{"id":"https://openalex.org/W2328035482","doi":"https://doi.org/10.1021/jm501123r","title":"Structure-Based Lead Optimization and Biological Evaluation of BAX Direct Activators as Novel Potential Anticancer Agents","display_name":"Structure-Based Lead Optimization and Biological Evaluation of BAX Direct Activators as Novel Potential Anticancer Agents","publication_year":2015,"publication_date":"2015-02-10","ids":{"openalex":"https://openalex.org/W2328035482","doi":"https://doi.org/10.1021/jm501123r","mag":"2328035482","pmid":"https://pubmed.ncbi.nlm.nih.gov/25668341"},"language":"en","primary_location":{"id":"doi:10.1021/jm501123r","doi":"https://doi.org/10.1021/jm501123r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm501123r","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11568/744873","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037952913","display_name":"Mariano Stornaiuolo","orcid":"https://orcid.org/0000-0003-2200-5083","observed_orcids":["https://orcid.org/0000-0003-2200-5083"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Mariano Stornaiuolo","raw_affiliation_strings":["Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079137929","display_name":"Giuseppe La Regina","orcid":"https://orcid.org/0000-0003-3252-1161","observed_orcids":["https://orcid.org/0000-0003-3252-1161"]},"institutions":[{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe La Regina","raw_affiliation_strings":["Istituto\rPasteur\u2014Fondazione Cenci Bolognetti, Dipartimento di Chimica\re Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma, Piazzale Aldo\rMoro 5, I-00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto\rPasteur\u2014Fondazione Cenci Bolognetti, Dipartimento di Chimica\re Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma, Piazzale Aldo\rMoro 5, I-00185 Roma, Italy","institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028347603","display_name":"Sara Passacantilli","orcid":"https://orcid.org/0000-0001-9781-0621","observed_orcids":["https://orcid.org/0000-0001-9781-0621"]},"institutions":[{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Passacantilli","raw_affiliation_strings":["Istituto\rPasteur\u2014Fondazione Cenci Bolognetti, Dipartimento di Chimica\re Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma, Piazzale Aldo\rMoro 5, I-00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto\rPasteur\u2014Fondazione Cenci Bolognetti, Dipartimento di Chimica\re Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma, Piazzale Aldo\rMoro 5, I-00185 Roma, Italy","institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065606348","display_name":"Gianluca Grassia","orcid":"https://orcid.org/0000-0001-7846-5594","observed_orcids":["https://orcid.org/0000-0001-7846-5594"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Grassia","raw_affiliation_strings":["Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058536580","display_name":"Antonio Coluccia","orcid":"https://orcid.org/0000-0002-7940-8206","observed_orcids":["https://orcid.org/0000-0002-7940-8206"]},"institutions":[{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Coluccia","raw_affiliation_strings":["Istituto\rPasteur\u2014Fondazione Cenci Bolognetti, Dipartimento di Chimica\re Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma, Piazzale Aldo\rMoro 5, I-00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto\rPasteur\u2014Fondazione Cenci Bolognetti, Dipartimento di Chimica\re Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma, Piazzale Aldo\rMoro 5, I-00185 Roma, Italy","institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072879742","display_name":"Valeria La Pietra","orcid":"https://orcid.org/0000-0001-8096-8377","observed_orcids":["https://orcid.org/0000-0001-8096-8377"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria La Pietra","raw_affiliation_strings":["Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059969159","display_name":"Mariateresa Giustiniano","orcid":"https://orcid.org/0000-0002-6856-414X","observed_orcids":["https://orcid.org/0000-0002-6856-414X"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariateresa Giustiniano","raw_affiliation_strings":["Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058661953","display_name":"Hilde Cassese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Hilde Cassese","raw_affiliation_strings":["Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086258533","display_name":"Salvatore Di Maro","orcid":"https://orcid.org/0000-0002-9286-4433","observed_orcids":["https://orcid.org/0000-0002-9286-4433"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore Di Maro","raw_affiliation_strings":["Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024121378","display_name":"Diego Brancaccio","orcid":"https://orcid.org/0000-0002-2256-5534","observed_orcids":["https://orcid.org/0000-0002-2256-5534"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Diego Brancaccio","raw_affiliation_strings":["Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002153460","display_name":"Sabrina Taliani","orcid":"https://orcid.org/0000-0001-8675-939X","observed_orcids":["https://orcid.org/0000-0001-8675-939X"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabrina Taliani","raw_affiliation_strings":["Dipartimento\rdi Farmacia, Universit\u00e0 di Pisa, Via Bonanno 6, 56126 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Farmacia, Universit\u00e0 di Pisa, Via Bonanno 6, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039818353","display_name":"Armando Ialenti","orcid":"https://orcid.org/0000-0002-8046-0116","observed_orcids":["https://orcid.org/0000-0002-8046-0116"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Armando Ialenti","raw_affiliation_strings":["Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057141634","display_name":"Romano Silvestri","orcid":"https://orcid.org/0000-0003-2489-0178","observed_orcids":["https://orcid.org/0000-0003-2489-0178"]},"institutions":[{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Romano Silvestri","raw_affiliation_strings":["Istituto\rPasteur\u2014Fondazione Cenci Bolognetti, Dipartimento di Chimica\re Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma, Piazzale Aldo\rMoro 5, I-00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto\rPasteur\u2014Fondazione Cenci Bolognetti, Dipartimento di Chimica\re Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma, Piazzale Aldo\rMoro 5, I-00185 Roma, Italy","institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067808979","display_name":"Claudia Martini","orcid":"https://orcid.org/0000-0001-9379-3027","observed_orcids":["https://orcid.org/0000-0001-9379-3027"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Martini","raw_affiliation_strings":["Dipartimento\rdi Farmacia, Universit\u00e0 di Pisa, Via Bonanno 6, 56126 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Farmacia, Universit\u00e0 di Pisa, Via Bonanno 6, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040940946","display_name":"Ettore Novellino","orcid":"https://orcid.org/0000-0002-2181-2142","observed_orcids":["https://orcid.org/0000-0002-2181-2142"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ettore Novellino","raw_affiliation_strings":["Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008036169","display_name":"Luciana Marinelli","orcid":"https://orcid.org/0000-0002-4084-8044","observed_orcids":["https://orcid.org/0000-0002-4084-8044"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luciana Marinelli","raw_affiliation_strings":["Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Farmacia, Universit\u00e0 di Napoli \u201cFederico II\u201d, via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008036169","https://openalex.org/A5037952913"],"corresponding_institution_ids":["https://openalex.org/I71267560"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.694,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.83793848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"58","issue":"5","first_page":"2135","last_page":"2148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.8640000224113464},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.9810000061988831},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6449999809265137},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9079999923706055},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.625},{"id":"https://openalex.org/keywords/pro-apoptotic-proteins","display_name":"pro-apoptotic proteins","score":0.6290000081062317},{"id":"https://openalex.org/keywords/small-molecule-activators","display_name":"small molecule activators","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8529171943664551},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.7029972076416016},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.7005318403244019},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.44163185358047485},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4318371117115021},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38214462995529175},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36399567127227783},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2789493203163147},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15945476293563843},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11279872059822083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0700395405292511}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1021/jm501123r","doi":"https://doi.org/10.1021/jm501123r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm501123r","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:25668341","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25668341","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Evaluation Study"},{"id":"pmh:oai:arpi.unipi.it:11568/744873","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11568/744873","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unicampania.it:11591/363129","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/363129","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/764095","doi":null,"is_oa":false,"landing_page_url":"http://pubs.acs.org/doi/abs/10.1021/jm501123r","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:arpi.unipi.it:11568/744873","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11568/744873","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W80462140","https://openalex.org/W1483773129","https://openalex.org/W1589900156","https://openalex.org/W1947696988","https://openalex.org/W1984547206","https://openalex.org/W1985588649","https://openalex.org/W1988363759","https://openalex.org/W1995666121","https://openalex.org/W2012076962","https://openalex.org/W2022665529","https://openalex.org/W2042912415","https://openalex.org/W2054260525","https://openalex.org/W2054917860","https://openalex.org/W2060335556","https://openalex.org/W2064560680","https://openalex.org/W2066571367","https://openalex.org/W2066798929","https://openalex.org/W2083113305","https://openalex.org/W2085419794","https://openalex.org/W2087238700","https://openalex.org/W2087947097","https://openalex.org/W2102377211","https://openalex.org/W2115388480","https://openalex.org/W2117060131","https://openalex.org/W2121201612","https://openalex.org/W2130122599","https://openalex.org/W2132629607","https://openalex.org/W2168632005","https://openalex.org/W2172242534","https://openalex.org/W3112630782","https://openalex.org/W4313314629"],"related_works":["https://openalex.org/W2086090273","https://openalex.org/W7139113527","https://openalex.org/W4314447448","https://openalex.org/W2886942290","https://openalex.org/W2953789780","https://openalex.org/W2792957500","https://openalex.org/W2167807253","https://openalex.org/W2885894157","https://openalex.org/W2042912415","https://openalex.org/W2315813386"],"abstract_inverted_index":{"The":[0],"first":[1,50],"direct":[2,57,67],"activator":[3],"of":[4,9,28,55],"BAX,":[5],"a":[6,18,25],"pro-apoptotic":[7],"member":[8],"the":[10,33,49,52,60],"BCL-2":[11],"family,":[12],"has":[13],"been":[14],"recently":[15],"identified.":[16],"Herein,":[17],"structure-based":[19],"lead":[20],"optimization":[21],"turned":[22],"out":[23],"into":[24],"small":[26],"series":[27],"analogues,":[29],"where":[30],"8":[31,40],"is":[32],"most":[34],"potent":[35],"compound":[36],"published":[37],"so":[38],"far.":[39],"was":[41],"used":[42],"as":[43],"pharmacological":[44],"tool":[45],"to":[46],"ascertain,":[47],"for":[48],"time,":[51],"anticancer":[53,72],"potential":[54,70],"BAX":[56,66],"activators":[58,68],"and":[59],"obtained":[61],"results":[62],"would":[63],"suggest":[64],"that":[65],"are":[69],"future":[71],"drugs":[73],"rather":[74],"than":[75],"venoms.":[76]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}