{"id":"https://openalex.org/W2328250085","doi":"https://doi.org/10.1097/nen.0000000000000108","title":"Neuropathology of the Anterior Midcingulate Cortex in Young Children With Autism","display_name":"Neuropathology of the Anterior Midcingulate Cortex in Young Children With Autism","publication_year":2014,"publication_date":"2014-08-07","ids":{"openalex":"https://openalex.org/W2328250085","doi":"https://doi.org/10.1097/nen.0000000000000108","mag":"2328250085","pmid":"https://pubmed.ncbi.nlm.nih.gov/25101703"},"language":"en","primary_location":{"id":"doi:10.1097/nen.0000000000000108","doi":"https://doi.org/10.1097/nen.0000000000000108","is_oa":false,"landing_page_url":"https://doi.org/10.1097/nen.0000000000000108","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology & Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114259666","display_name":"Neha Uppal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Neha Uppal","raw_affiliation_strings":["From the Fishberg Department of Neuroscience (NU, BW, PRH), Friedman Brain Institute (NU, BW, JDB, PRH), Seaver Autism Center for Research and Treatment (NU, JDB, PRH), Graduate School of Biomedical Sciences (NU, JDB, PRH), and Department of Psychiatry (JDB), Icahn School of Medicine at Mount Sinai, New York, New York; and Morphologic Brain Research Unit, Department of Psychiatry, University of W\u00fcrzburg, W\u00fcrzburg (HH); and Department of Neuroanatomy, Ludwig-Maximilians University of Munich, Munich (CS), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Fishberg Department of Neuroscience (NU, BW, PRH), Friedman Brain Institute (NU, BW, JDB, PRH), Seaver Autism Center for Research and Treatment (NU, JDB, PRH), Graduate School of Biomedical Sciences (NU, JDB, PRH), and Department of Psychiatry (JDB), Icahn School of Medicine at Mount Sinai, New York, New York; and Morphologic Brain Research Unit, Department of Psychiatry, University of W\u00fcrzburg, W\u00fcrzburg (HH); and Department of Neuroanatomy, Ludwig-Maximilians University of Munich, Munich (CS), Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042966285","display_name":"Bridget A. Wicinski","orcid":"https://orcid.org/0000-0002-2972-7081","observed_orcids":["https://orcid.org/0000-0002-2972-7081"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bridget Wicinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037444292","display_name":"Joseph D. Buxbaum","orcid":"https://orcid.org/0000-0001-8898-8313","observed_orcids":["https://orcid.org/0000-0001-8898-8313"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph D. Buxbaum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058004932","display_name":"Helmut Heinsen","orcid":"https://orcid.org/0000-0002-4688-4441","observed_orcids":["https://orcid.org/0000-0002-4688-4441"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helmut Heinsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077726948","display_name":"Christoph Schmitz","orcid":"https://orcid.org/0000-0002-4065-1241","observed_orcids":["https://orcid.org/0000-0002-4065-1241","https://orcid.org/0000-0002-6996-3062","https://orcid.org/0000-0002-5813-6627","https://orcid.org/0000-0003-4579-2454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph Schmitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073037534","display_name":"Patrick R. Hof","orcid":"https://orcid.org/0000-0002-3208-1154","observed_orcids":["https://orcid.org/0000-0002-3208-1154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick R. Hof","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5036,"currency":"USD","value_usd":5036},"apc_paid":null,"fwci":3.83,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.93921395,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"73","issue":"9","first_page":"891","last_page":"902"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13393","display_name":"Child Nutrition and Feeding Issues","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.8510000109672546},{"id":"https://openalex.org/keywords/anterior-midcingulate-cortex","display_name":"anterior midcingulate cortex","score":0.9789999723434448},{"id":"https://openalex.org/keywords/von-economo-neurons","display_name":"von Economo neurons","score":0.9769999980926514},{"id":"https://openalex.org/keywords/layer-v","display_name":"layer V","score":0.6200000047683716},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.9739999771118164},{"id":"https://openalex.org/keywords/neuron-size","display_name":"neuron size","score":0.8489999771118164},{"id":"https://openalex.org/keywords/autism-severity","display_name":"autism severity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/young-children","display_name":"young children","score":0.828000009059906},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.550000011920929},{"id":"https://openalex.org/keywords/stereology","display_name":"stereology","score":0.722000002861023},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/decision-making","display_name":"decision-making","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.8325777649879456},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.7990525960922241},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6612372398376465},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6331197023391724},{"id":"https://openalex.org/C2778402161","wikidata":"https://www.wikidata.org/wiki/Q2121931","display_name":"Anterior cingulate cortex","level":3,"score":0.622365415096283},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5308358073234558},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4548299312591553},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.40265679359436035},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.329184889793396},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3084707260131836},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24298155307769775},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15694281458854675},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10929843783378601}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011180","descriptor_name":"Postmortem Changes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/nen.0000000000000108","doi":"https://doi.org/10.1097/nen.0000000000000108","is_oa":false,"landing_page_url":"https://doi.org/10.1097/nen.0000000000000108","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology & Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:25101703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25101703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuropathology and experimental neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1832851023","display_name":"MRC Brain Banks: Joint Application to Underpin Neuroscience Research","funder_award_id":"MR/L022656/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320325356","display_name":"Julius-Maximilians-Universit\u00e4t W\u00fcrzburg","ror":"https://ror.org/00fbnyb24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W988307769","https://openalex.org/W1560420827","https://openalex.org/W1582697909","https://openalex.org/W1694363227","https://openalex.org/W1775562370","https://openalex.org/W1964795016","https://openalex.org/W1970848271","https://openalex.org/W1972030416","https://openalex.org/W1978611788","https://openalex.org/W1981718108","https://openalex.org/W1981725931","https://openalex.org/W1983230739","https://openalex.org/W1989389824","https://openalex.org/W2001597020","https://openalex.org/W2006953192","https://openalex.org/W2010460856","https://openalex.org/W2011524111","https://openalex.org/W2013610849","https://openalex.org/W2015446064","https://openalex.org/W2020331645","https://openalex.org/W2020754901","https://openalex.org/W2028365182","https://openalex.org/W2028850601","https://openalex.org/W2029172539","https://openalex.org/W2032408259","https://openalex.org/W2033303831","https://openalex.org/W2040739567","https://openalex.org/W2046683077","https://openalex.org/W2053264733","https://openalex.org/W2054766674","https://openalex.org/W2055838821","https://openalex.org/W2056575770","https://openalex.org/W2060850799","https://openalex.org/W2062178487","https://openalex.org/W2064029491","https://openalex.org/W2066040849","https://openalex.org/W2066612174","https://openalex.org/W2067033192","https://openalex.org/W2074457840","https://openalex.org/W2074615650","https://openalex.org/W2075684611","https://openalex.org/W2082646619","https://openalex.org/W2084577485","https://openalex.org/W2087404207","https://openalex.org/W2087838692","https://openalex.org/W2089781893","https://openalex.org/W2093991561","https://openalex.org/W2094232765","https://openalex.org/W2096702554","https://openalex.org/W2101682915","https://openalex.org/W2104135024","https://openalex.org/W2106089606","https://openalex.org/W2107029685","https://openalex.org/W2107751026","https://openalex.org/W2108752612","https://openalex.org/W2109301184","https://openalex.org/W2109473621","https://openalex.org/W2111405228","https://openalex.org/W2112135274","https://openalex.org/W2115440535","https://openalex.org/W2119674528","https://openalex.org/W2122544073","https://openalex.org/W2123574770","https://openalex.org/W2124712820","https://openalex.org/W2125375538","https://openalex.org/W2125823313","https://openalex.org/W2131541104","https://openalex.org/W2140077363","https://openalex.org/W2142438562","https://openalex.org/W2150382179","https://openalex.org/W2150993660","https://openalex.org/W2159011576","https://openalex.org/W2160790090","https://openalex.org/W2162500823","https://openalex.org/W2165266294","https://openalex.org/W2166945966","https://openalex.org/W2167126765","https://openalex.org/W2255119171","https://openalex.org/W2320580054","https://openalex.org/W2346906038","https://openalex.org/W2614349964","https://openalex.org/W2993036341","https://openalex.org/W4213073065","https://openalex.org/W4247665917","https://openalex.org/W4253449373"],"related_works":["https://openalex.org/W1981718108","https://openalex.org/W2066612174","https://openalex.org/W2094232765","https://openalex.org/W2941304317","https://openalex.org/W1487874592","https://openalex.org/W1546939270","https://openalex.org/W2066040849","https://openalex.org/W2010165945","https://openalex.org/W3087740593","https://openalex.org/W2144696231"],"abstract_inverted_index":{"The":[0],"anterior":[1,31],"cingulate":[2],"cortex,":[3],"which":[4,18],"is":[5,12,149],"involved":[6,67,150],"in":[7,14,17,22,39,44,68,85,122,151,165],"cognitive":[8],"and":[9,43,71,108,112],"affective":[10],"functioning,":[11],"important":[13],"investigating":[15],"disorders":[16],"individuals":[19],"exhibit":[20],"impairments":[21],"higher-order":[23],"functions.":[24],"In":[25],"this":[26],"study,":[27],"we":[28,78],"examined":[29],"the":[30,36,54,101,128,147,166,170],"midcingulate":[32],"cortex":[33],"(aMCC)":[34],"at":[35],"cellular":[37],"level":[38],"patients":[40],"with":[41,119,134],"autism":[42,120,135],"controls.":[45,145],"We":[46],"focused":[47,72],"our":[48],"analysis":[49],"on":[50],"layer":[51],"V":[52],"of":[53,169],"aMCC":[55,148],"because":[56],"it":[57],"contains":[58],"von":[59,86,113],"Economo":[60,87,114],"neurons,":[61],"specialized":[62],"cells":[63],"thought":[64],"to":[65],"be":[66],"emotional":[69],"expression":[70],"attention.":[73],"Using":[74],"a":[75,162],"stereologic":[76],"approach,":[77],"determined":[79],"whether":[80],"there":[81],"were":[82,103],"neuropathologic":[83],"changes":[84],"neuron":[88,91,95,111,115,158],"number,":[89,92],"pyramidal":[90,94,110,140,157],"or":[93],"size":[96,159],"between":[97],"diagnostic":[98],"groups.":[99],"When":[100],"groups":[102],"subdivided":[104],"into":[105],"young":[106,123],"children":[107,133],"adolescents,":[109],"numbers":[116],"positively":[117],"correlated":[118],"severity":[121],"children,":[124],"as":[125],"measured":[126],"by":[127],"Autism":[129],"Diagnostic":[130],"Interview-Revised.":[131],"Young":[132],"also":[136],"had":[137],"significantly":[138],"smaller":[139],"neurons":[141],"than":[142],"their":[143],"matched":[144],"Because":[146],"decision-making":[152],"during":[153],"uncertain":[154],"situations,":[155],"decreased":[156],"may":[160],"reflect":[161],"potential":[163],"reduction":[164],"functional":[167],"connectivity":[168],"aMCC.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}