{"id":"https://openalex.org/W2331375892","doi":"https://doi.org/10.1158/1538-7445.am2013-2802","title":"Abstract 2802: Salmonella typhimurium A1-R inhibits brain metastasis in an orthotropic breast cancer nude-mouse model.","display_name":"Abstract 2802: Salmonella typhimurium A1-R inhibits brain metastasis in an orthotropic breast cancer nude-mouse model.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2331375892","doi":"https://doi.org/10.1158/1538-7445.am2013-2802","mag":"2331375892"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-2802","doi":"https://doi.org/10.1158/1538-7445.am2013-2802","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-2802","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100419770","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0002-1303-0458","observed_orcids":["https://orcid.org/0000-0002-1303-0458","https://orcid.org/0000-0002-9916-3832","https://orcid.org/0000-0001-6577-5235"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100331321","display_name":"Nan Zhang","orcid":"https://orcid.org/0000-0003-0679-6188","observed_orcids":["https://orcid.org/0000-0003-0679-6188"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Zhang","raw_affiliation_strings":["AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Hoffman","raw_affiliation_strings":["AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083743508","display_name":"Ming Dan Zhao","orcid":"https://orcid.org/0000-0002-1025-8895","observed_orcids":["https://orcid.org/0000-0002-1025-8895"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Zhao","raw_affiliation_strings":["AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210121314"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"2802","last_page":"2802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salmonella-typhimurium-a1-r","display_name":"Salmonella typhimurium A1-R","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bacterial-therapy","display_name":"bacterial therapy","score":0.49000000953674316},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.8960000276565552},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9620000123977661},{"id":"https://openalex.org/keywords/4t1-cells","display_name":"4T1 cells","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tumor-targeting-bacteria","display_name":"tumor-targeting bacteria","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.747650682926178},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.7068274021148682},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6402203440666199},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.638237476348877},{"id":"https://openalex.org/C2780278673","wikidata":"https://www.wikidata.org/wiki/Q476743","display_name":"Nude mouse","level":3,"score":0.6348807215690613},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6148356199264526},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.4872206747531891},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48493459820747375},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3771781325340271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31666100025177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1740635335445404},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-2802","doi":"https://doi.org/10.1158/1538-7445.am2013-2802","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-2802","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2135756307","https://openalex.org/W7098674977","https://openalex.org/W1601954309","https://openalex.org/W1571300733","https://openalex.org/W1601817321","https://openalex.org/W2125698998","https://openalex.org/W2012057302","https://openalex.org/W2920853893","https://openalex.org/W2012741386","https://openalex.org/W2316070506"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"have":[2],"previously":[3],"developed":[4],"tumor-targeting":[5],"Salmonella":[6,184],"typhimurium":[7,29,115,156,185],"A1-R":[8,30,116,157,186],"(A1-R),":[9],"which":[10],"has":[11],"shown":[12],"efficacy":[13],"against":[14],"multiple":[15],"cancer":[16,53,194],"types":[17],"in":[18,37,61,190],"nude":[19,89],"mouse":[20,42],"models.":[21],"In":[22],"this":[23],"study,":[24],"we":[25],"demonstrated":[26],"that":[27],"S.":[28,114,155],"can":[31],"inhibit":[32],"and":[33],"eradicate":[34],"brain":[35,94,112,134,171,188],"metastasis":[36,95,189],"an":[38,191],"orthotopic":[39],"metastatic":[40,135],"BALB/c":[41],"model":[43],"of":[44,87,103,133,154,167,170,200,205],"breast":[45,52,193],"cancer.":[46],"To":[47],"establish":[48],"the":[49,70,80,107,123,141,164,201,206],"model,":[50],"4T1":[51],"cells":[54,78],"expressing":[55],"RFP":[56],"(5.0":[57],"\u00d7":[58],"106/100":[59],"\u03bcL)":[60],"100":[62],"\u03bcl":[63],"serum-free":[64],"solution":[65],"were":[66,83,91,109],"injected":[67,121],"slowly":[68],"into":[69,122],"right":[71],"second":[72],"mammary":[73],"gland.":[74],"Two":[75],"weeks":[76,100],"after":[77,101],"implantation,":[79],"primary":[81],"tumors":[82],"removed.":[84],"Approximately":[85],"30%":[86],"post-surgery":[88],"mice":[90,108],"found":[92,110],"with":[93,111,149],"using":[96],"fluorescence":[97,143],"imaging":[98,144],"4-5":[99],"injection":[102],"4T1-RFP":[104],"cells.":[105],"When":[106],"metastasis,":[113],"[5\u00d7107":[117],"CFU/100":[118],"\u03bcl]":[119],"was":[120,137],"tail":[124],"vein":[125],"once":[126],"a":[127],"week":[128],"for":[129,209],"3":[130],"weeks.":[131],"Inhibition":[132],"growth":[136],"observed":[138],"noninvasively":[139],"by":[140],"Maestro":[142],"system":[145],"(Perkin-Elmer":[146],"Inc.)":[147],"compared":[148],"untreated":[150],"mice.":[151],"Intravenous":[152],"administration":[153],"improved":[158],"survival":[159],"70%.":[160],"This":[161],"study":[162],"shows":[163],"important":[165],"potential":[166],"bacterial":[168],"therapy":[169],"metastasis.":[172],"Citation":[173],"Format:":[174],"Yong":[175],"Zhang,":[176,178],"Nan":[177],"Robert":[179],"M.":[180],"Hoffman,":[181],"Ming":[182],"Zhao.":[183],"inhibits":[187],"orthotropic":[192],"nude-mouse":[195],"model.":[196],"[abstract].":[197],"In:":[198],"Proceedings":[199],"104th":[202],"Annual":[203],"Meeting":[204],"American":[207],"Association":[208],"Cancer":[210,220],"Research;":[211],"2013":[212],"Apr":[213],"6-10;":[214],"Washington,":[215],"DC.":[216],"Philadelphia":[217],"(PA):":[218],"AACR;":[219],"Res":[221],"2013;73(8":[222],"Suppl):Abstract":[223],"nr":[224],"2802.":[225],"doi:10.1158/1538-7445.AM2013-2802":[226]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
