{"id":"https://openalex.org/W2329844306","doi":"https://doi.org/10.1021/ja202767g","title":"Cell Compatible Trimethoprim-Decorated Iron Oxide Nanoparticles Bind Dihydrofolate Reductase for Magnetically Modulating Focal Adhesion of Mammalian Cells","display_name":"Cell Compatible Trimethoprim-Decorated Iron Oxide Nanoparticles Bind Dihydrofolate Reductase for Magnetically Modulating Focal Adhesion of Mammalian Cells","publication_year":2011,"publication_date":"2011-06-10","ids":{"openalex":"https://openalex.org/W2329844306","doi":"https://doi.org/10.1021/ja202767g","mag":"2329844306","pmid":"https://pubmed.ncbi.nlm.nih.gov/21657789"},"language":"en","primary_location":{"id":"doi:10.1021/ja202767g","doi":"https://doi.org/10.1021/ja202767g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja202767g","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060276866","display_name":"Marcus J. C. Long","orcid":"https://orcid.org/0000-0002-0343-9671","observed_orcids":["https://orcid.org/0000-0002-0343-9671"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus J. C. Long","raw_affiliation_strings":["Graduate Program in Biochemistry and Biophysics, \u2021Department of Chemistry, and \u00a7Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Biochemistry and Biophysics, \u2021Department of Chemistry, and \u00a7Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038195480","display_name":"Yue Pan","orcid":"https://orcid.org/0000-0001-7709-0508","observed_orcids":["https://orcid.org/0000-0001-7709-0508","https://orcid.org/0009-0008-8107-3178"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Pan","raw_affiliation_strings":["Graduate Program in Biochemistry and Biophysics, \u2021Department of Chemistry, and \u00a7Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Biochemistry and Biophysics, \u2021Department of Chemistry, and \u00a7Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088391201","display_name":"Hsin\u2010Chieh Lin","orcid":"https://orcid.org/0000-0002-3596-3224","observed_orcids":["https://orcid.org/0000-0002-3596-3224"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsin-Chieh Lin","raw_affiliation_strings":["Graduate Program in Biochemistry and Biophysics, \u2021Department of Chemistry, and \u00a7Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Biochemistry and Biophysics, \u2021Department of Chemistry, and \u00a7Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083404534","display_name":"Lizbeth Hedstrom","orcid":"https://orcid.org/0000-0001-8432-3322","observed_orcids":["https://orcid.org/0000-0001-8432-3322"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lizbeth Hedstrom","raw_affiliation_strings":["Graduate Program in Biochemistry and Biophysics, \u2021Department of Chemistry, and \u00a7Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Biochemistry and Biophysics, \u2021Department of Chemistry, and \u00a7Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100602838","display_name":"Bing Xu","orcid":"https://orcid.org/0000-0002-4639-387X","observed_orcids":["https://orcid.org/0000-0002-4639-387X","https://orcid.org/0000-0001-7138-8936","https://orcid.org/0000-0002-7385-9954","https://orcid.org/0000-0002-7242-6495"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bing Xu","raw_affiliation_strings":["Graduate Program in Biochemistry and Biophysics, \u2021Department of Chemistry, and \u00a7Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Biochemistry and Biophysics, \u2021Department of Chemistry, and \u00a7Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States","institution_ids":["https://openalex.org/I6902469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100602838"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.0355,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91093117,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"133","issue":"26","first_page":"10006","last_page":"10009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.7602999806404114,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.7602999806404114,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.12290000170469284,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.04690000042319298,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trimethoprim","display_name":"trimethoprim","score":0.9990000128746033},{"id":"https://openalex.org/keywords/iron-oxide-nanoparticles","display_name":"iron oxide nanoparticles","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dihydrofolate-reductase","display_name":"dihydrofolate reductase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/magnetic-force","display_name":"magnetic force","score":0.41999998688697815},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.593999981880188},{"id":"https://openalex.org/keywords/protein-binding","display_name":"protein binding","score":0.4059999883174896},{"id":"https://openalex.org/keywords/biocompatible-nanoparticles","display_name":"biocompatible nanoparticles","score":0.6880000233650208},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8979982137680054},{"id":"https://openalex.org/C2781320022","wikidata":"https://www.wikidata.org/wiki/Q417149","display_name":"Dihydrofolate reductase","level":3,"score":0.8331655859947205},{"id":"https://openalex.org/C2778889443","wikidata":"https://www.wikidata.org/wiki/Q6073014","display_name":"Iron oxide nanoparticles","level":3,"score":0.6923347115516663},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6026883721351624},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5962653160095215},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5955274701118469},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.5698357820510864},{"id":"https://openalex.org/C87023908","wikidata":"https://www.wikidata.org/wiki/Q3870166","display_name":"Magnetic nanoparticles","level":3,"score":0.5547665953636169},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.545465886592865},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5423534512519836},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5174534916877747},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38069283962249756},{"id":"https://openalex.org/C2777697756","wikidata":"https://www.wikidata.org/wiki/Q721849","display_name":"Iron oxide","level":2,"score":0.3801947236061096},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3745540976524353},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35441866517066956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3478410243988037},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22506511211395264},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013762","descriptor_name":"Tetrahydrofolate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013762","descriptor_name":"Tetrahydrofolate Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014295","descriptor_name":"Trimethoprim","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022001","descriptor_name":"Focal Adhesions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D060328","descriptor_name":"Magnetic Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja202767g","doi":"https://doi.org/10.1021/ja202767g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja202767g","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:21657789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21657789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1510613202","https://openalex.org/W1970998858","https://openalex.org/W1972582749","https://openalex.org/W1976462184","https://openalex.org/W1978976337","https://openalex.org/W1983534198","https://openalex.org/W1985900564","https://openalex.org/W1986388826","https://openalex.org/W1986928683","https://openalex.org/W1990579572","https://openalex.org/W1992514216","https://openalex.org/W1993914603","https://openalex.org/W1994540310","https://openalex.org/W1995269182","https://openalex.org/W2002916007","https://openalex.org/W2011111272","https://openalex.org/W2012726986","https://openalex.org/W2020803551","https://openalex.org/W2038074501","https://openalex.org/W2039985275","https://openalex.org/W2052114294","https://openalex.org/W2052766715","https://openalex.org/W2061469673","https://openalex.org/W2065725244","https://openalex.org/W2071659125","https://openalex.org/W2076489998","https://openalex.org/W2078879977","https://openalex.org/W2084648630","https://openalex.org/W2085412371","https://openalex.org/W2091740986","https://openalex.org/W2092858957","https://openalex.org/W2100447989","https://openalex.org/W2101629470","https://openalex.org/W2103370171","https://openalex.org/W2106399070","https://openalex.org/W2107299572","https://openalex.org/W2116810900","https://openalex.org/W2117984724","https://openalex.org/W2125648213","https://openalex.org/W2132154625","https://openalex.org/W2134443476","https://openalex.org/W2140143553","https://openalex.org/W2167870331","https://openalex.org/W2322768231","https://openalex.org/W4237131637"],"related_works":["https://openalex.org/W2165404697","https://openalex.org/W2056709327","https://openalex.org/W2018804820","https://openalex.org/W4415947520","https://openalex.org/W3025835527","https://openalex.org/W2139424834","https://openalex.org/W2046883852","https://openalex.org/W2019592377","https://openalex.org/W1972819443","https://openalex.org/W1964958595"],"abstract_inverted_index":{"On":[0],"the":[1,4,45,55,58,72],"basis":[2],"of":[3,8,33,36,48,57,60,79],"high":[5,25],"affinity":[6,26],"binding":[7],"trimethoprim":[9],"(TMP)":[10],"to":[11,22,40,53,75],"Escherichia":[12],"coli":[13],"dihydrofolate":[14],"reductase":[15],"(eDHFR),":[16],"TMP-decorated":[17],"iron":[18],"oxide":[19,62],"nanoparticles":[20,49,63],"bind":[21,52],"eDHFR":[23],"with":[24],"and":[27,67],"specificity,":[28],"which":[29],"allows":[30],"magnetic":[31,83],"modulation":[32],"focal":[34],"adhesion":[35],"mammalian":[37],"cells":[38],"adhered":[39],"a":[41,65,82],"surface.":[42],"Besides":[43],"being":[44],"first":[46],"example":[47],"that":[50],"selectively":[51],"eDHFR,":[54],"biocompatibility":[56],"conjugate":[59],"TMP-iron":[61],"renders":[64],"convenient":[66],"versatile":[68],"platform":[69],"for":[70],"investigating":[71],"cellular":[73],"responses":[74],"specific,":[76],"mechanical":[77],"perturbation":[78],"proteins":[80],"via":[81],"force.":[84]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}