{"id":"https://openalex.org/W2329501015","doi":"https://doi.org/10.1158/1538-7445.am2013-3077","title":"Abstract 3077: TMPRSS2-ERG regulation of miRNA in prostate cancer.","display_name":"Abstract 3077: TMPRSS2-ERG regulation of miRNA in prostate cancer.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2329501015","doi":"https://doi.org/10.1158/1538-7445.am2013-3077","mag":"2329501015"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-3077","doi":"https://doi.org/10.1158/1538-7445.am2013-3077","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-3077","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088037220","display_name":"Jung Oh Kim","orcid":"https://orcid.org/0000-0002-4171-2034","observed_orcids":["https://orcid.org/0000-0002-4171-2034"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jung Kim","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080671979","display_name":"Longtao Wu","orcid":"https://orcid.org/0000-0003-3463-4127","observed_orcids":["https://orcid.org/0000-0003-3463-4127"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Longtao Wu","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063204371","display_name":"Hongjian Jin","orcid":"https://orcid.org/0000-0003-3833-7170","observed_orcids":["https://orcid.org/0000-0003-3833-7170"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong-Jian Jin","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036670708","display_name":"Jonathan C. Zhao","orcid":"https://orcid.org/0000-0002-3163-380X","observed_orcids":["https://orcid.org/0000-0002-3163-380X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Zhao","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026756753","display_name":"Jindan Yu","orcid":"https://orcid.org/0000-0002-2326-0409","observed_orcids":["https://orcid.org/0000-0002-2326-0409","https://orcid.org/0009-0002-2082-5141"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jindan Yu","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"3077","last_page":"3077"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.6532999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.6532999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.33079999685287476,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tmprss2-erg-fusion","display_name":"TMPRSS2-ERG fusion","score":0.9380000233650208},{"id":"https://openalex.org/keywords/erg","display_name":"ERG","score":0.6200000047683716},{"id":"https://openalex.org/keywords/mir-200c","display_name":"miR-200c","score":0.9279999732971191},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8740000128746033},{"id":"https://openalex.org/keywords/zeb1","display_name":"ZEB1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.4830000102519989},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5759999752044678},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.7900000214576721},{"id":"https://openalex.org/keywords/vcap-cells","display_name":"VCaP cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.5080000162124634},{"id":"https://openalex.org/keywords/chip-qpcr","display_name":"ChIP-qPCR","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8540627956390381},{"id":"https://openalex.org/C2778042024","wikidata":"https://www.wikidata.org/wiki/Q18032025","display_name":"TMPRSS2","level":5,"score":0.7145189046859741},{"id":"https://openalex.org/C205003668","wikidata":"https://www.wikidata.org/wiki/Q17113442","display_name":"Chromoplexy","level":5,"score":0.6767849326133728},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6613282561302185},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6572948694229126},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6384584903717041},{"id":"https://openalex.org/C103796816","wikidata":"https://www.wikidata.org/wiki/Q185153","display_name":"Erg","level":3,"score":0.6370407342910767},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.5713843107223511},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5352412462234497},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5255913734436035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5098087191581726},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.468000590801239},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.45462822914123535},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.41822952032089233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3263997435569763},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29410868883132935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2673734426498413},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2222481369972229},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.19923970103263855},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-3077","doi":"https://doi.org/10.1158/1538-7445.am2013-3077","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-3077","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098342163","https://openalex.org/W2045865134","https://openalex.org/W2319712168","https://openalex.org/W2374993604","https://openalex.org/W4380537414","https://openalex.org/W2564802170","https://openalex.org/W3169028382","https://openalex.org/W2000946983","https://openalex.org/W3028462953","https://openalex.org/W2939593660"],"abstract_inverted_index":{"Abstract":[0],"Prostate":[1],"cancer":[2,12,41,47,96,158,161,181,323],"is":[3,42,48,60,101,129,146,151,247],"the":[4,7,18,22,33,72,104,122,168,229,254,290,319,335,368,376,417,422],"cause":[5],"of":[6,11,25,55,74,103,121,170,298,321,337,381,408,416,421],"second":[8],"highest":[9,23],"number":[10,24],"related":[13],"deaths":[14],"in":[15,17,36,94,108,115,124,156,180,183,196,204,261,266,300,318,365,410],"men":[16],"United":[19],"States,":[20],"with":[21,51,154,231],"new":[26],"estimated":[27],"cases":[28],"every":[29],"year.":[30],"In":[31,163,276],"addition,":[32,277],"survival":[34],"rate":[35],"localized":[37],"and":[38,98,159,172,203,221,226,263,280,307,386],"regional":[39],"prostate":[40,46,157,184,340,411],"100%,":[43],"while":[44],"metastatic":[45],"about":[49,65],"29%,":[50],"a":[52,61,75,113,147,248,354],"wide":[53],"spectrum":[54],"biological":[56],"deregulations.":[57],"MicroRNA":[58],"(miRNA)":[59],"small":[62],"non-coding":[63],"RNA,":[64],"22":[66],"nucleotides":[67],"long,":[68],"that":[69,139,150,176,199,207,215,245,286,312],"mostly":[70],"targets":[71],"3\u2019UTR":[73],"gene":[76],"for":[77,357,425],"translational":[78],"repression":[79],"or":[80],"mRNA":[81],"degradation.":[82],"More":[83],"recently,":[84],"miRNAs":[85,191,214],"have":[86,208],"been":[87],"shown":[88],"to":[89,133,235,268,294,310,343,350],"play":[90,177],"an":[91,136,315,328],"important":[92,178,316,329],"role":[93,114,179,317],"tumorigenesis,":[95],"progression,":[97,182],"metastasis.":[99],"MiR-200c":[100],"one":[102],"miRNA":[105,194,274,409],"widely":[106],"studied":[107],"cancer,":[109],"as":[110,353],"it":[111,346],"has":[112],"regulating":[116],"epithelial-mesenchymal":[117],"transition":[118],"(EMT).":[119],"One":[120],"ways":[123],"which":[125],"miR-200c":[126,246,271,281,291,299,313,352],"inhibits":[127],"EMT":[128,137],"through":[130,192],"its":[131],"ability":[132],"downregulate":[134],"ZEB1,":[135],"activator":[138],"primarily":[140],"functions":[141],"by":[142,273,367],"repressing":[143],"E-cadherin.":[144],"ERG":[145,171,189,202,209,219,224,232,237,259,264,278,287,301,358],"transcription":[148],"factor":[149],"often":[152],"fused":[153],"TMPRSS2":[155],"promotes":[160],"progression.":[162,324],"our":[164,344],"study,":[165],"we":[166,187,243,257,304],"investigated":[167],"interaction":[169],"miR-200c,":[173,331],"two":[174],"factors":[175],"cancer.":[185,341,412],"First,":[186],"identified":[188],"regulated":[190,238],"utilizing":[193],"profiling":[195],"LNCaP":[197,262],"cells":[198,206],"were":[200],"overexpressing":[201],"VCaP":[205,267],"knocked":[210],"down.":[211],"We":[212],"selected":[213],"are":[216],"repressed":[217],"upon":[218,223],"overexpression":[220,260],"derepressed":[222],"knockdown":[225,265],"also":[227],"overlapped":[228],"results":[230],"ChIP-seq":[233],"data":[234],"identify":[236,295],"miRNAs.":[239],"Through":[240],"this":[241],"process":[242],"discovered":[244],"good":[249],"ERG-targeted":[250],"miRNA.":[251],"To":[252],"validate":[253],"bioinformatics":[255],"results,":[256,345],"used":[258],"measure":[269],"mature":[270],"levels":[272],"assay.":[275],"ChIP-qPCR":[279],"promoter":[282],"luciferase":[283],"assays":[284,309],"showed":[285],"binds":[288],"at":[289],"promoter.":[292],"Next,":[293],"functional":[296],"roles":[297],"overexpressed":[302],"cells,":[303],"performed":[305],"invasion":[306],"migration":[308],"show":[311],"plays":[314],"inhibition":[320],"ERG-mediated":[322],"This":[325,361],"study":[326],"identifies":[327],"factor,":[330],"whose":[332],"loss":[333],"mediates":[334],"progression":[336],"TMPRSS2:ERG":[338],"fusion-positive":[339],"According":[342],"might":[347],"be":[348],"possible":[349],"use":[351],"future":[355],"therapeutic":[356],"positive":[359],"patients.":[360],"work":[362],"was":[363],"supported":[364],"part":[366],"Research":[369],"Scholar":[370],"Award":[371],"RSG-12-085-01":[372],"(to":[373,384,392],"J.Y.)":[374,385],"from":[375],"American":[377,423],"Cancer":[378,426,436],"Society,":[379],"Department":[380],"Defense":[382],"PC080665":[383],"NRSA":[387],"pre-doctoral":[388],"fellowship":[389],"T32":[390],"CA080621":[391],"J.K.).":[393],"Citation":[394],"Format:":[395],"Jung":[396],"Kim,":[397],"Longtao":[398],"Wu,":[399],"Hong-Jian":[400],"Jin,":[401],"Jonathan":[402],"Zhao,":[403],"Jindan":[404],"Yu.":[405],"TMPRSS2-ERG":[406],"regulation":[407],"[abstract].":[413],"In:":[414],"Proceedings":[415],"104th":[418],"Annual":[419],"Meeting":[420],"Association":[424],"Research;":[427],"2013":[428],"Apr":[429],"6-10;":[430],"Washington,":[431],"DC.":[432],"Philadelphia":[433],"(PA):":[434],"AACR;":[435],"Res":[437],"2013;73(8":[438],"Suppl):Abstract":[439],"nr":[440],"3077.":[441],"doi:10.1158/1538-7445.AM2013-3077":[442]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}