{"id":"https://openalex.org/W2329909203","doi":"https://doi.org/10.1007/bf00920239","title":"Regulation of interleukin-6 (IL-6) expression: Evidence for a tissue-specific role of protein kinase C","display_name":"Regulation of interleukin-6 (IL-6) expression: Evidence for a tissue-specific role of protein kinase C","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W2329909203","doi":"https://doi.org/10.1007/bf00920239","mag":"2329909203","pmid":"https://pubmed.ncbi.nlm.nih.gov/8245177"},"language":"en","primary_location":{"id":"doi:10.1007/bf00920239","doi":"https://doi.org/10.1007/bf00920239","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00920239","pdf_url":null,"source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010436037","display_name":"Volker Gro\u00df","orcid":"https://orcid.org/0000-0002-0976-8986","observed_orcids":["https://orcid.org/0000-0002-0976-8986"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Volker Gross","raw_affiliation_strings":["Sam and Rose Stein Institute for Research on Aging, University of California San Diego, La Jolla 92093","Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sam and Rose Stein Institute for Research on Aging, University of California San Diego, La Jolla 92093","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, La Jolla","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Baoping Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baoping Zhang","raw_affiliation_strings":["Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, 92093, La Jolla, California","Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, 92093, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, La Jolla","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101041643","display_name":"Yu Geng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Geng","raw_affiliation_strings":["Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, 92093, La Jolla, California","Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, 92093, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, La Jolla","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081372430","display_name":"Peter  Matthias Villiger","orcid":"https://orcid.org/0000-0002-8859-9964","observed_orcids":["https://orcid.org/0000-0002-8859-9964"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter M. Villiger","raw_affiliation_strings":["Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, 92093, La Jolla, California","Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, 92093, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, La Jolla","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080699797","display_name":"Martin Lotz","orcid":"https://orcid.org/0000-0002-6299-8799","observed_orcids":["https://orcid.org/0000-0002-6299-8799"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Lotz","raw_affiliation_strings":["Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, 92093, La Jolla, California","Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, 92093, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Sam and Rose Stein Institute for Research on Aging and the Department of Medicine, University of California San Diego, La Jolla","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":1.4023,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.81567944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"13","issue":"5","first_page":"310","last_page":"320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9950000047683716},{"id":"https://openalex.org/keywords/il-6-mrna-expression","display_name":"IL-6 mRNA expression","score":0.6790000200271606},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9959999918937683},{"id":"https://openalex.org/keywords/blood-monocytes","display_name":"blood monocytes","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hep-2-cells","display_name":"HEp-2 cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.8920000195503235},{"id":"https://openalex.org/keywords/staurosporine","display_name":"staurosporine","score":0.9190000295639038},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9449999928474426},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8420000076293945},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.8650000095367432},{"id":"https://openalex.org/keywords/nf-il6","display_name":"NF-IL6","score":0.949999988079071},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7820000052452087},{"id":"https://openalex.org/keywords/tissue-specific-gene-regulation","display_name":"tissue-specific gene regulation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cytokine-induction","display_name":"cytokine induction","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C190139176","wikidata":"https://www.wikidata.org/wiki/Q598976","display_name":"Medical microbiology","level":2,"score":0.5265812277793884},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.46605002880096436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42867782711982727},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42776763439178467},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41752079129219055},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3691207468509674},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3045090436935425}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/bf00920239","doi":"https://doi.org/10.1007/bf00920239","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00920239","pdf_url":null,"source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:8245177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8245177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical immunology","raw_type":"Comparative Study"},{"id":"mag:267643468","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007%2FBF00920239.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1655645242","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR000833","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2247043896","display_name":"TGF BETA AND THE PATHOGENESIS OF HIV","funder_award_id":"R01CA051406","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7317032135","display_name":"PATHOGENETIC MEDIATORS IN ARTHRITIS","funder_award_id":"R01AR039799","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W179818011","https://openalex.org/W1486757560","https://openalex.org/W1501935155","https://openalex.org/W1514008783","https://openalex.org/W1518828758","https://openalex.org/W1595805439","https://openalex.org/W1596809011","https://openalex.org/W1825344511","https://openalex.org/W1855316965","https://openalex.org/W1863421095","https://openalex.org/W1871545670","https://openalex.org/W1931481640","https://openalex.org/W1940535066","https://openalex.org/W1967004332","https://openalex.org/W1967578063","https://openalex.org/W1969353460","https://openalex.org/W1971615288","https://openalex.org/W1972689256","https://openalex.org/W1986543207","https://openalex.org/W1987000956","https://openalex.org/W2002076761","https://openalex.org/W2005150284","https://openalex.org/W2007246198","https://openalex.org/W2020031471","https://openalex.org/W2021787599","https://openalex.org/W2022881613","https://openalex.org/W2046447229","https://openalex.org/W2049781724","https://openalex.org/W2051690744","https://openalex.org/W2052977964","https://openalex.org/W2054663403","https://openalex.org/W2054979170","https://openalex.org/W2056647549","https://openalex.org/W2059358614","https://openalex.org/W2062444650","https://openalex.org/W2063217800","https://openalex.org/W2081135713","https://openalex.org/W2089372467","https://openalex.org/W2094664478","https://openalex.org/W2094989950","https://openalex.org/W2095672355","https://openalex.org/W2109481978","https://openalex.org/W2133982451","https://openalex.org/W2134812217","https://openalex.org/W2140552959","https://openalex.org/W2168630735","https://openalex.org/W2407818799"],"related_works":["https://openalex.org/W267643468","https://openalex.org/W2134521609","https://openalex.org/W2010096977","https://openalex.org/W7100309661","https://openalex.org/W2408626480","https://openalex.org/W1822747056","https://openalex.org/W2090946250","https://openalex.org/W1974520908","https://openalex.org/W2039360786","https://openalex.org/W2042327558"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}