechnique Federale de Lausanne","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028899187","display_name":"Joe W. Gray","orcid":"https://orcid.org/0000-0001-9225-6756","observed_orcids":["https://orcid.org/0000-0001-9225-6756"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH","US"],"is_corresponding":true,"raw_author_name":"Joe Gray","raw_affiliation_strings":["Oregon Health and Science University Anguraj Sadanandam Ecole Polytechnique Federale de Lausanne","Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University Anguraj Sadanandam Ecole Polytechnique Federale de Lausanne","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I5124864"]},{"raw_affiliation_string":"Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028899187"],"corresponding_institution_ids":["https://openalex.org/I165690674","https://openalex.org/I5124864"],"apc_list":null,"apc_paid":null,"fwci":0.1639,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60325907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.968999981880188},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.7269999980926514},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8119999766349792},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.5189999938011169},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6959999799728394},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.968999981880188},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5410000085830688},{"id":"https://openalex.org/keywords/computational-pipeline","display_name":"computational pipeline","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.8328115940093994},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5674024820327759},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4473589062690735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3873487710952759},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3704115152359009},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30699148774147034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2987596392631531},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09116613864898682},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.04558134078979492}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1038/protex.2011.231","doi":"https://doi.org/10.1038/protex.2011.231","is_oa":true,"landing_page_url":"https://doi.org/10.1038/protex.2011.231","pdf_url":"https://www.researchsquare.com/article/nprot-2053/latest.pdf","source":{"id":"https://openalex.org/S2764931282","display_name":"Protocol Exchange","issn_l":"2043-0116","issn":["2043-0116"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protocol Exchange","raw_type":"journal-article"},{"id":"pmh:oai:zenodo.org:14633","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/14633","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5281/zenodo.14633","doi":"https://doi.org/10.5281/zenodo.14633","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.14633","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/protex.2011.231","doi":"https://doi.org/10.1038/protex.2011.231","is_oa":true,"landing_page_url":"https://doi.org/10.1038/protex.2011.231","pdf_url":"https://www.researchsquare.com/article/nprot-2053/latest.pdf","source":{"id":"https://openalex.org/S2764931282","display_name":"Protocol Exchange","issn_l":"2043-0116","issn":["2043-0116"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protocol Exchange","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2331586092.pdf","grobid_xml":"https://content.openalex.org/works/W2331586092.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1620997626","https://openalex.org/W2107665951","https://openalex.org/W2136787567","https://openalex.org/W2139345901","https://openalex.org/W2150926065","https://openalex.org/W2160697532","https://openalex.org/W3122709706"],"related_works":["https://openalex.org/W4236569739","https://openalex.org/W6939729150","https://openalex.org/W3106838559","https://openalex.org/W6958270596","https://openalex.org/W1497915798","https://openalex.org/W2285093314","https://openalex.org/W4396956904","https://openalex.org/W4317503034","https://openalex.org/W4306404916","https://openalex.org/W2944518357"],"abstract_inverted_index":{"In":[0],"this":[1],"protocol,":[2],"we":[3,23],"describe":[4,24],"methodologies":[5],"used":[6,28],"in":[7],"the":[8,25],"Nature":[9],"Medicine":[10],"manuscript":[11],"\"Subtypes":[12],"of":[13,32,44],"Pancreatic":[14],"Ductal":[15],"Adenocarcinoma":[16],"and":[17,36],"their":[18,37],"Differing":[19],"Response":[20],"to":[21,29],"Therapy\".Herein,":[22],"computational":[26],"pipeline":[27],"identify":[30],"subtypes":[31],"pancreatic":[33],"ductal":[34],"adenocarcinoma":[35],"associated":[38],"gene":[39,46],"signature":[40],"using":[41],"integrated":[42],"analysis":[43],"various":[45],"expression":[47],"pro":[48],"les":[49],"with":[50],"clinical":[51],"outcome.":[52]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}