{"id":"https://openalex.org/W2330128707","doi":"https://doi.org/10.5282/edoc.7092","title":"Genomische Instabilit\u00e4t beim malignen Melanom","display_name":"Genomische Instabilit\u00e4t beim malignen Melanom","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2330128707","doi":"https://doi.org/10.5282/edoc.7092","mag":"2330128707"},"language":"de","primary_location":{"id":"pmh:oai:edoc.ub.uni-muenchen.de:7092","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-70927","pdf_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-70927","source":{"id":"https://openalex.org/S4377196618","display_name":"Electronic Theses of LMU Munich (Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertationen"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-70927","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066557651","display_name":"Murat Y\u0131ld\u0131z","orcid":"https://orcid.org/0000-0001-7022-0760","observed_orcids":["https://orcid.org/0000-0001-7022-0760"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Yildiz, Murat","raw_affiliation_strings":["Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066557651"],"corresponding_institution_ids":["https://openalex.org/I8204097"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9819999933242798},{"id":"https://openalex.org/keywords/disseminated-tumor-cells","display_name":"disseminated tumor cells","score":0.6949999928474426},{"id":"https://openalex.org/keywords/sentinel-lymph-node","display_name":"sentinel lymph node","score":0.8999999761581421},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6039999723434448},{"id":"https://openalex.org/keywords/early-dissemination","display_name":"early dissemination","score":0.6850000023841858},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4432935118675232}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:edoc.ub.uni-muenchen.de:7092","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-70927","pdf_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-70927","source":{"id":"https://openalex.org/S4377196618","display_name":"Electronic Theses of LMU Munich (Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertationen"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-016091870","doi":null,"is_oa":false,"landing_page_url":"http://edoc.ub.uni-muenchen.de/7092/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},{"id":"doi:10.5282/edoc.7092","doi":"https://doi.org/10.5282/edoc.7092","is_oa":true,"landing_page_url":"https://doi.org/10.5282/edoc.7092","pdf_url":null,"source":{"id":"https://openalex.org/S7407052039","display_name":"Universit\u00e4tsbibliothek der LMU","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2330128707","doi":null,"is_oa":false,"landing_page_url":"https://edoc.ub.uni-muenchen.de/7092/1/Yildiz_Murat.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:edoc.ub.uni-muenchen.de:7092","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-70927","pdf_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-70927","source":{"id":"https://openalex.org/S4377196618","display_name":"Electronic Theses of LMU Munich (Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertationen"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2330128707.pdf","grobid_xml":"https://content.openalex.org/works/W2330128707.grobid-xml"},"referenced_works_count":118,"referenced_works":["https://openalex.org/W28268799","https://openalex.org/W99745159","https://openalex.org/W195835998","https://openalex.org/W316815813","https://openalex.org/W1215086530","https://openalex.org/W1501853290","https://openalex.org/W1509183744","https://openalex.org/W1515081362","https://openalex.org/W1516721515","https://openalex.org/W1528122836","https://openalex.org/W1533555842","https://openalex.org/W1544851750","https://openalex.org/W1572267688","https://openalex.org/W1577612079","https://openalex.org/W1602709607","https://openalex.org/W1756183899","https://openalex.org/W1897206684","https://openalex.org/W1919139351","https://openalex.org/W1920846434","https://openalex.org/W1951046932","https://openalex.org/W1965423355","https://openalex.org/W1966724428","https://openalex.org/W1968046362","https://openalex.org/W1968122151","https://openalex.org/W1971050728","https://openalex.org/W1971512164","https://openalex.org/W1973728202","https://openalex.org/W1974321818","https://openalex.org/W1975131304","https://openalex.org/W1975732704","https://openalex.org/W1979499502","https://openalex.org/W1982150427","https://openalex.org/W1983348452","https://openalex.org/W1990085600","https://openalex.org/W1992522801","https://openalex.org/W1997073961","https://openalex.org/W1997558707","https://openalex.org/W1998038367","https://openalex.org/W1999165015","https://openalex.org/W2001883065","https://openalex.org/W2007807118","https://openalex.org/W2010980929","https://openalex.org/W2012701739","https://openalex.org/W2015585836","https://openalex.org/W2017785964","https://openalex.org/W2019021865","https://openalex.org/W2019731805","https://openalex.org/W2021818582","https://openalex.org/W2027244873","https://openalex.org/W2027816396","https://openalex.org/W2029587245","https://openalex.org/W2030092260","https://openalex.org/W2032839233","https://openalex.org/W2038048085","https://openalex.org/W2039463309","https://openalex.org/W2040767119","https://openalex.org/W2042031899","https://openalex.org/W2044510046","https://openalex.org/W2044608785","https://openalex.org/W2050289401","https://openalex.org/W2051112657","https://openalex.org/W2051667102","https://openalex.org/W2055022031","https://openalex.org/W2061206375","https://openalex.org/W2064641360","https://openalex.org/W2064968804","https://openalex.org/W2065404328","https://openalex.org/W2066476807","https://openalex.org/W2066848701","https://openalex.org/W2066960417","https://openalex.org/W2068289276","https://openalex.org/W2070520491","https://openalex.org/W2072487610","https://openalex.org/W2073225422","https://openalex.org/W2074179023","https://openalex.org/W2074283639","https://openalex.org/W2075650416","https://openalex.org/W2077699851","https://openalex.org/W2080404550","https://openalex.org/W2080951374","https://openalex.org/W2084891010","https://openalex.org/W2085071454","https://openalex.org/W2086773265","https://openalex.org/W2087918564","https://openalex.org/W2088670352","https://openalex.org/W2099482139","https://openalex.org/W2101384929","https://openalex.org/W2102589505","https://openalex.org/W2104130003","https://openalex.org/W2106726562","https://openalex.org/W2110128078","https://openalex.org/W2115026428","https://openalex.org/W2116893702","https://openalex.org/W2120655386","https://openalex.org/W2123678542","https://openalex.org/W2126062698","https://openalex.org/W2127043919","https://openalex.org/W2127223524","https://openalex.org/W2129234309","https://openalex.org/W2131365547","https://openalex.org/W2136833729","https://openalex.org/W2138022504","https://openalex.org/W2140498741","https://openalex.org/W2140760216","https://openalex.org/W2141529421","https://openalex.org/W2143260563","https://openalex.org/W2146536860","https://openalex.org/W2147822352","https://openalex.org/W2150926065","https://openalex.org/W2153341643","https://openalex.org/W2159174770","https://openalex.org/W2160379492","https://openalex.org/W2160541843","https://openalex.org/W2163188200","https://openalex.org/W2167028317","https://openalex.org/W2321753125","https://openalex.org/W2408606979","https://openalex.org/W2414442091"],"related_works":["https://openalex.org/W6950549139","https://openalex.org/W2627015693","https://openalex.org/W7036045131","https://openalex.org/W2536885801","https://openalex.org/W2550229859","https://openalex.org/W6959956692","https://openalex.org/W2617676446","https://openalex.org/W2051871710","https://openalex.org/W3204696627","https://openalex.org/W7095685198"],"abstract_inverted_index":{"Der":[0],"Prozess":[1],"der":[2,6,17,27,50,64,123,155,199],"Metastasierung,":[3],"gerade":[4],"in":[5,130,161,168,178],"fr\u00fchen":[7],"Phase,":[8],"ist":[9],"beim":[10,115,171],"malignen":[11,116,172],"Melanom":[12,173],"noch":[13],"unzureichend":[14],"verstanden.":[15],"In":[16],"vorliegenden":[18,51],"Studie":[19],"wurden":[20],"einzelne":[21],"disseminierte":[22],"Melanomzellen":[23,57,136],"aus":[24,58,137],"W\u00e4chterlymphknoten":[25,59,163],"mit":[26,60],"komparativen":[28,200],"genomischen":[29,132,201],"Hybridisierung":[30,202],"auf":[31],"genomische":[32,166],"Ver\u00e4nderungen":[33,167],"untersucht.":[34],"F\u00fcr":[35],"ein":[36],"Teil":[37],"dieser":[38],"disseminierten":[39,72,135],"Tumorzellen":[40,73,124,170],"standen":[41],"die":[42,94,120,139,147,175,197],"entsprechenden":[43],"dazugeh\u00f6rigen":[44,65,80],"Prim\u00e4rtumore":[45,66],"zur":[46,191],"Verf\u00fcgung.":[47],"Das":[48],"Ziel":[49],"Arbeit":[52],"war,":[53],"chromosomale":[54],"Aberrationen":[55,63,77,133],"disseminierter":[56],"den":[61,131,162,169],"chromosomalen":[62],"zu":[67,78],"vergleichen.":[68],"Die":[69,101],"untersuchten":[70],"einzelnen":[71],"wiesen":[74],"bez\u00fcglich":[75],"chromosomaler":[76],"ihren":[79],"Prim\u00e4rtumoren":[81],"gro\u00dfe":[82],"Abweichungen":[83],"auf.":[84],"Dieses":[85],"Ergebnis":[86],"spricht":[87],"f\u00fcr":[88,188],"eine":[89,150,176],"fr\u00fche":[90,121],"Disseminierung":[91,122],"von":[92,113,193],"Tumorzellen,":[93,146],"sich":[95],"anschliessend":[96],"unabh\u00e4ngig":[97],"vom":[98],"Prim\u00e4rtumor":[99],"entwickeln.":[100],"oft":[102],"nach":[103],"einer":[104],"vollst\u00e4ndigen":[105],"Resektion":[106],"des":[107],"Prim\u00e4rtumors":[108],"beobachtete":[109],"zeitlich":[110],"verz\u00f6gerte":[111],"Entstehung":[112],"Fernmetastasen":[114],"Melanom,":[117],"kann":[118],"durch":[119],"erkl\u00e4rt":[125],"werden.":[126],"Es":[127],"gab":[128],"Unterschiede":[129],"zwischen":[134],"W\u00e4chterlymphknoten,":[138],"histopathologisch":[140,158],"als":[141,186],"tumorfrei":[142],"klassifiziert":[143],"waren,":[144],"und":[145],"bereits":[148],"erfolgreich":[149],"Lymphknotenmetastase":[151],"gegr\u00fcndet":[152],"hatten.":[153],"Mit":[154],"Progression":[156],"zum":[157],"nachweisbaren":[159],"Befall":[160],"werden":[164],"bestimmte":[165],"selektiert,":[174],"Expansion":[177],"manifeste":[179],"Metastasen":[180],"f\u00f6rdern.":[181],"Diese":[182],"Ergebnisse":[183],"k\u00f6nnen":[184],"nur":[185],"Ausgangspunkt":[187],"weiterf\u00fchrende":[189],"Arbeiten":[190],"Identifizierung":[192],"Tumorgenen":[194],"sein,":[195],"da":[196],"Aufl\u00f6sung":[198],"(CGH)":[203],"lediglich":[204],"zehn":[205],"Megabasen":[206],"betr\u00e4gt.":[207]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}