{"id":"https://openalex.org/W2330456986","doi":"https://doi.org/10.1055/s-0033-1351290","title":"Enhanced Immunoreceptor Tyrosine-based Activation Motif Signaling is Related to Pathological Bone Resorption During Critical Illness","display_name":"Enhanced Immunoreceptor Tyrosine-based Activation Motif Signaling is Related to Pathological Bone Resorption During Critical Illness","publication_year":2013,"publication_date":"2013-08-15","ids":{"openalex":"https://openalex.org/W2330456986","doi":"https://doi.org/10.1055/s-0033-1351290","mag":"2330456986","pmid":"https://pubmed.ncbi.nlm.nih.gov/23950035"},"language":"en","primary_location":{"id":"doi:10.1055/s-0033-1351290","doi":"https://doi.org/10.1055/s-0033-1351290","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0033-1351290","pdf_url":null,"source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lirias.kuleuven.be/retrieve/996e44e1-0c44-4ed3-8727-2aa0f6a7c76b","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113639071","display_name":"Ineke Vanhees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"I. Vanhees","raw_affiliation_strings":["Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040894632","display_name":"Jan Gunst","orcid":"https://orcid.org/0000-0003-2470-6393","observed_orcids":["https://orcid.org/0000-0003-2470-6393"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J. Gunst","raw_affiliation_strings":["Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Janssens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"T. Janssens","raw_affiliation_strings":["Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084815192","display_name":"Annet Wauters","orcid":"https://orcid.org/0000-0002-3302-2033","observed_orcids":["https://orcid.org/0000-0002-3302-2033"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"A. Wauters","raw_affiliation_strings":["Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110050343","display_name":"Eric Van Herck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"E. Van Herck","raw_affiliation_strings":["Laboratory of Experimental Medicine and Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Medicine and Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047510478","display_name":"Sophie J. Van Cromphaut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"S. Van Cromphaut","raw_affiliation_strings":["Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088025499","display_name":"Greet Van den Berghe","orcid":"https://orcid.org/0000-0002-5320-1362","observed_orcids":["https://orcid.org/0000-0002-5320-1362"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"G. Van den Berghe","raw_affiliation_strings":["Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108109310","display_name":"Helen C. Owen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"H. Owen","raw_affiliation_strings":["Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108109310"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":null,"apc_paid":null,"fwci":0.4033,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.52632051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"45","issue":"12","first_page":"862","last_page":"869"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/critical-illness","display_name":"critical illness","score":0.9269999861717224},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9430000185966492},{"id":"https://openalex.org/keywords/fcgammariii","display_name":"Fc\u03b3RIII","score":0.9520000219345093},{"id":"https://openalex.org/keywords/dap12","display_name":"DAP12","score":0.996999979019165},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.953000009059906},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/trabecular-bone","display_name":"trabecular bone","score":0.7720000147819519},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.781000018119812},{"id":"https://openalex.org/keywords/burns","display_name":"burns","score":0.746999979019165},{"id":"https://openalex.org/keywords/rank-rankl-opg-pathway","display_name":"RANK/RANKL/OPG pathway","score":0.8769999742507935},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.48100000619888306},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.7205219268798828},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6379656791687012},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6185864806175232},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6079257130622864},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5600012540817261},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5321654081344604},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.5264193415641785},{"id":"https://openalex.org/C29907709","wikidata":"https://www.wikidata.org/wiki/Q6005558","display_name":"Immunoreceptor tyrosine-based activation motif","level":5,"score":0.4537513554096222},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4414185583591461},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3367252051830292},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.2944610118865967},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23720782995224},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16119655966758728},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061625","descriptor_name":"Immunoreceptor Tyrosine-Based Activation Motif","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1055/s-0033-1351290","doi":"https://doi.org/10.1055/s-0033-1351290","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0033-1351290","pdf_url":null,"source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},{"id":"pmid:23950035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23950035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/420965","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/420965","pdf_url":"https://lirias.kuleuven.be/retrieve/996e44e1-0c44-4ed3-8727-2aa0f6a7c76b","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hormone and Metabolic Research, vol. 45 (12), (862-9)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/420965","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/420965","pdf_url":"https://lirias.kuleuven.be/retrieve/996e44e1-0c44-4ed3-8727-2aa0f6a7c76b","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hormone and Metabolic Research, vol. 45 (12), (862-9)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2662526218","display_name":null,"funder_award_id":"GOA2007/14","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2330456986.pdf","grobid_xml":"https://content.openalex.org/works/W2330456986.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1500219232","https://openalex.org/W1965677004","https://openalex.org/W1966478270","https://openalex.org/W1974610140","https://openalex.org/W1977285029","https://openalex.org/W1986884111","https://openalex.org/W1989810123","https://openalex.org/W1991151250","https://openalex.org/W1997966580","https://openalex.org/W2000158514","https://openalex.org/W2008952841","https://openalex.org/W2012568362","https://openalex.org/W2036774036","https://openalex.org/W2045358685","https://openalex.org/W2047274096","https://openalex.org/W2063232019","https://openalex.org/W2064467855","https://openalex.org/W2067199708","https://openalex.org/W2080784991","https://openalex.org/W2086128996","https://openalex.org/W2086894618","https://openalex.org/W2090457064","https://openalex.org/W2093707705","https://openalex.org/W2107277218","https://openalex.org/W2110115774","https://openalex.org/W2115193077","https://openalex.org/W2118379699","https://openalex.org/W2144294470","https://openalex.org/W2166035250","https://openalex.org/W2167775327","https://openalex.org/W2168100085","https://openalex.org/W2170471460","https://openalex.org/W2261093661"],"related_works":["https://openalex.org/W2064467855","https://openalex.org/W2080045135","https://openalex.org/W6989598406","https://openalex.org/W1861228342","https://openalex.org/W2152550140","https://openalex.org/W2016309452","https://openalex.org/W3033300655","https://openalex.org/W7002132627","https://openalex.org/W2017530514","https://openalex.org/W2048149512"],"abstract_inverted_index":{"Prolonged":[0],"critically":[1,60],"ill":[2,61],"patients":[3,62],"present":[4],"with":[5,231],"distinct":[6],"alterations":[7],"in":[8,36,59,64,67,92,106,112,122,133,167,184],"calcium":[9,115],"and":[10,19,31,46,116,129,141,153,160,199,202,228],"bone":[11,14,20,38,86,126,158,220],"metabolism.":[12],"Circulating":[13],"formation":[15,159],"markers":[16,22,173,187],"are":[17,23],"reduced":[18,225],"resorption":[21],"substantially":[24],"elevated,":[25],"indicating":[26,156],"an":[27,182],"uncoupling":[28],"between":[29],"osteoclast":[30,57,171],"osteoblast":[32,152,226],"activity,":[33],"possibly":[34,69,222],"resulting":[35],"pronounced":[37],"loss,":[39],"impaired":[40,161],"traumatic":[41],"or":[42],"surgical":[43],"fracture":[44],"healing,":[45],"osteoporosis.":[47],"In":[48,73],"addition,":[49],"we":[50,77],"have":[51],"previously":[52],"shown":[53,210],"that":[54,235],"increased":[55,65,232],"circulating":[56],"precursors":[58],"result":[63],"osteoclastogenesis":[66,233],"vitro,":[68],"through":[70],"Fc\u03b3RIII":[71],"signaling.":[72],"the":[74,79,89,147,168,175,189,240],"current":[75,207],"study,":[76],"investigated":[78],"effects":[80],"of":[81,97,151,170,186,214],"sustained":[82],"critical":[83,103,216],"illness":[84,217],"on":[85,218],"metabolism":[87],"at":[88],"tissue":[90],"level":[91],"a":[93,110,211],"standardized":[94],"rabbit":[95],"model":[96,108],"prolonged":[98,215],"(7":[99],"days),":[100],"burn":[101],"injury-induced":[102],"illness.":[104],"This":[105],"vivo":[107],"showed":[109],"reduction":[111],"serum":[113],"ionized":[114],"osteocalcin":[117],"levels,":[118],"as":[119,145],"is":[120],"seen":[121],"humans.":[123],"Trabecular":[124],"area,":[125],"mineral":[127],"content,":[128],"-density":[130],"were":[131],"decreased":[132,157],"sick":[134],"rabbits":[135],"[by":[136],"43%":[137],"(p<0.01),":[138,140],"31%":[139],"29%":[142],"(p<0.05),":[143],"respectively],":[144],"was":[146,164,181],"trabecular":[148,219],"gene":[149],"expression":[150,169,185],"angiogenesis":[154],"markers,":[155],"vascularization.":[162],"There":[163],"no":[165],"change":[166],"differentiation":[172,227],"from":[174,188],"canonical":[176],"RANK/RANKL/OPG":[177],"pathway,":[178,197],"however,":[179],"there":[180],"increase":[183],"non-canonical,":[190],"immunoreceptor":[191,242],"tyrosine-based":[192,243],"activation":[193,244],"motif":[194,245],"(ITAM)":[195],"signaling":[196,234,246],"Fc\u03b3RIII,":[198],"DAP12":[200],"(148%":[201],"59%,":[203],"respectively;":[204],"p<0.01).":[205],"The":[206],"study":[208],"has":[209],"detrimental":[212],"effect":[213],"integrity,":[221],"explained":[223],"by":[224],"angiogenesis,":[229],"coupled":[230],"may":[236],"be":[237],"mediated":[238],"via":[239],"non-canonical":[241],"pathway.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
