{"id":"https://openalex.org/W2330622688","doi":"https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3971","title":"Methacholine PC20 In African Americans And Whites With Asthma With Homozygous Genotypes At ADRB2 Codon 16","display_name":"Methacholine PC20 In African Americans And Whites With Asthma With Homozygous Genotypes At ADRB2 Codon 16","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W2330622688","doi":"https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3971","mag":"2330622688"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3971","doi":"https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3971","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3971","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"C22. ASTHMA THERAPY","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040408813","display_name":"Kathryn Blake","orcid":"https://orcid.org/0000-0001-9959-8572","observed_orcids":["https://orcid.org/0000-0001-9959-8572"]},"institutions":[{"id":"https://openalex.org/I4210086066","display_name":"Nemours Children\u2019s Clinic","ror":"https://ror.org/00f76x039","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086066","https://openalex.org/I4210108049"]},{"id":"https://openalex.org/I4210158181","display_name":"Nemours Children's Clinic","ror":"https://ror.org/050hscv31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210108049","https://openalex.org/I4210158181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn V. Blake","raw_affiliation_strings":["Center for Pharmacogenomics and Translational Research, Nemours Children's Clinic, 807 Children's Way, Jacksonville, FL, 32207 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pharmacogenomics and Translational Research, Nemours Children's Clinic, 807 Children's Way, Jacksonville, FL, 32207 USA","institution_ids":["https://openalex.org/I4210086066","https://openalex.org/I4210158181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033077951","display_name":"Jobayer Hossain","orcid":"https://orcid.org/0000-0003-2609-6605","observed_orcids":["https://orcid.org/0000-0003-2609-6605"]},"institutions":[{"id":"https://openalex.org/I1326254912","display_name":"Alfred I. duPont Hospital for Children","ror":"https://ror.org/00jyx0v10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1326254912","https://openalex.org/I4210108049"]},{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jobayer Hossain","raw_affiliation_strings":["The Center for Pediatric Research, Alfred I. DuPont Hospital of Children, 1600 Rockland Road, Wilmington, DE; Department of Food and Resource Economics,","University of Delaware, Newark, DE 19803 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Pediatric Research, Alfred I. DuPont Hospital of Children, 1600 Rockland Road, Wilmington, DE; Department of Food and Resource Economics,","institution_ids":["https://openalex.org/I1326254912"]},{"raw_affiliation_string":"University of Delaware, Newark, DE 19803 USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108423726","display_name":"John J. Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086066","display_name":"Nemours Children\u2019s Clinic","ror":"https://ror.org/00f76x039","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086066","https://openalex.org/I4210108049"]},{"id":"https://openalex.org/I4210158181","display_name":"Nemours Children's Clinic","ror":"https://ror.org/050hscv31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210108049","https://openalex.org/I4210158181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Lima","raw_affiliation_strings":["Center for Pharmacogenomics and Translational Research, Nemours Children's Clinic, 807 Children's Way, Jacksonville, FL, 32207 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pharmacogenomics and Translational Research, Nemours Children's Clinic, 807 Children's Way, Jacksonville, FL, 32207 USA","institution_ids":["https://openalex.org/I4210086066","https://openalex.org/I4210158181"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A3971","last_page":"A3971"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8429999947547913},{"id":"https://openalex.org/keywords/methacholine-pc20","display_name":"methacholine PC20","score":0.8399999737739563},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.6629999876022339},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.7820000052452087},{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.8309999704360962},{"id":"https://openalex.org/keywords/genotypes","display_name":"genotypes","score":0.3330000042915344},{"id":"https://openalex.org/keywords/airway-responsiveness","display_name":"airway responsiveness","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6997637748718262},{"id":"https://openalex.org/C2781260171","wikidata":"https://www.wikidata.org/wiki/Q413188","display_name":"Methacholine","level":4,"score":0.6307926177978516},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6254202127456665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3983486294746399},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36712777614593506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24913084506988525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20730766654014587},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19061881303787231},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.0796239972114563},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3971","doi":"https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3971","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3971","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"C22. ASTHMA THERAPY","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4267520232","display_name":"GENOMICS AND PHARMACOGENOMICS OF SYMPTOMS IN ASTHMA","funder_award_id":"R01NR013391","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337353","display_name":"National Institute of Nursing Research","ror":"https://ror.org/01y3zfr79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1965996210","https://openalex.org/W1966718625","https://openalex.org/W1968344650","https://openalex.org/W1984327463","https://openalex.org/W1991169230","https://openalex.org/W2005005699","https://openalex.org/W2010152569","https://openalex.org/W2010192251","https://openalex.org/W2037733478","https://openalex.org/W2039051609","https://openalex.org/W2049485050","https://openalex.org/W2065814537","https://openalex.org/W2090852662","https://openalex.org/W2092030888","https://openalex.org/W2105860244","https://openalex.org/W2108678383","https://openalex.org/W2111609315","https://openalex.org/W2116896520","https://openalex.org/W2122068252","https://openalex.org/W2125078269","https://openalex.org/W2129386678","https://openalex.org/W2135994980","https://openalex.org/W2155113787","https://openalex.org/W2157281923","https://openalex.org/W2159684987","https://openalex.org/W2187258174","https://openalex.org/W2327225526","https://openalex.org/W2331910068","https://openalex.org/W4230991751","https://openalex.org/W4243262508"],"related_works":["https://openalex.org/W2044366369","https://openalex.org/W2131798051","https://openalex.org/W3005057130","https://openalex.org/W2165029967","https://openalex.org/W2010623410","https://openalex.org/W1029029897","https://openalex.org/W3043256747","https://openalex.org/W7119369600","https://openalex.org/W2010436516","https://openalex.org/W6960056565"],"abstract_inverted_index":{"BACKGROUND-African":[0],"Americans":[1],"have":[2,16],"worse":[3],"asthma":[4],"outcomes":[5],"compared":[6],"to":[7],"whites.Adrenoceptor":[8],"beta":[9],"2,":[10],"surface":[11],"gene":[12],"(ADRB2)":[13],"Gly16Arg":[14],"genotypes":[15],"been":[17],"associated":[18],"with":[19],"\u03b2":[20],"2":[21],"-":[22]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}