{"id":"https://openalex.org/W2329211971","doi":"https://doi.org/10.1021/jp208731g","title":"Positioning of Antioxidant Quercetin and Its Metabolites in Lipid Bilayer Membranes: Implication for Their Lipid-Peroxidation Inhibition","display_name":"Positioning of Antioxidant Quercetin and Its Metabolites in Lipid Bilayer Membranes: Implication for Their Lipid-Peroxidation Inhibition","publication_year":2011,"publication_date":"2011-12-27","ids":{"openalex":"https://openalex.org/W2329211971","doi":"https://doi.org/10.1021/jp208731g","mag":"2329211971","pmid":"https://pubmed.ncbi.nlm.nih.gov/22201287"},"language":"en","primary_location":{"id":"doi:10.1021/jp208731g","doi":"https://doi.org/10.1021/jp208731g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp208731g","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033433001","display_name":"Pavl\u00edna Ko\u0161inov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120619","display_name":"Regional Centre of Advanced Technologies and Materials","ror":"https://ror.org/02mt5f456","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210120619"]},{"id":"https://openalex.org/I4405256079","display_name":"Laboratoire de chimie des substances naturelles","ror":"https://ror.org/03r9r2649","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4405256079","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]},{"id":"https://openalex.org/I70703428","display_name":"Palack\u00fd University Olomouc","ror":"https://ror.org/04qxnmv42","country_code":"CZ","type":"education","lineage":["https://openalex.org/I70703428"]}],"countries":["CZ","FR"],"is_corresponding":false,"raw_author_name":"Pavl\u00edna Ko\u0161inov\u00e1","raw_affiliation_strings":["LCSN\u2212EA1069, School of Pharmacy, Universit\u00e9 de Limoges, 2 rue du Dr. Marcland, 87025 Limoges, France","Regional Center of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palack\u00fd University, 17. listopadu 1192/12, 77146 Olomouc, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LCSN\u2212EA1069, School of Pharmacy, Universit\u00e9 de Limoges, 2 rue du Dr. Marcland, 87025 Limoges, France","institution_ids":["https://openalex.org/I4405256079","https://openalex.org/I65806277"]},{"raw_affiliation_string":"Regional Center of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palack\u00fd University, 17. listopadu 1192/12, 77146 Olomouc, Czech Republic","institution_ids":["https://openalex.org/I4210120619","https://openalex.org/I70703428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049457524","display_name":"Karel Berka","orcid":"https://orcid.org/0000-0001-9472-2589","observed_orcids":["https://orcid.org/0000-0001-9472-2589"]},"institutions":[{"id":"https://openalex.org/I4210120619","display_name":"Regional Centre of Advanced Technologies and Materials","ror":"https://ror.org/02mt5f456","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210120619"]},{"id":"https://openalex.org/I70703428","display_name":"Palack\u00fd University Olomouc","ror":"https://ror.org/04qxnmv42","country_code":"CZ","type":"education","lineage":["https://openalex.org/I70703428"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Karel Berka","raw_affiliation_strings":["Regional Center of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palack\u00fd University, 17. listopadu 1192/12, 77146 Olomouc, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional Center of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palack\u00fd University, 17. listopadu 1192/12, 77146 Olomouc, Czech Republic","institution_ids":["https://openalex.org/I4210120619","https://openalex.org/I70703428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058350533","display_name":"Michael E.P Wykes","orcid":"https://orcid.org/0000-0001-6013-210X","observed_orcids":["https://orcid.org/0000-0001-6013-210X"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Michael Wykes","raw_affiliation_strings":["Laboratoire de Chimie des Mat\u00e9riaux Nouveaux, Universit\u00e9 de Mons, Place du Parc 20, 7000 Mons, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie des Mat\u00e9riaux Nouveaux, Universit\u00e9 de Mons, Place du Parc 20, 7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041529029","display_name":"Michal Otyepka","orcid":"https://orcid.org/0000-0002-1066-5677","observed_orcids":["https://orcid.org/0000-0002-1066-5677"]},"institutions":[{"id":"https://openalex.org/I4210120619","display_name":"Regional Centre of Advanced Technologies and Materials","ror":"https://ror.org/02mt5f456","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210120619"]},{"id":"https://openalex.org/I70703428","display_name":"Palack\u00fd University Olomouc","ror":"https://ror.org/04qxnmv42","country_code":"CZ","type":"education","lineage":["https://openalex.org/I70703428"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Michal Otyepka","raw_affiliation_strings":["Regional Center of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palack\u00fd University, 17. listopadu 1192/12, 77146 Olomouc, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional Center of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palack\u00fd University, 17. listopadu 1192/12, 77146 Olomouc, Czech Republic","institution_ids":["https://openalex.org/I4210120619","https://openalex.org/I70703428"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033121503","display_name":"Patrick Trouillas","orcid":"https://orcid.org/0000-0002-8832-9606","observed_orcids":["https://orcid.org/0000-0002-8832-9606"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]},{"id":"https://openalex.org/I4405256079","display_name":"Laboratoire de chimie des substances naturelles","ror":"https://ror.org/03r9r2649","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4405256079","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["BE","FR"],"is_corresponding":true,"raw_author_name":"Patrick Trouillas","raw_affiliation_strings":["LCSN\u2212EA1069, School of Pharmacy, Universit\u00e9 de Limoges, 2 rue du Dr. Marcland, 87025 Limoges, France","Laboratoire de Chimie des Mat\u00e9riaux Nouveaux, Universit\u00e9 de Mons, Place du Parc 20, 7000 Mons, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LCSN\u2212EA1069, School of Pharmacy, Universit\u00e9 de Limoges, 2 rue du Dr. Marcland, 87025 Limoges, France","institution_ids":["https://openalex.org/I4405256079","https://openalex.org/I65806277"]},{"raw_affiliation_string":"Laboratoire de Chimie des Mat\u00e9riaux Nouveaux, Universit\u00e9 de Mons, Place du Parc 20, 7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5033121503"],"corresponding_institution_ids":["https://openalex.org/I130929987","https://openalex.org/I4405256079","https://openalex.org/I65806277"],"apc_list":null,"apc_paid":null,"fwci":2.3514,"has_fulltext":false,"cited_by_count":154,"citation_normalized_percentile":{"value":0.89293026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"116","issue":"4","first_page":"1309","last_page":"1318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/quercetin-metabolites","display_name":"quercetin metabolites","score":0.8880000114440918},{"id":"https://openalex.org/keywords/lipid-peroxidation-inhibition","display_name":"lipid peroxidation inhibition","score":0.8610000014305115},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.7910000085830688},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7289999723434448},{"id":"https://openalex.org/keywords/molecular-orientation","display_name":"molecular orientation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.5659999847412109},{"id":"https://openalex.org/keywords/membrane-water-interface","display_name":"membrane-water interface","score":0.7329999804496765},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.7710000276565552},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.7853543758392334},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.7829549312591553},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.7452301979064941},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7278029918670654},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.6747534275054932},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5690178871154785},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5412423610687256},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5106247067451477},{"id":"https://openalex.org/C125501631","wikidata":"https://www.wikidata.org/wiki/Q1587185","display_name":"Biological membrane","level":3,"score":0.5086444616317749},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43201377987861633},{"id":"https://openalex.org/C76564549","wikidata":"https://www.wikidata.org/wiki/Q17154515","display_name":"Lipid bilayer phase behavior","level":4,"score":0.4168001413345337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0846298336982727}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005965","descriptor_name":"Glucuronates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005965","descriptor_name":"Glucuronates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005965","descriptor_name":"Glucuronates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/jp208731g","doi":"https://doi.org/10.1021/jp208731g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp208731g","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},{"id":"pmid:22201287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22201287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry. B","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00937903v1","doi":null,"is_oa":false,"landing_page_url":"https://unilim.hal.science/hal-00937903","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Physical Chemistry B, 2012, 116 (4), pp.1309-18. ⟨10.1021/jp208731g⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.6399999856948853}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W69913325","https://openalex.org/W937005068","https://openalex.org/W1491824558","https://openalex.org/W1879047861","https://openalex.org/W1964481275","https://openalex.org/W1966078827","https://openalex.org/W1978284036","https://openalex.org/W1978498560","https://openalex.org/W1985193176","https://openalex.org/W1986645535","https://openalex.org/W1988250175","https://openalex.org/W1988531962","https://openalex.org/W1989041284","https://openalex.org/W1989530212","https://openalex.org/W1989550657","https://openalex.org/W1991952322","https://openalex.org/W1993177346","https://openalex.org/W1993360693","https://openalex.org/W1995745181","https://openalex.org/W2000933179","https://openalex.org/W2004352246","https://openalex.org/W2014218268","https://openalex.org/W2016482080","https://openalex.org/W2024050667","https://openalex.org/W2024754142","https://openalex.org/W2026547315","https://openalex.org/W2029882213","https://openalex.org/W2032029565","https://openalex.org/W2032927626","https://openalex.org/W2035266068","https://openalex.org/W2035687084","https://openalex.org/W2035939859","https://openalex.org/W2041774824","https://openalex.org/W2048695976","https://openalex.org/W2053620862","https://openalex.org/W2061014069","https://openalex.org/W2066617101","https://openalex.org/W2067174909","https://openalex.org/W2071566170","https://openalex.org/W2079227073","https://openalex.org/W2079395341","https://openalex.org/W2081693079","https://openalex.org/W2086959952","https://openalex.org/W2092152759","https://openalex.org/W2109832508","https://openalex.org/W2114367386","https://openalex.org/W2123768693","https://openalex.org/W2125872855","https://openalex.org/W2127522551","https://openalex.org/W2128572087","https://openalex.org/W2131288855","https://openalex.org/W2132066544","https://openalex.org/W2132363861","https://openalex.org/W2133167615","https://openalex.org/W2134233041","https://openalex.org/W2141273392","https://openalex.org/W2160099189","https://openalex.org/W2167034306","https://openalex.org/W2169307394","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4367601614","https://openalex.org/W1983202382","https://openalex.org/W2061481432","https://openalex.org/W1963901611","https://openalex.org/W2100090167","https://openalex.org/W1993785346","https://openalex.org/W2117633153","https://openalex.org/W1975002378","https://openalex.org/W2039713723","https://openalex.org/W2072230736"],"abstract_inverted_index":{"Among":[0],"numerous":[1],"biological":[2,200],"activities,":[3],"natural":[4],"polyphenols":[5],"are":[6,119,148],"antioxidants":[7,28],"widely":[8],"distributed":[9],"in":[10,29,64,151,164,176,181,189,198],"plants":[11],"capable":[12],"of":[13,27,53,84,96,126,140,174],"inhibiting":[14],"lipid":[15,30,65,78,108,153],"peroxidation,":[16],"which":[17],"belongs":[18],"to":[19,36],"the":[20,37,41,49,77,82,94,102,107,122,127,130,141,152,158,171,182],"most":[21,57],"serious":[22],"degenerative":[23],"cell":[24],"processes.":[25],"Positioning":[26],"bilayers":[31],"can":[32],"provide":[33],"an":[34],"insight":[35],"lipid-peroxidation":[38],"inhibition":[39],"at":[40,47],"molecular":[42,68,88],"level.":[43],"This":[44],"work":[45],"aims":[46],"determining":[48],"location":[50],"and":[51,55,61,80,90,100,129,136,145],"orientation":[52,112],"quercetin":[54,74],"its":[56],"representative":[58],"(glucuronidated,":[59],"methylated,":[60],"sulfated)":[62],"metabolites":[63],"bilayer":[66,79,109,128,154],"via":[67],"dynamic":[69],"simulations.":[70],"We":[71],"show":[72],"that":[73,81],"derivatives":[75,147],"penetrate":[76],"depths":[83],"penetration":[85],"depend":[86],"on":[87,115,157],"charge":[89],"substitutional":[91],"variations.":[92],"In":[93],"presence":[95],"charged":[97],"substituents":[98],"(sulfates":[99],"glucuronidates),":[101],"molecule":[103],"is":[104],"pulled":[105],"toward":[106],"surface.":[110],"The":[111],"also":[113],"depends":[114],"substitution":[116],"as":[117],"H-bonds":[118],"formed":[120],"between":[121],"polar":[123],"head":[124],"groups":[125],"(i)":[131],"OH":[132],"groups,":[133],"(ii)":[134],"sugar,":[135],"(iii)":[137],"sulfate":[138],"moieties":[139],"antioxidants.":[142],"As":[143],"flavonoids":[144,175],"their":[146,178,186,195],"preferentially":[149],"localized":[150],"membrane":[155,168,183],"or":[156],"bilayer/water":[159],"interface,":[160],"they":[161],"readily":[162],"concentrate":[163],"a":[165],"relatively":[166],"narrow":[167],"region.":[169],"Despite":[170],"low":[172],"concentrations":[173],"food,":[177],"spatial":[179],"confinement":[180],"greatly":[184],"enhances":[185],"local":[187],"concentration":[188],"this":[190],"vital":[191],"region,":[192],"thus":[193],"increasing":[194],"importance":[196],"for":[197],"vivo":[199],"activities":[201],"including":[202],"oxidative":[203],"stress":[204],"defense.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2025-10-10T00:00:00"}