{"id":"https://openalex.org/W2331134493","doi":"https://doi.org/10.1158/1538-7445.am2012-2831","title":"Abstract 2831: Studies on the mechanistic basis of the anticancer activity of 2,4-disulfonyl-PBN (OKN-007)","display_name":"Abstract 2831: Studies on the mechanistic basis of the anticancer activity of 2,4-disulfonyl-PBN (OKN-007)","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2331134493","doi":"https://doi.org/10.1158/1538-7445.am2012-2831","mag":"2331134493"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-2831","doi":"https://doi.org/10.1158/1538-7445.am2012-2831","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-2831","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109321252","display_name":"Robert A. Floyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Floyd","raw_affiliation_strings":["1Oklahoma Medical Research Foundation, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Oklahoma Medical Research Foundation, Oklahoma City, OK","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057478199","display_name":"Hema Kumar Chandru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hema Chandru","raw_affiliation_strings":["1Oklahoma Medical Research Foundation, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Oklahoma Medical Research Foundation, Oklahoma City, OK","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029977799","display_name":"Charles A. Stewart","orcid":"https://orcid.org/0000-0001-7936-447X","observed_orcids":["https://orcid.org/0000-0001-7936-447X"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Stewart","raw_affiliation_strings":["1Oklahoma Medical Research Foundation, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Oklahoma Medical Research Foundation, Oklahoma City, OK","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073331119","display_name":"Rheal A. Towner","orcid":"https://orcid.org/0000-0001-7368-8983","observed_orcids":["https://orcid.org/0000-0001-7368-8983"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rheal A. Towner","raw_affiliation_strings":["1Oklahoma Medical Research Foundation, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Oklahoma Medical Research Foundation, Oklahoma City, OK","institution_ids":["https://openalex.org/I30558944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I30558944"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"2831","last_page":"2831"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfatase-2","display_name":"SULF2","score":0.9610000252723694},{"id":"https://openalex.org/keywords/suramin","display_name":"suramin","score":0.8999999761581421},{"id":"https://openalex.org/keywords/breast-cancer-xenografts","display_name":"breast cancer xenografts","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.6850000023841858},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.9020000100135803},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6079999804496765},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.781000018119812},{"id":"https://openalex.org/keywords/growth-factor-binding","display_name":"growth factor binding","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2780871851","wikidata":"https://www.wikidata.org/wiki/Q7636184","display_name":"Sulfatase","level":3,"score":0.672252893447876},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5904160141944885},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5729766488075256},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.47642192244529724},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.46830904483795166},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4586600661277771},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.45618951320648193},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.43613603711128235},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41511163115501404},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36711496114730835},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3664858937263489},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35972869396209717},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.35371679067611694},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3299320936203003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2407481074333191},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17907992005348206},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08997565507888794}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-2831","doi":"https://doi.org/10.1158/1538-7445.am2012-2831","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-2831","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2036426904","https://openalex.org/W2313436221","https://openalex.org/W4253801019","https://openalex.org/W302370349","https://openalex.org/W2084253807","https://openalex.org/W2080389264","https://openalex.org/W2994570818","https://openalex.org/W2098036519","https://openalex.org/W2162137259","https://openalex.org/W2079722301"],"abstract_inverted_index":{"Abstract":[0],"Sulfatase":[1],"2":[2],"(Sulf2)":[3],"is":[4,43,283,314],"a":[5,157,209,300,352],"protein":[6],"which":[7,247],"resides":[8],"in":[9,34,36,73,208,235,269,299,319,351,361,372,387],"the":[10,21,61,74,114,122,131,143,179,192,236,249,255,270,290,303,320,383,399,404],"extracellular":[11,62],"matrix":[12,63],"of":[13,24,54,64,76,118,134,146,166,194,274,279,281,292,322,367,398,403],"cancer":[14,211,227,296,340,349,368],"cells":[15,65,228,334,341],"and":[16,66,84,97,126,170,229,306],"enzymatically":[17],"removes":[18],"sulfate":[19],"from":[20],"6-O-sulfate":[22,144],"esters":[23],"heparin.":[25,105,147],"Several":[26],"tumors":[27],"have":[28,175,183,197,266,288],"been":[29,68,172,263],"shown":[30,69,173,184,264],"to":[31,38,60,70,104,111,127,174,190,201,265,294,316,358],"be":[32,71,317,359],"enriched":[33],"Sulf2":[35,55,86,119,135,149],"comparison":[37],"normal":[39],"tissues":[40],"where":[41],"it":[42,137],"either":[44],"absent":[45],"or":[46],"present":[47],"at":[48,233,243,246,345],"very":[49],"low":[50,346],"levels.":[51],"The":[52,148,239,276,311],"action":[53,280],"alters":[56],"growth":[57,89,94,100],"factor":[58,95],"binding":[59],"has":[67,160,171,205,262],"important":[72,318],"development":[75],"many":[77],"cancers":[78],"including":[79],"breast,":[80],"lung,":[81],"liver,":[82],"colon,":[83],"pancreas.":[85],"mobilizes":[87],"fibroblast":[88],"factors":[90],"(FGFs),":[91],"vascular":[92],"endothelial":[93],"(VEGF)":[96],"stromal":[98],"derived":[99],"factor-1":[101],"(SDF-1)":[102],"bound":[103],"We":[106,196],"found":[107],"that":[108,159,185,252,343],"OKN-007":[109,204,230,253,261,282,293,344],"acts":[110,138],"weakly":[112],"inhibit":[113,130],"aryl":[115],"sulfatase":[116],"activity":[117,133,151,193,207,268],"acting":[120],"on":[121],"substrate":[123,142,181],"4-methylumbelliferyl-sulfate":[124],"(4-MUS)":[125],"more":[128,362],"effectively":[129],"enzymatic":[132,150],"when":[136],"upon":[139],"its":[140,167,307],"natural":[141,180],"ester":[145],"was":[152,231,241],"potently":[153],"inhibited":[154],"by":[155,259,374],"suramin,":[156],"compound":[158],"6":[161],"phenyl-sulfonyl":[162],"groups":[163],"as":[164,335,337],"part":[165,373],"chemical":[168],"structure":[169],"anti-cancer":[176,206,267,277],"activity.":[177],"Utilizing":[178],"we":[182,287],"other":[186],"sulfonyl-phenyl":[187],"compounds":[188],"act":[189],"suppress":[191],"Sulf2.":[195],"conducted":[198],"preliminary":[199],"studies":[200],"see":[202],"if":[203],"breast":[210,226,339],"mouse":[212],"xenograph":[213],"model.":[214],"Balb/c":[215],"female":[216],"ovariectomized":[217],"Estradiol":[218],"pellet-implanted":[219],"nude":[220],"mice":[221],"were":[222],"implanted":[223],"with":[224,326],"MCF-7":[225,338],"administered":[232],"250mg/kg/day":[234],"drinking":[237],"water.":[238],"experiment":[240],"terminated":[242],"week":[244],"5":[245],"time":[248],"data":[250],"showed":[251],"decreased":[254],"average":[256],"tumor":[257],"volume":[258],"33%.":[260],"rat":[271,327],"C6":[272,328],"model":[273],"glioma.":[275],"mechanism":[278],"still":[284],"unknown.":[285],"Recently":[286],"explored":[289,360],"potential":[291],"alter":[295],"cell":[297],"migration":[298,350],"gradient":[301,313],"involving":[302],"chemokine":[304],"SDF-1":[305],"cellular":[308],"receptor":[309],"CXCR4.":[310],"CXCL4/SDF-1":[312],"considered":[315],"metastasis":[321],"primary":[323],"cancers.":[324],"Results":[325],"glioma":[329,333],"cells,":[330],"U87MG":[331],"human":[332],"well":[336],"indicate":[342],"concentrations":[347],"inhibits":[348],"CXCR4/SDF-1":[353],"gradient.":[354],"These":[355],"observations":[356],"need":[357],"depth":[363],"utilizing":[364],"animal":[365],"models":[366],"metastasis.":[369],"Research":[370],"supported":[371],"US":[375],"Army":[376],"Concept":[377],"Grant":[378],"W81XWH-09-1-0352.":[379],"Dr.":[380],"Floyd":[381],"holds":[382],"Merrick":[384],"Foundation":[385],"Chair":[386],"Aging":[388],"Research.":[389],"Citation":[390],"Format:":[391],"{Authors}.":[392],"{Abstract":[393],"title}":[394],"[abstract].":[395],"In:":[396],"Proceedings":[397],"103rd":[400],"Annual":[401],"Meeting":[402],"American":[405],"Association":[406],"for":[407],"Cancer":[408,419],"Research;":[409],"2012":[410],"Mar":[411],"31-Apr":[412],"4;":[413],"Chicago,":[414],"IL.":[415],"Philadelphia":[416],"(PA):":[417],"AACR;":[418],"Res":[420],"2012;72(8":[421],"Suppl):Abstract":[422],"nr":[423],"2831.":[424],"doi:1538-7445.AM2012-2831":[425]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}