{"id":"https://openalex.org/W2328870268","doi":"https://doi.org/10.1055/s-0031-1296619","title":"N'-[2-(2-Thiophene)ethyl]-N'-[2-(5-bromopyridyl)]thiourea (HI-443), a Rationally Designed Non-Nucleoside Reverse Transcriptase Inhibitor Compound with Potent Anti-HIV Activity","display_name":"N'-[2-(2-Thiophene)ethyl]-N'-[2-(5-bromopyridyl)]thiourea (HI-443), a Rationally Designed Non-Nucleoside Reverse Transcriptase Inhibitor Compound with Potent Anti-HIV Activity","publication_year":2011,"publication_date":"2011-12-21","ids":{"openalex":"https://openalex.org/W2328870268","doi":"https://doi.org/10.1055/s-0031-1296619","mag":"2328870268","pmid":"https://pubmed.ncbi.nlm.nih.gov/17598700"},"language":"en","primary_location":{"id":"doi:10.1055/s-0031-1296619","doi":"https://doi.org/10.1055/s-0031-1296619","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0031-1296619","pdf_url":null,"source":{"id":"https://openalex.org/S132758211","display_name":"Arzneimittelforschung","issn_l":"0004-4172","issn":["0004-4172","1616-7066"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittelforschung","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091381226","display_name":"Fatih Mehmet Uckun","orcid":"https://orcid.org/0000-0001-9334-183X","observed_orcids":["https://orcid.org/0000-0001-9334-183X"]},"institutions":[{"id":"https://openalex.org/I4210120419","display_name":"Paradigm Pharmaceuticals (United States)","ror":"https://ror.org/02krbtc48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120419"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fatih Uckun","raw_affiliation_strings":["Paradigm Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paradigm Pharmaceuticals","institution_ids":["https://openalex.org/I4210120419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111972691","display_name":"Sanjive Qazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120419","display_name":"Paradigm Pharmaceuticals (United States)","ror":"https://ror.org/02krbtc48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120419"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjive Qazi","raw_affiliation_strings":["Paradigm Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paradigm Pharmaceuticals","institution_ids":["https://openalex.org/I4210120419"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048956276","display_name":"Taracad K. Venkatachalam","orcid":"https://orcid.org/0000-0001-9747-1105","observed_orcids":["https://orcid.org/0000-0001-9747-1105"]},"institutions":[{"id":"https://openalex.org/I4210120419","display_name":"Paradigm Pharmaceuticals (United States)","ror":"https://ror.org/02krbtc48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120419"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taracad Venkatachalam","raw_affiliation_strings":["Paradigm Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paradigm Pharmaceuticals","institution_ids":["https://openalex.org/I4210120419"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091381226"],"corresponding_institution_ids":["https://openalex.org/I4210120419"],"apc_list":null,"apc_paid":null,"fwci":0.8772,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75176418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"57","issue":"05","first_page":"278","last_page":"285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thiourea-derivatives","display_name":"thiourea derivatives","score":0.6629999876022339},{"id":"https://openalex.org/keywords/non-nucleoside-reverse-transcriptase-inhibitors","display_name":"non-nucleoside reverse transcriptase inhibitors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/antiretroviral-drug-design","display_name":"antiretroviral drug design","score":0.7689999938011169},{"id":"https://openalex.org/keywords/nrti-resistance","display_name":"NRTI resistance","score":0.8500000238418579},{"id":"https://openalex.org/keywords/nnrti-resistance","display_name":"NNRTI resistance","score":0.9639999866485596},{"id":"https://openalex.org/keywords/multidrug-resistant-hiv","display_name":"multidrug-resistant HIV","score":0.9390000104904175},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.7455259561538696},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7264079451560974},{"id":"https://openalex.org/C2909970146","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Nucleoside Reverse Transcriptase Inhibitor","level":5,"score":0.6802045702934265},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.6794913411140442},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.5374525189399719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46456944942474365},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4606900215148926},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.44193288683891296},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.432952880859375},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3833923935890198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35007303953170776},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.29888471961021423},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.24514997005462646},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.20298346877098083},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.15705665946006775},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.14589202404022217},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.11785447597503662},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06015065312385559},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.059562087059020996},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.042214035987854004}],"mesh":[{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010948","descriptor_name":"Viral Plaque Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D024921","descriptor_name":"Drug Resistance, Multiple, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0031-1296619","doi":"https://doi.org/10.1055/s-0031-1296619","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0031-1296619","pdf_url":null,"source":{"id":"https://openalex.org/S132758211","display_name":"Arzneimittelforschung","issn_l":"0004-4172","issn":["0004-4172","1616-7066"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittelforschung","raw_type":"journal-article"},{"id":"pmid:17598700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17598700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2330399890","https://openalex.org/W2076578204","https://openalex.org/W2314351573","https://openalex.org/W2156229229","https://openalex.org/W2319375073","https://openalex.org/W2107500997","https://openalex.org/W2169046292","https://openalex.org/W2322443628","https://openalex.org/W1971012106","https://openalex.org/W1985600843"],"abstract_inverted_index":{"The":[0,88],"in":[1],"vitro":[2],"activity":[3],"profile":[4],"of":[5,18,26,28,33,38,51,66,76,81,90,104],"N'-":[6],"[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]":[7],"thiourea":[8],"(CAS":[9],"258340-15-7,":[10],"HI-443)":[11],"was":[12],"examined":[13],"against":[14,92],"38":[15],"clinical":[16,93],"isolates":[17,32,41,56,69,95],"HIV-1.":[19],"HI-443":[20,91],"inhibited":[21],"the":[22,29,39,52,67,77,101],"replication":[23],"and/or":[24],"infectivity":[25],"each":[27,37,50,65,75],"7":[30],"HIV-1":[31,94],"non-B":[34],"envelope":[35],"subtype,":[36],"22":[40],"with":[42,57,70,83,96],"genotypic":[43,58],"nucleoside":[44],"reverse":[45,60],"transcriptase":[46,61],"inhibitor":[47,62],"(NRTI)":[48],"resistance,":[49,64],"6":[53],"multidrug-resistant":[54],"HIV":[55],"NRTI/non-nucleoside":[59],"(NNRTI)":[63],"3":[68,78],"no":[71],"RT":[72],"mutations,":[73],"and":[74],"laboratory":[79],"strains":[80],"HIV-I":[82],"NNRTI":[84,108],"or":[85,98],"NNRTI/NRTI":[86],"resistance.":[87],"potency":[89],"NRTI-":[97],"NNRTI-resistance":[99],"warrants":[100],"further":[102],"development":[103],"this":[105],"rationally":[106],"designed":[107],"as":[109],"a":[110],"new":[111],"anti-HIV":[112],"agent.":[113]},"counts_by_year":[{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}