{"id":"https://openalex.org/W2329200435","doi":"https://doi.org/10.2146/news140056","title":"Belinostat approved for use in treating rare lymphoma","display_name":"Belinostat approved for use in treating rare lymphoma","publication_year":2014,"publication_date":"2014-07-29","ids":{"openalex":"https://openalex.org/W2329200435","doi":"https://doi.org/10.2146/news140056","mag":"2329200435","pmid":"https://pubmed.ncbi.nlm.nih.gov/25074945"},"language":"en","primary_location":{"id":"doi:10.2146/news140056","doi":"https://doi.org/10.2146/news140056","is_oa":false,"landing_page_url":"https://doi.org/10.2146/news140056","pdf_url":null,"source":{"id":"https://openalex.org/S105051383","display_name":"American Journal of Health-System Pharmacy","issn_l":"1079-2082","issn":["1079-2082","1535-2900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Health-System Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003166105","display_name":"Cheryl A. Thompson","orcid":"https://orcid.org/0000-0002-8825-2944","observed_orcids":["https://orcid.org/0000-0002-8825-2944"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Cheryl A. Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003166105"],"corresponding_institution_ids":[],"apc_list":{"value":4448,"currency":"USD","value_usd":4448},"apc_paid":null,"fwci":3.2196,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.91650753,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"71","issue":"16","first_page":"1328","last_page":"1328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/belinostat","display_name":"belinostat","score":1.0},{"id":"https://openalex.org/keywords/peripheral-t-cell-lymphoma","display_name":"peripheral T-cell lymphoma","score":0.9390000104904175},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.9020000100135803},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/fda-drug-approval","display_name":"FDA drug approval","score":0.8059999942779541},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.843999981880188},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.765999972820282},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8542698621749878},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7001190781593323},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5822057127952576},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5688455104827881},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5041500329971313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4428889751434326},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4238879084587097},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40299975872039795},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40002313256263733},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2542271614074707}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016411","descriptor_name":"Lymphoma, T-Cell, Peripheral","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2146/news140056","doi":"https://doi.org/10.2146/news140056","is_oa":false,"landing_page_url":"https://doi.org/10.2146/news140056","pdf_url":null,"source":{"id":"https://openalex.org/S105051383","display_name":"American Journal of Health-System Pharmacy","issn_l":"1079-2082","issn":["1079-2082","1535-2900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Health-System Pharmacy","raw_type":"journal-article"},{"id":"pmid:25074945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25074945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","raw_type":"News"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2104425103","https://openalex.org/W2343743605","https://openalex.org/W1581172001","https://openalex.org/W2126558952","https://openalex.org/W2084893501","https://openalex.org/W4292578564","https://openalex.org/W2109716912","https://openalex.org/W4385508425","https://openalex.org/W2491830239","https://openalex.org/W2486896794"],"abstract_inverted_index":{"FDA":[0],"on":[1,77,160],"July":[2],"3":[3],"announced":[4],"it":[5],"approved":[6,46],"the":[7,14,36,39,43,50,89,95,100,137,156,161,182,189],"marketing":[8],"of":[9,16,27,30,52,65,71,80,94,200],"belinostat,":[10,57],"or":[11,18,132,141,164],"Beleodaq,":[12],"for":[13,49,56,88,174],"treatment":[15,51,83,145,191],"relapsed":[17],"refractory":[19],"peripheral":[20],"T-cell":[21],"lymphoma":[22],"(PTCL).":[23],"Richard":[24],"Pazdur,":[25],"head":[26],"FDA\u2019s":[28],"Office":[29],"Hematology":[31],"and":[32,171],"Oncology":[33],"Products,":[34],"said":[35],"drug":[37],"is":[38],"third":[40],"one":[41],"that":[42],"agency":[44],"has":[45],"since":[47],"2009":[48],"PTCL.":[53],"The":[54],"labeling":[55,183],"a":[58,63,81,92,144,149],"histone":[59],"deacetylase":[60],"inhibitor,":[61],"recommends":[62,184],"dosage":[64],"1000":[66],"mg":[67,106],"per":[68,107],"square":[69,108],"meter":[70],"body":[72],"surface":[73],"area":[74],"once":[75],"daily":[76],"days":[78,178],"1\u20135":[79],"21-day":[82],"cycle.":[84],"In":[85],"patients":[86],"homozygous":[87],"UGT1A1*28":[90],"allele,":[91],"variant":[93],"uridine":[96],"glucuronosyltransferase":[97],"1A1":[98],"gene,":[99],"starting":[101],"dose":[102,154,187],"should":[103,111],"be":[104,112,124],"750":[105],"meter.":[109],"Doses":[110],"given":[113],"by":[114,193],"i.v.":[115],"infusion":[116,121,138],"over":[117],"30":[118],"minutes.":[119],"This":[120],"time":[122],"may":[123,147],"extended":[125],"to":[126,136],"45":[127],"minutes":[128],"if":[129],"infusion-site":[130],"pain":[131],"other":[133],"symptoms":[134],"attributable":[135],"occur.":[139],"Thrombocytopenia":[140],"neutropenia":[142],"during":[143,155],"cycle":[146,192],"necessitate":[148,198],"25%":[150],"decrease":[151],"in":[152,188],"each":[153,186],"next":[157,190],"cycle,":[158],"depending":[159],"patient\u2019s":[162],"platelet":[163],"absolute":[165],"neutrophil":[166],"count.":[167],"If":[168],"nausea,":[169],"vomiting,":[170],"diarrhea":[172],"occur":[173],"more":[175],"than":[176],"seven":[177],"despite":[179],"supportive":[180],"management,":[181],"decreasing":[185],"25%.":[194],"Two":[195],"such":[196],"reductions":[197],"discontinuation":[199],"belinostat":[201],"therapy.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
