{"id":"https://openalex.org/W23312526","doi":null,"title":"Regulation of p53 expression in HeLa cells.","display_name":"Regulation of p53 expression in HeLa cells.","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W23312526","mag":"23312526","pmid":"https://pubmed.ncbi.nlm.nih.gov/8829621"},"language":"en","primary_location":{"id":"pmid:8829621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8829621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and molecular biology international","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087602737","display_name":"Z P Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Z P Chen","raw_affiliation_strings":["Department of Biochemistry, University of Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034987797","display_name":"David C. M. Yeung","orcid":"https://orcid.org/0000-0002-3466-9322","observed_orcids":["https://orcid.org/0000-0002-3466-9322"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D C Yeung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3959,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.61825747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"3","first_page":"607","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.8050000071525574},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/vanadate","display_name":"vanadate","score":0.9390000104904175},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.8700000047683716},{"id":"https://openalex.org/keywords/phosphotyrosine","display_name":"phosphotyrosine","score":0.9229999780654907},{"id":"https://openalex.org/keywords/p53-mrna-expression","display_name":"p53 mRNA expression","score":0.6589999794960022},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.6510000228881836},{"id":"https://openalex.org/keywords/tumor-suppressor-regulation","display_name":"tumor suppressor regulation","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.7826756238937378},{"id":"https://openalex.org/C2780307904","wikidata":"https://www.wikidata.org/wiki/Q2701649","display_name":"Phosphoserine","level":4,"score":0.7826420068740845},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.5616358518600464},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.47574421763420105},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4695349931716919},{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.4452965557575226},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4432607889175415},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4230841398239136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41935253143310547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40610548853874207},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36402037739753723},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3280028700828552},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22312813997268677},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10179263353347778},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014638","descriptor_name":"Vanadates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8829621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8829621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and molecular biology international","raw_type":"Journal Article"},{"id":"mag:23312526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8829621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1480977656","https://openalex.org/W1507511940","https://openalex.org/W1509699090","https://openalex.org/W1521131994","https://openalex.org/W1586810339","https://openalex.org/W1604195904","https://openalex.org/W1910834158","https://openalex.org/W1970079995","https://openalex.org/W1970325836","https://openalex.org/W1970445701","https://openalex.org/W1972868461","https://openalex.org/W1973836515","https://openalex.org/W1976590851","https://openalex.org/W1977906889","https://openalex.org/W1980521160","https://openalex.org/W1981165045","https://openalex.org/W1985056536","https://openalex.org/W1989843341","https://openalex.org/W1996123272","https://openalex.org/W1996874802","https://openalex.org/W2001566989","https://openalex.org/W2006751526","https://openalex.org/W2009914532","https://openalex.org/W2012252610","https://openalex.org/W2020762311","https://openalex.org/W2021768951","https://openalex.org/W2025371899","https://openalex.org/W2028154221","https://openalex.org/W2030345583","https://openalex.org/W2040124307","https://openalex.org/W2043426395","https://openalex.org/W2045519551","https://openalex.org/W2045738040","https://openalex.org/W2052737534","https://openalex.org/W2054025896","https://openalex.org/W2054465718","https://openalex.org/W2059049804","https://openalex.org/W2063350240","https://openalex.org/W2066009496","https://openalex.org/W2066400502","https://openalex.org/W2073512103","https://openalex.org/W2074501647","https://openalex.org/W2083433631","https://openalex.org/W2087790185","https://openalex.org/W2094576805","https://openalex.org/W2095787854","https://openalex.org/W2097180131","https://openalex.org/W2099107381","https://openalex.org/W2107300011","https://openalex.org/W2108154271","https://openalex.org/W2112777955","https://openalex.org/W2113114335","https://openalex.org/W2117502634","https://openalex.org/W2123204198","https://openalex.org/W2125737923","https://openalex.org/W2133204176","https://openalex.org/W2133280087","https://openalex.org/W2138856572","https://openalex.org/W2138886716","https://openalex.org/W2139903462","https://openalex.org/W2154697573","https://openalex.org/W2156227088","https://openalex.org/W2160996295","https://openalex.org/W2163506404","https://openalex.org/W2165416206","https://openalex.org/W2168138935","https://openalex.org/W2168558032","https://openalex.org/W2168614460","https://openalex.org/W2168798147","https://openalex.org/W2172122397","https://openalex.org/W2398741376"],"related_works":["https://openalex.org/W7095828888","https://openalex.org/W2102639058","https://openalex.org/W1493260667","https://openalex.org/W2072892256","https://openalex.org/W2006565381","https://openalex.org/W2048489220","https://openalex.org/W2025753330","https://openalex.org/W1548798005","https://openalex.org/W3082767488","https://openalex.org/W2037474068"],"abstract_inverted_index":{"Incubation":[0],"of":[1,7,12,16,22,35,44,68,91,103,110],"Hela":[2,50],"cells":[3,17,51,62],"in":[4,10,32,65,75,99],"the":[5,33,39,66,104,111],"presence":[6,67,90],"insulin":[8,93],"results":[9],"suppression":[11,102],"p53":[13,36,45,76,86,105],"expression.":[14,77,87],"Treatment":[15],"with":[18],"vanadate,":[19],"an":[20,83],"inhibitor":[21],"protein":[23,57],"tyrosine":[24,58],"phosphatase,":[25],"likewise":[26],"led":[27],"to":[28,54],"a":[29,56,72,100],"dramatic":[30],"reduction":[31],"level":[34],"transcript.":[37],"On":[38],"other":[40],"hand,":[41],"significant":[42],"induction":[43],"message":[46,106],"was":[47,71,113],"demonstrated":[48],"when":[49,108],"were":[52,63],"exposed":[53],"genistein,":[55],"kinase":[59],"inhibitor.":[60],"When":[61],"cultured":[64],"phosphotyrosine,":[69],"there":[70],"marked":[73],"decrease":[74],"Neither":[78],"phosphoserine":[79],"nor":[80],"phosphothreonine":[81],"had":[82],"effect":[84],"on":[85],"Furthermore,":[88],"simultaneous":[89],"both":[92],"and":[94],"phosphotyrosine":[95],"did":[96],"not":[97],"result":[98],"greater":[101],"than":[107],"either":[109],"agents":[112],"acting":[114],"singly.":[115]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
