{"id":"https://openalex.org/W2329330191","doi":"https://doi.org/10.1097/00001622-199911000-00012","title":"Immune reconstitution in AIDS: oncologic implications and hematologic approaches","display_name":"Immune reconstitution in AIDS: oncologic implications and hematologic approaches","publication_year":1999,"publication_date":"1999-11-01","ids":{"openalex":"https://openalex.org/W2329330191","doi":"https://doi.org/10.1097/00001622-199911000-00012","mag":"2329330191","pmid":"https://pubmed.ncbi.nlm.nih.gov/10550015"},"language":"en","primary_location":{"id":"doi:10.1097/00001622-199911000-00012","doi":"https://doi.org/10.1097/00001622-199911000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001622-199911000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S179395531","display_name":"Current Opinion in Oncology","issn_l":"1040-8746","issn":["1040-8746","1080-8140","1531-703X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083648953","display_name":"David T. Scadden","orcid":"https://orcid.org/0000-0001-9821-7133","observed_orcids":["https://orcid.org/0000-0001-9821-7133"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David T. Scadden","raw_affiliation_strings":["Massachusetts General Hospital, Dana-Farber/Partners Cancer Care, Harvard Medical School, Boston 02129, USA. scadden.david@mgh.harvard.edu","Massachusetts General Hospital, Dana-Farber/Partners Cancer Care, Harvard Medical School, Boston, Massachusetts, USA","e-mail: [email\u00a0protected]","fax: 617-726-4691","tel: 617-726-5615"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Dana-Farber/Partners Cancer Care, Harvard Medical School, Boston 02129, USA. scadden.david@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital, Dana-Farber/Partners Cancer Care, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: 617-726-4691","institution_ids":[]},{"raw_affiliation_string":"tel: 617-726-5615","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083648953"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":0.0388,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.05617978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"6","first_page":"503","last_page":"503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-reconstitution","display_name":"immune reconstitution","score":0.8460000157356262},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.8429999947547913},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hiv-associated-malignancies","display_name":"HIV-associated malignancies","score":0.968999981880188},{"id":"https://openalex.org/keywords/adoptive-cellular-therapy","display_name":"adoptive cellular therapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.5410000085830688},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7890216708183289},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7480481266975403},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6053887605667114},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5514451861381531},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5487492680549622},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4556747376918793},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.4388885498046875},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2954983115196228},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.13417616486549377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11897757649421692},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09889361262321472},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00001622-199911000-00012","doi":"https://doi.org/10.1097/00001622-199911000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001622-199911000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S179395531","display_name":"Current Opinion in Oncology","issn_l":"1040-8746","issn":["1040-8746","1080-8140","1531-703X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Oncology","raw_type":"journal-article"},{"id":"pmid:10550015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10550015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W79630512","https://openalex.org/W237249694","https://openalex.org/W1509269909","https://openalex.org/W1510768077","https://openalex.org/W1555983429","https://openalex.org/W1576259632","https://openalex.org/W1580217007","https://openalex.org/W1975999249","https://openalex.org/W1976620670","https://openalex.org/W1987483457","https://openalex.org/W2017589058","https://openalex.org/W2019646425","https://openalex.org/W2022825300","https://openalex.org/W2026545608","https://openalex.org/W2032647057","https://openalex.org/W2037343680","https://openalex.org/W2068398543","https://openalex.org/W2090642065","https://openalex.org/W2097059235","https://openalex.org/W2098611636","https://openalex.org/W2112072045","https://openalex.org/W2156912242","https://openalex.org/W2158035002","https://openalex.org/W2178218273","https://openalex.org/W2318621273","https://openalex.org/W2322849685","https://openalex.org/W2328637330","https://openalex.org/W2394720881","https://openalex.org/W2404590204","https://openalex.org/W2406583270","https://openalex.org/W4256177308"],"related_works":["https://openalex.org/W2390355527","https://openalex.org/W2359001966","https://openalex.org/W1997515479","https://openalex.org/W2003673147","https://openalex.org/W2057519605","https://openalex.org/W1978695471","https://openalex.org/W2089194271","https://openalex.org/W2807165077","https://openalex.org/W2118530404","https://openalex.org/W2046135856"],"abstract_inverted_index":{"Combination":[0],"anti-retroviral":[1],"therapy":[2],"for":[3,31,44,91],"HIV":[4,50,72,112],"disease":[5],"has":[6,35,52,62],"profoundly":[7],"altered":[8,63],"the":[9,12,16,28,42,56,64,80,86,89,109],"nature":[10],"of":[11,18,49,58,66,83,108,111],"AIDS":[13,32],"epidemic.":[14],"Mitigating":[15],"impact":[17,115],"an":[19,38],"uncontrollable":[20],"decline":[21],"in":[22,71,85,94],"immune":[23,45,96],"function":[24],"is":[25,98],"no":[26],"longer":[27],"focal":[29],"point":[30],"therapy,":[33],"but":[34],"evolved":[36],"to":[37],"emphasis":[39],"on":[40,105,116],"maximizing":[41],"potential":[43,90],"regeneration.":[46],"Improved":[47],"control":[48],"replication":[51],"diminished,":[53],"albeit":[54],"unevenly,":[55],"frequency":[57],"AIDS-related":[59],"malignancies":[60],"and":[61,68,79,113],"focus":[65],"hematologic":[67],"oncologic":[69],"interventions":[70],"disease.":[73],"Now,":[74],"with":[75],"adoptive":[76],"cellular":[77,92],"therapies":[78],"genetic":[81],"engineering":[82],"cells":[84],"clinical":[87],"arena,":[88],"therapeutics":[93],"enhancing":[95],"restoration":[97],"being":[99],"tested.":[100],"These":[101],"approaches":[102],"are":[103],"based":[104],"better":[106],"understanding":[107],"immunobiology":[110],"its":[114],"hematopoietic":[117],"tissues.":[118]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
