{"id":"https://openalex.org/W2329468263","doi":"https://doi.org/10.1042/bj1700129","title":"Effect of hepatic injury on prolyl 3-hydroxylase and 4-hydroxylase activities in rat liver and on immunoreactive prolyl 4-hydroxylase concentrations in the liver and serum","display_name":"Effect of hepatic injury on prolyl 3-hydroxylase and 4-hydroxylase activities in rat liver and on immunoreactive prolyl 4-hydroxylase concentrations in the liver and serum","publication_year":1978,"publication_date":"1978-01-15","ids":{"openalex":"https://openalex.org/W2329468263","doi":"https://doi.org/10.1042/bj1700129","mag":"2329468263","pmid":"https://pubmed.ncbi.nlm.nih.gov/204299","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1183869"},"language":"en","primary_location":{"id":"doi:10.1042/bj1700129","doi":"https://doi.org/10.1042/bj1700129","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1700129","pdf_url":"https://portlandpress.com/biochemj/article-pdf/170/1/129/569624/bj1700129.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/170/1/129/569624/bj1700129.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103600445","display_name":"Juha Risteli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J Risteli","raw_affiliation_strings":["Department ofMedical Biochemistry, University of Oulu, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMedical Biochemistry, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019854258","display_name":"Leena Tuderman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"L Tuderman","raw_affiliation_strings":["Department ofMedical Biochemistry, University of Oulu, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMedical Biochemistry, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000224317","display_name":"Karl Tryggvason","orcid":"https://orcid.org/0000-0002-0879-3290","observed_orcids":["https://orcid.org/0000-0002-0879-3290","https://orcid.org/0000-0003-1292-9266"]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"K Tryggvason","raw_affiliation_strings":["Department ofMedical Biochemistry, University of Oulu, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMedical Biochemistry, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064900083","display_name":"Kari I. Kivirikko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"K I Kivirikko","raw_affiliation_strings":["Department ofMedical Biochemistry, University of Oulu, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMedical Biochemistry, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I98381234"],"apc_list":null,"apc_paid":null,"fwci":6.3372,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.96110863,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"170","issue":"1","first_page":"129","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prolyl-4-hydroxylase","display_name":"prolyl 4-hydroxylase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.972000002861023},{"id":"https://openalex.org/keywords/n-nitrosodimethylamine","display_name":"N-nitrosodimethylamine","score":0.9449999928474426},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.972000002861023},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/enzyme-tetramer","display_name":"enzyme tetramer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.44200000166893005},{"id":"https://openalex.org/keywords/rat-liver","display_name":"rat liver","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.7313148379325867},{"id":"https://openalex.org/C193363816","wikidata":"https://www.wikidata.org/wiki/Q1617865","display_name":"Size-exclusion chromatography","level":3,"score":0.628385603427887},{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.597610592842102},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5807633399963379},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.546808123588562},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4978907108306885},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.47141170501708984},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4632706642150879},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41699811816215515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2814791202545166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16605272889137268},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004128","descriptor_name":"Dimethylnitrosamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011393","descriptor_name":"Procollagen-Proline Dioxygenase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011393","descriptor_name":"Procollagen-Proline Dioxygenase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011393","descriptor_name":"Procollagen-Proline Dioxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj1700129","doi":"https://doi.org/10.1042/bj1700129","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1700129","pdf_url":"https://portlandpress.com/biochemj/article-pdf/170/1/129/569624/bj1700129.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1183869","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1183869","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:204299","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/204299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj1700129","doi":"https://doi.org/10.1042/bj1700129","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1700129","pdf_url":"https://portlandpress.com/biochemj/article-pdf/170/1/129/569624/bj1700129.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2329468263.pdf","grobid_xml":"https://content.openalex.org/works/W2329468263.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W4741964","https://openalex.org/W169276775","https://openalex.org/W1491180863","https://openalex.org/W1589112374","https://openalex.org/W1775749144","https://openalex.org/W1842464023","https://openalex.org/W1985552650","https://openalex.org/W1985704223","https://openalex.org/W1996056346","https://openalex.org/W2004347556","https://openalex.org/W2004572328","https://openalex.org/W2008732663","https://openalex.org/W2020471728","https://openalex.org/W2021964163","https://openalex.org/W2022405303","https://openalex.org/W2025170825","https://openalex.org/W2026037838","https://openalex.org/W2030108882","https://openalex.org/W2032153212","https://openalex.org/W2076604899","https://openalex.org/W2079631384","https://openalex.org/W2081387688","https://openalex.org/W2088259989","https://openalex.org/W2095993947","https://openalex.org/W2157485550","https://openalex.org/W2171627417","https://openalex.org/W2416728194","https://openalex.org/W2419806871","https://openalex.org/W2911392392","https://openalex.org/W4242582175"],"related_works":["https://openalex.org/W1842464023","https://openalex.org/W169276775","https://openalex.org/W4741964","https://openalex.org/W1980067744","https://openalex.org/W2076314755","https://openalex.org/W2416935857","https://openalex.org/W2981875949","https://openalex.org/W2462807091","https://openalex.org/W2416288804","https://openalex.org/W2743277341"],"abstract_inverted_index":{"After":[0],"severe":[1],"hepatic":[2,12,80],"injury":[3],"induced":[4],"by":[5,59,91,144],"dimethylnitrosamine,":[6],"approximately":[7],"a":[8,145,159],"4-fold":[9],"increase":[10,97,110,147],"in":[11,23,30,44,70,79,98,105,114,134,148,155,175],"prolyl":[13,26,31,46,84,151],"4-hydroxylase":[14,27,47,85,152],"activity":[15,33,100,127],"occurred":[16,113],"within":[17],"4":[18],"days,":[19],"whereas":[20],"the":[21,42,45,57,71,88,96,115,125,129,149,156,172,176],"increases":[22,43,69,173],"total":[24,121],"immunoreactive":[25,150],"protein":[28,90,153],"and":[29,48,108,158],"3-hydroxylase":[32,49],"were":[34,51],"only":[35],"about":[36],"1.4-fold.":[37],"The":[38,62,137],"different":[39],"magnitudes":[40],"of":[41,56,73,76,83,117,128,139],"activities":[50,72],"verified":[52],"after":[53,165],"partial":[54],"purification":[55],"enzymes":[58,75],"gel":[60,92],"filtration.":[61],"data":[63],"support":[64],"previous":[65],"reports":[66],"indicating":[67],"differential":[68],"individual":[74],"collagen":[77],"biosynthesis":[78],"injury.":[81,136],"Separation":[82],"tetramers":[86,119,130],"from":[87],"monomer-size":[89],"filtration":[93],"indicated":[94],"that":[95,104,171],"enzyme":[99,106,118,122],"was":[101,141,162],"similar":[102,160],"to":[103,120],"tetramers,":[107],"an":[109],"had":[111,131],"also":[112,142,163],"ratio":[116],"protein.":[123],"Thus":[124],"specific":[126],"remained":[132],"unchanged":[133],"liver":[135],"administration":[138],"dimethylnitrosamine":[140],"accompanied":[143],"marked":[146],"concentration":[154],"serum,":[157],"effect":[161],"noted":[164],"carbon":[166],"tetrachloride":[167],"administration,":[168],"results":[169],"suggesting":[170],"originated":[174],"liver.":[177]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
