{"id":"https://openalex.org/W2329348752","doi":"https://doi.org/10.1097/hjh.0000000000000844","title":"G protein-coupled receptor 30 regulates trophoblast invasion and its deficiency is associated with preeclampsia","display_name":"G protein-coupled receptor 30 regulates trophoblast invasion and its deficiency is associated with preeclampsia","publication_year":2016,"publication_date":"2016-02-05","ids":{"openalex":"https://openalex.org/W2329348752","doi":"https://doi.org/10.1097/hjh.0000000000000844","mag":"2329348752","pmid":"https://pubmed.ncbi.nlm.nih.gov/26848992"},"language":"en","primary_location":{"id":"doi:10.1097/hjh.0000000000000844","doi":"https://doi.org/10.1097/hjh.0000000000000844","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hjh.0000000000000844","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2381/38173","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060491389","display_name":"Chao Tong","orcid":"https://orcid.org/0000-0003-0828-2674","observed_orcids":["https://orcid.org/0000-0003-0828-2674"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN","NZ"],"is_corresponding":false,"raw_author_name":"Chao Tong","raw_affiliation_strings":["aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University bCanada - China - New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China cLiggins Institute, University of Auckland, Auckland, New Zealand","Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University bCanada - China - New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China cLiggins Institute, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210129459","https://openalex.org/I87780372"]},{"raw_affiliation_string":"Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109900622","display_name":"Xiang Feng","orcid":"https://orcid.org/0009-0006-5961-1182","observed_orcids":["https://orcid.org/0009-0006-5961-1182"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Feng","raw_affiliation_strings":["Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450187","display_name":"Jun Chen","orcid":"https://orcid.org/0000-0002-4327-4330","observed_orcids":["https://orcid.org/0000-0002-4327-4330"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Chen","raw_affiliation_strings":["Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091188491","display_name":"Xingchen Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingchen Qi","raw_affiliation_strings":["Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101622398","display_name":"Liyuan Zhou","orcid":"https://orcid.org/0000-0001-7485-8163","observed_orcids":["https://orcid.org/0000-0001-7485-8163"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyuan Zhou","raw_affiliation_strings":["Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102000562","display_name":"Shuming Shi","orcid":"https://orcid.org/0009-0007-0594-8000","observed_orcids":["https://orcid.org/0009-0007-0594-8000"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuming Shi","raw_affiliation_strings":["Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070065142","display_name":"Kamana Kc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kamana KC","raw_affiliation_strings":["Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010251943","display_name":"Joanna L. Stanley","orcid":"https://orcid.org/0000-0001-6364-3415","observed_orcids":["https://orcid.org/0000-0001-6364-3415"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Joanna L. Stanley","raw_affiliation_strings":["Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031968879","display_name":"Philip Newton Baker","orcid":"https://orcid.org/0000-0002-4592-6427","observed_orcids":["https://orcid.org/0000-0002-4592-6427","https://orcid.org/0000-0002-2834-5436"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Philip N. Baker","raw_affiliation_strings":["Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100408738","display_name":"Hua Zhang","orcid":"https://orcid.org/0000-0003-3501-8385","observed_orcids":["https://orcid.org/0000-0003-3501-8385"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hua Zhang","raw_affiliation_strings":["to Hua Zhang, MD, PhD, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Canada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, People's Republic of China. Tel: +86 23 89011102; fax: +86 23 89011082; e-mail: [email\u00a0protected]","Abbreviations: AKT, protein kinase B; Accepted 6 December, 2015; CK7, cytokeratin7; CON, control; DAB,, 3,3\u2032-diaminobenzidine; E2, 17-\u03b2-estradiol; ECM, extracellular matrix; EVT, extravillous trophoblast; GMC, gestational matched control; GPR30, G protein-coupled receptor 30; IHC, immunohistochemistry; MAP, mean arterial pressure; PI3K, phosphoinositide 3-kinase; Received 20 August, 2015; Revised 28 October, 2015; aDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University; bCanada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, People's Republic of China; cLiggins Institute, University of Auckland, Auckland, New Zealand; e-mail: [email\u00a0protected]; fax: +86 23 89011082"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"to Hua Zhang, MD, PhD, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Canada \u2013 China \u2013 New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, People's Republic of China. 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