{"id":"https://openalex.org/W2328033639","doi":"https://doi.org/10.4172/2161-1149.1000e102","title":"Foxp3+ Regulatory T Cells: a Protagonist in the \u201cMovie\u2019\u2019 of Autoimmune Diseases?","display_name":"Foxp3+ Regulatory T Cells: a Protagonist in the \u201cMovie\u2019\u2019 of Autoimmune Diseases?","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2328033639","doi":"https://doi.org/10.4172/2161-1149.1000e102","mag":"2328033639"},"language":"en","primary_location":{"id":"doi:10.4172/2161-1149.1000e102","doi":"https://doi.org/10.4172/2161-1149.1000e102","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2161-1149.1000e102","pdf_url":null,"source":{"id":"https://openalex.org/S4210240078","display_name":"Rheumatology Current Research","issn_l":"2161-1149","issn":["2161-1149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology : Current Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101522508","display_name":"Anping Xu","orcid":"https://orcid.org/0009-0003-7300-8353","observed_orcids":["https://orcid.org/0009-0003-7300-8353"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anping Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100459732","display_name":"Ya Liu","orcid":"https://orcid.org/0000-0002-0750-4979","observed_orcids":["https://orcid.org/0000-0002-0750-4979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024307673","display_name":"Bernhard Ryffel","orcid":"https://orcid.org/0000-0003-2897-8230","observed_orcids":["https://orcid.org/0000-0003-2897-8230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernhard Ryffel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1316,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52358275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"01","issue":"02","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxp3-regulatory-t-cells","display_name":"Foxp3+ regulatory T cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.8309999704360962},{"id":"https://openalex.org/keywords/self-tolerance","display_name":"self-tolerance","score":0.8080000281333923},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.7630000114440918},{"id":"https://openalex.org/keywords/ipex-syndrome","display_name":"IPEX syndrome","score":0.949999988079071},{"id":"https://openalex.org/keywords/treg-therapy","display_name":"Treg therapy","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8686281442642212},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.6245120167732239},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.5625144839286804},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4819883704185486},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.12575846910476685},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.11168032884597778}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4172/2161-1149.1000e102","doi":"https://doi.org/10.4172/2161-1149.1000e102","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2161-1149.1000e102","pdf_url":null,"source":{"id":"https://openalex.org/S4210240078","display_name":"Rheumatology Current Research","issn_l":"2161-1149","issn":["2161-1149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology : Current Research","raw_type":"journal-article"},{"id":"mag:2187854801","doi":null,"is_oa":false,"landing_page_url":"https://omicsonline.org/foxp3-regulatory-t-cells-a-protagonist-in-the-movie-of-autoimmune-diseases-2161-1149.1000e102.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1499151513","https://openalex.org/W1503647569","https://openalex.org/W1518759830","https://openalex.org/W1567420244","https://openalex.org/W1575585006","https://openalex.org/W1736404394","https://openalex.org/W1756044145","https://openalex.org/W1787048953","https://openalex.org/W1845494926","https://openalex.org/W1967348106","https://openalex.org/W1972187865","https://openalex.org/W1977630588","https://openalex.org/W1978011938","https://openalex.org/W1981008354","https://openalex.org/W1987470436","https://openalex.org/W1992631484","https://openalex.org/W1993751578","https://openalex.org/W2001740313","https://openalex.org/W2002726823","https://openalex.org/W2004181951","https://openalex.org/W2021603971","https://openalex.org/W2030682069","https://openalex.org/W2030963386","https://openalex.org/W2039198873","https://openalex.org/W2042073660","https://openalex.org/W2045236396","https://openalex.org/W2048152449","https://openalex.org/W2051235406","https://openalex.org/W2053862070","https://openalex.org/W2071872861","https://openalex.org/W2083826829","https://openalex.org/W2093383759","https://openalex.org/W2094245959","https://openalex.org/W2095091733","https://openalex.org/W2097811455","https://openalex.org/W2108131087","https://openalex.org/W2111329034","https://openalex.org/W2113523651","https://openalex.org/W2116961420","https://openalex.org/W2120010406","https://openalex.org/W2123166427","https://openalex.org/W2123249923","https://openalex.org/W2130865756","https://openalex.org/W2137482508","https://openalex.org/W2139019810","https://openalex.org/W2147454918","https://openalex.org/W2150505180","https://openalex.org/W2150747144","https://openalex.org/W2168419126"],"related_works":["https://openalex.org/W2187854801","https://openalex.org/W2358548170","https://openalex.org/W7144312922","https://openalex.org/W2392029942","https://openalex.org/W2006732787","https://openalex.org/W2158225802","https://openalex.org/W2073166085","https://openalex.org/W2043858100","https://openalex.org/W2122722718","https://openalex.org/W2555923103"],"abstract_inverted_index":{"Although":[0],"CD4+CD25+Foxp3+":[1],"regulatory":[2],"or":[3,164,171],"suppressor":[4,69],"T":[5,114],"cells":[6,41,70,85],"(Tregs)":[7],"play":[8,26],"a":[9,129,190],"crucial":[10,90],"role":[11,24],"in":[12,27,42,86,179,183,187,203,208,215],"the":[13,22,63,87,92,132,143,153,167,209,216,223],"maintenance":[14],"of":[15,39,94,131,136,147,166,177,213,227],"self-tolerance":[16],"and":[17,52,56,77,105,145,149,189,211,225],"immune":[18,196],"homeostasis":[19],"against":[20],"self-antigen,":[21],"true":[23],"they":[25,81],"autoimmune":[28,43,193,229],"diseases":[29,44],"is":[30,45,99,109,139,150],"still":[31],"less":[32],"defined.":[33],"The":[34,206],"prospect":[35],"for":[36,91,103,142,156],"therapeutic":[37],"roles":[38],"these":[40,54],"somehow":[46],"fuzzy.":[47],"This":[48],"editorial":[49],"will":[50],"discuss":[51],"update":[53],"issues":[55],"proposes":[57],"several":[58],"new":[59],"directions":[60],"to":[61,111],"address":[62],"relative":[64],"concerns.":[65],"Thymus-derived,":[66],"naturally-occurring":[67],"CD4+CD25+":[68,84],"(nTregs)":[71],"were":[72],"originally":[73],"described":[74],"by":[75],"Sakaguchi":[76],"his":[78],"colleagues":[79],"where":[80],"identified":[82],"that":[83,119,127],"thymus":[88],"are":[89],"control":[93],"autoimmunity":[95],"[1].":[96],"As":[97],"CD25":[98],"also":[100],"activation":[101],"marker":[102,155],"lymphocytes":[104],"therefore":[106],"its":[107],"expression":[108],"unable":[110],"exclude":[112],"other":[113],"effector":[115],"(Teff)":[116],"cell":[117],"population":[118],"may":[120],"contaminate":[121],"Tregs.":[122],"Subsequent":[123],"studies":[124],"have":[125],"demonstrated":[126],"Foxp3,":[128],"member":[130],"forkhead/":[133],"winged-helix":[134],"family":[135],"transcription":[137],"factors,":[138],"essentially":[140],"important":[141],"differentiation":[144],"function":[146,212],"Tregs,":[148],"considered":[151],"as":[152],"best":[154],"their":[157],"phenotypic":[158],"identification":[159],"so":[160],"far":[161],"[2-4].":[162],"Mutation":[163],"disruption":[165],"Foxp3":[168,178],"(in":[169,173],"mouse)":[170,180],"FOXP3":[172],"human,":[174],"an":[175],"analogue":[176],"gene":[181],"resulted":[182],"fatal":[184],"lymphoproliferative":[185],"disorder":[186],"mice,":[188],"severe":[191],"multiple":[192],"disease":[194],"called":[195],"dysregulation,":[197],"polyendocrinopathy,":[198],"enteropathy":[199],"X-linked":[200],"syndrome":[201],"(IPEX)":[202],"humans":[204],"[5-7].":[205],"abnormality":[207],"numbers":[210],"Tregs":[214],"periphery":[217],"has":[218],"been":[219],"widely":[220],"associated":[221],"with":[222],"development":[224],"progression":[226],"many":[228],"diseases.":[230]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}