{"id":"https://openalex.org/W2331293876","doi":"https://doi.org/10.1080/10426509908546356","title":"The Synthesis of Phosphinic Acid Based Proteinase Inhibitors","display_name":"The Synthesis of Phosphinic Acid Based Proteinase Inhibitors","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2331293876","doi":"https://doi.org/10.1080/10426509908546356","mag":"2331293876"},"language":"en","primary_location":{"id":"doi:10.1080/10426509908546356","doi":"https://doi.org/10.1080/10426509908546356","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10426509908546356","pdf_url":null,"source":{"id":"https://openalex.org/S70121411","display_name":"Phosphorus, sulfur, and silicon and the related elements","issn_l":"1026-7719","issn":["1026-7719","1042-6507","1563-5325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phosphorus, Sulfur, and Silicon and the Related Elements","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032959541","display_name":"Robert Hamilton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert Hamilton","raw_affiliation_strings":["a  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","b  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","c  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","d  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"b  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"c  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"d  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103516665","display_name":"Scott Wharry","orcid":"https://orcid.org/0000-0003-4857-4866","observed_orcids":["https://orcid.org/0000-0003-4857-4866"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Scott Wharry","raw_affiliation_strings":["a  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","b  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","c  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","d  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"b  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"c  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"d  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066982091","display_name":"Brian Walker","orcid":"https://orcid.org/0000-0001-5610-7139","observed_orcids":["https://orcid.org/0000-0001-5610-7139","https://orcid.org/0000-0001-7345-2110"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian Walker","raw_affiliation_strings":["a  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","b  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","c  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","d  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"b  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"c  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"d  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066982091","display_name":"Brian Walker","orcid":"https://orcid.org/0000-0001-5610-7139","observed_orcids":["https://orcid.org/0000-0001-5610-7139","https://orcid.org/0000-0001-7345-2110"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian Walker","raw_affiliation_strings":["a  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","b  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","c  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","d  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"b  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"c  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"d  School of Chemistry and The Queen's University of Belfast , Belfast, BT9 5AG, N. Ireland.,  U.K","institution_ids":["https://openalex.org/I126231945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126231945"],"apc_list":null,"apc_paid":null,"fwci":0.5844,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57469121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"144","issue":"1","first_page":"761","last_page":"764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphinic-acids","display_name":"phosphinic acids","score":0.8040000200271606},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/valine","display_name":"valine","score":0.7360000014305115},{"id":"https://openalex.org/keywords/phenylalanine","display_name":"phenylalanine","score":1.0},{"id":"https://openalex.org/keywords/racemic-synthesis","display_name":"racemic synthesis","score":0.597000002861023},{"id":"https://openalex.org/keywords/optical-purity","display_name":"optical purity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/stereoselective-inhibition","display_name":"stereoselective inhibition","score":0.6190000176429749},{"id":"https://openalex.org/keywords/hiv-inhibitors","display_name":"HIV inhibitors","score":0.531000018119812},{"id":"https://openalex.org/keywords/enzyme-inhibition-kinetics","display_name":"enzyme inhibition kinetics","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2780645613","wikidata":"https://www.wikidata.org/wiki/Q2036402","display_name":"Phosphinate","level":3,"score":0.9724436402320862},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.7651220560073853},{"id":"https://openalex.org/C2777573094","wikidata":"https://www.wikidata.org/wiki/Q483752","display_name":"Valine","level":3,"score":0.7031600475311279},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6537799835205078},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5571232438087463},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4911958873271942},{"id":"https://openalex.org/C45803636","wikidata":"https://www.wikidata.org/wiki/Q2937959","display_name":"Asymmetric carbon","level":3,"score":0.4775068163871765},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.37540140748023987},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2526252865791321},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24325424432754517},{"id":"https://openalex.org/C3019471444","wikidata":"https://www.wikidata.org/wiki/Q530648","display_name":"Optically active","level":2,"score":0.17300596833229065},{"id":"https://openalex.org/C205474432","wikidata":"https://www.wikidata.org/wiki/Q1354051","display_name":"Fire retardant","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/10426509908546356","doi":"https://doi.org/10.1080/10426509908546356","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10426509908546356","pdf_url":null,"source":{"id":"https://openalex.org/S70121411","display_name":"Phosphorus, sulfur, and silicon and the related elements","issn_l":"1026-7719","issn":["1026-7719","1042-6507","1563-5325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phosphorus, Sulfur, and Silicon and the Related Elements","raw_type":"journal-article"},{"id":"doi:10.1080/10426509908039671","doi":"https://doi.org/10.1080/10426509908039671","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10426509908039671","pdf_url":null,"source":{"id":"https://openalex.org/S70121411","display_name":"Phosphorus, sulfur, and silicon and the related elements","issn_l":"1026-7719","issn":["1026-7719","1042-6507","1563-5325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phosphorus, Sulfur, and Silicon and the Related Elements","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1966331330","https://openalex.org/W1978209831","https://openalex.org/W1995396220","https://openalex.org/W2006460863","https://openalex.org/W2016842935","https://openalex.org/W2072409481","https://openalex.org/W2104779523","https://openalex.org/W2146497498","https://openalex.org/W2168363627","https://openalex.org/W2952435091"],"related_works":["https://openalex.org/W1981230777","https://openalex.org/W1978209831","https://openalex.org/W2156061051","https://openalex.org/W2803699670","https://openalex.org/W1972042330","https://openalex.org/W1978328487","https://openalex.org/W2950096588","https://openalex.org/W2064163623","https://openalex.org/W2056095516","https://openalex.org/W2951876063"],"abstract_inverted_index":{"The":[0],"phenyl":[1],"phosphinate":[2],"analogues":[3,33],"of":[4],"valine":[5],"and":[6,19],"phenylalanine":[7],"with":[8],"extended":[9],"chains":[10],"at":[11,37],"phosphorus":[12],"have":[13],"been":[14],"prepared":[15],"as":[16],"racemic":[17],"mixtures":[18],"also":[20],"in":[21],"high":[22],"optical":[23],"purity.":[24],"Kinetic":[25],"data":[26],"clearly":[27],"indicate":[28],"specific":[29],"inhibitory":[30],"activity":[31],"for":[32],"having":[34],"(R)":[35],"configuration":[36],"\u03b1-carbon.":[38],"A":[39],"similar":[40],"synthetic":[41],"approach":[42],"provides":[43],"a":[44],"simplified":[45],"route":[46],"to":[47],"reported":[48],"C2":[49],"symmetrical":[50],"HIV":[51],"inhibitors.":[52]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}