{"id":"https://openalex.org/W2328097860","doi":"https://doi.org/10.1097/01.pcc.0000449022.67001.28","title":"ABSTRACT 296","display_name":"ABSTRACT 296","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W2328097860","doi":"https://doi.org/10.1097/01.pcc.0000449022.67001.28","mag":"2328097860"},"language":"en","primary_location":{"id":"doi:10.1097/01.pcc.0000449022.67001.28","doi":"https://doi.org/10.1097/01.pcc.0000449022.67001.28","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pcc.0000449022.67001.28","pdf_url":null,"source":{"id":"https://openalex.org/S180821644","display_name":"Pediatric Critical Care Medicine","issn_l":"1529-7535","issn":["1529-7535","1947-3893"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058539102","display_name":"Kaitlin M. Best","orcid":"https://orcid.org/0000-0003-1543-8489","observed_orcids":["https://orcid.org/0000-0003-1543-8489"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.M. Best","raw_affiliation_strings":["School of Nursing, University of Pennsylvania, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011667673","display_name":"Martha A. Q. Curley","orcid":"https://orcid.org/0000-0001-5228-6694","observed_orcids":["https://orcid.org/0000-0001-5228-6694"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.A.Q. Curley","raw_affiliation_strings":["School of Nursing, University of Pennsylvania, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":null,"first_page":"70","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.17520000040531158,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.031300000846385956,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iatrogenic-withdrawal-syndrome","display_name":"iatrogenic withdrawal syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/opioid-withdrawal","display_name":"opioid withdrawal","score":0.8450000286102295},{"id":"https://openalex.org/keywords/benzodiazepine-withdrawal","display_name":"benzodiazepine withdrawal","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sedation-weaning","display_name":"sedation weaning","score":0.828000009059906},{"id":"https://openalex.org/keywords/critically-ill-children","display_name":"critically ill children","score":0.8140000104904175},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/conceptual-model","display_name":"conceptual model","score":0.8610000014305115},{"id":"https://openalex.org/keywords/weaning-protocols","display_name":"weaning protocols","score":0.7860000133514404},{"id":"https://openalex.org/keywords/protocol-adherence","display_name":"protocol adherence","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9239621162414551},{"id":"https://openalex.org/C2781145037","wikidata":"https://www.wikidata.org/wiki/Q5011772","display_name":"CINAHL","level":3,"score":0.6328555941581726},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.5877617001533508},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5862922072410583},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5176718235015869},{"id":"https://openalex.org/C2777602617","wikidata":"https://www.wikidata.org/wiki/Q847705","display_name":"Sedative","level":2,"score":0.4706650972366333},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.46080517768859863},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4237425923347473},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3551344871520996},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.16656216979026794},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.16436219215393066},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15054520964622498},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.pcc.0000449022.67001.28","doi":"https://doi.org/10.1097/01.pcc.0000449022.67001.28","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pcc.0000449022.67001.28","pdf_url":null,"source":{"id":"https://openalex.org/S180821644","display_name":"Pediatric Critical Care Medicine","issn_l":"1529-7535","issn":["1529-7535","1947-3893"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Critical Care Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1963833289","https://openalex.org/W2514321669","https://openalex.org/W2009946097","https://openalex.org/W2912125288","https://openalex.org/W2177607895","https://openalex.org/W2979672788","https://openalex.org/W2320951585","https://openalex.org/W4400613639","https://openalex.org/W4311071593","https://openalex.org/W3136730000"],"abstract_inverted_index":{"Background":[0],"and":[1,87,100,103,111,132,145,159,210],"aims:":[2],"Iatrogenic":[3],"withdrawal":[4],"syndrome":[5],"(IWS)":[6],"\u2013":[7,26],"physiologic":[8,214],"symptoms":[9],"that":[10],"manifest":[11],"following":[12],"rapid":[13],"weaning":[14,157],"or":[15,20],"abrupt":[16],"cessation":[17],"of":[18,36,41,50,57,71,91,120,148,152,161,192,198,207],"opioids":[19],"benzodiazepines":[21],"in":[22,29,126,216],"drug":[23],"tolerant":[24],"patients":[25],"is":[27,186],"prevalent":[28],"critically":[30,127],"ill":[31,128],"children":[32],"receiving":[33],">5":[34],"days":[35],"sedation.":[37],"Aims:":[38],"The":[39,200],"purpose":[40],"this":[42],"study":[43],"was":[44,81],"to":[45,54,59,77,138,188,195],"develop":[46],"a":[47,61,173,218],"conceptual":[48,202],"model":[49,203],"risk":[51,121,197,220],"factors":[52,122,136,178,194,212],"contributing":[53],"the":[55,72,88,139,190,205],"development":[56],"IWS,":[58],"provide":[60],"theoretical":[62],"basis":[63],"for":[64,221],"future":[65],"research.":[66],"Methods:":[67],"A":[68],"systematic":[69],"review":[70],"literature":[73,116],"(1":[74],"January":[75],"1980":[76],"10":[78],"December":[79],"2013)":[80],"conducted,":[82],"using":[83],"PubMed,":[84],"EMBASE,":[85],"CINAHL,":[86],"Cochrane":[89],"Registry":[90],"Clinical":[92],"Trials.":[93],"Search":[94],"terms":[95],"included":[96],"\u201crespiration,":[97],"artificial,\u201d":[98],"\u201cweaning,\u201d":[99],"\u201canalgesics,":[101],"opioid\u201d":[102],"\u201cbenzodiazepines.\u201d":[104],"Data":[105],"were":[106],"extracted":[107],"into":[108],"pre-determined":[109],"tables":[110],"qualitatively":[112],"synthesized.":[113],"Results:":[114],"Current":[115],"suggests":[117],"three":[118],"categories":[119],"associated":[123],"with":[124,213],"IWS":[125],"children:":[129],"patient-,":[130,208],"process-":[131],"system-level":[133,193,211],"factors.":[134,167],"Risk":[135],"specific":[137],"patient":[140],"include":[141],"age,":[142],"disease":[143],"severity,":[144],"cumulative":[146],"dose":[147],"sedative":[149],"medication.":[150],"Use":[151],"validated":[153],"assessment":[154],"tools,":[155],"standardized":[156],"protocols,":[158],"prescription":[160],"multiple":[162],"adjunctive":[163],"agents":[164],"are":[165],"process-level":[166],"Finally,":[168],"sedation":[169],"therapy":[170],"occurs":[171],"within":[172],"system":[174],"context,":[175],"which":[176],"determines":[177],"such":[179],"as":[180],"protocol":[181],"compliance.":[182],"However,":[183],"further":[184],"work":[185],"needed":[187],"elucidate":[189],"contributions":[191],"overall":[196],"IWS.FigureConclusions:":[199],"proposed":[201],"illustrates":[204],"convergence":[206],"process-,":[209],"tolerance":[215],"determining":[217],"patient\u2019s":[219],"IWS.":[222]},"counts_by_year":[],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2016-06-24T00:00:00"}