{"id":"https://openalex.org/W23299981","doi":null,"title":"Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled study.","display_name":"Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled study.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W23299981","mag":"23299981","pmid":"https://pubmed.ncbi.nlm.nih.gov/16475496"},"language":"en","primary_location":{"id":"pmid:16475496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16475496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutis","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056537776","display_name":"Pearl E. Grimes","orcid":"https://orcid.org/0000-0001-6663-2471","observed_orcids":["https://orcid.org/0000-0001-6663-2471","https://orcid.org/0000-0003-3642-756X"]},"institutions":[{"id":"https://openalex.org/I4210126237","display_name":"Vitiligo and Pigmentation Institute of Southern California","ror":"https://ror.org/032685859","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126237"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pearl Grimes","raw_affiliation_strings":["Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA. pegrimesmd@earthlink.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA. pegrimesmd@earthlink.net","institution_ids":["https://openalex.org/I4210126237"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055242180","display_name":"Valerie Dawn Callender","orcid":"https://orcid.org/0000-0003-1297-5270","observed_orcids":["https://orcid.org/0000-0003-1297-5270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valerie Callender","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1188,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.93036152,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"77","issue":"1","first_page":"45","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.06560000032186508,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tazarotene","display_name":"tazarotene","score":0.9819999933242798},{"id":"https://openalex.org/keywords/post-inflammatory-hyperpigmentation","display_name":"post-inflammatory hyperpigmentation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":1.0},{"id":"https://openalex.org/keywords/darker-skin","display_name":"darker skin tones","score":0.9319999814033508},{"id":"https://openalex.org/keywords/topical-retinoids","display_name":"topical retinoids","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hyperpigmentation-treatment","display_name":"hyperpigmentation treatment","score":0.722000002861023},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.6039999723434448},{"id":"https://openalex.org/keywords/skin-of-color","display_name":"skin of color","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C2779306117","wikidata":"https://www.wikidata.org/wiki/Q3981685","display_name":"Tazarotene","level":3,"score":0.960739016532898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9248006939888},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.8653789162635803},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.8331239819526672},{"id":"https://openalex.org/C2776728111","wikidata":"https://www.wikidata.org/wiki/Q1641068","display_name":"Hyperpigmentation","level":2,"score":0.7321317791938782},{"id":"https://openalex.org/C2779121184","wikidata":"https://www.wikidata.org/wiki/Q1166142","display_name":"Erythema","level":2,"score":0.6696971654891968},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.41831862926483154},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.20184779167175293}],"mesh":[{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003879","descriptor_name":"Dermatologic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003879","descriptor_name":"Dermatologic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009539","descriptor_name":"Nicotinic Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009539","descriptor_name":"Nicotinic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017495","descriptor_name":"Hyperpigmentation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017495","descriptor_name":"Hyperpigmentation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16475496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16475496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutis","raw_type":"Journal Article"},{"id":"mag:23299981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16475496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W2106049785","https://openalex.org/W4230630703","https://openalex.org/W2049451182","https://openalex.org/W2006281165","https://openalex.org/W2072635842","https://openalex.org/W1987898599","https://openalex.org/W2154255513","https://openalex.org/W2020953309","https://openalex.org/W2136704851","https://openalex.org/W2333236619","https://openalex.org/W2001929859","https://openalex.org/W2023354370","https://openalex.org/W2045722328","https://openalex.org/W2054753483","https://openalex.org/W2020923303","https://openalex.org/W1978138251","https://openalex.org/W1963773353","https://openalex.org/W2093589275","https://openalex.org/W2086506499","https://openalex.org/W2030127286","https://openalex.org/W2049011119","https://openalex.org/W1993174716","https://openalex.org/W2082733300","https://openalex.org/W2022209325","https://openalex.org/W2322673496","https://openalex.org/W2067257866","https://openalex.org/W1989908627","https://openalex.org/W2008726717","https://openalex.org/W2102244068","https://openalex.org/W2082302775","https://openalex.org/W2135328233","https://openalex.org/W2171583016","https://openalex.org/W2075771267"],"related_works":["https://openalex.org/W4384469465","https://openalex.org/W183340638","https://openalex.org/W2067876339","https://openalex.org/W3012957862","https://openalex.org/W87515525","https://openalex.org/W1992149643","https://openalex.org/W1989915765","https://openalex.org/W2145682122","https://openalex.org/W7133335748","https://openalex.org/W4242720948"],"abstract_inverted_index":{"Previous":[0],"investigations":[1],"have":[2],"reported":[3],"the":[4,11,30,78,106,132],"efficacy":[5],"of":[6,13,32,42,55,82,92,111,134],"tazarotene":[7,26,56,124],"0.1%":[8,27],"cream":[9,28,57,125],"for":[10,19,29],"treatment":[12,31,133],"dyschromia":[14],"associated":[15],"with":[16,70,138],"photoaging":[17],"and":[18,76,80,95,108,128],"acne":[20],"vulgaris.":[21],"The":[22],"present":[23],"investigation":[24],"assessed":[25],"postinflammatory":[33],"hyperpigmentation":[34,83],"(PIH)":[35],"in":[36,72,77,102,118,131,136],"a":[37],"double-blind,":[38],"randomized,":[39],"vehicle-controlled":[40],"study":[41],"74":[43],"patients":[44,137],"from":[45],"darker":[46,139],"racial":[47],"ethnic":[48],"groups":[49,104],"who":[50],"had":[51],"acne.":[52],"Once-daily":[53],"application":[54],"was":[58,126],"shown":[59],"to":[60],"be":[61],"effective":[62,127],"against":[63],"PIH,":[64],"achieving":[65],"significantly":[66],"greater":[67],"reductions":[68],"compared":[69],"vehicle":[71],"overall":[73],"disease":[74],"severity":[75],"intensity":[79],"area":[81],"within":[84],"18":[85],"weeks":[86],"(P<":[87],"or":[88],"=.05).":[89],"Mean":[90],"levels":[91,110],"erythema,":[93],"burning,":[94],"peeling":[96],"were":[97,113],"no":[98,114],"more":[99,115],"than":[100,116],"trace":[101],"both":[103,119],"throughout":[105],"study,":[107,123],"mean":[109],"dryness":[112],"mild":[117],"groups.":[120],"In":[121],"our":[122],"well":[129],"tolerated":[130],"PIH":[135],"skin.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}