{"id":"https://openalex.org/W2328816005","doi":"https://doi.org/10.1097/01.mib.0000438738.51780.01","title":"P-059 YI Clinical Characteristics of Patients with Ileal Pouch-Anal Anastomosis and Persistent or Recurrent Clostridium Difficile Infection","display_name":"P-059 YI Clinical Characteristics of Patients with Ileal Pouch-Anal Anastomosis and Persistent or Recurrent Clostridium Difficile Infection","publication_year":2013,"publication_date":"2013-11-18","ids":{"openalex":"https://openalex.org/W2328816005","doi":"https://doi.org/10.1097/01.mib.0000438738.51780.01","mag":"2328816005"},"language":"en","primary_location":{"id":"doi:10.1097/01.mib.0000438738.51780.01","doi":"https://doi.org/10.1097/01.mib.0000438738.51780.01","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.mib.0000438738.51780.01","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112087266","display_name":"Darren Seril","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seril Darren","raw_affiliation_strings":["The Cleveland Clinic Foundation, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Cleveland Clinic Foundation, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082459823","display_name":"Bo Shen","orcid":"https://orcid.org/0000-0002-7229-4840","observed_orcids":["https://orcid.org/0000-0002-7229-4840"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shen Bo","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":{"value":3862,"currency":"USD","value_usd":3862},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":null,"first_page":"S51","last_page":"S51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.24979999661445618,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12518","display_name":"Diverticular Disease and Complications","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clostridium-difficile-infection","display_name":"Clostridium difficile infection","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ileal-pouch-anal-anastomosis","display_name":"ileal pouch-anal anastomosis","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C2779454807","wikidata":"https://www.wikidata.org/wiki/Q3392956","display_name":"Pouchitis","level":4,"score":0.9028398394584656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8849347829818726},{"id":"https://openalex.org/C2780101441","wikidata":"https://www.wikidata.org/wiki/Q949930","display_name":"Pouch","level":2,"score":0.8455063104629517},{"id":"https://openalex.org/C2994496256","wikidata":"https://www.wikidata.org/wiki/Q27031090","display_name":"Clostridium difficile","level":3,"score":0.7233348488807678},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7054312229156494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7018454074859619},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.6890970468521118},{"id":"https://openalex.org/C2777077811","wikidata":"https://www.wikidata.org/wiki/Q7247499","display_name":"Proctocolectomy","level":4,"score":0.5842466354370117},{"id":"https://openalex.org/C8443397","wikidata":"https://www.wikidata.org/wiki/Q15177","display_name":"Anastomosis","level":2,"score":0.5723133683204651},{"id":"https://openalex.org/C2776667177","wikidata":"https://www.wikidata.org/wiki/Q1779148","display_name":"Colectomy","level":4,"score":0.5285742878913879},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.442003458738327},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3115076422691345},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2440333366394043},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.mib.0000438738.51780.01","doi":"https://doi.org/10.1097/01.mib.0000438738.51780.01","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.mib.0000438738.51780.01","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2977927986","https://openalex.org/W2027943655","https://openalex.org/W2312358103","https://openalex.org/W2034266611","https://openalex.org/W2944106853","https://openalex.org/W3007579238","https://openalex.org/W2606882460","https://openalex.org/W2406066279","https://openalex.org/W2325450115","https://openalex.org/W2402637652"],"abstract_inverted_index":{"Clostridium":[0],"difficile":[1,102,161],"(C":[2],"difficile)":[3],"infection":[4],"(CDI)":[5],"is":[6,450],"increasingly":[7],"recognized":[8],"in":[9,74,207,274,293,381,403,409,446,469,493],"ulcerative":[10],"colitis":[11],"(UC)":[12],"patients":[13,75,79,112,147,298,331,348,357,369,408,470],"who":[14],"have":[15,250],"undergone":[16],"restorative":[17],"proctocolectomy":[18],"with":[19,76,90,113,148,186,221,236,299,332,370,414,453,460,471],"ileal":[20],"pouch-anal":[21],"anastomosis":[22],"(IPAA).":[23],"CDI":[24,28,52,73,127,138,149,153,184,210,216,223,238,261,271,279,301,306,339,347,356,377,384,390,439,473,492],"and":[25,38,95,105,150,174,182,195,213,247,277,283,318,449,462,478],"recurrence":[26,156,437],"of":[27,29,35,53,58,123,131,152,228,254,259,265,297,313,328,368,398,431,438,440,458],"the":[30,54,59,82,106,136,180,208,214,257,269,275,324,329,341,375,382,388,404,429,432,441],"pouch":[31,36,40,442],"may":[32,484],"be":[33,485],"causes":[34],"dysfunction":[37],"ultimately":[39],"failure.":[41],"Previously,":[42],"male":[43,203,447],"gender":[44],"was":[45,62,205,272,378,401],"identified":[46,104],"as":[47,232],"a":[48,96,129,225,251,294,463],"risk":[49,66,486],"factor":[50],"for":[51,68,92,100,192,199,488],"pouch.":[55],"The":[56,263,311,366,396],"aim":[57],"current":[60],"study":[61],"to":[63,88,146,234,249,268,374,444],"identify":[64],"clinical":[65,119],"factors":[67,477,487],"treatment":[69,165],"resistant":[70],"or":[71,120,125,155,289,416,436,490],"recurrent":[72,126,491],"IPAA.":[77],"Consecutive":[78],"evaluated":[80],"at":[81,256,428],"CCF":[83],"Pouchitis":[84],"Center":[85],"from":[86],"2010":[87],"2013":[89],"IPAA":[91,111,231,255,494],"underlying":[93,482],"UC":[94,229],"positive":[97,159],"stool":[98],"test":[99,117,191,198],"C":[101,115,160],"were":[103,109,144,177,321,412],"medical":[107],"records":[108],"examined.":[110],"one":[114],"difficile-positive":[116],"without":[118],"biochemical":[121],"evidence":[122,151],"persistent":[124,489],"during":[128,340],"minimum":[130],"3":[132],"months":[133],"follow-up":[134,342],"after":[135],"index":[137,260,270,376,433],"(\u201csingle\u201d":[139],"CDI,":[140,167],"N":[141,168],"=":[142,169,309],"20)":[143],"compared":[145,178,233],"persistence":[154],"(based":[157],"on":[158],"PCR)":[162],"despite":[163],"adequate":[164],"(\u201cmultiple\u201d":[166],"16).":[170],"Twenty-three":[171],"demographic,":[172],"clinical,":[173],"surgical":[175],"variables":[176],"between":[179,323],"single":[181,209,237,276,305,355,389],"multiple":[183,215,222,278,300,338,346,383,424,472],"groups,":[185],"comparisons":[187],"made":[188],"by":[189],"Chi-squared":[190],"categorical":[193],"variables,":[194],"Student\u2019s":[196],"t":[197],"quantitative":[200],"variables.":[201],"A":[202,456],"preponderance":[204],"noted":[206],"(16/20,":[211],"80%)":[212],"groups":[217,280,411],"([11/16,":[218],"69%][NS]).":[219],"Patients":[220],"had":[224,337],"shorter":[226,252],"duration":[227,253],"until":[230],"those":[235],"(median":[239],"4":[240,330],"versus":[241,360],"8.5":[242],"years,":[243],"P":[244],"<":[245,364,394],"0.05),":[246],"tended":[248],"time":[258,430],"(NS).":[262],"prevalence":[264],"pouchitis":[266],"prior":[267,373,466],"similar":[273,322,402],"(13/20":[281],"[65%]":[282],"10/16":[284],"[63%],":[285],"respectively).":[286],"Post-operative":[287],"mechanical":[288,467,476],"infectious":[290],"complications":[291,468],"occurred":[292],"greater":[295],"proportion":[296],"(11/16,":[302],"69%)":[303],"than":[304,354,387,481],"(10/20,":[307],"50%)(P":[308],"0.257).":[310],"frequencies":[312],"concurrent":[314],"autoimmune":[315],"disorders":[316],"(AID)":[317],"autoantibody":[319],"expression":[320],"2":[325,405],"groups.":[326,406],"None":[327],"primary":[333],"sclerosing":[334],"cholangitis":[335],"(PSC)":[336],"period.":[343],"Significantly":[344],"fewer":[345],"reported":[349],"extra-intestinal":[350],"disease":[351],"manifestations":[352],"(EIM)":[353],"(3/16":[358],"[19%]":[359],"11/20":[361],"[55%],":[362],"respectively)(P":[363],"0.05).":[365,395],"number":[367],"antibiotic":[371,454],"use":[372,397],"significantly":[379],"lower":[380],"(4/16,":[385],"25%)":[386],"group":[391],"(13/20,":[392],"65%)(P":[393],"immunosuppressive":[399],"medications":[400],"Most":[407],"both":[410],"treated":[413],"vancomycin":[415,417],"plus":[418],"metronidazole":[419],"(single":[420],"CDI:":[421,425],"20/20":[422],"[100%];":[423],"15/16":[426],"[94%])":[427],"CDI.":[434],"Persistence":[435],"appears":[443],"predominate":[445],"patients,":[448],"not":[451],"associated":[452],"use.":[455],"lack":[457],"association":[459],"EIM":[461],"trend":[464],"towards":[465],"indicate":[474],"that":[475],"ischemia":[479],"(rather":[480],"autoimmunity)":[483],"patients.":[495]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}