{"id":"https://openalex.org/W2328320163","doi":"https://doi.org/10.5152/akd.2012.181","title":"Effect of overnight nasal continuous positive airway pressure treatment on the endothelial function in patients with obstructive sleep apnea","display_name":"Effect of overnight nasal continuous positive airway pressure treatment on the endothelial function in patients with obstructive sleep apnea","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2328320163","doi":"https://doi.org/10.5152/akd.2012.181","mag":"2328320163","pmid":"https://pubmed.ncbi.nlm.nih.gov/22804976"},"language":"en","primary_location":{"id":"doi:10.5152/akd.2012.181","doi":"https://doi.org/10.5152/akd.2012.181","is_oa":false,"landing_page_url":"https://doi.org/10.5152/akd.2012.181","pdf_url":null,"source":{"id":"https://openalex.org/S4210176549","display_name":"The Anatolian Journal of Cardiology","issn_l":"1302-8723","issn":["1302-8723","1308-0032","2149-2263","2149-2271"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318429","host_organization_name":"KARE Publishing","host_organization_lineage":["https://openalex.org/P4310318429"],"host_organization_lineage_names":["KARE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047633700","display_name":"Murat Tulma\u00e7","orcid":"https://orcid.org/0000-0001-7491-5447","observed_orcids":["https://orcid.org/0000-0001-7491-5447"]},"institutions":[{"id":"https://openalex.org/I45642913","display_name":"K\u0131r\u0131kkale University","ror":"https://ror.org/01zhwwf82","country_code":"TR","type":"education","lineage":["https://openalex.org/I45642913"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Murat Tulmac","raw_affiliation_strings":["Department of Cardiology, Faculty of Medicine, K\u0131r\u0131kkale University, K\u0131r\u0131kkale-Turkey. mtulmac@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Faculty of Medicine, K\u0131r\u0131kkale University, K\u0131r\u0131kkale-Turkey. mtulmac@yahoo.com","institution_ids":["https://openalex.org/I45642913"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020343827","display_name":"E. Tireli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emine Tireli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019972773","display_name":"Haksun Ebin\u00e7","orcid":"https://orcid.org/0000-0001-5362-5037","observed_orcids":["https://orcid.org/0000-0001-5362-5037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haksun Ebinc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032018060","display_name":"Vedat \u015eim\u015fek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vedat Simsek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027238288","display_name":"Mehmet Do\u011fru","orcid":"https://orcid.org/0000-0002-2287-2913","observed_orcids":["https://orcid.org/0000-0002-2287-2913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehmet Tolga Dogru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060866682","display_name":"Neslig\u00fcl Y\u0131ld\u0131r\u0131m","orcid":"https://orcid.org/0000-0001-6522-0723","observed_orcids":["https://orcid.org/0000-0001-6522-0723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nesligul Yildirim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084813734","display_name":"\u00dc\u00e7ler K\u0131sa","orcid":"https://orcid.org/0000-0002-8131-6810","observed_orcids":["https://orcid.org/0000-0002-8131-6810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ucler Kisa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103220300","display_name":"Mehmet Savas Ekici","orcid":"https://orcid.org/0000-0002-9382-3780","observed_orcids":["https://orcid.org/0000-0002-9382-3780"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehmet Savas Ekici","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4102,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.66767125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"12","issue":"7","first_page":"560","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9369999766349792},{"id":"https://openalex.org/keywords/continuous-positive-airway-pressure","display_name":"continuous positive airway pressure","score":0.949999988079071},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9079999923706055},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9210000038146973},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/brachial-artery","display_name":"brachial artery","score":0.859000027179718},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.8939999938011169},{"id":"https://openalex.org/keywords/apnea-hypopnea-index","display_name":"apnea-hypopnea index","score":0.8339999914169312},{"id":"https://openalex.org/keywords/oxygen-desaturation","display_name":"oxygen desaturation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cpap-titration","display_name":"CPAP titration","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9314181804656982},{"id":"https://openalex.org/C2779547634","wikidata":"https://www.wikidata.org/wiki/Q5165502","display_name":"Continuous positive airway pressure","level":3,"score":0.8919052481651306},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.7366230487823486},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.62259441614151},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5437435507774353},{"id":"https://openalex.org/C2777604165","wikidata":"https://www.wikidata.org/wiki/Q503643","display_name":"Brachial artery","level":3,"score":0.5075119733810425},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.48715659976005554},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.46127817034721375},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.45578163862228394},{"id":"https://openalex.org/C2775867611","wikidata":"https://www.wikidata.org/wiki/Q1024207","display_name":"Positive airway pressure","level":3,"score":0.4197719693183899},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2712262272834778}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001916","descriptor_name":"Brachial Artery","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D045422","descriptor_name":"Continuous Positive Airway Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5152/akd.2012.181","doi":"https://doi.org/10.5152/akd.2012.181","is_oa":false,"landing_page_url":"https://doi.org/10.5152/akd.2012.181","pdf_url":null,"source":{"id":"https://openalex.org/S4210176549","display_name":"The Anatolian Journal of Cardiology","issn_l":"1302-8723","issn":["1302-8723","1308-0032","2149-2263","2149-2271"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318429","host_organization_name":"KARE Publishing","host_organization_lineage":["https://openalex.org/P4310318429"],"host_organization_lineage_names":["KARE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology","raw_type":"journal-article"},{"id":"pmid:22804976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22804976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W174047837","https://openalex.org/W1730924775","https://openalex.org/W1788205751","https://openalex.org/W1944246003","https://openalex.org/W1971373573","https://openalex.org/W1977325333","https://openalex.org/W2023666431","https://openalex.org/W2034556696","https://openalex.org/W2034713111","https://openalex.org/W2044863207","https://openalex.org/W2044972872","https://openalex.org/W2050244432","https://openalex.org/W2075965559","https://openalex.org/W2088639163","https://openalex.org/W2089636521","https://openalex.org/W2093400445","https://openalex.org/W2099694698","https://openalex.org/W2107945456","https://openalex.org/W2110301362","https://openalex.org/W2113446450","https://openalex.org/W2125813445","https://openalex.org/W2128816052","https://openalex.org/W2129851857","https://openalex.org/W2131418380","https://openalex.org/W2136431713","https://openalex.org/W2137272432","https://openalex.org/W2142930560","https://openalex.org/W2163566951","https://openalex.org/W2172298523","https://openalex.org/W2355257372","https://openalex.org/W3023775830"],"related_works":["https://openalex.org/W2724460450","https://openalex.org/W7140030696","https://openalex.org/W1615367021","https://openalex.org/W1531836827","https://openalex.org/W3032775683","https://openalex.org/W1730924775","https://openalex.org/W2013679956","https://openalex.org/W1966272886","https://openalex.org/W2461629517","https://openalex.org/W2142930560"],"abstract_inverted_index":{"OBJECTIVE:":[0],"In":[1,169],"this":[2,56],"prospective":[3],"study,":[4],"we":[5],"aimed":[6],"to":[7,162],"investigate":[8],"acute":[9,166,181],"effect":[10],"of":[11,23,66,112,147,165,183],"nasal":[12],"continuous":[13],"positive":[14],"airway":[15],"pressure":[16],"(CPAP)":[17],"therapy":[18,91,117,155,176],"on":[19],"the":[20,148],"endothelial":[21,149,157,187],"function":[22,150],"patients":[24,45,67,113,161],"with":[25,46,78,151,186],"obstructive":[26],"sleep":[27],"apnea":[28,92],"syndrome":[29],"(OSA)":[30],"by":[31],"using":[32],"brachial":[33],"artery":[34],"flow":[35],"mediated":[36],"dilatation":[37],"(FMD)":[38],"method.":[39],"METHODS:":[40],"Newly":[41],"diagnosed":[42],"thirty":[43],"OSA":[44,160,173],"ages":[47],"between":[48],"29":[49],"and":[50,59,70,101,171],"72":[51],"years":[52],"were":[53,76,95,138],"included":[54],"in":[55,159,180],"study.":[57],"FMD":[58,122],"high":[60],"sensitivity":[61],"C-reactive":[62],"protein":[63],"(hsCRP)":[64],"values":[65,123,135],"obtained":[68],"before":[69],"after":[71,115,126,136],"CPAP":[72,90,116,127,137,154,175],"dose":[73],"titration":[74],"test":[75,82],"compared":[77],"paired":[79],"samples":[80],"t":[81],"or":[83],"Wilcoxon":[84],"signed":[85],"ranks":[86],"test.":[87],"RESULTS:":[88],"With":[89],"hypopnea":[93],"indices":[94,104],"reduced":[96],"(60.6\u00b124.9/h":[97],"vs.":[98,107,119,130],"9.6\u00b17.9/h;":[99],"p<0.001)":[100],"oxygen":[102],"desaturation":[103],"recovered":[105],"(50\u00b127/h":[106],"6\u00b17/h;":[108],"p<0.001).":[109],"Heart":[110],"rates":[111],"decreased":[114],"(80\u00b110/min":[118],"73\u00b18/min;":[120],"p=0.003).":[121,133],"significantly":[124],"increased":[125],"(8.55\u00b15.82":[128],"percent":[129],"12.08\u00b17.17":[131],"percent;":[132],"HsCRP":[134],"not":[139],"different":[140],"from":[141],"baseline":[142],"values.":[143],"CONCLUSION:":[144],"Acute":[145],"improvement":[146],"one":[152],"night":[153],"suggests":[156],"dysfunction":[158],"be":[163,178],"result":[164],"pathophysiologic":[167],"factors.":[168],"intermediate":[170],"severe":[172],"patients,":[174],"may":[177],"considered":[179],"treatment":[182],"diseases":[184],"associated":[185],"dysfunction.":[188]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}