{"id":"https://openalex.org/W2328675759","doi":"https://doi.org/10.1002/chem.201504955","title":"Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors","display_name":"Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2328675759","doi":"https://doi.org/10.1002/chem.201504955","mag":"2328675759","pmid":"https://pubmed.ncbi.nlm.nih.gov/27037933","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4962924"},"language":"en","primary_location":{"id":"doi:10.1002/chem.201504955","doi":"https://doi.org/10.1002/chem.201504955","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chem.201504955","pdf_url":null,"source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4962924","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065292763","display_name":"Katherine M. Byrd","orcid":"https://orcid.org/0000-0002-7203-6980","observed_orcids":["https://orcid.org/0000-0002-7203-6980"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine M. Byrd","raw_affiliation_strings":["Department of Medicinal Chemistry, The University of Kansas, Wescoe Hall Drive, Malott 4070, Lawrence, KS, 66045-7563 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, The University of Kansas, Wescoe Hall Drive, Malott 4070, Lawrence, KS, 66045-7563 USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075065118","display_name":"Chitra Subramanian","orcid":"https://orcid.org/0000-0003-1871-2834","observed_orcids":["https://orcid.org/0000-0003-1871-2834"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chitra Subramanian","raw_affiliation_strings":["Department of Surgery, University of Michigan, Ann Arbor, MI, 48109 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Michigan, Ann Arbor, MI, 48109 USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jacqueline Sanchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Sanchez","raw_affiliation_strings":["Department of Surgery, University of Michigan, Ann Arbor, MI, 48109 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Michigan, Ann Arbor, MI, 48109 USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064042324","display_name":"Hashim F. Motiwala","orcid":"https://orcid.org/0000-0001-5926-3743","observed_orcids":["https://orcid.org/0000-0001-5926-3743"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hashim F. Motiwala","raw_affiliation_strings":["Department of Surgery, University of Michigan, Ann Arbor, MI, 48109 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Michigan, Ann Arbor, MI, 48109 USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107846031","display_name":"Weiya Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiya Liu","raw_affiliation_strings":["Department of Urology, The University of Kansas Medical Center, 3901 Rainbow Boulevard,Stop 3016, Kansas City, Kansas, 66160 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center, 3901 Rainbow Boulevard,Stop 3016, Kansas City, Kansas, 66160 USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057675169","display_name":"Mark Steven Cohen","orcid":"https://orcid.org/0000-0002-2517-0757","observed_orcids":["https://orcid.org/0000-0002-2517-0757"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S. Cohen","raw_affiliation_strings":["Department of Surgery, University of Michigan, Ann Arbor, MI, 48109 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Michigan, Ann Arbor, MI, 48109 USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110610667","display_name":"Jeffrey M. Holzbeierlein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Holzbeierlein","raw_affiliation_strings":["Department of Urology, The University of Kansas Medical Center, 3901 Rainbow Boulevard,Stop 3016, Kansas City, Kansas, 66160 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center, 3901 Rainbow Boulevard,Stop 3016, Kansas City, Kansas, 66160 USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062921807","display_name":"Brian S. J. Blagg","orcid":"https://orcid.org/0000-0002-6200-3480","observed_orcids":["https://orcid.org/0000-0002-6200-3480"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian S. J. Blagg","raw_affiliation_strings":["Department of Medicinal Chemistry, The University of Kansas, Wescoe Hall Drive, Malott 4070, Lawrence, KS, 66045-7563 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, The University of Kansas, Wescoe Hall Drive, Malott 4070, Lawrence, KS, 66045-7563 USA","institution_ids":["https://openalex.org/I146416000"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062921807"],"corresponding_institution_ids":["https://openalex.org/I146416000"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":3.1321,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.92438532,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"22","issue":"20","first_page":"6921","last_page":"6931"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/novobiocin","display_name":"novobiocin","score":0.8050000071525574},{"id":"https://openalex.org/keywords/coumermycin","display_name":"coumermycin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.8429999947547913},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6949999928474426},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6880000233650208},{"id":"https://openalex.org/keywords/natural-product-derivatives","display_name":"natural product derivatives","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2779904463","wikidata":"https://www.wikidata.org/wiki/Q1639291","display_name":"Novobiocin","level":3,"score":0.9518711566925049},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.7188374996185303},{"id":"https://openalex.org/C2781338262","wikidata":"https://www.wikidata.org/wiki/Q111812","display_name":"Coumarin","level":2,"score":0.6955010294914246},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5672067999839783},{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.5303084850311279},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.5262359976768494},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.4502227008342743},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44373106956481934},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4303121566772461},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.3964993953704834},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33344346284866333},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14474424719810486},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1340343952178955},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0924098789691925},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009675","descriptor_name":"Novobiocin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009675","descriptor_name":"Novobiocin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049933","descriptor_name":"Aminocoumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D060326","descriptor_name":"Chemistry Techniques, Synthetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/chem.201504955","doi":"https://doi.org/10.1002/chem.201504955","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chem.201504955","pdf_url":null,"source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},{"id":"pmid:27037933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27037933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry (Weinheim an der Bergstrasse, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4270404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4962924","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4962924","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4962924","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chemistry","raw_type":"Text"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/136281","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/136281","pdf_url":"https://hdl.handle.net/2027.42/136281","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4270404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4962924","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7059067082","display_name":"Development and Evaluation of Purine and Coumarin Based Hsp90 Inhibitors","funder_award_id":"U01CA120458","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8770490743","display_name":"Development and Evaluation of Purine and Coumarin Based Hsp90 Inhibitors","funder_award_id":"R01CA120458","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2328675759.pdf","grobid_xml":"https://content.openalex.org/works/W2328675759.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1034360234","https://openalex.org/W1692324497","https://openalex.org/W1856945769","https://openalex.org/W1967308926","https://openalex.org/W1974208995","https://openalex.org/W1988884951","https://openalex.org/W1992279709","https://openalex.org/W1993105675","https://openalex.org/W2007106751","https://openalex.org/W2008672350","https://openalex.org/W2009899654","https://openalex.org/W2010809759","https://openalex.org/W2013226867","https://openalex.org/W2013431834","https://openalex.org/W2014811899","https://openalex.org/W2015811986","https://openalex.org/W2018211494","https://openalex.org/W2020742237","https://openalex.org/W2022254839","https://openalex.org/W2022531767","https://openalex.org/W2025623674","https://openalex.org/W2034930480","https://openalex.org/W2051275249","https://openalex.org/W2052151051","https://openalex.org/W2052697091","https://openalex.org/W2054290614","https://openalex.org/W2060902443","https://openalex.org/W2062519929","https://openalex.org/W2064630223","https://openalex.org/W2069185856","https://openalex.org/W2073412922","https://openalex.org/W2073750962","https://openalex.org/W2076981817","https://openalex.org/W2082327766","https://openalex.org/W2083030025","https://openalex.org/W2092960638","https://openalex.org/W2095024990","https://openalex.org/W2111863174","https://openalex.org/W2119910460","https://openalex.org/W2132496156","https://openalex.org/W2134175129","https://openalex.org/W2139295917","https://openalex.org/W2139427201","https://openalex.org/W2140432698","https://openalex.org/W2143006255","https://openalex.org/W2175029576","https://openalex.org/W2185686976","https://openalex.org/W2187584967","https://openalex.org/W2314386464","https://openalex.org/W2319525448","https://openalex.org/W2327551283","https://openalex.org/W2335420712"],"related_works":["https://openalex.org/W2020656210","https://openalex.org/W7034459339","https://openalex.org/W2000458221","https://openalex.org/W2114823895","https://openalex.org/W2760147019","https://openalex.org/W2550764931","https://openalex.org/W2139910389","https://openalex.org/W2327551283","https://openalex.org/W2073750962","https://openalex.org/W2080384696"],"abstract_inverted_index":{"Development":[0],"of":[1,18,105],"heat":[2],"shock":[3],"protein":[4],"90":[5],"(Hsp90)":[6],"C-terminal":[7],"inhibitors":[8],"has":[9],"emerged":[10],"as":[11],"an":[12],"exciting":[13],"strategy":[14],"for":[15,48],"the":[16,27,37,49,67,91],"treatment":[17],"cancer.":[19],"Previous":[20],"efforts":[21],"have":[22,42,52],"focused":[23],"on":[24],"modifications":[25],"to":[26],"natural":[28],"products":[29],"novobiocin":[30],"and":[31,39,64,69,83,93,98],"coumermycin.":[32],"Moreover,":[33],"variations":[34],"in":[35],"both":[36],"sugar":[38,68,92],"amide":[40,70,94],"moieties":[41,95],"been":[43],"extensively":[44],"studied,":[45],"whereas":[46],"replacements":[47],"coumarin":[50],"core":[51],"received":[53],"less":[54],"attention.":[55],"Herein,":[56],"24":[57],"cores":[58],"were":[59,87],"synthesized":[60],"with":[61,103],"varying":[62],"distances":[63],"angles":[65,104],"between":[66,96],"moieties.":[71],"Compounds":[72],"that":[73,89],"exhibited":[74],"good":[75],"anti-proliferative":[76],"activity":[77],"against":[78],"multiple":[79],"cancer":[80],"cell":[81],"lines":[82],"Hsp90":[84],"inhibitory":[85],"activity,":[86],"those":[88],"placed":[90],"7.7":[97],"12.1":[99],"\u00c5":[100],"apart":[101],"along":[102],"180\u00b0.":[106]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}