{"id":"https://openalex.org/W2331109239","doi":"https://doi.org/10.1515/hsz-2012-0291","title":"Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor","display_name":"Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor","publication_year":2012,"publication_date":"2012-11-08","ids":{"openalex":"https://openalex.org/W2331109239","doi":"https://doi.org/10.1515/hsz-2012-0291","mag":"2331109239","pmid":"https://pubmed.ncbi.nlm.nih.gov/23152405"},"language":"en","primary_location":{"id":"doi:10.1515/hsz-2012-0291","doi":"https://doi.org/10.1515/hsz-2012-0291","is_oa":false,"landing_page_url":"https://doi.org/10.1515/hsz-2012-0291","pdf_url":null,"source":{"id":"https://openalex.org/S18118477","display_name":"Biological Chemistry","issn_l":"1431-6730","issn":["1431-6730","1437-4315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bchm","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042535682","display_name":"Thomas Kryza","orcid":"https://orcid.org/0000-0003-1668-8551","observed_orcids":["https://orcid.org/0000-0003-1668-8551"]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas Kryza","raw_affiliation_strings":["Universit\u00e9 Fran\u00e7ois Rabelais, EA 6305, F-37032 Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Fran\u00e7ois Rabelais, EA 6305, F-37032 Tours, France","institution_ids":["https://openalex.org/I110017253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031359497","display_name":"Gilles Lalmanach","orcid":"https://orcid.org/0000-0001-8562-4821","observed_orcids":["https://orcid.org/0000-0001-8562-4821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilles Lalmanach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076544611","display_name":"Marion Lavergne","orcid":"https://orcid.org/0000-0002-1337-1121","observed_orcids":["https://orcid.org/0000-0002-1337-1121"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marion Lavergne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059973323","display_name":"Fabien Lecaille","orcid":"https://orcid.org/0000-0003-1060-4222","observed_orcids":["https://orcid.org/0000-0003-1060-4222"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabien Lecaille","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049091370","display_name":"Pascale Reverdiau","orcid":"https://orcid.org/0000-0002-7530-6237","observed_orcids":["https://orcid.org/0000-0002-7530-6237"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pascale Reverdiau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073374209","display_name":"Yves Courty","orcid":"https://orcid.org/0000-0003-3694-8517","observed_orcids":["https://orcid.org/0000-0003-3694-8517"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yves Courty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014402504","display_name":"Nathalie Heuz\u00e9\u2010Vourc'h","orcid":"https://orcid.org/0000-0003-4929-5068","observed_orcids":["https://orcid.org/0000-0003-4929-5068"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nathalie Heuz\u00e9-Vourc\u2019h","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014402504"],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"EUR","value_usd":0},"apc_paid":null,"fwci":1.0226,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.7728784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"394","issue":"3","first_page":"385","last_page":"391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/pulmonary-endothelial-cells","display_name":"pulmonary endothelial cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/kinin-b2-receptor","display_name":"kinin B2 receptor","score":0.7919999957084656},{"id":"https://openalex.org/keywords/high-molecular-weight-kininogen","display_name":"high molecular weight kininogen","score":0.9319999814033508},{"id":"https://openalex.org/keywords/kinin-release","display_name":"kinin release","score":0.7110000252723694},{"id":"https://openalex.org/keywords/kininogenase-activity","display_name":"kininogenase activity","score":0.7039999961853027},{"id":"https://openalex.org/keywords/proangiogenic-effects","display_name":"proangiogenic effects","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2776246183","wikidata":"https://www.wikidata.org/wiki/Q421924","display_name":"Kinin","level":4,"score":0.9394869208335876},{"id":"https://openalex.org/C2777902427","wikidata":"https://www.wikidata.org/wiki/Q6413860","display_name":"Kininogen","level":4,"score":0.9095170497894287},{"id":"https://openalex.org/C2781317560","wikidata":"https://www.wikidata.org/wiki/Q24721273","display_name":"High-molecular-weight kininogen","level":5,"score":0.8736666440963745},{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.7304962873458862},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6436648964881897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6312853097915649},{"id":"https://openalex.org/C152328610","wikidata":"https://www.wikidata.org/wiki/Q7240014","display_name":"Prekallikrein","level":4,"score":0.6253514289855957},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5203618407249451},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.44299980998039246},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.39536601305007935},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36301904916763306},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3348225951194763},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3290413022041321},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30960869789123535},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2411140501499176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18000277876853943},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11567673087120056}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007705","descriptor_name":"Kinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D043782","descriptor_name":"Receptor, Bradykinin B2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043925","descriptor_name":"Angiogenesis Inducing Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1515/hsz-2012-0291","doi":"https://doi.org/10.1515/hsz-2012-0291","is_oa":false,"landing_page_url":"https://doi.org/10.1515/hsz-2012-0291","pdf_url":null,"source":{"id":"https://openalex.org/S18118477","display_name":"Biological Chemistry","issn_l":"1431-6730","issn":["1431-6730","1437-4315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bchm","raw_type":"journal-article"},{"id":"pmid:23152405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23152405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1984583460","https://openalex.org/W2802125325","https://openalex.org/W1987754580","https://openalex.org/W2025021827","https://openalex.org/W2027346283","https://openalex.org/W2088440571","https://openalex.org/W7099227292","https://openalex.org/W4300445766","https://openalex.org/W2345457773","https://openalex.org/W2066409713"],"abstract_inverted_index":{"Kallikrein-12":[0],"(KLK12)":[1],"may":[2],"play":[3],"an":[4,25],"important":[5],"role":[6],"in":[7,90,107],"angiogenesis":[8,28],"modulating":[9],"proangiogenic":[10,103],"factor":[11],"bioavailability":[12],"and":[13,29,100],"activating":[14],"the":[15,30,38,54,69,73,77,102],"kinin":[16,33,78,116],"receptor":[17,34],"B2":[18,35],"pathway.":[19],"We":[20],"studied":[21],"whether":[22],"KLK12":[23,43,63,99,106],"had":[24],"impact":[26],"on":[27],"activation":[31],"of":[32,41,57,62,72,76,84,93,105],"results":[36],"from":[37],"KLK12-dependent":[39],"generation":[40],"kinins.":[42,58],"efficiently":[44],"hydrolyzed":[45],"high":[46,94],"molecular":[47,95],"weight":[48,96],"kininogen,":[49],"liberating":[50],"a":[51,115],"fragment":[52],"containing":[53],"carboxy-terminal":[55],"end":[56],"The":[59],"kininogenase":[60],"activity":[61,104],"was":[64,86,111],"poor,":[65],"however,":[66],"due":[67],"to":[68,114],"cleavage":[70],"resistance":[71],"N-terminal":[74],"side":[75],"sequence.":[79],"A":[80],"very":[81],"low":[82],"amount":[83],"kinins":[85],"accordingly":[87],"released":[88],"after":[89],"vitro":[91],"incubation":[92],"kininogen":[97],"with":[98],"thus":[101],"lung":[108],"endothelial":[109],"cells":[110],"not":[112],"related":[113],"release.":[117]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}