{"id":"https://openalex.org/W2330701323","doi":"https://doi.org/10.1016/j.clpt.2005.12.270","title":"PIII-62Metabolism of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, by human cytochrome P-450 CYP3A4, 3A5, 1A1, and 1A2","display_name":"PIII-62Metabolism of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, by human cytochrome P-450 CYP3A4, 3A5, 1A1, and 1A2","publication_year":2006,"publication_date":"2006-02-01","ids":{"openalex":"https://openalex.org/W2330701323","doi":"https://doi.org/10.1016/j.clpt.2005.12.270","mag":"2330701323"},"language":"en","primary_location":{"id":"doi:10.1016/j.clpt.2005.12.270","doi":"https://doi.org/10.1016/j.clpt.2005.12.270","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clpt.2005.12.270","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100336810","display_name":"Jing Li","orcid":"https://orcid.org/0000-0001-8669-4901","observed_orcids":["https://orcid.org/0000-0001-8669-4901"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J LI","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090637113","display_name":"Ming Zhao","orcid":"https://orcid.org/0009-0005-9985-4448","observed_orcids":["https://orcid.org/0009-0005-9985-4448"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M ZHAO","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077260725","display_name":"Sharyn D. Baker","orcid":"https://orcid.org/0000-0003-3062-3252","observed_orcids":["https://orcid.org/0000-0003-3062-3252"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S BAKER","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":0.2017,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.56192838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"79","issue":"2","first_page":"P75","last_page":"P75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9900000095367432},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cyp3a5","display_name":"CYP3A5","score":1.0},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":1.0},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyp3a7","display_name":"CYP3A7","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cyp1b1","display_name":"CYP1B1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors","display_name":"epidermal growth factor receptor tyrosine kinase inhibitors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pharmacokinetic-variability","display_name":"pharmacokinetic variability","score":0.7429999709129333},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.8888623118400574},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.6703760623931885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.669549286365509},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6251552104949951},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6212429404258728},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5615888833999634},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4862478971481323},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.46741461753845215},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46413275599479675},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.33726662397384644},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26301613450050354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25347065925598145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16618004441261292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16133368015289307},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.clpt.2005.12.270","doi":"https://doi.org/10.1016/j.clpt.2005.12.270","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clpt.2005.12.270","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2125129553","https://openalex.org/W6940405078","https://openalex.org/W2067104291","https://openalex.org/W2932761119","https://openalex.org/W1977134449","https://openalex.org/W2076136110","https://openalex.org/W4408739869","https://openalex.org/W2591373827","https://openalex.org/W2581290931","https://openalex.org/W3021081493"],"abstract_inverted_index":{"BACKGROUND":[0],"Erlotinib":[1],"(E),":[2],"an":[3],"EGFR":[4],"inhibitor,":[5],"is":[6,17],"approved":[7],"for":[8,58,115,131,171,192,210],"the":[9],"treatment":[10,227],"of":[11,143,152,158,199],"non-small":[12],"cell":[13],"lung":[14],"cancer.":[15],"E":[16,32,39,61,90,121,194,223],"extensively":[18],"metabolized":[19,92],"and":[20,52,62,97,105,112,127,137,147,167,177,186,215,217,226],"exhibits":[21],"wide":[22],"inter-subject":[23],"pharmacokinetic":[24],"(PK)":[25],"variability.":[26],"The":[27,140],"objective":[28],"was":[29,42,73,91],"to":[30,81,99,106,183,222],"characterize":[31],"metabolism":[33],"by":[34,66,75,94,103,110,156],"human":[35,46],"CYP":[36],"enzymes.":[37],"METHODS":[38],"(1.5\u201350":[40],"\u03bcM)":[41],"incubated":[43],"with":[44,68,133,173],"recombinant":[45],"CYP3A4,":[47,95,134,174,184],"3A5,":[48,96,135,175],"3A7,":[49],"1A1,":[50,98,136,176],"1A2,":[51,104,138,178],"1B1":[53],"(10\u2013160":[54],"pmol/ml)":[55],"at":[56],"370C":[57],"30":[59],"min.":[60],"metabolites":[63],"were":[64,123,154,163],"monitored":[65],"HPLC":[67],"PDA":[69],"detector.":[70],"Enzyme":[71],"kinetics":[72,142],"examined":[74],"fitting":[76],"substrate":[77],"concentration-reaction":[78],"velocity":[79],"curve":[80],"Hill":[82],"equation":[83],"or":[84],"Michealis-Menten":[85],"function":[86],"using":[87],"WinNonlin.":[88],"RESULTS":[89],"primarily":[93],"a":[100,107,145,206],"lesser":[101],"extent":[102,109],"negligible":[108],"3A7":[111],"1B1.":[113],"Values":[114],"maximum":[116],"clearance":[117,160],"(CLmax),":[118],"representing":[119],"overall":[120,193],"metabolism,":[122],"0.24,":[124],"0.21,":[125],"0.31,":[126],"0.15":[128],"ml/min/nmol":[129,169],"P450":[130,170],"reactions":[132,172],"respectively.":[139,179],"formation":[141],"OSI-420,":[144],"main":[146],"active":[148],"in":[149,213],"vivo":[150],"metabolite":[151],"E,":[153],"characterized":[155],"assessment":[157],"intrinsic":[159],"(CLint);":[161],"values":[162],"0.09,":[164],"0.05,":[165],"0.02,":[166],"0.03":[168],"CONCLUSIONS":[180],"In":[181,196],"addition":[182],"3A5":[185],"1A1":[187],"have":[188],"significant":[189],"metabolic":[190],"capability":[191],"metabolism.":[195],"smokers,":[197],"induction":[198],"hepatic":[200],"and/or":[201],"intratumoral":[202],"CYP1A1":[203,216],"may":[204,220],"represent":[205],"predominant":[207],"elimination":[208],"pathway":[209],"E.":[211],"Polymorphisms":[212],"CYP3A4/5":[214],"smoking":[218],"status":[219],"contribute":[221],"PK":[224],"variability":[225],"outcome.":[228],"Clinical":[229],"Pharmacology":[230],"&":[231],"Therapeutics":[232],"(2005)":[233],"79,":[234],"P75\u2013P75;":[235],"doi:":[236],"10.1016/j.clpt.2005.12.270":[237]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}
