{"id":"https://openalex.org/W2330760281","doi":"https://doi.org/10.1097/00005344-199603000-00012","title":"Effect of Cyclic GMP Reduction on Regional Myocardial Mechanics and Metabolism in Experimental Left Ventricular Hypertrophy","display_name":"Effect of Cyclic GMP Reduction on Regional Myocardial Mechanics and Metabolism in Experimental Left Ventricular Hypertrophy","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W2330760281","doi":"https://doi.org/10.1097/00005344-199603000-00012","mag":"2330760281","pmid":"https://pubmed.ncbi.nlm.nih.gov/8907801"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-199603000-00012","doi":"https://doi.org/10.1097/00005344-199603000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199603000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027046472","display_name":"Xiaobing Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Guo","raw_affiliation_strings":["Department of Surgery, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, USA","institution_ids":["https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007661483","display_name":"Joseph Kedem","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Kedem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038761711","display_name":"Harvey R. Weiss","orcid":"https://orcid.org/0000-0001-5998-3943","observed_orcids":["https://orcid.org/0000-0001-5998-3943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. R. Weiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111875072","display_name":"James Tse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Tse","raw_affiliation_strings":["Anesthesia, and \u2020Physiology &amp","Biophysics and Heart and Brain Circulation Laboratory, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesia, and \u2020Physiology &amp","institution_ids":[]},{"raw_affiliation_string":"Biophysics and Heart and Brain Circulation Laboratory, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, U.S.A","institution_ids":["https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044958319","display_name":"Alexander Roitstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Roitstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102895922","display_name":"Peter M. Scholz","orcid":"https://orcid.org/0009-0001-8382-6582","observed_orcids":["https://orcid.org/0009-0001-8382-6582"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. M. Scholz","raw_affiliation_strings":["and reprint requests to Dr. P. M. Scholz at Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, One Robert Wood Johnson Place, New Brunswick, NJ 08903-0019, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"and reprint requests to Dr. P. M. Scholz at Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, One Robert Wood Johnson Place, New Brunswick, NJ 08903-0019, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111875072"],"corresponding_institution_ids":["https://openalex.org/I4405286694"],"apc_list":null,"apc_paid":null,"fwci":1.136,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.77977627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"3","first_page":"392","last_page":"400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.3149000108242035,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.05779999867081642,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9610000252723694},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.9620000123977661},{"id":"https://openalex.org/keywords/methylene-blue","display_name":"methylene blue","score":0.9160000085830688},{"id":"https://openalex.org/keywords/intracoronary-injection","display_name":"intracoronary injection","score":0.8289999961853027},{"id":"https://openalex.org/keywords/regional-myocardial-work","display_name":"regional myocardial work","score":0.8220000267028809},{"id":"https://openalex.org/keywords/myocardial-oxygen-consumption","display_name":"myocardial oxygen consumption","score":0.9459999799728394},{"id":"https://openalex.org/keywords/myocardial-metabolism","display_name":"myocardial metabolism","score":0.8460000157356262},{"id":"https://openalex.org/keywords/sonomicrometry","display_name":"sonomicrometry","score":0.8500000238418579},{"id":"https://openalex.org/keywords/radioimmunoassay","display_name":"radioimmunoassay","score":0.6980000138282776},{"id":"https://openalex.org/keywords/regional-blood-flow","display_name":"regional blood flow","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C2779191827","wikidata":"https://www.wikidata.org/wiki/Q422134","display_name":"Methylene blue","level":4,"score":0.7260103225708008},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.6994906067848206},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6276006698608398},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5783200263977051},{"id":"https://openalex.org/C2775938633","wikidata":"https://www.wikidata.org/wiki/Q7562206","display_name":"Sonomicrometry","level":3,"score":0.5561900734901428},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5320319533348083},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46821168065071106},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.431140661239624},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.4161810874938965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33662277460098267},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.30224767327308655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09284493327140808},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008751","descriptor_name":"Methylene Blue","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005344-199603000-00012","doi":"https://doi.org/10.1097/00005344-199603000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199603000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:8907801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8907801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1443425613","display_name":"MECHANICAL FACTORS AND ENERGY LOSS IN MYOCARDIAL REGIONS","funder_award_id":"5r01hl049138-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1769324659","display_name":null,"funder_award_id":"HL-40320","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2227828031","display_name":null,"funder_award_id":"HL 49138","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1877828639","https://openalex.org/W1903381892","https://openalex.org/W1972143566","https://openalex.org/W1978879584","https://openalex.org/W1979026148","https://openalex.org/W1982113013","https://openalex.org/W1986123592","https://openalex.org/W1988855688","https://openalex.org/W1997817999","https://openalex.org/W2000823544","https://openalex.org/W2008972531","https://openalex.org/W2012060880","https://openalex.org/W2014905160","https://openalex.org/W2019496271","https://openalex.org/W2023161709","https://openalex.org/W2031383268","https://openalex.org/W2042549881","https://openalex.org/W2049489176","https://openalex.org/W2056841549","https://openalex.org/W2058370708","https://openalex.org/W2065337602","https://openalex.org/W2073754852","https://openalex.org/W2077969074","https://openalex.org/W2088328109","https://openalex.org/W2090446737","https://openalex.org/W2091918282","https://openalex.org/W2096084168","https://openalex.org/W2112837617","https://openalex.org/W2113130764","https://openalex.org/W2180374505","https://openalex.org/W2280605152","https://openalex.org/W2411987091"],"related_works":["https://openalex.org/W2045059302","https://openalex.org/W2023161709","https://openalex.org/W2019496271","https://openalex.org/W2006422381","https://openalex.org/W1972452377","https://openalex.org/W2081330400","https://openalex.org/W2119830953","https://openalex.org/W2073525697","https://openalex.org/W2099478743","https://openalex.org/W1999871663"],"abstract_inverted_index":{"We":[0],"tested":[1],"the":[2,32,70,77,90,129,181,221,249,263,297,302],"hypotheses":[3],"that":[4,31,228],"decreased":[5,239],"myocardial":[6,20,102,281],"cyclic":[7,28,39,126,218,234,310],"GMP":[8,29,40,127,219,235,311],"levels":[9,216,236],"produced":[10,49],"by":[11,50,138,240],"intracoronary":[12,276],"injection":[13,204],"of":[14,93,125,205,217],"methylene":[15,65,139,148,206,241,277],"blue":[16,66,140,149,207,242,278],"would":[17],"increase":[18],"local":[19],"work":[21,86,152,190,282],"and":[22,30,38,57,97,112,133,144,167,198,211,243,286],"O2":[23,36,103,114,196,199],"consumption":[24,104,200],"while":[25],"decreasing":[26],"intracellular":[27,123],"relation":[33],"between":[34],"work,":[35],"consumption,":[37],"may":[41],"be":[42],"altered":[43],"in":[44,128,141,165,180,187,208,220,229,248,262,284,309],"left":[45,71],"ventricular":[46],"hypertrophy":[47],"(LVH)":[48],"aortic":[51],"valve":[52],"plication.":[53],"In":[54,231],"8":[55,58],"control":[56,83,143,210,264,285],"LVH":[59,145,182,212,222,250,287],"open-chest":[60],"anesthetized":[61],"dogs,":[62],"1":[63],"mg/kg/min":[64],"was":[67,87,105,119],"infused":[68],"into":[69],"anterior":[72],"descending":[73],"coronary":[74],"artery":[75],"(LAD);":[76],"circumflex":[78],"region":[79],"(CFX)":[80],"served":[81],"as":[82,89],"area.":[84],"Regional":[85,101,193],"calculated":[88,106],"integrated":[91],"product":[92],"force":[94],"(miniature":[95],"transducer)":[96],"segment":[98],"shortening":[99],"(sonomicrometry).":[100],"from":[107,153,168],"flow":[108],"measurements":[109],"(radioactive":[110],"microspheres),":[111],"regional":[113,151,189,280,291],"saturations":[115],"(microspectrophotometry).":[116],"A":[117],"radioimmunoassay":[118],"used":[120],"to":[121,157,172,244,256,270],"determine":[122],"level":[124],"myocardium.":[130],"Global":[131],"hemodynamics":[132],"blood":[134,194],"gases":[135],"were":[136,191,224,237],"unchanged":[137,202],"both":[142,209,232],"animals.":[146,213],"Intracoronary":[147],"increased":[150,279,294,299],"762":[154],"+/-":[155,159,170,174,254,258,268,272],"129":[156],"1,451":[158],"307":[160],"g":[161,176],"center":[162,177],"dot":[163,178],"mm/min":[164,179],"controls":[166],"912":[169],"173":[171],"1581":[173],"253":[175],"groups.":[183],"No":[184],"significant":[185],"changes":[186],"CFX":[188],"observed.":[192],"flow,":[195],"extraction,":[197],"remained":[201],"after":[203],"The":[214],"basal":[215],"group":[223],"fivefold":[225],"higher":[226],"than":[227,261],"controls.":[230],"groups,":[233],"significantly":[238],"a":[245,306],"greater":[246,307],"extent":[247],"animals":[251,265],"(from":[252,266],"6.16":[253],"1.2":[255],"3.34":[257],"0.44":[259],"pmol/g)":[260],"1.32":[267],"0.20":[269],"1.09":[271],"0.19":[273],"pmol/g).":[274],"Therefore,":[275],"equally":[283],"hearts":[288],"without":[289],"affecting":[290],"metabolism":[292],"(i.e.,":[293],"efficiency).":[295],"For":[296],"same":[298],"mechanical":[300],"function,":[301],"hypertrophic":[303],"myocardium":[304],"exhibited":[305],"reduction":[308],"pool":[312],"size.":[313]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}