{"id":"https://openalex.org/W2330734723","doi":"https://doi.org/10.1158/1538-7445.am2013-896","title":"Abstract 896: miR-198 silencing is a mechanism of gemcitabine resistance in human pancreatic adenocarcinoma.","display_name":"Abstract 896: miR-198 silencing is a mechanism of gemcitabine resistance in human pancreatic adenocarcinoma.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2330734723","doi":"https://doi.org/10.1158/1538-7445.am2013-896","mag":"2330734723"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-896","doi":"https://doi.org/10.1158/1538-7445.am2013-896","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-896","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053687018","display_name":"Olorunseun Olatunji Ogunwobi","orcid":"https://orcid.org/0000-0003-3388-2137","observed_orcids":["https://orcid.org/0000-0003-3388-2137"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olorunseun O. Ogunwobi","raw_affiliation_strings":["Univ. of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402608","display_name":"Jian Li","orcid":"https://orcid.org/0000-0003-3320-7924","observed_orcids":["https://orcid.org/0000-0003-3320-7924","https://orcid.org/0000-0001-9289-8177"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Li","raw_affiliation_strings":["Univ. of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010635399","display_name":"Xiangxuan Zhao","orcid":"https://orcid.org/0000-0003-1209-9995","observed_orcids":["https://orcid.org/0000-0003-1209-9995"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangxuan Zhao","raw_affiliation_strings":["Univ. of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052737510","display_name":"Jose Gilberto Trevino","orcid":"https://orcid.org/0000-0002-0265-8151","observed_orcids":["https://orcid.org/0000-0002-0265-8151"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Trevino","raw_affiliation_strings":["Univ. of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020154592","display_name":"Thomas J. George","orcid":"https://orcid.org/0000-0002-6249-9180","observed_orcids":["https://orcid.org/0000-0002-6249-9180"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas George","raw_affiliation_strings":["Univ. of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100322216","display_name":"Chen Liu","orcid":"https://orcid.org/0009-0003-0430-6146","observed_orcids":["https://orcid.org/0009-0003-0430-6146","https://orcid.org/0009-0008-6552-1719"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Liu","raw_affiliation_strings":["Univ. of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"896","last_page":"896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-198","display_name":"miR-198","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gemcitabine-resistance","display_name":"gemcitabine resistance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mirna-silencing","display_name":"microRNA silencing","score":0.7799999713897705},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7799999713897705},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5619999766349792},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.7360000014305115},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.675000011920929},{"id":"https://openalex.org/keywords/tumor-growth-in-nude-mice","display_name":"tumor growth in nude mice","score":0.40400001406669617},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.8434571623802185},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.7069129347801208},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6186965107917786},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6067515015602112},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.49226298928260803},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.48954853415489197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4808424413204193},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.47723010182380676},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4567883610725403},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.44393351674079895},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.4393545389175415},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4223294258117676},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2792308032512665},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18804001808166504},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.15973049402236938},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10146364569664001}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-896","doi":"https://doi.org/10.1158/1538-7445.am2013-896","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-896","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2217881085","https://openalex.org/W2754125524","https://openalex.org/W2990161293","https://openalex.org/W7020693660","https://openalex.org/W2323386077","https://openalex.org/W2086334115","https://openalex.org/W2975333647","https://openalex.org/W3211669689","https://openalex.org/W4293201851","https://openalex.org/W2061797905"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1],"adenocarcinoma":[2],"(PAC)":[3],"is":[4,18,29,34,321,357],"a":[5,19,66,199,249,322,358],"very":[6],"aggressive":[7],"disease":[8],"with":[9,15],"extremely":[10],"high":[11],"mortality":[12],"rate.":[13],"Chemotherapy":[14],"gemcitabine":[16,361],"(G)":[17],"standard":[20],"of":[21,38,44,56,81,87,110,121,135,161,182,198,203,214,248,276,291,304,311,316,324,360,370,375],"care":[22],"for":[23,379],"advanced":[24],"disease,":[25],"but":[26,148],"chemotherapy":[27,90],"resistance":[28,91,362],"commonly":[30],"noted.":[31],"Human":[32],"PAC":[33,51,93,114,287,297],"characterized":[35],"by":[36,75,196,230,238],"overexpression":[37],"the":[39,78,85,105,111,119,129,165,171,179,193,371,376],"proto-oncogene":[40],"c-met.":[41,218],"Increased":[42],"activation":[43],"c-met":[45,73,82,136,144,215],"has":[46,59,94],"been":[47,60,97],"reported":[48],"in":[49,89,92,100,123,164,168,185,192,211,296,326,338,363],"G-resistant":[50,108,124,130,166,285],"cells.":[52],"Also,":[53],"aberrant":[54],"expression":[55,74,134,163,191,213,301,334],"microRNAs":[57],"(miRNAs)":[58],"linked":[61],"to":[62,77,117,170,331],"cancer":[63],"progression.":[64],"Furthermore,":[65,154,263,328],"recent":[67],"study":[68,102],"showed":[69],"that":[70,128,207,284],"miR-198":[71,88,122,162,183,190,208,220,264,294,319,333,355],"regulates":[72],"binding":[76],"3\u2032-untranslated":[79],"region":[80],"mRNA.":[83],"However,":[84,252],"role":[86,120],"not":[95,149],"previously":[96],"studied.":[98],"Consequently,":[99],"this":[101],"we":[103,157,188],"used":[104],"G-sensitive":[106,172,194],"and":[107,139,142,216,235,273,302,309,314],"subclones":[109],"L3.6pl":[112],"human":[113,286,364],"cell":[115,236,277,307],"line":[116],"examine":[118],"PAC.":[125,327,339],"We":[126,205,282],"observed":[127,158,206],"subclone":[131,167,173,195],"had":[132],"increased":[133,212,225,300,306],"(using":[137,145,259],"qPCR":[138,156],"western":[140,146],"blotting)":[141],"phosphorylated":[143,217],"blotting),":[147],"hepatocyte":[150],"growth":[151],"factor":[152],"(HGF).":[153],"using":[155,243],"significant":[159,253],"silencing":[160,184,209,221,265,290,295,320,356],"comparison":[169],"(P":[174,232,240,270,279],"<":[175,233,241,271,280],"0.01).":[176],"To":[177],"determine":[178],"functional":[180],"significance":[181],"G":[186],"resistance,":[187],"silenced":[189],"transfection":[197],"specific":[200],"oligonucleotide":[201],"inhibitor":[202],"miR-198.":[204,292],"resulted":[210],"Further,":[219],"on":[222,255],"its":[223],"own":[224],"total":[226],"RNA":[227],"concentration":[228],"significantly":[229,266],"146%":[231],"0.05)":[234,272],"viability":[237,278],"14.3%":[239],"0.05;":[242],"MTT":[244],"assay),":[245],"both":[246],"suggestive":[247],"proliferative":[250],"effect.":[251],"effects":[254],"apoptosis":[256,269,313],"were":[257],"undetectable":[258],"Hoechst":[260],"nuclear":[261],"staining).":[262],"abrogated":[267],"G-induced":[268,274,312],"reduction":[275],"0.05).":[281],"conclude":[283],"cells":[288,298],"have":[289],"Moreover,":[293],"induces":[299],"phosphorylation":[303],"c-met,":[305],"proliferation":[308],"abrogation":[310],"induction":[315],"proliferation.":[317],"Therefore,":[318],"mechanism":[323,359],"G-resistance":[325],"therapeutic":[329],"strategies":[330],"enhance":[332],"may":[335],"be":[336],"beneficial":[337],"Citation":[340],"Format:":[341],"Olorunseun":[342],"O.":[343],"Ogunwobi,":[344],"Jian":[345],"Li,":[346],"Xiangxuan":[347],"Zhao,":[348],"Jose":[349],"Trevino,":[350],"Thomas":[351],"George,":[352],"Chen":[353],"Liu.":[354],"pancreatic":[365],"adenocarcinoma.":[366],"[abstract].":[367],"In:":[368],"Proceedings":[369],"104th":[372],"Annual":[373],"Meeting":[374],"American":[377],"Association":[378],"Cancer":[380,390],"Research;":[381],"2013":[382],"Apr":[383],"6-10;":[384],"Washington,":[385],"DC.":[386],"Philadelphia":[387],"(PA):":[388],"AACR;":[389],"Res":[391],"2013;73(8":[392],"Suppl):Abstract":[393],"nr":[394],"896.":[395],"doi:10.1158/1538-7445.AM2013-896":[396]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2016-06-24T00:00:00"}